• Journal of Korean Society for Quality Management
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• v.17 no.1
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• pp.19-34
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• 1989

In this paper, we propose the Bayes estimators of the reliability for a system consisting of the left-truncated exponential components under the truncated normal distribution as a conjugate prior distribution and squared - error loss function on the series, parallel and k-out-of-m : G system. And we compare the proposed Bayes estimators of the system reliability each other in terms of MSE performances and stabilities by the Monte Carlo simulation.

• Archives of Pharmacal Research
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• v.27 no.8
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• pp.878-883
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• 2004

Tacrolimus (FK506), which is isolated from Streptomyces tsukubaensis, is a new potent immu-nosuppressant. Because of poor solubility in water, the conventional intravenous dosage forms of tacrolimus contain surfactants such as cremophor EL (BASF Wyandotte Co.) or hydroge-nated polyoxy 60 castor oil (HCO-60) which may cause adverse effects. This study relates to a polymer-tacrolimus conjugate, which can be dissolved in water, formed by chemically binding the sparingly soluble drug, tacrolimus, with the water soluble polymer, methoxypoly(ethylene glycol) (mPEG). Water soluble tacrolimus-mPEG conjugates have been synthesized and shown to be function in vitro as prodrugs. These conjugates are in the form of an ester wherein the 24-, 32- or 24,32-positions are esterified. The desired 24-, 32- or 24,32-esterified com-pounds were obtained by initially acylating of tacrolimus with iodoacetic acid at the 24-,32-, or 24,32-positions and then reacting the resulting acylated tacrolimus with a mPEG in the pres-ence of a base such as sodium bicarbonate. These conjugates were converted again into tac-rolimus by the action of enzymes in human liver homogenate, and the half-lives of the conjugates are approximately 10 min in the homogenate, indicating that the esterified tacroli-mus derivatives may be practically applicable as a prod rug for the immunosuppressant.

• Steel and Composite Structures
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• v.26 no.6
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• pp.663-672
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• 2018

This paper contains a consistent couple-stress theory to capture size effects in Euler-Bernoulli nano-beams made of three-directional functionally graded materials (TDFGMs). These models can degenerate into the classical models if the material length scale parameter is taken to be zero. In this theory, the couple-stress tensor is skew-symmetric and energy conjugate to the skew-symmetric part of the rotation gradients as the curvature tensor. The material properties except Poisson's ratio are assumed to be graded in all three axial, thickness and width directions, which it can vary according to an arbitrary function. The governing equations are obtained using the concept of minimum potential energy. Generalized differential quadrature method (GDQM) is used to solve the governing equations for various boundary conditions to obtain the natural frequencies of TDFG nano-beam. At the end, some numerical results are performed to investigate some effective parameter on buckling load. In this theory the couple-stress tensor is skew-symmetric and energy conjugate to the skew-symmetric part of the rotation gradients as the curvature tensor.

• Proceedings of the KSRS Conference
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• 2007.10a
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• pp.14-17
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• 2007

To make use of surveying data obtained from different sensors and different techniques in a common reference frame, it is a pre-requite step to register them in a common coordinate system. For this purpose, we have developed a methodology to register IKONOS-2 Satellite Imagery using ALS data. To achieve this, conjugate features from these data should be extracted in advance. In the study, linear features are chosen as conjugate features because they can be accurately extracted from man-made structures in urban area, and more easily than point features from ALS data. Then, observation equations are established from similarity measurements of the extracted features. During the process, considering the characteristics of systematic errors in IKONOS-2 satellite imagery, the transformation function were selected and used. In addition, we also analyzed how the number of linear features and their spatial distribution used as control features affect the accuracy of registration. Finally, the results were evaluated statistically and the results clearly demonstrated that the proposed algorithms are appropriate to register these data.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.7 no.4
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• pp.566-576
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• 1995

A Computational code has been developed in order to design axial fans by the numerical optimization techniques incorporated with flow analysis code solving three-dimensional Navier-Stokes equation. The steepest descent method and the conjugate gradient method are used to look for the search direction in the design space, and the golden section method is used for one-dimensional search. To solve the constrained optimization problem, sequential unconstrained minimization technique, SUMT, is used with imposed quadratic extended interior penalty functions. In the optimization of two-dimensional cascade design, the ratio of drag coefficient to lift coefficient is minimized by the design variables such as maximum thickness, maximum ordinate of camber and chord wise position of maximum ordinate. In the application of this numerical optimization technique to the design of an axial fan, the efficiency is maximized by the design variables related to the sweep angle distributed by quadratic function along the hub to tip of fan.

