• Title/Summary/Keyword: concurrent

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Adjuvant Chemotherapy with or without Concurrent Radiotherapy for Patients with Stage IB Gastric Cancer: a Subgroup Analysis of the Adjuvant Chemoradiotherapy in Stomach Tumors (ARTIST) Phase III Trial

  • Kim, Youjin;Kim, Kyoung-Mee;Choi, Min Gew;Lee, Jun Ho;Sohn, Tae Sung;Bae, Jae Moon;Kim, Sung;Lee, Su Jin;Kim, Seung Tae;Lee, Jeeyun;Park, Joon Oh;Park, Young Suk;Lim, Ho Yeong;Kang, Won Ki;Park, Se Hoon
    • Journal of Gastric Cancer
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    • v.18 no.4
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    • pp.348-355
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    • 2018
  • Purpose: We aimed to discuss the roles of radiation and chemotherapy as adjuvant treatment in patients with staged IB GC who were enrolled in the adjuvant chemoradiotherapy in stomach tumors (ARTIST) trial. Materials and Methods: Among the 458 patients who were enrolled in the ARTIST trial, 99 had stage IB disease. The patients were randomly assigned to receive either adjuvant chemoradiotherapy with capecitabine plus cisplatin (XP, n=50) or chemoradiotherapy (XPRT, n=49). Survival analyses were performed in accordance with the AJCC 2010 staging system. Results: According to the AJCC 2010 system, stage migration from IB to II occurred in 71% of the patients; 98% of the T2 N0 cases were reclassified as T3 N0, and 42% of the T1 N1 cases were reclassified as T1 N2. When comparing survival outcomes between the XPRT and XP arms for stage IB cancer (AJCC 2002), no significant difference in 5-year disease-free survival (DFS) between the 2 arms was found. (median 5-year DFS, not reached, P=0.256). The patients classified as having stage IB cancer (AJCC 2002) and reclassified as having stage II cancer (AJCC 2010) exhibited worse prognoses than those who remained in stage IB, although the difference was not statistically significant (5-year DFS rate, 83% vs. 93%). When we compared 5-year DFS in 70 patients with stage II (AJCC 2010), the addition of radiotherapy to XP chemotherapy did not show better outcome than XP alone (P=0.137). Conclusions: The role of adjuvant chemoradiotherapy in the treatment of stage IB GC (AJCC 2002) warrants further investigation.

The Validity of Activity Participation Assessment for School-Age Children (학령기 아동을 위한 활동 참여 평가도구(Activity Participation Assessment)의 타당도 연구)

  • Kim, Se-Yun
    • The Journal of Korean Academy of Sensory Integration
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    • v.17 no.1
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    • pp.19-29
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    • 2019
  • Objective : The aim of this study was to verify validity of the Activity Participation Assessment for school-age children. Methods : A questionnaire consisting of 30 items from the APA, 75 items from the PACS, and 55 items from the CAPE was administered to elementary school students. A total of 207 questionnaires were analyzed. Confirmatory factor analysis was performed to confirm the construct validity of the APA. Convergence validity and discriminant validity were verified with the average variance extracted (AVE) and the square of the correlation coefficient. The discriminant validity was the Pearson correlation coefficient of the APA, PACS, and CAPE. Results : The results of the analysis were as follows: 1) For construct validity, the goodness of fit of the modified hierarchical second-order factor model was found to be appropriate (p < .001), 2) For convergent validity, the AVE was higher than .50 for all latent variables, 3) For discriminant validity, the AVE of the latent variable was greater than the square of the correlation coefficient (0.239), 4) For concurrent validity, the correlation between the total sum of the APA and PACS scores showed a positive correlation in all domains, and the correlation coefficient ranged from .303 to .647 at a statistically significant level (p < .01), 5) The correlation coefficient between the total sum of the APA and CAPE scores was .490 for recreational activities, .329 for physical activities, .571 for social activities, .401 for skill-based activities, and .390 for self-improvement activities. All domains showed a positive correlation, and were statistically significant (p < .01). Conclusion : APA can be used as a valid assessment tool to measure the participation of school aged children.

