• The Korean Journal of Physiology and Pharmacology
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• v.19 no.5
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• pp.451-460
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• 2015

Sirtuin 1 (SIRT1) is a mammalian $NAD^+$-dependent protein deacetylase that regulates cellular metabolism and inflammatory response. The organ-specific deletion of SIRT1 induces local inflammation and insulin resistance in dietary and genetic obesity. Macrophage-mediated inflammation contributes to insulin resistance and metabolic syndrome, however, the macrophage-specific SIRT1 function in the context of obesity is largely unknown. C57/BL6 wild type (WT) or myeloid-specific SIRT1 knockout (KO) mice were fed a high-fat diet (HFD) or normal diet (ND) for 12 weeks. Metabolic parameters and markers of hepatic steatosis and inflammation in liver were compared in WT and KO mice. SIRT1 deletion enhanced HFD-induced changes on body and liver weight gain, and increased glucose and insulin resistance. In liver, SIRT1 deletion increased the acetylation, and enhanced HFD-induced nuclear translocation of nuclear factor kappa B (NF-${\kappa}B$), hepatic inflammation and macrophage infiltration. HFD-fed KO mice showed severe hepatic steatosis by activating lipogenic pathway through sterol regulatory element-binding protein 1 (SREBP-1), and hepatic fibrogenesis, as indicated by induction of connective tissue growth factor (CTGF), alpha-smooth muscle actin (${\alpha}$-SMA), and collagen secretion. Myeloid-specific deletion of SIRT1 stimulates obesity-induced inflammation and increases the risk of hepatic fibrosis. Targeted induction of macrophage SIRT1 may be a good therapy for alleviating inflammation-associated metabolic syndrome.

• Laboraroty Animal Research
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• v.34 no.4
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• pp.223-231
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• 2018

Regulation of gastrointestinal hormones have been reported in animal models for constipation undergoing laxative therapy when administered herbal products. We undertook to investigate whether the laxative activity of gallotannin-enriched extracts isolated from Galla Rhois (GEGR) affects the regulation of gastrointestinal hormones, by examining the concentration of four hormones and the activation of their receptors in the loperamide (Lop)-induced constipation model. Stool parameters, including number, weight and water content, were significantly recovered in the Lop+GEGR treated group, relative to the Lop+ vehicle treated group; however, food intake and water consumption were maintained at a constant level. Also, a similar recovery was detected for thickness of mucosa, muscle and flat luminal surface in the Lop+GEGR treated group. Furthermore, concentration of the four gastrointestinal hormones evaluated, namely, cholecystokinin (CCK), gastrin (GAS), somatostatin (SS) and motilin (MTL), were lower in the Lop+vehicle treated group than the No treated group, but were remarkably enhanced in the Lop+GEGR treated group. Moreover, the downstream signaling pathway of MTL and SS receptors were recovered after GEGR administration. Results of the present study therefore indicate that the laxative effects of GEGR treatment may be tightly related with the regulation of gastrointestinal hormones in the Lopinduced constipation model.

• Asia-Pacific Journal of Business
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• v.10 no.1
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• pp.1-11
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• 2019

Asian countries have been striving for economic integration for decades. This effort may lead to the convergence of income level through externalities across countries. This paper investigates whether the convergence phenomenon holds for income levels in Asian countries for the periods between 1975-2015 applying the traditional methodology of ${\sigma}-$ and ${\beta}-convergence$. Although the absolute ${\beta}-convergence$ of income levels in Asian and ASEAN+3 countries do hold, ${\sigma}-convergence$ and conditional ${\beta}-convergence$ of income level generally do not exist. This suggests that the benefits of economic integration in Asian countries were not yet realized to be significant. A plausible explanation is that the economies of Asian countries are largely based on low trade openness and a high level of informal economy.

• Journal of Broadcast Engineering
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• v.14 no.3
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• pp.332-341
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• 2009

Terrestrial digital multimedia broadcasting(T-DMB) is one of mobile broadcasting services, and the commercial service was started in December 2005 in Korea. The performance targets of T-DMB are providing VCD(video CD) quality video and FM radio quality audio. In recent years, the researches for providing high quality video or audio service on T-DMB environments have been being carried out. To provide high-quality video or audio service, some additional data should be transmitted to the receiver as well as T-DMB video and audio data. Since the data rate for one T-DMB program is low, it is important to transmit the additional data at a low bit rate. In this paper, we propose a packetizing method for efficient transmission of the additional data to provide multichannel audio service on T-DMB environment.

• Carbon letters
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• v.18
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• pp.30-36
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• 2016

Well-dispersed Ag₃VO₄ nanoparticles @polyacrylonitrile (PAN) nanofibers were synthesized by an easily controlled, template-free method as a photo-catalyst for the degradation of methylene blue. Their structural, optical, and photocatalytic properties have been studied by X-ray diffraction, transmission electron microscopy, field-emission scanning electron microscopy equipped with rapid energy dispersive analysis of X-ray, photoluminescence, and ultraviolet-visible spectroscopy. The characterization procedures revealed that the obtained material is PAN nanofibers decorated by Ag₃VO₄ nanoparticles. Photocatalytic degradation of methylene blue investigated in an aqueous solution under irradiation showed 99% degradation of the dye within 75 min. Finally, the antibacterial performance of Ag₃VO₄ nanoparticles @PAN composite nanofibers was experimentally verified by the destruction of Escherichia coli. These results suggest that the developed inexpensive and functional nanomaterials can serve as a non-precious catalyst for environmental applications.

