• 제목/요약/키워드: critical parameters

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해안 유사에서 수체로의 플라스틱 입자 방출에 관한 실험적 연구 (Experimental study on release of plastic particles from coastal sediments to fluid body)

  • 황동욱;박용성
    • 한국수자원학회논문집
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    • 제56권2호
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    • pp.125-137
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    • 2023
  • 지속적으로 증가하는 플라스틱의 사용으로 인하여 현재 해안·해양 환경에서 플라스틱을 찾기란 어렵지 않은 일이 되었다. 하천을 통해 해양으로 유출된 플라스틱 폐기물은 해안 지역에서 장기간 머물며, 파랑, 바람, 유사, 인간 활동 등과 같은 다양한 요인들과 상호작용하며 물리적·화학적 변화를 겪게 된다. 이에, 실험적 연구를 통하여 해안 유사에서 수체로의 플라스틱 입자 방출 과정을 고찰하고자 하였다. 본 연구는 고 레이놀즈 수를 가지는 왕복 흐름과 유사 이동을 구현하기 위한 왕복흐름발생장치를 제작하여 진행되었고, 세 가지의 크기를 가지는 매끈한 구형의 플라스틱 입자를 사용하였다. 실험 결과, 유사 내 플라스틱 입자의 방출은 유사 이동에 가장 큰 영향을 받았으며, 이는 흐름의 세기에 비례한다. 더불어, 입자가 작을수록 더 많은 입자가 방출되었다. 결과를 종합하여 입자의 방출을 결정하는 무차원 매개변수들의 임계값을 제시하였다.

공정분석기술: 제약산업에서의 기술개발 사례 및 현황 (Process analytical technology (PAT): field applications and current status in pharmaceutical industries)

  • 우영아;김종윤;박용준;연제원;송규석;김효진
    • 분석과학
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    • 제22권1호
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    • pp.35-43
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    • 2009
  • 단순히 완제품만을 평가하는 기존의 방법에서 제조 공정의 보다 깊은 이해와 공정 제어를 통한 품질 확보가 PAT (공정분석기술, process analytical technology)가 지향하고 있는 핵심이다. 생산 상 위험 요소가 많이 발생하는 공정을 제어할 수 있는 목적으로 새로운 실시간 공정 제어 기술을 개발하는 것이 PAT 연구 내용이다. 공정 단계에 대한 이해, 공정에 필요한 여러 가지 변수 및 공정 생산품의 평가 기술은 PAT를 수행하기 위한 기술적 핵심 요소이다. 이에 관련하여 다국적 제약회사의 실제 공정에서의 실시간 품질관리 사례는 상당히 많은 것으로 알려져 있으나, 제조공정 및 분석 기술 자체가 기업 비밀인 경우가 많아 관련 정보는 극히 제한되어 있다. 본 총설을 통하여 실제 제약 산업 현장에서 활용되고 있는 적용사례를 소개하고, 각 제조 공정 및 완제품 실시간 품질 관리를 위한 PAT 연구 사례 및 기술개발 현황에 대하여 언급하고자 한다.

Studying Thermochemical Conversion of Sm2O3 to SmCl3 using AlCl3 in LiCl-KCl Eutectic Melt

