• Journal of Physiology & Pathology in Korean Medicine
• /
• v.36 no.1
• /
• pp.23-27
• /
• 2022

This study aims to evaluate the anti-inflammatory effect of 80% ethanol extracts of Stachys affinis (MQ) on 1-fluoro-2,4-Dinitrofluorobenzene (DNFB) induced atopic dermatitis (AD) in Balb/c mice. AD-like allergic contact dermatitis was induced by challenge of DNFB on the ear after DNFB sensitization on the back sides of mice. MQ alleivated clinical severity in AD-like skin lesions. In addition, ear thickness of epidermis and penetration of inflammatory cells in AD-like skin lesions were decreased by topical application of MQ. The the serum levels of tumor necrosis factor-α (TNF-α) and interleukin-4 (IL-4) were measured in AD mice using ELISA kits. Levels of TNF-α and IL-4 in serum were significantly decreased by topical application of MQ. Therefore, this study could give a clinical basis that MQ could be a agent to prevent AD.

• Journal of the Korean Society for Precision Engineering
• /
• v.14 no.5
• /
• pp.85-91
• /
• 1997

Air grinding time in grinding process has a great effect on its efficiency due to low feedrate. This paper presents a reduction methos of air grinding time in cylindrical plunge grinding operation. Tje reduction of air grinding time is accomplished by finding the distance between contact point and rising point of ultra- sonic signal of the grinding wheel to workpiece. It uses a variation of sound signal generated by the flow of coolant when the grinding wheel approaches to workpiece. The ultrasonic sensor with 23 kHz center fre- quency and 8 kHz bandwidth is used to find the nearest approaching point(NAP). Monitoring and control system of the grinding conditions is implemented with CNC controller to control feedrate override and ultrasonic sensor to find NAP. The experimental result shows that the ultrasonic signal is a good measure- ment to find NAP. But it needs the considerations for the effect of the relationship between flowrate of coolant and diameter of workpiece.

• Journal of the Korean Burn Society
• /
• v.22 no.2
• /
• pp.21-24
• /
• 2019

Incidence of low-temperature contact burn by use of an electric pad is increased recently, especially in depressed sensory. Acquired immune deficiency syndrome patient using antiretroviral agent suffered with sensory depression as side effect. There are many limitations in wounds treatment of these patients. These patients are vulnerable to infection due to their weak immunity, so it is necessary to keep them in a state of isolation when a wound occurs. We report a case of a third degree burn by electric pad with a surface area of approximately 5% of the body surface of a patient who underwent a sensory depression, which is a side effect of antiretroviral drugs used for treatment in patients with AIDS. In this regard, we report the case with literature review, which is safely recovered using negative-pressure wound therapy and split-thickness skin graft.

• Geomechanics and Engineering
• /
• v.35 no.2
• /
• pp.209-219
• /
• 2023

This paper presents numerical investigations into the particle crushing effect on the shear properties of gravel under direct shear condition. A novel particle crushing model was developed based on the octahedral shear stress criterion and fragment replacement method. A series of direct shear tests were carried out on unbreakable particles and breakable particles with different strengths. The evolutions of the particle crushing, shear strength, volumetric strain behavior, and contact force fabric during shearing were analyzed. It was observed that the number of crushed particles increased with the increase of the shear displacement and axial pressure and decreased with the particle strength increasing. Moreover, the shear strength and volume dilatancy were obviously decreased with particle crushing. The shear displacement of particles starting to crush was close to that corresponding to the peak shear stress got. Besides, the shear-hardening behavior was obviously affected by the number of crushed particles. A microanalysis showed that due to particle crushing, the contact forces and anisotropy decreased. The mechanism of the particle crushing effect on the shear strength was further clarified in terms of the particle friction and interlock.

• Tribology and Lubricants
• /
• v.40 no.3
• /
• pp.84-90
• /
• 2024

This study investigates the effect of the surface microstructure on the tribological characteristics of glass substrates. Chemical etching using hydrofluoric acid and ammonium hydrogen fluoride was employed to create controlled asperity structures on glass surfaces. By varying the etching time from 10 to 50 min, different surface morphologies were obtained and characterized using optical microscopy, surface roughness measurements, and water contact angle analysis. Friction tests were performed using a stainless steel ball as the counter surface to evaluate the tribological behavior of the etched specimens. The results showed that the specimen etched for 20 min exhibited the lowest and most stable friction coefficient, which was attributed to the formation of a uniform and dense asperity structure that effectively reduced the stress concentration and wear at the contact interface. In contrast, specimens etched for shorter (10 min) or longer (30-50 min) durations displayed higher friction coefficients and accelerated wear owing to nonuniform asperity structures that led to local stress concentration. Optical microscopy of the wear tracks further confirmed the superior wear resistance of the 20-minute etched specimen. These findings highlight the importance of optimizing the etching process parameters to achieve the desired surface morphology for enhanced tribological performance, suggesting the potential of chemical etching as a surface modification technique for various materials in tribological applications.

• Geomechanics and Engineering
• /
• v.38 no.6
• /
• pp.571-581
• /
• 2024

Concrete linings in tunnels constructed by drilling and blasting such as NATM serve as a secondary support structure. However, these linings can face unexpected earth pressures if the primary support deteriorates or if ground conditions become unfavorable. It is crucial to determine the loosening earth pressure that allows the lining to maintain its structural integrity and prevent damage caused by this pressure. This study proposes a numerical model for simulating the trapdoor test and developing a method for calculating the loosening earth pressure. The discrete element method (DEM) was employed to describe the soil characteristics around the tunnel. Using this numerical model, a sequence of experimental trapdoor steps was simulated, and the loosening earth pressure was analyzed. Contact parameters were calibrated based on an analysis of a triaxial compression test. The reliability of the developed model was confirmed through a comparison between simulation results and laboratory test findings. The model was used to calculate the contact force applied to the trapdoor plate and to assess the settlement of soil particles. Furthermore, the model accounted for the soil-arching effect, which effectively redistributes the load to the surrounding areas. The proposed model can be applied to analyze the tunnel's cross-sectional dimensions and design stability under various ground conditions.