• Nuclear Engineering and Technology
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• v.53 no.8
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• pp.2646-2651
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• 2021

A rectangular-shaped PET system with an adjustable gantry (AGPET) has been developed for imaging small animals. The AGPET system employs a new depth of interaction (DOI) method using a depth dependent reflector patterns and a new digital time pickoff method based on the pulse reconstruction method. To evaluate the performance of the AGPET, timing resolution, intrinsic spatial resolution and point source images were acquired. The timing resolution and intrinsic spatial resolution were measured using two detector modules and Na-22 gamma source. The PET images were acquired in two field of view (FOV) sizes, 30 mm and 90 mm, to demonstrate the characteristic of the AGPET. As a result of in the experiment results, the timing resolution was 0.9 ns using the pulse reconstruction method based on the bi-exponential model. The intrinsic spatial resolution was an average of 1.7 mm and the spatial resolution of PET images after DOI correction was 2.08 mm and 2.25 mm at the centers of 30 mm and 90 mm FOV, respectively. The results show that the proposed AGPET system provided higher sensitivity and resolution for small animal imaging.

• Nuclear Engineering and Technology
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• v.55 no.3
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• pp.1009-1014
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• 2023

Muon tomography is a useful method for monitoring special nuclear materials (SNMs) such as spent nuclear fuel inside dry cask storage. Multiple Coulomb scattering of muons can be used to provide information about the 3-dimensional structure and atomic number(Z) of the inner materials. Tomography using muons is less affected by the shielding material and less harmful to health than other measurement methods. We developed a muon detector for muon tomography, which consists of a plastic scintillator, 64 long wavelength-shifting (WLS) fibers attached to the top of the plastic scintillator, and silicon photomultipliers (SiPMs) connected to both ends of each WLS fiber. The muon detector can acquire X and Y positions simultaneously using a position determination algorithm. The design parameters of the muon detector were optimized using DETECT2000 and Geant4 simulations, and a muon detector prototype was built based on the results. Spatial resolution measurement was performed using simulations and experiments to evaluate the feasibility of the muon detector. The experimental results were in good agreement with the simulation results. The muon detector has been confirmed for use in a muon tomography system.

• Journal of The Korean Society of Agricultural Engineers
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• v.64 no.1
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• pp.15-26
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• 2022

3D open-field farm model developed from UAV (Unmanned Aerial Vehicle) data could make crop monitoring easier, also could be an important dataset for various fields like remote sensing or precision agriculture. It is essential to separate crops from the non-crop area because labeling in a manual way is extremely laborious and not appropriate for continuous monitoring. We, therefore, made a 3D open-field farm model based on UAV images and developed a crop segmentation model using a supervised machine learning algorithm. We compared performances from various models using different data features like color or geographic coordinates, and two supervised learning algorithms which are SVM (Support Vector Machine) and KNN (K-Nearest Neighbors). The best approach was trained with 2-dimensional data, ExGR (Excess of Green minus Excess of Red) and z coordinate value, using KNN algorithm, whose accuracy, precision, recall, F1 score was 97.85, 96.51, 88.54, 92.35% respectively. Also, we compared our model performance with similar previous work. Our approach showed slightly better accuracy, and it detected the actual crop better than the previous approach, while it also classified actual non-crop points (e.g. weeds) as crops.

• Journal of Environmental Science International
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• v.30 no.12
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• pp.1027-1039
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• 2021

In this study, we investigated the optimal meteorological conditions for cloud seeding using aircraft over the Korean Peninsula. The weather conditions were analyzed using various data sources such as a weather chart, upper air observation, aircraft observation, and a numerical model for cloud seeding experiments conducted from 2018 to 2019 by the National Institute of Meteorological Sciences, Korea Meteorological Administration. Cloud seeding experiments were performed in the seasons of autumn (37.0%) and winter (40.7%) in the West Sea and Gangwon-do. Silver iodide (70.4%) and calcium chloride (29.6%) were used as cloud seeding materials for the experiments. The cloud seeding experiments used silver iodide in cold clouds. Aircraft observation revealed relatively low temperatures, low liquid water content, and strong wind speeds in clouds with a weak updraft. In warm clouds, the cloud seeding experiments used calcium chloride. Observations included relatively high temperatures, high liquid water content, and weak wind speeds in clouds with a weak updraft. Based upon these results, we determined the comprehensive meteorological conditions for cloud seeding experiments using aircraft over the Korean Peninsula. The understanding of optimal weather conditions for cloud seeding gained from this study provide information critical for performing successful cloud seeding and rain enhancement.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.7 no.2
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• pp.79-84
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• 2021

Radiopharmaceuticals are important for tumor diagnosis and therapy. To deliver a radiotracer at the desired target excluding non-targeted tissues is difficult The development of a targeted tracer that has a good clearance profile while maintaining high biostability and biocompatibility is key to optimizing its biodistribution and transport across biological barriers. Improving the hydrophilicity of radiotracers by PEGylation can reduce serum binding, allowing the tracer to circulate without retention and reducing its affinity for non-targeted tissues. In this study, we synthesized a new benzamido tracer (SnBz-PEG₃₆) with the introduction of a low molecular weight polyethylene glycol unit (PEG₃₆, ~2,100 Da). The tumor targeting efficiency and biodistribution of [¹³¹I]-Bz-PEG₃₆ or radiotracer-loaded liposomes were evaluated after their administration to normal mice or mouse tumor models including CT26 (xenograft) and 4T1 (xenograft and orthotopic). Most of the radiotracer was cleared out rapidly (1-24 h post-administration) through the kidney and there was little tumor uptake.