• Journal of the Society of Cosmetic Scientists of Korea
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• v.22 no.2
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• pp.174-181
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• 1996

The novel synthesis of 3-aminopropyl dihydrogen phosphate(3-APPA; 3-Aminopropane phosphoric acid), and its applicability to the skin as a cosmetic raw material in terms of its efficacy and toxicology were presented. The phosphorylation of 3-amino-1-propanol was carried out via cyclization into 6-membered 2, 6-oxaza-phosphoryl ring in the presence of phosphorous oxychloried and an organic base. The subsequent ring-opening hydrolysis and crystallization afforded the highly purified product in 90% isoloated yield. The method is much superior to the previous literature phosphorylation methodsm, as the procedure is simple and high-yielding. To confirm the efficacy of 3-APPA, several activities related to anti-aging capacity were measured. In-vitro human fibroblast, linear and 3-dimensional collagen matrix culture revealed that 3-APPA stimulated the proliferation of fibroblasts, and enhanced the synthesis of collagen, which showed 3-APPA's potency for skin wrinkle reduction. The toxicolgical aspect of 3-APPA was also extensively examined. In vivo toxicity tests such as acute oral toxicity, eye irritation, human patch, and the repeat insult human patch test proved 3-APPA to be a safe material. Thus 3-APPA can be used as an effective anti-aging agent for various cosmetic formulations.

• Proceedings of the Korean Society of Toxicology Conference
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• 2002.05a
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• pp.138-138
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• 2002

In recent years, the safety of sunscreens has been challenged based on the reports of its adverse effect on users; dermatitis, allergic contact dermatitis, photoallergic contact dermatitis. To investigate a correlation between sun protection factor (SPF) and the safety of sunscreens, we measured in vitro SPF index using homosalate as a standard and examined the toxicity tests on cosmetics; primary and cumulative skin irritation tests, ocular irritation test, and skin sensitization test.(omitted)

• Proceedings of the Korean Society of Toxicology Conference
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• 2002.11b
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• pp.195-195
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• 2002

In recent years, the safety of sunscreens has been challenged based on the reports of its adverse effect on users; dermatitis, allergic contact dermatitis, photoallergic contact dermatitis. To investigate a correlation between sun protection factor (SPF) and the safety of sunscreens, we measured in vitro SPF index using homosalate as a standard and examined the toxicity tests on cosmetics; primary skin irritation tests, ocular irritation test, and skin sensitization test.(omitted)

• Korean Chemical Engineering Research
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• v.50 no.4
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• pp.610-613
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• 2012

In this study, plant extracts including 25% Saururus chinensis, 20% Morus bombycis stem and 20% Morus papyrifera stem were tested to use as possible cosmetic agent. As cosmetic effect test, cell toxicity test, elastase inhibition assay, tyrosinase inhibition assay, anti-oxidation assay and temperature stability test were done as cosmetic assays. Plant extract showed low cell toxicity, excellent elastase inhibition and anti-oxidation effect, however, tyrosinase inhibition effect was lower. Skin, lotion and essence formulation was made using plant extracts and temperature stability test was done. Skin and essence indicated good stability, however, lotion showed phase separation and severe viscosity variation, which means lotion formulation change. From the research, plant extracts including Saururus chinensis, Morus bombycis stem and Morus papyrifera stem were suitable for possible cosmetic agent.

• Journal of Fashion Business
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• v.4 no.3
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• pp.141-155
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• 2000

The purpose of this study is to offer basic data to adolescents' cosmetic culture by investigating and analysing the choices made by female students who have been becoming principle consumers of cosmetics these days. Firstly, social and cultural backgrounds and concepts of N generation, and then characteristics and influencing powers of female students were reviewed. And this study also included questionnaire surveys of 500 female students in middle and high schools located in Seoul. Data were processed using a SPSS$^+$ program and analyzed by using frequency, percentage and the $X^2$-test. The major findings run as follows: Female students have the effects of spreading their words quickly and abilities of making a decision what to buy. And they accept consuming behaviors itself as a part of cultural lives. Therefore, industries have acknowledged them as new principal consumers with a powerful influence in the market. They also play an important role in active consumer as emotional generation who has distinct personalities and prefer fashion trends, changes and innovations. They show conformities with their peer groups and they also want to identify themselves with characters or stars. The cosmetic behaviors of female students relating to demographic characteristics showed a significant relation to grades, majors, school groups and places of residence. Female students have a lot of interest and knowledge about cosmetics. And they use various cosmetic products. This study demonstrated the age for using make-up for the first time has been becoming younger more and more. Recently, female adolescents tend to use face powder, lip gloss, mascara and eye shadow. It is assumed that cosmetic purchases of female students can be considered as an impulsive aspects. However, before purchases, the proportion of students having any particular cosmetic brand in mind previously has been increasing. They take into consideration skin safety, the quality of product and color, when purchasing cosmetic products.

