• Biomolecules & Therapeutics
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• 제20권2호
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• pp.234-238
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• 2012

Propofol is an anesthetic commonly used to provide sedation or to induce and maintain an anesthetic stated. However, there are reports which indicate propofol may cause psychological dependence or be abused. In the present study, we used various behavioral tests including climbing test, jumping test, conditioned place preference, and self-administration test to assess the dependence potential and abuse liability of propofol compared to a positive control (methamphetamine) or a negative control (saline or intralipid). Among the tests, the conditioned place preference test was conducted with a biased method, and the selfadministration test was performed under a fixed ratio (FR) 1 schedule, 1 h per session. No difference was found in the climbing test and jumping test, but propofol (30 mg/kg, i.p.) increased the rewarding effect in the conditioned place preference test, and it showed a positive reinforcing effect compared to the vehicle. These results indicate that propofol tends to show psychological dependence rather than physical dependence, and it seems not to be related with dopaminergic system.

• 근관절건강학회지
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• 제24권1호
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• pp.37-46
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• 2017

Purpose: The purpose of this study was to examine the effects of the program to improve on smoking patients' after acute coronary syndrome (ACS) smoking cessation rate, smoking cessation related self-efficacy, carbone monoxide (CO), nicotine dependence, and pain sense. Methods: This study used a non-equivalent control group pretest-posttest design. The participants of this study were 60 ACS patients: experimental group (30), control group (30), who received percutaneous coronary intervention. The study lasted from Aug 16, 2016 to Jan 13, 2017. Smoking cessation rate, smoking cessation related self-efficacy, CO, nicotine dependence, and pain sense were measured using the structured questionnaires and CO monitor Results: An examination of the effects of this program revealed the experimental group to have a significant increase in smoking cessation rate, smoking cessation related self-efficacy than the control group, and a significant decrease in CO, nicotine dependence and pain sense than in the control group. Conclusion: The findings indicate that this smoking cessation self-efficacy improvement program is effective for hospitalized patients after ACS.

• 대한인간공학회지
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• 제19권1호
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• pp.1-9
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• 2000

This study was performed to investigate some characteristics on human error proneness in the computerized work environment. Our concerning theme was on human error likelihood according to personal temperament. Two experiments were performed. The first experiment was to study the effect of field- independence/dependence on error likelihood. The second experiment was on error proneness. These experiments were performed in information search task. which was most frequent task in computerized work environment such as the control room of nuclear power plant. Ten subjects were participated in this study. Analyzed results are as follows. Field-independence/dependence had a significant effect in both information search time and error frequency. Error proneness had a significant effect in both factors, too. And, a positive correlation was found between error frequency and information search time. These results will be utilized as a basis to study operator's error proneness in the computerized control room of nuclear power plant. later on.

• Journal of Preventive Medicine and Public Health
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• 제51권1호
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• pp.1-5
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• 2018

Smokers keep smoking despite knowing that tobacco claims many lives, including their own and others'. What makes it hard for them to quit smoking nonetheless? Tobacco companies insist that smokers choose to smoke, according to their right to self-determination. Moreover, they insist that with motivation and willpower to quit smoking, smokers can easily stop smoking. Against this backdrop, this paper aims to discuss the addictive disease called tobacco use disorder, with an assessment of the addictiveness of tobacco and the reasons why smoking cessation is challenging, based on neuroscientific research. Nicotine that enters the body via smoking is rapidly transmitted to the central nervous system and causes various effects, including an arousal response. The changes in the nicotine receptors in the brain due to continuous smoking lead to addiction symptoms such as tolerance, craving, and withdrawal. Compared with other addictive substances, including alcohol and opioids, tobacco is more likely to cause dependence in smokers, and smokers are less likely to recover from their dependence. Moreover, the thinning of the cerebral cortex and the decrease in cognitive functions that occur with aging accelerate with smoking. Such changes occur in the structure and functions of the brain in proportion to the amount and period of smoking. In particular, abnormalities in the neural circuits that control cognition and decision-making cause loss of the ability to exert self-control and autonomy. This initiates nicotine dependence and the continuation of addictive behaviors. Therefore, smoking is considered to be a behavior that is repeated due to dependence on an addictive substance, nicotine, instead of one's choice by free will.

• 노동경제논집
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• 제41권3호
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• pp.95-128
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• 2018

본 연구는 우리나라 기혼여성들의 시간제, 전일제 등 근로형태가 오래 지속되는지 아니면 근로형태간 이동이 활발한지를 상태의존성(state dependence) 추정을 통하여 살펴보고, 최근의 변화를 분석하였다. 동태적 다항로짓모형(dynamic multinomial logit model) 추정결과 시간제와 전일제 상호간 이동성이 최근 낮아지면서 각 근로형태의 상태의존성은 강화되는 모습을 보였다. 따라서 시간제일자리는 전일제와 미취업 사이에서 근로형태간 이동을 활발하게 하는 디딤돌 또는 쉼터의 역할이 약화되고 전일제 외에 노동시장 참여 옵션을 제공하는, 전일제와는 구분된 추가적 일자리형태로 기능하고 있는 것으로 판단된다.

• 보건교육건강증진학회지
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• 제12권2호
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• pp.146-161
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• 1995

This study is an effort to bring our attention to social dependence on alcohol, focusing on previous studies of drinking behaviors. Although drinking behavior and problems must be understood in a biopsychosocial framework, a certain aspect is often ignored in alcohol research. A few attention has been paid to social aspect of alcohol abuse or dependence. Social processes of drinking behavior deserve to have same attention as other aspects, psychological and physical aspects of the behavior. Literature show that the interdependence among group members exists to regulate individual's drinking behavior. Such social interactions tend to control drinking level for individual in terms of amounts, frequency, and preference. The drinking level tends to be dependent on desires for heavy drinkers, ignoring variabilities of individual's sensitivity to alcohol. However, such a heavy-oriented tendency in drinking behavior may have different patterns which are function of normative orientation of alcohol. negotiation among group members, and ethnoreligious characteristics. Perspectives from conflict tradition and symbolic interactionism are welcomed to illuminate multi-dimentional aspects of social dependence. Policy implication were discussed from public health perspective.

