• Earthquakes and Structures
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• 제26권1호
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• pp.59-75
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• 2024

This paper presents a dam-reservoir interaction model that includes, water compressibility, sloshing of surface water, and radiation damping at the far-end reservoir, to investigate the influence of concrete deterioration on seismic behavior along with seismic performance of gravity dams. Investigations on seismic performance of the dam body have been conducted using the linear time-history responses obtained under six real and 0.3 g normalized earthquake records with time durations from 10 sec to 80 sec. The deterioration of concrete is assumed to develop due to mechanical and chemical actions over the dam lifespan. Several computer programs have been developed in FORTRAN 90 and MATLAB programming languages to analyze the coupled problem considering two-dimensional (2D) plane-strain condition. According to the results obtained from this study, the dam structure shows critical responses at the later ages (75 years) that could cause disastrous consequences; the critical effects of some earthquake loads such as Chi-Chi with 36.5% damage and Loma with 56.2% damage at the later ages of the selected dam body cannot be negligible; and therefore, the deterioration of concrete along with its effects on the dam response should be considered in analysis and design.

• Journal of Veterinary Science
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• 제25권1호
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• pp.10.1-10.11
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• 2024

In livestock industry, there is growing interest in methods to increase the production efficiency of livestock to address food shortages, given the increasing global population. With the advancements in gene engineering technology, it is a valuable tool and has been intensively utilized in research specifically focused on human disease. In historically, this technology has been used with livestock to create human disease models or to produce recombinant proteins from their byproducts. However, in recent years, utilizing gene editing technology, cattle with identified genes related to productivity can be edited, thereby enhancing productivity in response to climate change or specific disease instead of producing recombinant proteins. Furthermore, with the advancement in the efficiency of gene editing, it has become possible to edit multiple genes simultaneously. This cattle breed improvement has been achieved by discovering the genes through the comprehensive analysis of the entire genome of cattle. The cattle industry has been able to address gene bottlenecks that were previously impossible through conventional breeding systems. This review concludes that gene editing is necessary to expand the cattle industry, improving productivity in the future. Additionally, the enhancement of cattle through gene editing is expected to contribute to addressing environmental challenges associated with the cattle industry. Further research and development in gene editing, coupled with genomic analysis technologies, will significantly contribute to solving issues that conventional breeding systems have not been able to address.

• 한국해양공학회지
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• 제38권3호
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• pp.137-147
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• 2024

Green hydrogen presents a sustainable and environmentally friendly solution for clean energy production and transportation. This study aims to identify the optimal profile of green hydrogen transportation risers originating from a floating offshore wind turbine (FOWT) integrated with a hydrogen production facility. Employing the Cummins equation, a fully coupled dynamic analysis for FOWT with a flexible riser was conducted, with the tower, mooring lines, and risers described using a lumped mass line model. Initially, motion response amplitude operators (RAOs) were compared with openly published results to validate the numerical model for the FOWT. Subsequently, a parametric study was conducted on the length of the buoyancy module section and the upper bare section of the riser by comparing the riser's tension and bending moment. The results indicated that as the length of the buoyancy module increases, the maximum tension of the riser decreases, while it increases with the lengthening of the bare section. Furthermore, shorter buoyancy modules are expected to experience less fatigue damage, with the length of the bare section having a relatively minor impact on this phenomenon. Consequently, to ensure safety under extreme environmental conditions, both the upper bare section and the buoyancy module section should be relatively short.

• Structural Engineering and Mechanics
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• 제91권1호
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• pp.63-73
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• 2024

Improving the blast resistance of structural establishments has become an imperative engineering commitment to prevent property damage and fatalities in terrorist incidents. This study investigates the effects of blast mass and stand-off distance on CFRP skin concrete core sandwich bunkers of varying thicknesses using ABAQUS/Explicit software with CONWEP functionality. The considered parameters include TNT masses of 1, 10, and 25 kg and stand-off distances of 0.1, 1, 2, and 2.5 meters on structures with 200, 250, and 500 mm core thicknesses. The study finds that there exists a declining response corresponding to the blasting mass reduction coupled with increases in the stand-off distance and core thickness. The 500 mm thick bunker sustains less damage compared to those with 200 mm and 250 mm core thicknesses. The sandwich configuration remains structurally advantageous vs. those without skins. The sandwich bunker with a 500 mm thick concrete core gives the best performance against the 10 kg TNT blast load with a 1 m standoff distance exhibiting a 22.8% reduction in damage vs. that without skins. Mathematical expressions are then formulated for predicting maximum von Mises stress, principal stress, and displacement of sandwich bunkers as functions of TNT masses, stand-off distances, and core thicknesses.