• Journal of Fashion Business
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• v.4 no.4
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• pp.107-121
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• 2000

The purpose of this study is to offer basic data to adolescents' cosmetic culture by investigating and analysing the choices made by female students who have been becoming principle consumers of cosmetics these days. Firstly, social and cultural backgrounds and concepts of N generation, and then characteristics and influencing powers of female students were reviewed. And this study also included questionnaire surveys of 500 female students in middle and high schools located in Seoul. Data were processed using a SPSS$^+$ program and analyzed by using frequency, percentage and the $X^2$-test. The major findings run as follows: Female students have the effects of spreading their words quickly and abilities of making a decision what to buy. And they accept consuming behaviors itself as a part of cultural lives. Therefore, industries have acknowledged them as new principal consumers with a powerful influence in the market. They also play an important role in active consumer as emotional generation who has distinct personalities and prefer fashion trends, changes and innovations. They show conformities with their peer groups and they also want to identify themselves with characters or stars. The cosmetic behaviors of female students relating to demographic characteristics showed a significant relation to grades, majors, school groups and places of residence. Female students have a lot of interest and knowledge about cosmetics. And they use various cosmetic products. This study demonstrated the age for using make-up for the first time has been becoming younger more and more. Recently, female adolescents tend to use face powder, lip gloss, mascara and eye shadow. It is assumed that cosmetic purchases of female students can be considered as an impulsive aspects. However, before purchases, the proportion of students having any particular cosmetic brand in mind previously has been increasing. They take into consideration skin safety, the quality of product and color, when purchasing cosmetic products.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.28 no.3
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• pp.109-145
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• 2002

Council Directive 76/768/EEC forms the basis of the actual legislation of cosmetics in the European Union (EU). After a short introduction on the background and philosophy of this legislation, the key points will be discussed. In particular, attention will be given to the basic principles for safety and in this context the effects of the implementation of the 6th Amendment (Council Directive 93/35/EC) will be analysed. The major points for discussion will be: the safety requirements for cosmetics and the final responsibility for bringing these products on the EU market; the EU concept of safety of the finished product based on the safety of the individual ingredients; the existence of positive and negative lists of ingredients and the requirement for a European dossier for all finished products. Special attention will be given to the use of validated alternative methods and the consequences of the new proposal of a 7th Amendment. Finally, the safety evaluation as it is done by the SCCNFP (Scientific Committee on Cosmetics and Non-Food Products) in the case of an ingredient present on the positive lists and the evaluation done by a safety assessor in the case of a technical information file for a finished product, both will be discussed in detail.

• Journal of Acupuncture Research
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• v.25 no.1
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• pp.199-209
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• 2008

Objectives : To explore the adverse events and safety following facial cosmetic acupuncture treatment (Miso-Acupuncture). Subjects and methods : This study was a retrospective survey of practitioner's reports. The practitioners worked as facial cosmetic acupuncturists, gave informed consent, and completed a case report form between July and November of 2007. On this form, practitioners were asked to report the degree of adverse events relating to the Miso-Acupuncture, the total safety of the treatment, and reasons patients gave for quitting treatment. The practitioners in this study were all Oriental Medicine Doctors(OMD) who had trained at the Miso-Acupuncture Academy for 40 hours we received 23 final report cases. Results : In this study, adverse events following Miso-Acupuncture treatment were mild bruising(15 ; 65.2%), bleeding(12 ; 52.2%), pain(8 ; 34.8%), fatigue(7 ; 30.4%), headache(5 ; 21.7%), and others(10 ; 43.5%). The average degree of adverse events was between mild and moderate, which needs no extra treatment. The total safety of treatment for 16 weeks was between safe and nearly safe, and there was no need to quit treatment in spite of mild adverse events. Eight patients(34.8%) quit treatment, almost all for personal reasons unrelated to the Miso-Acupuncture. Conclusions : These results suggest that the Miso-Acupuncture has no serious adverse events and is a relatively safe treatment.

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2002.11a
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• pp.195-195
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• 2002

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2002.05a
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• pp.138-138
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• 2002