• Asian Pacific Journal of Cancer Prevention
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• 제13권1호
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• pp.343-346
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• 2012

Two methods of identifying smokers with high nicotine dependence, the heaviness of smoking index (HSI) and number of cigarettes per day (CPD) were compared with the Fagerstrom test for nicotine dependence (FTND). The HSI, CPD and the FTND were administered to 316 adult Malaysian male, daily smokers aged between 25-64 years old in the Malaysian NCD Surveillance-1 Survey using a two-stage stratified random sampling of enumeration blocks and living quarters, via an interview based on a validated questionnaire. The cut-off point for classification of high nicotine dependence on the HSI was a score of four or higher, and for the heavy smoking category, smoking more than 20 cigarettes per day. Classification using each method was compared with classification by the FTND (score of six or more) as the reference standard. Sensitivity, specificity and kappa statistics for concordance between both measures and the FTND were evaluated. The HSI gave a similar prevalence rate of high nicotine dependence as the FTND. There was substantial agreement between the HSI and the FTND (kappa=0.63.), with moderate sensitivity (69.8%) and high specificity (92.5%). However, prevalence of high nicotine dependence using the CPD was 7% lower than the FTND. The heavy smoking category also showed fair agreement with the FTND (kappa=0.45) and moderate sensitivity (67.0%), but specificity was high (86.9%). The findings indicate that the HSI can be used as an alternative to the FTND in screening for high nicotine dependence among daily smokers in large population-based studies, while CPD may not be a suitable alternative to the FTND.

• 생물정신의학
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• 제11권1호
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• pp.33-39
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• 2004

Objective:Nitric oxide(NO) has been known to be associated with tolerance and preference to alcohol. It has also been known to affect various alcohol drinking behavior, alcohol withdrawal symptoms and alcohol- induced brain damage. The purpose of this study was to determine the difference, among alcohol dependence group, alcohol drinking group and abstinence group, in serum concentration of nitrite, a stable metabolite of NO, and it's relationship to clinical and biochemical markers of alcoholism. Methods:Forty subjects diagnosed as alcohol dependence according to DSM-IV diagnostic criteria were evaluated for the clinical characteristics and biochemical markers of alcohol dependence including nitrite with their CIWA-Ar scores checked just after admission. Thirty-nine healthy controls were also evaluated, divided into twenty-three alcohol drinking group and sixteen abstinence group. Clinical characteristics were evaluated by CIWA-Ar, CAGE and AUDIT questionnaires. Aspartate aminotransferase(AST), alanine aminotransferase (ALT), gamma glutamyltransferase(GGT) and mean corpuscular volume(MCV) were used as the biochemical markers of alcohol dependence. Serum nitrite concentrations were measured by Griess reaction. Results:1) The concentrations of nitrite in alcohol dependence patients were not different from those in the control subjects. 2) There were no significant association between the nitrite concentrations and the CIWA-Ar scores in alcohol dependence patients. 3) Nitrites are significantly increased in alcohol dependence group and alcohol drinking group compared with abstinence group. Conclusions:These findings suggest that serum nitrite concentration has no relation with alcohol withdrawal symptoms, but alcohol drinking increases serum nitrite concentration influenced by general condition of the body.

• Communications for Statistical Applications and Methods
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• 제23권6호
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• pp.497-515
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• 2016

Modern processes often monitor more than one quality characteristic that are referred to as multivariate statistical process control (MSPC) procedures. The MSPC is the most rapidly developing sector of statistical process control and increases interest in the simultaneous inspection of several related quality characteristics. Most multivariate detection procedures based on a multi-normality assumptions are independent, but there are many processes that assume non-normality and correlation. Many multivariate control charts have a lack of related joint distribution. Copulas are tool to construct multivariate modelling and formalizing the dependence structure between random variables and applied in several fields. From copula literature review, there are a few copula to apply in MSPC that have multivariate control charts, and represent a successful tool to identify an out-of-control process. This paper presents various types of copulas modelling for the multivariate control chart. The performance measures of the control chart are the average run length (ARL) and the average number of observations to signal (ANOS). Furthermore, a Monte Carlo simulation is shown when the observations were from an exponential distribution.

• 한국기계가공학회지
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• 제3권2호
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• pp.67-72
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• 2004

Electro-Rheological(ER) fluids consist of suspensions of fine polarizable particles In a dielectric oil, which upon application of an external electric field control take on the characteristics of the Bingham solid. In this study, the temperature dependence of the viscosity was Investigated for an ER fluid consisting of 35 weight % of zeolite particles in hydraulic oil 46cSt. Thermal activation analysis was performed by changing the ER fluid's temperature from $-10^{\circ}C$ to $50^{\circ}C$. According to the analysis, the activation energy for flow of the ER fluid was 79.6 kJ/mole without applying electric field. On the other hand, with the electric field of 2kV/mm, the linearity between viscosity and temperature was not existed By changing the temperatures the viscosity (or shear stress) versus shear rates were measured. In this experiment shear rates were increased from 0 to $200s^{-1}$ in 2 minutes. Generally, the hydraulic oil 46cSt will be operated at the temperature of about $40^{\circ}C$, thus, the ER fluid's electric field dependence of viscosity was examined at this temperature. Also, an influence of adding the dispersant(Carbopl 940) on ER effect was discussed.