Design of IoT Gateway based Event-Driven Architecture for Intelligent Buildings. (IoT 게이트웨이 기반 지능형 건물의 이벤트 중심 아키텍쳐 설계)

  • Nkenyereye, Lionel;Jang, Jong-Wook
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2016.10a
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    • pp.256-259
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    • 2016
  • The growth of mobile devices in Internet of Things (IoT) leads to a number of intelligent buildings related IoT applications. For instance, home automation controlling system uses client system such web apps on smartphone or web service to access the home server by sending control commands. The home server receives the command, then controls for instance the light system. The gateway based RESTful technology responsible for handling clients' requests attests an internet latency in case a large number of clients' requests submit toward the gateway increases. In this paper, we propose the design tasks of the IoT gateway for handling concurrency events. In the procedure of designing tasks, concurrency is best understood by employing multiple levels of abstraction. The way that is eminently to accomplish concurrency is to build an object-oriented environment with support for messages passing between concurrent objects. We also investigate the performance of event-driven architecture for building IoT gateway using node.js on one side and communication protocol based message-oriented middleware known as XMPP to handle communications of intelligent building control devices connected to the gateway through a centralized hub. The Node.JS is 40% faster than the traditional web server side features thread-based approach. The use of Node.js server-side handles a large number of clients' requests, then therefore, reduces delay in performing predefined actions automatically in intelligent building IoT environment.

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The Development of Protocol for Construction of Smart Factory (스마트 팩토리 구축을 위한 프로토콜 개발)

  • Lee, Yong-Min;Lee, Won-Bog;Lee, Seung-Ho
    • Journal of IKEEE
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    • v.23 no.3
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    • pp.1096-1099
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    • 2019
  • In this paper, we propose the protocol for construction of smart factory. The proposed protocol for construction of smart factory consists of an OPC UA Server/Client, a technology of TSN realtime communication, a NTP & PTP time synchronization protocol, a FieldBus protocol and conversion module, a technology of saving data for data transmit latency and synchronization protocol. OPC UA server/client is a system integration protocol which makes interface industrial hardware device and supports standardization which allows in all around area and also in not independent from any platform. A technology of TSN realtime communication provides an high sensitive time management and control technology in a way of sharing specific time between devices in the field of high speed network. NTP & PTP time synchronization protocol supports IEEE1588 standardization. A fieldbus protocol and conversion module provide an extendable connectivity by converting industrial protocol to OPC. A technology of saving data for data transmit latency and synchronization protocol provide a resolution function for a loss and latency of data. Results from testing agencies to assess the performance of proposed protocol for construction of smart factory, response time was 0.1367ms, synchronization time was 0.404ms, quantity of concurrent access was 100ea, quantity of interacting protocol was 5ea, data saving and synchronization was 1,000 nodes. It produced the same result as the world's highest level.

A Study on the Preparation of Contents for Promoting the Establishment of a Disaster Safety Village in Rural Areas (농촌지역 재난안전마을 만들기 활성화를 위한 컨텐츠 마련에 관한 연구)

  • Koo, Wonhoi;Bae, Minho
    • Journal of the Society of Disaster Information
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    • v.14 no.4
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    • pp.387-398
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    • 2018
  • Purpose: The purpose of this study is to promote the disaster safety village establishment project that fits the characteristics of rural areas by investigating and analyzing the operation cases of contents with regard to disaster safety villages in Korea and Japan. Method: The contents of project related to disaster safety villages in Korea and Japan were classified into resident participation contents, structured contents and unstructured contents, for examining the characteristics of such contents through investigation and analysis, and the contents (draft) of disaster safety village that fitted the characteristics of rural areas were presented. Result: The contents of resident participation include basic safety education, CPR education, life experience training of evacuation shelter, evacuation training, concurrent training of farming activity and disaster activity and creating a village safety map in connection with competent authorities. The enactment of an act and an ordinance for the establishment of disaster safety village, expert dispatch system, storm and flood insurance system and funding system to raise the fund for establishing a village were presented as unstructured contents. In addition, the production of self supporting evacuation shelter, wireless evacuation announcement system, disaster prevention system for a river, emergency evacuation sign, village safety map sign and the establishment of disaster prevention park were presented as structured contents. Conclusion: The unstructured contents are the establishment of foundation for preparing laws and institutions and the structured contents should be installed by utilizing eco-friendly methods in consideration of the environments of rural areas along with securing the safety. Moreover, resident participation should utilize the contents by considering various items such as age, characteristics and environments of residents in rural villages.