  • Samanta, Nibedita;Chandra, Manish;Maji, S.;Venkatesh, P.;Annapoorani, S.;Jain, Ashish
    • Journal of Electrochemical Science and Technology
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    • 제13권2호
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    • pp.279-291
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    • 2022
  • In this report the thermochemical conversion of Sm2O3 to SmCl3 using AlCl3 in LiCl-KCl melt at 773 K is discussed. The final product was a mixture of SmCl3, Al2O3, unreacted Sm2O3 and AlCl3 in the chloride melt. The electrochemical attributes of the mixture was analyzed with cyclic voltammetry (CV) and square wave voltammetry (SWV). The crystallographic phases of the mixture were studied with X-ray diffraction (XRD) technique. The major chemical conversion was optimized by varying the effective parameters, such as concentrations of AlCl3, duration of reaction and the amount of LiCl-KCl salt. The extent of conversion and qualitative assessment of efficiency of the present protocol were evaluated with fluorescence spectroscopy, UV-Vis spectrophotometry and inductively coupled plasma atomic emission spectroscopy (ICP-AES) studies of the mixture. Thus, a critical assessment of the thermochemical conversion efficiency was accomplished by analysing the amount of SmCl3 in LiCl-KCl melt. In the process, a conversion efficiency of 95% was achieved by doubling the stoichiometric requirement of AlCl3 in 50 g of LiCl-KCl salt. The conversion reaction was found to be very fast as the reaction reached equilibrium in 15 min.

시멘트 모르타르의 황산염침식 저항성에 대한 SO42- 이온 농도의 영향 (Influence of SO42- Ions Concentration on Sulfate Resistance of Cement Mortars)

  • 이승태
    • 대한토목학회논문집
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    • 제28권5A호
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    • pp.757-764
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    • 2008
  • 본 연구는 농도조건을 달리한 시험용액에 침지한 모르타르의 내구성을 평가하기 위하여 수행되었다. 3종류 시멘트 모르타르를 제조한 후, ${SO_4}^{2-}$ 이온의 농도가 4225, 8450, 16900 및 33800 ppm인 4종류 황산나트륨 용액에 540일간 침지하였으며, 침지재령별 압축강도 및 선형팽창을 측정하므로써 모르타르의 황산염침식 저항성을 실험적으로 평가하였다. 실험결과에 의하면, 고농도 황산나트륨 용액에 침지한 모르타르 공시체가 가장 심한 성능저하 현상을 나타내었다. 특히, 고농도 환경에서 모르타르의 팽창 특성은 사용된 시멘트의 $C_3A$량과 직접적인 관련이 있었으며, GGBS를 대체한 SGC 모르타르는 조직구조의 투수성이 상대적으로 낮은 탓으로 인하여 시험용액의 농도조건에 관계없이 우수한 황산염침식 저항성을 나타내었다.

국내 해안의 해빈-해안사구 지형 및 퇴적물 특성과 입도기반 사구유형 분석 (Morphological and Textural Characteristics of the Beach-dune System in South Korea, with the Possibility of a Dune Type Scheme Based on Grain-size Trend)

  • 류호상;강지현
    • 한국지형학회지
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    • 제27권3호
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    • pp.53-73
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    • 2020
  • Morphology and grain size distribution of coastal dunes should be well documented because they are critical to dune's buffering capacity and resilience against storm surges. The nationwide coastal dune survey produced the dataset, including beach-dune topographic profiles and grain size parameters for frontal beaches, foredunes, and inland dunes. This research investigated the dataset to describe geomorphic and textural properties of coastal dunes: foredune slopes, dune heights above approximately highest high water, mean size, and sorting, together with associated variables of coastal setting that influence coastal dunes. It also explores the possibility of a dune type scheme based on gran size trends. The results are as follows. First, the coast in which dunes are developed is the primary control on foredune morphology and sediment texture. Coastal dunes on the east coast were developed more alongshore rather than inland, with gentler slopes on the higher ground and out of coarser sand. The shore aspect contributes to this pattern because the east coast cannot benefit from prevailing northwesterly. Second, grain size trends from beaches through foredunes to inland dunes were little identified. Third, 12 dune types were identified from 69 dunes, showing the indicative capability for the status of beaches and dunes. We confirmed that the dataset could increase our understanding of the overall characteristics of coastal dune morphology and texture, though there is something to be improved, for example, establishing the refined and comprehensive field survey protocol.

