• Journal of Microbiology and Biotechnology
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• 제22권1호
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• pp.156-158
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• 2012

A synthetic coprisin analog peptide, 9-mer dimer CopA3 (CopA3) was designed based on a defensin-like peptide, Coprisin, isolated from the bacteria-immunized dung beetle Copris tripartitus. Here, CopA3 was investigated for its antimicrobial activity and cancer cell growth inhibition. CopA3 showed antimicrobial activities against various pathogenic bacteria and yeast fungus with MIC values in 2~32 ${\mu}M$ ranges, and inhibited the cell viabilities of pancreatic and hepatocellular cancer cells, except MIA-Paca2, Hep3B, and HepG2 cells, in a dose-dependent manner. The average $IC_{50}$ values of CopA3 against pancreatic and hepatocellular cancer cells were 61.7 ${\mu}M$ and 67.8 ${\mu}M$, respectively. The results indicate that CopA3 has potential in the treatments of pancreatic and hepatocellular cancers as well as microorganism infection disease.

• 한국전문물리치료학회지
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• 제23권3호
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• pp.40-47
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• 2016

Background: Assessments of Sit-to-Stand (STS) and gait functions are essential procedures in evaluating level of independence for the patients after stroke. In a previous study, we developed the software to analyze center of pressure (COP) in standing position on Wii Balance Board (WBB). Objects: This purpose of this study is to measure test-retest reliability of ground reaction forces, COP and time using WBB on STS and gait in healthy adults. Methods: Fifteen healthy participants performed three trials of STS and gait on WBB. The time (s), vertical peak (%) and COP path-length (cm) were measured on both tasks. Additionally, counter (%), different peak (%), symmetry ratio, COP x-range and COP y-range were analyzed on STS, 1st peak (%), 2nd peak (%) of weight were analyzed on gait. Intra-class correlation coefficient (ICC), standard error measurement (SEM) and smallest real difference (SRD) were analyzed for test-retest reliability. Results: ICC of all variables except COP path-length appeared to .676~.946 on STS, and to .723~.901 on gait. SEM and SRD of all variables excepting COP path-length appeared .227~8.886, .033~24.575 on STS. SEM and SRD excepting COP path-length appeared about .019~3.933, .054~11.879 on gait. Conclusion: WBB is not only cheaper than force plate, but also easier to use clinically. WBB is considered as an adequate equipment for measuring changes of weight bearing during balance, STS and gait test which are normally used for functional assessment in patients with neurological problems and elderly. The further study is needed concurrent validity on neurological patients, elderly patients using force plate and WBB.

• PNF and Movement
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• 제13권3호
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• pp.119-125
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• 2015

Purpose: The current study seeks to examine the effects of stabilizing reversal(SR) and rhythmic stabilization(RS) in proprioceptive neuromuscular facilitation (PNF) techniques on static balance in normal female adults. Methods: Subjects included 20 healthy women in their 20s. They were randomly divided into SR and RS groups. To assess static balance before and after PNF intervention, the good balance system was used to measure the interior and exterior center of pressure (COP) movement distance, front and rear COP movement distance before and after the intervention, and velocity moment. Results: Interior and exterior COP movement distance, front and rear COP movement distance, and velocity moment decreased in the SR group, but no statistically significant differences were observed. In the RS group, the interior and exterior COP movement distance declined without any significant difference, while the front and rear COP movement distance and velocity moment significantly decreased. The interior and exterior COP movement distance, front and rear COP movement distance, and velocity moment declined more in the RS group than in the SR group. Conclusion: The findings of the current study indicate that the RS technique is more effective than the SR technique for improving the balance ability of healthy female adults. The results of this study can thus be utilized in the selection of effective interventions for improving the balance ability of healthy female adults.

• BMB Reports
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• 제52권7호
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• pp.445-450
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• 2019

TTYH2 is a calcium-activated, inwardly rectifying anion channel that has been shown to be related to renal cancer and colon cancer. Based on the topological prediction, TTYH2 protein has five transmembrane domains with the extracellular N-terminus and the cytoplasmic C-terminus. In the present study, we identified a vesicle transport protein, ${\beta}$-COP, as a novel specific binding partner of TTYH2 by yeast two-hybrid screening using a human brain cDNA library with the C-terminal region of TTYH2 (TTYH2-C) as a bait. Using in vitro and in vivo binding assays, we confirmed the protein-protein interactions between TTYH2 and ${\beta}$-COP. We also found that the surface expression and activity of TTYH2 were decreased by co-expression with ${\beta}$-COP in the heterologous expression system. In addition, ${\beta}$-COP associated with TTYH2 in a native condition at a human colon cancer cell line, LoVo cells. The over-expression of ${\beta}$-COP in the LoVo cells led to a dramatic decrease in the surface expression and activity of endogenous TTYH2. Collectively, these data suggested that ${\beta}$-COP plays a critical role in the trafficking of the TTYH2 channel to the plasma membrane.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2009년도 춘계학술대회 논문집
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• pp.925-926
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• 2009