• 한국해안·해양공학회논문집
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• 제26권5호
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• pp.300-313
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• 2014

파-지반의 상호작용 해석에 지금까지는 대부분 무한두께를 갖는 해저지반 상의 진행파와 무한두께 혹은 유한두께의 해저지반 상에서 완전중복파에 대해서만 해석해가 제안되어 있다. 본 연구에서는 임의반사율의 부분중복파동장에 선형파 이론과 유한두께를 갖는 해저지반에 Biot(1941) 3차원 압밀이론 및 지반탄성론에 기초한 유효응력 개념을 각각 적용하여 지반 내 동적응답에 관한 해석해를 새롭게 유도하며, 이에 수심과 반사율만을 변화시킴으로서 기존의 해석해가 간단히 얻어지기 때문에 그의 적용성이 보다 넓다. 본 해석해의 타당성은 무한지반 상의 진행파동장 및 완전중복파동장에 대한 Yamamoto et al.(1978) 및 Tsai & Lee(1994)의 해석해와 비교 검토로부터 검증된다. 또한, 본문에서는 유한깊이를 갖는 해저지반 상의 진행파동장, 완전중복파동장 및 임의반사율의 부분중복파동장에 대해 수심과 주기의 변화에 따른 본 해석해의 변화특성을 면밀히 검토한다. 이로부터 유한깊이의 지반은 무한두께의 경우와는 매우 상이한 지반응답(간극수압, 전단응력, 수평 및 연직 유효응력)을 나타내고, 반사율의 함수인 부분중복파동장에서 지반응답은 완전중복파동장에서의 값보다 일반적으로 작은 값을 나타낸다는 것을 확인할 수 있었다.

• 한국지진공학회논문집
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• 제14권3호
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• pp.11-22
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• 2010

이 논문에서는 댐-호소계의 선형 및 비선형 지진응답 해석을 시간영역에서 엄밀히 수행할 수 있는 해석법을 제시하였다. 댐-호소계는 (1) 선형 또는 비선형으로 거동하는 댐체와 (2) 깊이가 균일하다고 가정한 호소 원역 및 (3) 댐체와 호소 원역 사이 불규칙한 형상의 근역의 세가지 부구조물로 구성된 연계 시스템으로 정식화되었다. 댐체는 선형 또는 비선형 유한 요소로 모델링되고, 호소 원역은 무한 영역으로의 에너지 방사를 엄밀하게 표현할 수 있도록 주파수영역에서 개발된 변위기반 전달경계를 시간영역에서의 포갬적분으로 변환하여 시간증분법과 결합이 용이하게 하였다. 호소 근역을 댐체와 호소 원역이라는 두 개의 부구조물 사이에 저장된 압축성 유체로 모델링하였다. 이 논문에서는 세 개의 부구조물로 구성되는 댐-호소계에 대해 비선형 시간영역 해석을 용이하게 하는 시간증분법을 유도하여 제시하였고 개발된 해석법을 다양한 형상의 댐-호소계의 지진응답 해석에 적용하여 그 정확성을 검증하였다. 이에 추가하여 제시한 기법을 콘크리트 댐의 비선형 지진응답 해석에 적용하여 손상 정도와 부위를 해석 결과로서 보여주었으며 동시에 제시한 기법이 내진성능 평가 등 실무에 바로 활용될 수 있음을 입증하였다.

