• Bulletin of the Korean Chemical Society
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• 제6권4호
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• pp.210-214
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• 1985

Urokinase, a plasminogen activator, was conjugated with dextran by the cyanogen bromide activation-coupling method. The resulting water-soluble conjugate was purified by gel permeation chromatography on Sephadex G-200. The maximal activity was obtained when the ratio of urokinase/dextran was 1/20 for the coupling. The final preparation showed 5 CTA units/mg conjugate, 300 CTA units/mg protein, 8.4 % activity retention, and 47 % protein retention. The urokinase-dextran conjugate had good thermal, pH and storage stabilities. In addition, it showed greater resistance to the inhibitory effect of human plasma than native urokinase. Also in vitro biological half-life of urokinase increased 40 times by this conjugation. In view of activity, excellent stability and increased half-life, the conjugate can be a potential fibrinolytic agent in an injectable form.

• 한국의류학회지
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• 제1권1호
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• pp.25-29
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• 1977

The warmth retentivity of natural and syntheic waddings as bedding stuff, and further, the machanism of heat transmission through conduction, radiation and convection were analysed. The materials used were cotton, silk, and wool as natural waddings, and polyamide, polyester, regular acrylic, conjugate acrylic, regular polyprepylene and conjugate polypropylene as synthetic waddings. The results of this study are as follow: 1. The warmth retentivity is highest in silk. Following silk in descending order is cotton, conjugate acrylic, polyester, regular acrylic, wool, polyamide, conjugate polypropylene and regular polypropylene. There is not any significant relationship between warmth retentivity and the conductivity of the fibers. 2. Transmission by radiation through the fiber waddings is highest in conjugate polypropylene. Following conjugate polypropylene in descending order is regular polypropylene. polyester. polyamide, conjugate acrylic, regular acrylic, wool, cotton, and silk. This is seen to be in nearly reversed order to the abovementioned order of warmth retentivity. In this respect, warmth retentivity with loose fibreous material as in the case of bedding stuff is primarily affected by the interceptive function of the fibers in heat radiation. 3. Warmth retentivity becomes lower with increasing air content of the waddings. This is because heat transmission by radiation incrases as air content increases. The air content increase is due to the fact that the air is unable to intercept heat radiation. In addition, heat transmission accelates in proportion to the increase in convection as the air gap enlarges.

• Bulletin of the Korean Chemical Society
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• 제16권8호
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• pp.783-786
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• 1995

• 한국광학회:학술대회논문집
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• 한국광학회 1990년도 제5회 파동 및 레이저 학술발표회 5th Conference on Waves and lasers 논문집 - 한국광학회
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• pp.95-101
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• 1990

Parallel optical arithmetic techniques have been developed using the correlation property of optical phase conjugate wave generated by degenerated four wave-mixing. In this paper, conventional rectangular-type coded pattern used for optical logic system is replaced by circular one for effective beam coupling in a photorefractive $BaTiO_3$ material. By adequately adjusting the distance between circular-type pixels of the input pattern and grouping the correlated output, optical binary half addition/subtraction, binary multiplication and, matrix-matrix computation are demonstrated.

• Korean Journal of Mathematics
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• 제24권3호
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• pp.397-407
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• 2016

In this paper, the concepts of k-smoothness, k-very smoothness and k-strongly smoothness of Banach spaces are dealt with together briefly by introducing three types k-denting point regarding different topology of conjugate spaces of Banach spaces. In addition, the characterization of first type ${\omega}^*-k$ denting point is described by using the slice of closed unit ball of conjugate spaces.

• 한국경영과학회:학술대회논문집
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• 대한산업공학회/한국경영과학회 1991년도 춘계공동학술대회 발표논문 및 초록집; 전북대학교, 전주; 26-27 Apr. 1991
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• pp.6-22
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• 1991

This thesis presents a parallel implementation of an iterative method for large scale, sparse linear system and gives result of computational experiments performed on both single transputer and multi transputer parallel computers. To solve linear system, we use conjugate gradient method and develope data storage techinique, data communication scheme. In addition to the explanation of conjugate gradient method, the result of computational experiment is summarized.