• 한국운동역학회지
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• 제22권3호
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• pp.261-268
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• 2012

The purpose of this study was to qualitatively analyze pressure intensity and the center of pressure(COP) trajectory according to shoe type. Subjects were ten first-year female university students. The EMED-AT 25/D(Novel, Germany) was used to measure pressure intensity and COP trajectory. The COP Excursion Index(CPEI) was used for within subject test design. Independent variables were bare feet and six types of shoes. Dependent variables were center of pressure trajectory and pressure intensity. Barefeet and five toed shoes had a similar pressure intensity and COP trajectory. COP trajectory for all other shoe types showed a medial wobble at the heel. Pressure intensity for all other shoe types was related to the structure of the shoes. In conclusion, different shoe types can not only affect gait, but they can also influence foot deformities, pain, and dysfunction.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2004년도 추계학술대회 논문집
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• pp.944-947
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• 2004

The purpose of this study was to identify the characteristics of muscular power by COP(center of pressure) training according to the angle variation of tilting bed. We changed the angles of tilting bed(up-down direction 0$^{\circ}$, 15$^{\circ}$, 30$^{\circ}$, 45$^{\circ}$ and right-left direction -15$^{\circ}$, 0$^{\circ}$, +15$^{\circ}$) for the correlation between angles and muscular power. And we measured EMG(electormyography) of lower limbs muscle(rectus femoris, biceps femoris, and gastrocnemius, tibialisa anterior) during COP training. COP training was divided by the COP trace training(in all direction) and sine wave trace training(vertical and horizontal direction). As the result, we obtained the improvement effect of COP training and we showed that electromyography(EMG) variations of lower limbs muscle on the angle variations of tilting bed were investigated.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2007년도 춘계학술대회
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• pp.460-465
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• 2007

유출지하수는 지하공간이 깊고 넓게 분포하는 건물에서 자연적으로 유출되어 배출되는 낮은 심도의 지하수이다. 본 연구에서는 신축된 교회건물에서 유출되는 지하수를 열원으로 밀폐형태와 개방형태의 열교환기를 활용하여 각각 5RT급 히트펌프시스템을 난방모드로 운전한 결과를 정리하였다. 실험은 난방순환수의 온도를 $43{\sim}49$ $^{\cdot}C$ 범위에서 제어하면서 진행하였으며, 시스템 COP에 있어서 밀폐형은 $4.12{\sim}4.75$, 개방형은 $3.42{\sim}3.98$의 범위에서 측정되었다. 이는 기존의 지열히트펌프시스템의 COP와 대동 소이한 우수한 성능이라고 판단된다. 또한 펌프동력을 제외한 히트펌프 자체 난방COP에 있어서 밀폐형은 $4.69{\sim}5.81$, 개방형은 $4.38{\sim}5.43$의 범위에서 나타났다. 유출지하수의 온도가 겨울철에도 약 $12{\sim}14^{\cdot}C$를 유지하므로 히트펌프와 시스템전체의 COP가 매우 우수한 값을 나타내고 있음이 확인되었다.

• 한국식품위생안전성학회지
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• 제9권4호
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• pp.199-203
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• 1994

The oxidation of cholesterol in tallow heated at three frying temperatures, 130, 150 and 18$0^{\circ}C$ was studied by assaying cholesterol oxidation products(COP)by GC-MS. The correlation between levels of COP and changes of physicochemical parameters (peroxide value, polymer, polar components and dielectric constant) in tallow heated were studied. As temperature increased, the amount of cholesterol was decreased proportionally with heating time. However, the levels of COP did not increase considerably with increased frying temperature. The rate of cholesterol disappearance was the greatest at 18$0^{\circ}C$ and the smallest at 13$0^{\circ}C$. Larger amounts of COP formed were found at 15$0^{\circ}C$ than at 18$0^{\circ}C$. The levels of COP formed in tallow heated showed highly correlation with(r=0.94, n=30, p<0.01) polymer, polar components and dielectric constant, respectively.

• 대한설비공학회:학술대회논문집
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• 대한설비공학회 2008년도 하계학술발표대회 논문집
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• pp.163-170
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• 2008

Auxiliary port which had been known to be used to reduce the expansion loss of a refrigeration system was applied to a R134a reciprocating compressor in a household refrigerator cycle with an intention of improving the compressor performance. Effects of the auxiliary port on the compressor performance was investigated by a computer simulation program. When a simple hole was made on the side wall of the cylinder as an auxiliary port and surrounding gas inside the compressor shell was assumed to be drawn into the cylinder through the hole, maximum COP improvement of 1.66% was obtained. With auxiliary port equipped with a plate type of check valve, maximum COP was raised to be 1.99%. COP improvement was more distinctive with decreasing the discharge pressure; COP improvement was 5% with discharge pressure of 7 bar.