• 한국산학기술학회논문지
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• 제17권3호
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• pp.24-30
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• 2016

현재까지 지열 열펌프 시스템의 지중열교환기는 수직 밀폐형과 개방형 지중열교환기가 주로 설치되어 열응답시험을 이용한 열특성 평가가 수행되어 왔다. 본 논문에서는 열응답시험과 선형열원법을 이용하여 수평형 지중열교환기의 열특성을 분석하였다. 또한 지열 열펌프 시스템은 매일 단속 운전되어지므로 일일부하시험을 수행하여 수평형 지중열교환기의 지중온도 및 순환수 평균온도 일별 변화를 고찰하였다. 시험을 위해 경기도 안산에 직선식 수평형 지중열교환기(심도 2 m, 길이 50 m 8줄)를 설치하였다. 시험결과 수평형 지중열교환기의 지중 열전도율은 연중 $1.43{\sim}1.64W/m{\cdot}K$ 범위로 비교적 큰 변화가 없으며 12월에 최대값을, 5월에 최소값을 갖는 것으로 나타났다. 12일간 지중 열교환기로 하루 10시간동안 6.0 kW의 열량을 투입하는 연속 부하시험을 6월, 9월, 12월에 수행한 결과 지중온도는 이 기간 동안 각각 $4.31^{\circ}C$, $3.14^{\circ}C$, $1.21^{\circ}C$ 상승하는 것으로 나타났다.

• Biomolecules & Therapeutics
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• 제22권2호
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• pp.129-135
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• 2014

Previously, we reported that lysophosphatidylethanolamine (LPE), a lyso-type metabolite of phosphatidylethanolamine, can increase intracellular $Ca^{2+}$ ($[Ca^{2+}]_i$) via type 1 lysophosphatidic acid (LPA) receptor ($LPA_1$) and CD97, an adhesion G-protein-coupled receptor (GPCR), in MDA-MB-231 breast cancer cells. Furthermore, LPE signaling was suggested as like $LPA_1/CD97-G_{i/o}$ proteins-phospholipase $C-IP_3-Ca^{2+}$ increase in these cells. In the present study, we further investigated actions of LPE not only in the $[Ca^{2+}]_i$ increasing effect but also in cell proliferation and migration in MDA-MB-231 breast cancer cells. We utilized chemically different LPEs and a specific inhibitor of $LPA_1$, AM-095 in comparison with responses in SK-OV3 ovarian cancer cells. It was found that LPE-induced $Ca^{2+}$ response in MDA-MB-231 cells was evoked in a different manner to that in SK-OV3 cells in terms of structural requirements. AM-095 inhibited LPE-induced $Ca^{2+}$ response and cell proliferation in MDA-MB-231 cells, but not in SK-OV3 cells, supporting $LPA_1$ involvement only in MDA-MB-231 cells. LPA had significant effects on cell proliferation and migration in MDA-MB-231 cells, whereas LPE had less or no significant effect. However, LPE modulations of MAPKs (ERK1/2, JNK and p38 MAPK) was not different to those by LPA in the cells. These data support the involvement of LPA1 in LPE-induced $Ca^{2+}$ response and cell proliferation in breast MDA-MB-231 cells but unknown GPCRs (not $LPA_1$) in LPE-induced responses in SK-OV3 cells. Furthermore, although LPE and LPA utilized $LPA_1$, LPA utilized more signaling cascades than LPE, resulting in stronger responses by LPA in proliferation and migration than LPE in MDA-MB-231 cells.

• The Korean Journal of Physiology and Pharmacology
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• 제5권4호
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• pp.287-297
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• 2001