• Archives of Pharmacal Research
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• 제16권3호
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• pp.205-208
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• 1993

($\pm$)-Myodesmone was synthesized, starting from 2-cyclopentenone. The key reaction involved $\alpha$-dimethoxymethylation of 2-cyclopentenone and organocopper conjugate addition reaction.

• 한국환경농학회지
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• 제15권1호
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• pp.37-45
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• 1996

수도재배환경(水稻栽培環境) 및 현탁배양세포(懸濁培養細胞) 조건에서 생성된 PCP의 수용성대사물(水溶性代謝物)을 확인에 필요한 정보를 확보하기 위해서 이를 여러 chromatography로 충분히 정제한 다음 이것의 aglycons과 glycon(전보(前報)에서 ${\beta}-glucose$ conjugates인 것으로 추정)을 GC/MS로 분석, 동정하였다. Glycon, 즉 대사물의 polar부위(endocon)가 glucose임을 확인하므로써 전보에서 효소특이성을 통해 추론한 것을 입증할 수 있었다. 또한 conjugates의 source에 따라 다르기는 하였지만 배양세포에서의 aglycon(exocon)s는 주로 PCP, tetrachlorophenol이성체 및 tetra chlorocatechol을, 그리고 수도재배환경에서는 이 외에도 2,4,5- 및 2,4,6-trichlorophenol을 각각 확인할 수 있었다. 이러한 사실은 PCP glucose conjugates의 구조는 PCP뿐만 아니라 이것의 대사물인 Polychlorinated phenols가 개별적으로 glucose와 ${\beta}-anomeric$ conjugation을 이루고 있는 것으로 판단할 수 있었다. 그리고, 대사초기에 이미 여러 종류의 aglycon이 생성되는 것으로 보아 PCP자체도 빠르게 PCPs로 전환되는 것을 알 수 있었다.

• Clinical and Experimental Pediatrics
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• 제54권4호
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• pp.146-151
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• 2011

Streptococcus pneumoniae remains a leading cause of invasive infections including bacteremia and meningitis, as well as mucosal infections such as otitis media and pneumonia among children and adults. The 7-valent pneumococcal conjugate vaccine (PCV7) was licensed for use among infants and young children in many countries including Korea. The routine use of PCV7 has resulted in a decreased incidence of invasive pneumococcal disease (IPD) by the vaccine serotypes among the vaccinees and substantial declines in IPD among unvaccinated populations such as older children and adults as well. In addition, there are increasing evidences to suggest that routine immunization with PCV7 is changing the epidemiology of pneumococcal diseases such as serotype distribution of IPD, nasopharyngeal colonization, and antibiotic resistance patterns. In contrast, there is an increase in the number of IPDs caused by nonvaccine serotypes, though it is much smaller than overall declines of vaccine serotype diseases. Several vaccines containing additional serotypes have been developed and tested clinically in order to expand the range of serotypes of Streptococcus pneumoniae. Recently two new pneumococcal protein conjugate vaccines, 10-valent pneumococcal conjugate vaccine (PCV10) and 13-valent pneumococcal conjugate vaccine (PCV13), have been approved for use in several countries including Korea. This report summarizes the recommendations approved by the Committee on Infectious Diseases, the Korean Pediatric Society.

• Nonlinear Functional Analysis and Applications
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• 제26권4호
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• pp.811-837
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• 2021

In this paper, we propose a new conjugate gradient method for solving unconstrained optimization models. By using exact and strong Wolfe line searches, the proposed method possesses the sufficient descent condition and global convergence properties. Numerical results show that the proposed method is efficient at small, medium, and large dimensions for the given test functions. In addition, the proposed method was applied to solve practical application problems in portfolio selection.