Validity and Reliability of a Korean version of the Nursing Students' Perception of Instructor Caring (K-NSPIC) (간호대학생이 지각한 임상실습현장지도자의 돌봄에 대한 한국어판 측정도구의 타당도와 신뢰도 분석)

  • Lee, Shinae;Park, Hyojung
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.19 no.12
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    • pp.218-226
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    • 2018
  • The purpose of this study was to examine the validity and reliability of the Korean version of the nursing students' perception of instructor caring (NSPIC) scale developed by Wade and Kasper for nursing students. We collected data from 219 nursing students in the 3rd to 4th year at three nursing colleges from June 4 to June 20, 2018. Data were analyzed using SPSS 21.0 and AMOS 21.0. An exploratory factor analysis with varimax rotation was performed, resulting in five factors (respectful sharing, confidence through caring, control versus flexibility, supportive learning climate, appreciation of life's meanings) with a total of 27 items. Confirmatory factor analysis supported good convergent and discriminant validities. In addition, the concurrent validity test confirmed that the K-NSPIC scale was a validity tool as the correlation of the clinical learning environment (CLE) scale appeared as r=.64 (p<.001). The Cronbach's alpha coefficient of the K-NSPIC was .88, and Cronbach's alpha coefficient for each of the five factors was .91, .86, .80, .76, and .85; internal consistency was confirmed. It is significant that the K-NSPIC proved applicable as a useful tool for assessing instructor caring. It is also expected that it will assist in the design of programs to improve the caring ability of instructors.

The Validation of the Play Participation Attitude Scale for Parents of Preschoolers (영유아 부모의 놀이참여태도 척도 타당화 연구)

  • Lee, So-yean;Wui, Yeong-hee;Yoo, Jae-ryoung;Chyung, Yun-joo;Lee, Young-ae;Kim, Lee-jin
    • Korean Journal of Play Therapy
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    • v.21 no.4
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    • pp.491-507
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    • 2018
  • The purpose of this study is to validate the Play Participation Attitude Scale for parents of preschoolers, which was developed by the Delphi survey. 447 parents of 9 daycare centers in Seoul and Incheon were recruited for this study and, finally, data from 339 parents were used to perform exploratory factor analysis, confirmatory factor analysis, correlation analysis, multiple regression analysis, and reliability analysis. The results of the study are as follows. First, factor analyses revealed that the global fit of the sensitively play (7 items), responsively play (6 items), and delightfully play(7 items) three-factor model was good. Second, the internal consistency of the Play Participation Attitude Scale was good. Third, there was a statistically significant positive correlation between the current scale and the parents' playfulness scale, indicating concurrent validity. Finally, higher scores of the Play Participation Attitude Scale and its three factors significantly predicted lower scores of parenting stress and higher scores of the preschoolers' self-control ability. These findings revealed that this new measure to be both valid and reliable and specifically suggests what kind of attitude is appropriate for parents to adopt when participating in preschoolers' play.

Social Value and Intangible Assets (사회적 가치와 무형자산)

  • Jeong, Kwang-Hwa;Lee, Sang-Ryul;Kim, Yi-Bae
    • Asia-Pacific Journal of Business
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    • v.11 no.3
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    • pp.153-167
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    • 2020
  • Purpose - The purpose of this study is to examine whether social value-related expenditures can be recognized as intangible assets in financial statements. Design/methodology/approach - This study examined social values defined in the economic and management fields and analyzed whether the social values have the characteristics of intangible assets. For this, the general definition of social value was derived from the concept of social value covered in previous studies. Next, we reviewed the definitions and recognition requirements for intangible assets under the current accounting standards. Based on this, we tried to suggest new criteria and disclosure methods for reporting social value-related expenditures that are not currently reported in financial statements as intangible assets in the financial statements and notes. Findings - First, as a criterion for recognizing social value-related expenditure as an intangible asset, we propose a relationship between social value-related expenditure and enterprise value. Where social value-related expenditures have a statistically significant positive impact on corporate value, they are recognized as intangible assets. If social value-related expenditures have a statistically significant negative influence on business value, or the impact of social value-related expenditures on the enterprise value is not statistically significant, it is not recognized as asset. Second, new disclosure plans are proposed according to the combination of intangible assets by category and the relevance of enterprise value. After dividing social value-related expenditures into separate intangible asset categories, if social value-related expenditures have a statistically significant positive impact on corporate value, they are recognized as intangible assets in the financial statements. If expenditures have a statistically significant negative impact on business value, they should be recorded as essential notes. Finally, if the impact of social value-related expenditure on corporate value is not statistically significant, it should be listed as a supplement. Research implications or Originality - This study contributes to the concurrent research in that it is a priori study on whether social value-related expenditure can be recognized as an asset. This study suggests that the economic effect of social expenditure can be recognized in corporate financial statements, thereby providing companies with justification and effectiveness of social value-related expenditure.

