• Tuberculosis and Respiratory Diseases
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• v.82 no.1
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• pp.42-52
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• 2019

Background: Transforming growth factor ${\beta}$ (TGF-${\beta}$), retinoic acid (RA), p38 mitogen-activated protein kinase (MAPK), and MEK signaling play critical roles in cell differentiation, proliferation, and apoptosis. We investigated the effect of RA and the role of these signaling molecules on the phosphorylation of Smad2/3 (p-Smad2/3) induced by TGF-${\beta}1$. Methods: A549 epithelial cells and CCD-11Lu fibroblasts were incubated and stimulated with or without all-trans RA (ATRA) and TGF-${\beta}1$ and with MAPK or MEK inhibitors. The levels of p-Smad2/3 were analyzed by western blotting. For animal models, we studied three experimental mouse groups: control, bleomycin, and bleomycin+ATRA group. Changes in histopathology, lung injury score, and levels of TGF-${\beta}1$ and Smad3 were evaluated at 1 and 3 weeks. Results: When A549 cells were pre-stimulated with TGF-${\beta}1$ prior to RA treatment, RA completely inhibited the p-Smad2/3. However, when A549 cells were pre-treated with RA prior to TGF-${\beta}1$ stimulation, RA did not completely suppress the p-Smad2/3. When A549 cells were pre-treated with MAPK inhibitor, TGF-${\beta}1$ failed to phosphorylate Smad2/3. In fibroblasts, p38 MAPK inhibitor suppressed TGF-${\beta}1$-induced p-Smad2. In a bleomycin-induced lung injury mouse model, RA decreased the expression of TGF-${\beta}1$ and Smad3 at 1 and 3 weeks. Conclusion: RA had inhibitory effects on the phosphorylation of Smad induced by TGF-${\beta}1$ in vitro, and RA also decreased the expression of TGF-${\beta}1$ at 1 and 3 weeks in vivo. Furthermore, pre-treatment with a MAPK inhibitor showed a preventative effect on TGF-${\beta}1$/Smad phosphorylation in epithelial cells. As a result, a combination of RA and MAPK inhibitors may suppress the TGF-${\beta}1$-induced lung injury and fibrosis.

• Journal of Korean Society for Quality Management
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• v.38 no.1
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• pp.64-74
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• 2010

Since management of information resources is getting more complicated in the distributed, heterogeneous computing environment, the capability of monitoring and controlling the dispersed information resources is perceived as a critical success factor for the effective enterprise-wide information resource management. Integrated Control Architecture(ICA) provides that capability. Utilizing such architecture, we can manage corporate information resources more efficiently, perform impact analysis for changes in information resources, and alleviate the human effort by automating the monitoring of critical information resources. In this paper, we propose a conceptual framework and metamodel of ICA.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.46 no.5
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• pp.361-366
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• 2020

Guided bone regeneration (GBR) is a surgical procedure that utilizes bone grafts with barrier membranes to reconstruct small defects around dental implants. This procedure is commonly deployed on dehiscence or fenestration defects ≥2 mm, and mixing with autogenous bone is recommended on larger defects. Tension-free primary closure is a critical factor to prevent wound dehiscence, which is critical cause of GBR failure. A barrier membrane should be rigidly fixed without mobility. If the barrier is exposed, closed monitoring should be utilized to prevent secondary infection.

• Proceedings of the Korea Society of Design Studies Conference
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• 2004.05a
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• pp.350-351
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• 2004

• Information Systems Review
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• v.1 no.2
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• pp.137-152
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• 1999

• Proceedings of the Korean Nuclear Society Conference
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• 1998.10a
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• pp.191-191
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• 1998

• Proceedings of the Korean Nuclear Society Conference
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• 1999.05a
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• pp.226-226
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• 1999

• Journal of the military operations research society of Korea
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• v.24 no.1
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• pp.41-57
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• 1998

Since the aircraft has a property of moving in the three-dimensional space, it may cause personally and financially critical damage in the case of an accident. Among the causes of aircraft accident, human factor has occupied about 70% of all accidents. Specially, fatigue among human's problems has been studied earlier than any other factor. Fatigue has been the cause of 75% of accidents that are related to human factor. So many studies have been conducted. But the direction of these studies mainly attach importance to the sleep loss and circadian rhythm. Limitation for flight time of ICAO is 8 hours per day, civil airlines in domestic line also adopt the limitation. But this rule is not based on human's performance but compromise between labor and management. The long-haul flight brings about a mental block to pilot. This mental block decreases performance of pilot and loses a lot of important information. So this may cause many accidents. This paper is to offer optimal flight time according to the amount of fatigue due to increasing flight time. The optimal flight time is searched through the field experiment. The experiment has adopted two methods. One is to examine pilot's objective fatigue accumulation rate through the critical fusion frequency, and another is to investigate pilot's subjective fatigue feeling through the fatigue subjective symptoms investigation table.

• Journal of Korean Association for Spatial Structures
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• v.3 no.3 s.9
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• pp.85-93
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• 2003

Steel, concrete and their combination materials are the most 6commonly used materials for civil engineering structural systems such as buildings, bridge structures and other structures. Recently, however, fiber reinforced polymer (FRP) composites, a relatively new composite material made of fibers and polymer resins, have been gradually used in structural systems as an alternative structural material. This paper describes a comparison of design strength equations for steel column and FRP composite column based on design philosophies. The safety factors used in allowable stress design (ASD) are relatively higher in FRP structural design than steel structural design. Column critical stress equations of FRP composites column from an experimental study can be represented by Euler elastic buckling equation at the long-range of slenderness, and an exponential form at the short-range of slenderness as defined in Load and Resistance Factor Design (LRFD) of steel column. The column strength of steel and FRP composite columns in large slenderness is independent of material strength, this result verified the elastic buckling equation as derived by Eq. (15) and Eq. (5).

• Transactions of the Korean Society of Automotive Engineers
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• v.13 no.4
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• pp.174-181
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• 2005

In order to investigate the behavior of fatigue crack growth of SiC-particulate- reinforced Al-Si alloy composites, fatigue tests using single edge notched tension(SENT) specimens were performed. Composite materials were manufactured by using both permanent die casting and extrusion processes with different volume fractions of $10\%\;and\;20\%$. $SiC_p-reinfurced$ Al-Si composites showed the increased levels of threshold stress intensity factor range, ${\Delta}K_{th}$, for the increased volume fractions of SiC particles, which implies the increased fatigue crack growth resistance at the threshold or low ${\Delta}K$ levels, compared to the unreinforced Al-Si alloy. In the Paris region, however, the composites showed the increased rate of crack growth resulting in the unfavorable effects on the fatigue crack growth resistance. Critical stress intensity factor range at unstable crack growth leading to final fracture decreased as the volume fraction of SiC particle increased, because of the reduced fracture toughness of the composites. Extruded materials showed higher threshold and critical values than the cast materials.