• 생체재료학회지
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• 제22권4호
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• pp.211-220
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• 2018

Background: Recently, cancer immunotherapy has become standard for cancer treatment. Immunotherapy not only treats primary tumors, but also prevents metastasis and recurrence, representing a major advantage over conventional cancer treatments. However, existing cancer immunotherapies have limited clinical benefits because cancer antigens are often not effectively delivered to immune cells. Furthermore, unlike lymphoma, solid tumors evade anti-cancer immunity by forming an immune-suppressive tumor microenvironment (TME). One approach for overcoming these limitations of cancer immunotherapy involves nanoparticles based on biomaterials. Main body: Here, we review in detail recent trends in the use of nanoparticles in cancer immunotherapy. First, to illustrate the unmet needs for nanoparticles in this field, we describe the mechanisms underlying cancer immunotherapy. We then explain the role of nanoparticles in the delivery of cancer antigens and adjuvants. Next, we discuss how nanoparticles can be helpful within the immune-suppressive TME. Finally, we summarize current and future uses of nanoparticles with image-guided interventional techniques in cancer immunotherapy. Conclusion: Recently developed approaches for using nanoparticles in cancer immunotherapy have enormous potential for improving cancer treatment. Cancer immunotherapy based on nanoparticles is anticipated not only to overcome the limitations of existing immunotherapy, but also to generate synergistic effects via cooperation between nanoparticles and immune cells.

• 전기전자학회논문지
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• 제25권2호
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• pp.280-284
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• 2021

본 논문에서는 스냅백 특성을 개선시키기 위해 일반적인 SCR의 구조적 변경 및 Stack 기술을 적용한 새로운 구조의 ESD 보호회로를 제안한다. 펜타-웰과 더블 트리거를 이용한 구조에 대한 전기적 특성을 분석하고 Stack 구조를 적용해 트리거 전압과 홀딩 전압을 개선하였다. 시뮬레이션을 통한 전자 전류와 총 전류 흐름을 분석 하였다. 이를 통해 레치-업 면역 특성과 우수한 홀딩전압 특성을 확인 하였다. 제안된 ESD 보호회로의 전기적 특성은 TCAD 시뮬레이터를 통해 구조를 형성하고 HBM 모델링을 통해 분석 하였다.

• Tribology and Lubricants
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• 제36권6호
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• pp.350-358
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• 2020

Hot stamping is an effective and suitable process widely used in automotive applications, though critical issues such as the transfer of the coating materials and build-up of these materials on tool surfaces have been encountered. Past researches figured out the resultant wear phenomenon using pin-on-disc and drawing (for example, strip drawing and deep drawing) methods to mimic the process and analyzed the wear behavior with respect to the influencing factors such as surface coating, load, and roughness. Although the pin-on-disc is a conventional and widely-used method, it presented a methodological limitation when simulating the hot stamping process by forming a new blank each time, and hence, a drawing-based friction method has been proposed and developed. Each drawing method applies loads in a different way, resulting in a different wear behavior. Notably, the deep drawing process is most similar to the hot stamping process compared to other drawing methods. In this paper we present a review of the friction testing methods mimicking the hot stamping process and the associated wear behavior. This can be helpful in presenting a step-by-step approach and different perspectives on the wear behavior in the hot stamping process.

• BMB Reports
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• 제55권3호
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• pp.154-159
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• 2022

Protein S-glutathionylation is a reversible post-translational modification on cysteine residues forming a mixed disulfide with glutathione. S-glutathionylation, not only protects proteins from oxidation but also regulates the functions of proteins involved in various cellular signaling pathways. In this study, we developed a method for the detection of S-glutathionylated proteins (ProSSG) using eosin-glutathione (E-GSH) and mouse glutaredoxin 1 (mGrx1). ProSSG was efficiently and specifically labeled with E-GSH to form ProSSG-E via thiol-disulfide exchange. ProSSG-E was readily luminescent allowing the detection of ProSSG with semi-quantitative determination. In addition, a deglutathionylation enzyme mGrx1 specifically released E-GSH from ProSSG-E, which increased fluorescence allowing a sensitive determination of ProSSG levels. Application of the method to the adipocyte differentiation of 3T3-L1 cells showed specific detection of ProSSG and its increase upon differentiation induction, which was consistent with the result obtained by conventional immunoblot analysis, but with greater specificity and sensitivity.

• 한국정보기술학회 영문논문지
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• 제10권2호
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• pp.199-214
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• 2020

An important technique of the present invention is primarily to parallel light detection, self-pulse therapy after diagnosis. Herpes zoster is a disease caused by varicella zoster virus, and the virus that has been latent in the dorsal root ganglion that controls the skin segment loses its immune system and physically damages it. It is an acute skin disease in which acute pain and bullous rash occur along the sensory ganglia, which are rehab by inducers such as malignant tumors. Dorsal root ganglion after complete recovery of varicella, relapsed after incubation in brain ganglion, latent virus sometimes suppressed activity by cell mediated immunity, and in cell ganglion with reduced cellular immunity. It proliferates and destroys neurons, causing pain while forming a rash and blisters. This can reduce cell necrosis and increase the phagocytosis and enzymatic activity through the movement of ions through the cell membrane, depolarization and membrane potential change, growth factor secretion, calcium ion transfer, chondrocyte synthesis, etc., And may offer treatment options for lesions of herpes zoster and post-herpetic neuralgia (PHN).Therefore, according to the present research, the diagnosis and treatment device of treating paing for herpes zoster and post-herpetic pain can be implemented in the early stage of herpes zoster, and conventional analgesic regulation, anti-inflammatory effect, post-herpetic neuralgia.