Contraction of smooth muscle is initiated by an increase in cytosolic $Ca^{2+}$ leading to activation of $Ca^{2+}$/ calmodulin-dependnet myosin light chain (MLC) kinase and phosphorylation of MLC. The types of contraction and signaling mechanisms mediating contraction differ depending on the region. The involvement of these different mechanisms varies depending on the source of $Ca^{2+}$ and the kinetic of $Ca^{2+}$ mobilization. $Ca^{2+}$ mobilizing agonists stimulate different phospholipases $(PLC-{\beta},\;PLD\;and\;PLA_2)$ to generate one or more $Ca^{2+}$ mobilizing messengers $(IP_3\;and\;AA),$ and diacylglycerol (DAG), an activator of protein kinase C (PKC). The relative contributions of $PLC-{\beta},\;PLA_2$ and PLD to generate second messengers vary greatly between cells and types of contraction. In smooth muscle cell derived form the circular muscle layer of the intestine, preferential hydrolysis of $PIP_2$ and generation of $IP_3$ and $IP_3-dependent\;Ca^{2+}$ release initiate the contraction. In smooth muscle cells derived from longitudinal muscle layer of the intestine, preferential hydrolysis of PC by PLA2, generation of AA and AA-mediated $Ca^{2+}$ influx, cADP ribose formation and $Ca^{2+}-induced\;Ca^{2+}$ release initiate the contraction. Sustained contraction, however, in both cell types is mediated by $Ca^{2+}-independent$ mechanism involving activation of $PKC-{\varepsilon}$ by DAG derived form PLD. A functional linkage between $G_{13},$ RhoA, ROCK, $PKC-{\varepsilon},$ CPI-17 and MLC phosphorylation in sustained contraction has been implicated. Contraction of normal esophageal circular muscle (ESO) in response to acetylcholine (ACh) is linked to $M_2$ muscarinic receptors activating at least three intracellular phospholipases, i.e. phosphatidylcholine-specific phospholipase C (PC-PLC), phospholipase D (PLD) and the high molecular weight (85 kDa) cytosolic phospholipase $A_2\;(cPLA_2)$ to induce phosphatidylcholine (PC) metabolism, production of diacylglycerol (DAG) and arachidonic acid (AA), resulting in activation of a protein kinase C (PKC)-dependent pathway. In contrast, lower esophageal sphincter (LES) contraction induced by maximally effective doses of ACh is mediated by muscarinic $M_3$ receptors, linked to pertussis toxin-insensitive GTP-binding proteins of the $G_{q/11}$ type. They activate phospholipase C, which hydrolyzes phosphatidylinositol bisphosphate $(PIP_2),$ producing inositol 1, 4, 5-trisphosphate $(IP_3)$ and DAG. $IP_3$ causes release of intracellular $Ca^{2+}$ and formation of a $Ca^{2+}$-calmodulin complex, resulting in activation of myosin light chain kinase and contraction through a calmodulin-dependent pathway.

• Journal of Radiation Protection and Research
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• 제39권3호
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• pp.150-158
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• 2014

각 의료기관 내 방사선 관련 종사자나 방사선 치료환자들은 진단 및 치료 시 필연적으로 의료상 피폭을 수반하게 된다. 국제방사선방호위원회(ICRP) 권고나 국제원자력기구(IAEA)의 기준에 따라 기준선량 제약치를 적용 및 권고 받고 있지만 1차 피폭대상자인 종사자나 환자들의 피폭최적관리를 위해서는 잠재적인 피폭대상자들에게 기존의 피폭관리 시스템보다 직접적이고 가용성이 높은 측정 및 분석 방법이 필요하다. 따라서 본 연구에서는 기존에 구비된 휴대용 단말과 연동하여 원거리에서 실시간으로 방사선 모니터링이 가능한 시스템을 개발하였다. 모니터링 시스템은 검출부, 영상부, 통신부 세 부분으로 구성되었다. 검출부는 시스템의 소형화를 위해 실리콘 광증배소자(silicon photomultiplier) 기반 섬광검출기를 설계하였으며, 영상부는 무선 CCD (charge-coupled device)카메라 모듈을 사용하여 검출부와 함께 Bluetooth 통신모듈을 통해 휴대용 단말로 측정된 방사선 정보와 영상이 전송된다. 제작된 시스템은 성능 평가를 위해 진단용 X-ray 발생장치와 $^{137}Cs$, $^{22}Na$, $^{60}Co$, $^{204}Tl$, $^{90}Sr$ 선원을 사용하였다. 측정결과를 통해 개발된 시스템은 gamma, beta, X-ray에 대해서 검출 반응성을 확인하였고, 방사선 세기에 따른 응답 선형성과 MCNPX 전산코드를 이용한 측정 거리에 따른 시스템의 검출 정확도 평가 시 3% 내외의 오차범위를 확인하였다. 본 연구의 결과는 방사선 검출 시스템 구성의 비용절감 효과와 개인피폭정도관리에 기여할 것으로 기대한다.