Seismic control of high-speed railway bridge using S-shaped steel damping friction bearing

  • Guo, Wei;Wang, Yang;Zhai, Zhipeng;Du, Qiaodan
    • Smart Structures and Systems
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    • 제30권5호
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    • pp.479-500
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    • 2022
  • In this study, a new type of isolation bearing is proposed by combining S-shaped steel plate dampers (SSDs) with a spherical steel bearing, and the seismic control effect of a five-span standard high-speed railway bridge is investigated. The advantages of the proposed S-shaped steel damping friction bearing (SSDFB) are that it cannot only lengthen the structural periods, dissipate the seismic energy, but also prevent bridge unseating due to the restraint effectiveness of SSDs in the large relative displacements between the girders and piers. This study first presents a detailed description and working principle of the SSDFB. Then, mechanical modeling of the SSDFB was derived to fundamentally define its cyclic behavior and obtain key mechanical parameters. The numerical model of the SSDFB's critical component SSD was verified by comparing it with the experimental results. After that, parameter studies of the dimensions and number of SSDs, the friction coefficient, and the gap length of the SSDFBs were conducted. Finally, the longitudinal seismic responses of the bridge with SSDFBs were compared with the bridge with spherical bearing and spherical bearing with strengthened shear keys. The results showed that the SSDFB can not only significantly mitigate the shear force responses and residual displacement in bridge substructures but also can effectively reduce girder displacement and prevent bridge unseating, at a cost of inelastic deformation of the SSDs, which is easy to replace. In conclusion, the SSDFB is expected to be a cost-effective option with both multi-stage energy dissipation and restraint capacity, making it particularly suitable for seismic isolation application to high-speed railway bridges.

단축질소제거 공정을 이용한 가축분뇨의 적정 처리조건 연구 (Optimal Operation Condition of Livestock Wastewater Treatment Using Shortcut Biological Nitrogen Removal Process)

  • 강진영;장영호;정병환;김연진;김용호
    • 한국물환경학회지
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    • 제39권5호
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    • pp.390-395
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    • 2023
  • The feasibility of applying the shortcut nitrogen removal process to treat livestock wastewater on individual farms was examined, and appropriate operating parameters were established. As a result,, it was determined that the nitrification reaction was carried out under 550 mg/L of ammonium nitrogen concentration, but it was less effective under conditions of high ammonia concentration. Consequently, it was confirmed that a partial injection of inflow water was necessary to minimize the effects of ammonia toxicity. Following the sequential batch reactor (SBR) operation results, it was difficult to achieve the effluent quality standard without an external carbon source. Also, selection of the appropriate hydraulic retention time was critical for the optimal SBR operation. Following the livestock farm application, with external carbon source injecting, the total nitrogen concentration in the effluent was 85.1 mg/L. This result revealed that the standard could be accomplished through a single treatment on individual livestock farms. The ratio of nitrite nitrogen to ammonia nitrogen in the effluent was verified to be suitable for implementing the anammox process with a 10 days of hydraulic retention time. This study demonstrated the potential applicability of process in the future. However, in order to apply to livestock farms, managing variations in wastewater load across individual farms and addressing reduced nitrogen oxidation efficiency during the winter season are crucial.

이식형 흡수성 융복합 의료제품 규제 비교 연구 -미국, 유럽, 한국을 중심으로- (A Comparative Study on the Regulations on Implantable Bioabsorbable Combination Products -Focusing on the U.S., Europe and Korea-)