• 한국펄프종이공학회:학술대회논문집
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• 한국펄프종이공학회 2006년도 PAN PACIFIC CONFERENCE vol.1
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• pp.19-29
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• 2006

Drying is the least developed of all unit operations of paper and board manufacture. While groundbreaking developments were Introduced during the several past decades in forming, pressing and calendering, no radical changes occurred in drying. The cylinder-drying technology is now more than 200 years old and, while it was subject to many incremental improvements, many of its inherent problems persist. We believe that conventional drying is now approaching the end of its life and the industry is ready for a major breakthrough in drying. Indeed several innovative technologies already exist at various stages of development or commercialization. In general, the novel drying technologies are striving to increase the drying rate, improve the product quality and boost the energy efficiency of drying. A novel, drying method, $Papridry^{TM}$, which combines conductive and convective heat transfer to obtain very high drying rates, is at an advanced stage of development at Paprican. The results obtained when drying printing paper ana board on a self-standing pilot $Papridry^{TM}$ machine and on the pilot paper machine equipped with a tandem of two $Papridry^{TM}$ units demonstrate both, the high drying rate and improved product quality achieved by using this drying method. A mathematical model of this operation has been developed and the software compiled with this model was used to calculate the effect of installing a $Papridry^{TM}$ unit into an existing dryer section. The model also allows to calculate the z-direction distribution of moisture and temperature at various points of the dryer section.

• 국제학술발표논문집
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• The 2th International Conference on Construction Engineering and Project Management
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• pp.30-40
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• 2007

The demand for light-rail construction projects has recently been increasing, and they are mostly supervised by private construction companies. Therefore, a private construction company that aim to raise gains from the operation of the facilities during the contract period greater than what they invested should b able to accurately calculate the costs from the aspect of Life Cycle Cost (LCC). In particular, a light-rail transit bridge that has a heavier portion from the aspect of the cost of light-rail transit construction requires a more accurate calculation method than the conventional LCC calculation method. For this, an LCC analysis model was developed and a cost breakdown structure was suggested based on literature review. The construction costs by shape of the upper part of a light-rail transit were calculated based on the cost breakdown system presented in this paper, and the cost generation cycle and cost unit price were collected and analyzed based on records on maintenance costs, rehabilitation and replacement. In addition, after forming some hypotheses in order to perform the LCC analysis, economic evaluation was conducted from the aspect of the LCC by using performance data by item.

• 통합자연과학논문집
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• 제15권1호
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• pp.37-48
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• 2022

Metabus, a three-dimensional virtual environment for digital communication, has gained a lot of attention recently. Even so, there are still many unanswered questions about the user's consciousness and behavior. A difference in nature from conventional digital communication is also unclear. This paper aims to study Metabus on a hypothetical premise by organizing the possibility of Metabus for communication activation based on a research project aimed at using Metabus to support the formation of a community of school dormitories and studio rental residents. After reviewing the establishment process and application cases of Metabus, we focus on the character (avatar) used as the user's alter ego within the metabus, which will allow customization of both form and content different from text-based communication. The "physicality" and the "spatiality" of the metaverse and the "immersion" they bring are among the most important, functional innovations. Based on this summary, a case of using metabuses will be reviewed to describe the research plan aimed at supporting community formation.

• Journal of Information Science Theory and Practice
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• 제10권spc호
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• pp.12-24
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• 2022

This study attempted to investigate changes in collaboration structure for each stage of national Research and Development (R&D) in the artificial intelligence (AI) field through analysis of a co-author network for papers written under national R&D projects. For this, author information was extracted from national R&D outcomes in AI from 2014 to 2019. For such R&D outcomes, NTIS (National Science & Technology Information Service) information from the KISTI (Korea Institute of Science and Technology Information) was utilized. In research collaboration in AI, power function structure, in which research efforts are led by some influential researchers, is found. In other words, less than 30 percent is linked to the largest cluster, and a segmented network pattern in which small groups are primarily developed is observed. This means a large research group with high connectivity and a small group are connected with each other, and a sporadic link is found. However, the largest cluster grew larger and denser over time, which means that as research became more intensified, new researchers joined a mainstream network, expanding a scope of collaboration. Such research intensification has expanded the scale of a collaborative researcher group and increased the number of large studies. Instead of maintaining conventional collaborative relationships, in addition, the number of new researchers has risen, forming new relationships over time.

• 한국정밀공학회지
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• 제10권3호
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• pp.198-204
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• 1993

The study is concerned with finite element analysis and design of axisymmetric deep drawing by local heating. When the bottom shape of a cup is not flat but in complex-shaped, i.e., hemispherical, the cup cannot be drawn in one or two processes in the conventional deep drawing process and the limit drawing ratio is limited as well. By introducing local heating selectively with regards to the heating position, the formability of the sheet metal can be greatly increased with the reduced number of processes. In the Process analysisthe rigid- viscoplastic finite element method is employed and the temperature effect is incorporated. Bishop's step-wise decoupled method is employed to analyze the thermomechanical interaction between deformation and heat transfer. Axisymmetric deep drawing of a hemisphere-bottomed cup has been analyzed for various combinations of heat application in the punch and the die. At the first stage of deep drawing stretch forming is practically carried out by firmly pressing the blankholder with the punch and the die heated at various levels of temperature. Then at the second stage the same cup is drawn for the saame or different combination of temperature. From the computation, it has thus been shown that the fromability of a cup is greatly increased in two-stage deep drawing with increased limet drawing ratio.