Exploring the Transnational Mobility and Work Experience of Young Koreans in Singapore (초국적 이동성과 일 경험: 한국 청년들의 싱가포르 해외취업 사례 연구)

  • YUK, Joowon
    • The Southeast Asian review
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    • v.28 no.3
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    • pp.111-158
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    • 2018
  • This paper pays attention to the recent increase of young Koreans working in the low-skilled service sector in Singapore. Such rapid increase largely results from the Korean government's initiatives to promote labour migration of young people and the concurrent proliferation of migration agencies, against the background of growing youth unemployment in South Korea. By exploring the motivations and trajectories of young people's labour migration to Singapore, this study examines to what extent they think their expectations have been met and how they interpret their migration and work experiences. There has been little research that examines the actual voices of young migrants as part of migration studies, whilst the majority of previous research focuses on the evaluation of government support programmes based on job matching rates, surveys of participant satisfaction and etc. Young people who went to Singapore to improve their English language skills and qualifications for future employment in Korea have become frustrated due to low-skilled service jobs that consist of low pay and high labour intensity. Their credentials are devalued and they experience deskilling through this migration process. Most of them were discontent with the Korean migration agencies they used and critical about programmes offered by government institutions and universities/colleges. Despite being subject to deskilling, they did try to actively cope or resist this situation. This study focuses on the various ways these migrants attempted to manage the gap between their initial expectations and reality. It also demonstrates how these migrants interpreted their work experiences after returning to Korea: whilst most of them did not cash off their Singapore work experience for a decent job after returning to Korea, they did not define their experience as a complete failure. Adding to cultural, social capital they gained through this experience, they acquired 'mobility capital' which includes confidence, the desire to move, and capacity to control one's own movement.

Growth factors improve the proliferation of Jeju black pig muscle cells by regulating myogenic differentiation 1 and growth-related genes

  • Park, Jinryong;Lee, Jeongeun;Song, Ki-Duk;Kim, Sung-Jo;Kim, Dae Cheol;Lee, Sang Cheol;Son, Young June;Choi, Hyun Woo;Shim, Kwanseob
    • Animal Bioscience
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    • v.34 no.8
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    • pp.1392-1402
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    • 2021
  • Objective: The growth rate of pigs is related to differentiation and proliferation of muscle cells, which are regulated by growth factors and expression of growth-related genes. Thus, the objective of this study was to establish optimal culture conditions for Jeju black pig (JBP) muscle cells and determine the relationship of various factors involved in muscle growth with the proliferation of JBP muscle cells. Methods: Muscles were taken from the femur skeletal muscle of JBP embryos. After isolation of the muscle cells, cells were cultured in a 6-well plate under four different culture conditions to optimize culture conditions for JBP muscle cells. To analyze proliferation rate of JBP muscle cells, these muscle cells were seeded into 6-well plates at a density of 1.5×105 cells per well and cultured for 3 days. Western blot and quantitative real-time polymerase chain reaction were applied to verify the myogenic differentiation 1 (MyoD) expression and growth-related gene expression in JBP muscle cells, respectively. Results: We established a muscle cell line from JBP embryos and optimized its culture conditions. These muscle cells were positive for MyoD, but not for paired box 7. The proliferation rate of these muscle cells was significantly higher in a culture medium containing bFGF and epidermal growth factor + basic fibroblast growth factor (EGF+bFGF) than that without a growth factor or containing EGF alone. Treatment with EGF and bFGF significantly induced the expression of MyoD protein, an important transcription factor in muscle cells. Moreover, we checked the changes of expression of growth-related genes in JBP muscle cells by presence or absence of growth factors. Expression level of collagen type XXI alpha 1 gene was changed only when EGF and bFGF were added together to culture media for JBP muscle cells. Conclusion: Concurrent use of EGF and bFGF increased the expression of MyoD protein, thus regulating the proliferation of JBP muscle cells and the expression of growth-related genes.