  • 이현정;김미혜;설주은;김수동;김주희
    • 대한의용생체공학회:의공학회지
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    • 제44권6호
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    • pp.414-427
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    • 2023
  • Implantable bioabsorbable combination products undergo inherent degradation and systemic absorption within the physiological environment, thereby streamlining the therapeutic regimen and obviating the imperative for invasive extraction procedures. This inherent property not only enhances patient convenience and therapeutic efficacy but also underpins a paradigm of support characterized by heightened safety parameters. Within the regulatory landscapes of Korea, the United States, and Europe, implantable bioabsorbable combination products are meticulously classified into distinct categories, either as pharmaceutical implants or as implantable medical devices, depending on their primary mode of action. This scholarly investigation systematically examines the regulatory frameworks governing implantable bioabsorbable combination products in South Korea, the United States, and Europe. Notable discrepancies across national jurisdictions emerge concerning regulatory specifics, including terminology, product classification, and product name associated with these products. The conspicuous absence of standardized approval regulations presents a formidable barrier to the commercialization of these advanced medical devices. This academic discourse passionately emphasizes the critical need for formulating and implementing a sophisticated regulatory framework capable of streamlining the product approval process, thereby paving the way for a seamless path to commercializing implantable bioabsorbable combination products.

고위력 폭약의 화강암 내 장약공 폭발에 의한 지반진동 전파특성에 관한 연구 (Propagation Characteristics of Ground Vibration Caused by Blast Hole Explosion of High Explosives in Granite)

  • 김경규;신찬휘;김한림;양주석;배상호;윤경재;조상호
    • 화약ㆍ발파
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    • 제41권4호
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    • pp.29-40
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    • 2023
  • 암반발파는 광업, 터널공사, 지하 구조물 구축 등 다양한 분야에서 활용되고 있으며, 특히 지하공간의 활용이 증가하면서 암반발파 기술이 더 중요한 역할을 하고 있다. 암반발파 시 발파공에서 발생하는 발파공의 압력은 파쇄도, 발파진동 등에 직접적인 영향을 미치는 변수이며, 폭약의 성능 평가 및 발파 결과 예측에 있어서 가장 중요한 매개변수 중 하나이다. 이와 같은 발파공 압력은 몇몇 연구자들에 의해 연구가 수행된 바가 있지만, 폭약의 종류, 폭약량, 발파조건 등 실험조건으로 인하여 비교가 어려운 실정이다. 본 연구에서는 발파공 압력센서와 관측공 압력센서를 제작하여 단일공 발파 시 발파공과 관측공의 압력을 측정하였다. 실험결과를 바탕으로 발파공 주변 압력 전파특성과 발파진동 전파특성에 대해 고찰하였다.

Application of T1 Map Information Based on Synthetic MRI for Dynamic Contrast-Enhanced Imaging: A Comparison Study with the Fixed Baseline T1 Value Method

  • Dong Jae Shin;Seung Hong Choi;Roh-Eul Yoo;Koung Mi Kang;Tae Jin Yun;Ji-Hoon Kim;Chul-Ho Sohn;Sang Won Jo;Eun Jung Lee
    • Korean Journal of Radiology
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    • 제22권8호
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    • pp.1352-1368
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    • 2021
  • Objective: For an accurate dynamic contrast-enhanced (DCE) MRI analysis, exact baseline T1 mapping is critical. The purpose of this study was to compare the pharmacokinetic parameters of DCE MRI using synthetic MRI with those using fixed baseline T1 values. Materials and Methods: This retrospective study included 102 patients who underwent both DCE and synthetic brain MRI. Two methods were set for the baseline T1: one using the fixed value and the other using the T1 map from synthetic MRI. The volume transfer constant (Ktrans), volume of the vascular plasma space (vp), and the volume of the extravascular extracellular space (ve) were compared between the two methods. The interclass correlation coefficients and the Bland-Altman method were used to assess the reliability. Results: In normal-appearing frontal white matter (WM), the mean values of Ktrans, ve, and vp were significantly higher in the fixed value method than in the T1 map method. In the normal-appearing occipital WM, the mean values of ve and vp were significantly higher in the fixed value method. In the putamen and head of the caudate nucleus, the mean values of Ktrans, ve, and vp were significantly lower in the fixed value method. In addition, the T1 map method showed comparable interobserver agreements with the fixed baseline T1 value method. Conclusion: The T1 map method using synthetic MRI may be useful for reflecting individual differences and reliable measurements in clinical applications of DCE MRI.