• Korean Journal of Materials Research
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• v.13 no.8
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• pp.550-554
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• 2003

Current nanogold cluster synthesized by chemical routine with 11 or 55 atoms of gold has been widely used for immuno chemistry probe as a form of nanocluster conjugated with biomolecules. It would be an undeveloped region that the 1 nm size of nanogold could be made by materials engineering processing. Therefore, objective of this study is to minimize the size of gold nanocluster as a function of operating temperature and chamber pressure in inert gas condensation (IGC) processing. Evaporation temperature was controlled by input current from 50 A to 65 A. Chamber pressure was controlled by argon gas with a range of 0.05 to 2 torr. The gold nanocluster by IGC was evaluated by X-ray diffraction (XRD) and transmission electron microscopy (TEM). The gold nanocluster for TEM analysis was directly sampled with special in-situ method during the processing. Atomic force microscopy (AFM) was used to observe 3-D nanogold layer surfaces on a slide glass for the following biomolecule conjugation step. The size of gold nanoclusters had a close relationship with the processing condition such as evaporation temperature and chamber pressure. The approximately 1 nm size of nanogold was obtained at the processing condition for 1 torr at $1124 ^{\circ}C$.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.22 no.1
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• pp.35-44
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• 2009

This paper describes an application of domain decomposition method for parallel finite element analysis which is required to large scale 3D structural analysis. A parallel finite element method system which adopts a domain decomposition method is developed. Node is generated if its distance from existing node points is similar to the node spacing function at the point. The node spacing function is well controlled by the fuzzy knowledge processing. The Delaunay triangulation method is introduced as a basic tool for element generation. Domain decomposition method using automatic mesh generation system holds great benefits for 3D analyses. Aa parallel numerical algorithm for the finite element analyses, domain decomposition method was combined with an iterative solver, i.e. the conjugate gradient(CG) method where a whole analysis domain is fictitiously divided into a number of subdomains without overlapping. Practical performance of the present system are demonstrated through several examples.

• Geophysics and Geophysical Exploration
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• v.9 no.1
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• pp.121-128
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• 2006

Magnetic survey flights by helicopters are usually parallel to the topographic surface, with a nominal clearance, but especially in high-resolution surveys the altitudes at which observations are made may be too variable to be regarded as a smooth surface. We have developed a reduction procedure for such data using the method of equivalent sources, where surrounding sources are included to control edge effects, and data from points distributed randomly in three dimensions are directly modelled. Although the problem is generally underdetermined, the method of conjugate gradients can be used to find a minimum-norm solution. There is freedom to select the harmonic function that relates the magnetic anomaly with the source. When the upward continuation function operator is selected, the equivalent source is the magnetic anomaly itself. If we select as source a distribution of magnetic dipoles in the direction of the ambient magnetic field, we can easily derive reduction-to-pole anomalies by rotating the direction of the magnetic dipoles to vertical.

• Composites Research
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• v.12 no.1
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• pp.1-10
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• 1999

In order to predict the dynamic behavior of composite laminated plate accurately, the parametric identification is performed using its mechanical properties- $E_1,\;E_2,\;V_{12},\;G_{12}$ as design parameters. After natural frequencies are measured through simple vibration test, the objective function consists of the sum of errors between experimental and numerical frequencies of a structure. As optimization algorithm, conjugate gradient method is used to minimize the objective function. Sensitivity Analysis is performed to update design parameters during this process and can explain the result of parametric identification. In order to check the propriety of result, mode shapes are compared before and after identification. The improved prediction of natural frequencies of composite laminated plate is obtained with updated properties. For the application of result, updated properties is applied to the composite laminated plate that has different stacking sequence.

• Proceedings of the KSME Conference
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• 2007.05b
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• pp.2666-2671
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• 2007

This work presents microchannel heat sink shape optimization procedure using Kriging method. Design variables relating to microchannel width, depth and fin width are selected, and thermal resistance has been taken as objective function. Design points are selected through a three-level fractional factorial design of sampling method. Navier-Stokes and energy equations for laminar flow and conjugate heat transfer are solved at these design points using a finite volume solver. Solutions are carefully validated with experimental results. Using the numerically evaluated objective function, a surrogate model (Kriging) is constructed and optimum point is searched by sequential quadratic programming. The process of shape optimization greatly improves the thermal performance of microchannel heat sink under constant pumping power.