• The Journal of Korean Academy of Prosthodontics
• /
• v.49 no.3
• /
• pp.214-221
• /
• 2011

Purpose: To date most of finite element analysis assumed the presence of 100% contact between bone and implant, which is inconsistent with clinical reality. In human retrieval study bone-implant contact (BIC) ratio ranged from 20 to 80%. The objective of this study was to explore the influence of bone-implant contact pattern on bone of the interface using nonlinear 3-dimensional finite element analysis. Materials and methods: A computer tomography-based finite element models with two types of implant (Mark III Br${\aa}$nemark$^{(R)}$, Inplant$^{(R)}$) which placed in the maxillary 2nd premolar area were constructed. Two different degrees of bone-implant contact ratio (40, 70%) each implant design were simulated. 5 finite element models were constructed each bone-implant contact ratio and implant design, and sum of models was 40. The position of bone-implant contact was determined according to random shuffle method. Elements of bone-implant contact in group W (wholly randomized osseointegration) was randomly selected in terms of total implant length including cortical and cancellous bone, while ones in group S (segmentally randomized osseointegration) was randomly selected each 0.75 mm vertically and horizontally. Results: Maximum von Mises strain between group W and group S was not significantly different regardless of bone-implant contact ratio and implant design (P=.939). Peak von Mises strain of 40% BIC was significantly lower than one of 70% BIC (P=.007). There was no significant difference between Mark III Br${\aa}$nemark$^{(R)}$ and Inplant$^{(R)}$ in 40% BIC, while average of peak von Mises strain for Inplant$^{(R)}$ was significantly lower ($4886{\pm}1034\;{\mu}m/m$) compared with MK III Br${\aa}$nemark$^{(R)}$ ($7134{\pm}1232\;{\mu}m/m$) in BIC 70% (P<.0001). Conclusion: Assuming bone-implant contact in finite element method, whether the contact elements in bone were wholly randomly or segmentally randomly selected using random shuffle method, both methods could be effective to be no significant difference regardless of sample size.

• JSTS:Journal of Semiconductor Technology and Science
• /
• v.16 no.2
• /
• pp.204-209
• /
• 2016

The analyses on self-heating effect in 7 nm node non-rectangular Bulk FinFET device were performed using 3D device simulation with consideration to contact via and pad. From self-heating effect simulation, the position where the maximum lattice temperature occurs in Bulk FinFET device was investigated. Through the comparison of thermal resistance at each node, main heat transfer path in Bulk FinFET device can be determined. Self-heating effect with device parameter and operation temperature was also analyzed and compared. In addition, the impact of interconnects which are connected between the device on self-heating effect was investigated.

• Journal of Pharmaceutical Investigation
• /
• v.1 no.1
• /
• pp.30-33
• /
• 1971

Comparative studies were made on the analgesic effect of salicylamide, used individually and combined with parasympatholytics (propantheline and atropine) and antihistaminics (tripelennamine, diphenhydramine) as regards the analgesic effect (in thermal contact method) were examined by its oral administration with each combined drug to mouse (three assumption cross-over test), and the following effects were found. 1. The increasing order of the parasympatholytics to the analgesic effect of salicylamide is as follows: propantheline>atropine. 2. The increasing order of the antihistaminics to the analgesic effect of salicylamide is as follows: chlorpheniramine>diphenhdramine>tri pelennamine. In the ratio '1 : 1' salicylamide to parasympatholytics and antihistaminics, the analgesic effect of salicylamide was more increase than the other ratio in this study.

• Environmental Sciences Bulletin of The Korean Environmental Sciences Society
• /
• v.2 no.2
• /
• pp.99-108
• /
• 1998

Results obtained from this research showed that the anaerobic contact process was applicable to pear waste with COD removal efficiencies of up to $95\%$ depending on conditions, provided ammonium and phosphate salts were added as well as other nutrients, present in the commercial fertilizer, Milorganite or in yeast extract. These latter materials were required in minimum concentrations of 5 and 1.5 g/L, respectively, in the feed independent of HRT and volatile solids loading rate, with part of the effect due to the mineral fraction. Digestion was satisfactory over the whole range of volatile solids loading rates and liquid retention time of 30 to 0.5 days tested, although treatment efficiency dropped off noticeably between 1 and 0.5 day liquid retention time because of poorer flocculation and separation of anaerobic bacteria. Settling of anaerobic bacteria including methane producing bacteria was related to settling of mixed liquor suspended solids only at 1 to 5 days liquid retention times, at other liquid retention times anaerobic microorganism settled markedly less efficiently than mixed liquor suspended solids. Further studies are being made to provide information of practical and basic interest. Data on the composition of the active fraction of yeast extract might solve many practical nutrient problems encountered with the anaerobic contact process and improve its economics. Further improvement in the flocculation and settling of anaerobic bacteria as well as other bacteria would improve overall performance and allow the use of shorter liquid retention times with dilute waste. Knowledge about the numbers of methane formers present would allow a degree of understanding and control of the process not presently attainable.