• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1995년도 춘계학술대회
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• pp.78-78
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• 1995

Increasing evidence indicates that the production of nitric oxide (NO) by inducible NO synthase (NOS) is tightely regulated. Transforming growth factor-${\beta}$ (TGF-${\beta}$) is a homodimeric protein secreted during macrophage activation, but several lines of evidence suggest that TGF-${\beta}$ is selectively suppressive for macrophage NO production. We therefore reasoned that a strategy employing oligodeoxynucleotides(ODNs) complemently to TGF-${\beta}$ mRNA (antisense ODNs) might increase NO production in IFN-${\gamma}$-treated murine peritoneal macrophages. To evaluate this concept, we tested the effects of antisense ODNs targeted to TGF-${\beta}$ mRNA (25-mer ODNs complemently to TGF-${\beta}$mRNA sequences) by introducing it into the medium of cultured macrophages. Phosphorothiolation of ODNs were employed to retard their degradation. Antisense ODNs had no effect on NO production by itself, whereas IFN-${\gamma}$ alone had modest effect. When antisense ODNs were used in combination with IFN-${\gamma}$, there was a marked cooperative induction of NO production, These effects of antisense ODNs were associated with decreased TGF-${\beta}$ expression in activated macrophages. ODNs with the same nucleotides but a scrambled sequence had no effect. Adding anti-TGF-${\beta}$ antibodies to the IFN-${\gamma}$-treated macrophages mimicked the positive effect of antisense ODNs on NO production. In addition, the effects of either antisense ODNs or anti-TGF-${\beta}$ antibodies were blocked by adding TGF-${\beta}$ in cultured macrophages. These results indicate that the generation of TGF-${\beta}$ by activated macrophages provides a self-regulating mechanism by which the temporal and perhaps spatial production of NO, a reactive and potentially toxic mediator, can be finely regulated.

• 한국수자원학회논문집
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• 제33권4호
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• pp.447-459
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• 2000

수자원 개발이 인문 사회적 여건으로 날로 어려워짐에 따라 공급위주의 물 관리 정책이 한계에 달하고 이어 수요관리개념에 따른 적용 가능한 수자원관리 기법의 개발이 필요해지고 있다. 무효방류량을 최소화하여 한정된 물 자원 배분을 합리적으로 이룰 수 있는 실제 적용 가능한 수요관리기법은 수자원의 효율적 이용과 유역물관리 시스템의 방법론적 완성을 위해 반드시 필요하다. 본 연구는 기존의 물수지분석 기법을 댐 연계운영 모형과 조합하여 MIP 기법에 의해 이수목적 다목적댐 최적연계운영모형을 개발하고 낙동강 수계를 대상으로 모형의 적용성에 대한 검증을 실시하였으며 낙동강 수계의 용수공급능력을 재평가하였다. 이 결과를 계획 당시 자료 및 다른 모형에 의한 운영결과와 비교한 바 개발된 모형은 훌륭히 물 부족량 공급방식으로 수계의 물 공급을 보장할 수 있고 기존 모형등에 의한 방식보다 물배분과 관리에 효율적으로 활용 될 수 있음이 평가되었다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제14권10호
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• pp.3989-4006
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• 2020

The intelligent agriculture monitoring is based on the perception and analysis of environmental data, which enables the monitoring of the production environment and the control of environmental regulation equipment. As the scale of the application continues to expand, a large amount of data will be generated from the perception layer and uploaded to the cloud service, which will bring challenges of insufficient bandwidth and processing capacity. A fog-based offline and real-time hybrid data analysis architecture was proposed in this paper, which combines offline and real-time analysis to enable real-time data processing on resource-constrained IoT devices. Furthermore, we propose a data process-ing algorithm based on the incremental principal component analysis, which can achieve data dimensionality reduction and update of principal components. We also introduce the concept of Squared Prediction Error (SPE) value and realize the abnormal detection of data through the combination of SPE value and data fusion algorithm. To ensure the accuracy and effectiveness of the algorithm, we design a regular-SPE hybrid model update strategy, which enables the principal component to be updated on demand when data anomalies are found. In addition, this strategy can significantly reduce resource consumption growth due to the data analysis architectures. Practical datasets-based simulations have confirmed that the proposed algorithm can perform data fusion and exception processing in real-time on resource-constrained devices; Our model update strategy can reduce the overall system resource consumption while ensuring the accuracy of the algorithm.

• 한방재활의학과학회지
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• 제25권2호
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• pp.111-118
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• 2015

Objectives Through the clinical records of Seungjeongwon Ilgi, we reviewed the usage of Bi-Jeung to know the concept of the word and studied therapeutic strategies for managing Bi-Jeung. Methods We investigated the clinical records of the mid-Chosun dynasty containing the key word "Bi" from electronic database (Seungjeongwon Ilgi). Results Of 4,039 records, 249 articles thought to have medicinal value were lastly selected. We subdivided the cases into 13 categories according to time, the connection of contents and the change of associated symptoms. "Bi" was not used alone but used in combination with body parts or other symptoms. Etiological causes of "Bi" involved dampness, phlegm, fire, heat and qi disorders. We suggested that "Bi" of the mid-Chosun dynasty meant a symptom group mainly of sensory impairment and additionally pain or motor disturbance. Among the 22 herbal medicine formulas used, 15 were based on internal medical pattern identifications and 7 were symptomatic treatments. Acupuncture and moxibustion therapy were primarily applied to adjacent acupoints. In addition, External therapies were used together, such as washing therapy, plaster therapy, cupping therapy and thermotherapy. Conclusions "Bi" principally indicated sensory impairment on limbs and the main etiological cause was considered to be dampness. Herbal medicine, acupuncture, moxibustion and external therapies were used to cure Bi-Jeung.

• 대한안전경영과학회지
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• 제16권4호
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• pp.331-341
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• 2014

Internet of Thing(IoT), which is recently talked about with the development of information and communication technology, provides big data to all nodes such as companies and homes, means of transportation etc. by connecting all things with all people through the integrated global network and connecting all actual aspects of economic and social life with Internet of Thing through sensor and software. Defining Internet of Thing, it plays the role of a connector of providing various information required for the decision-making of companies in the cloud computing environment for the Insight usage by collecting and storing Raw Data of the production site through the sensor network and extracting big data in which data is accumulated and Insight through this. In addition, as the industry showing the largest linkage with other root industries among root industries, the mold industry is the core technology for controlling the quality and performance of the final product and realizing the commercialization of new industry such as new growth power industry etc. Recently, awareness on the mold industry is changing from the structure of being labor-intensive, relying on the experience of production workers and repeating modification without the concept of cost to technology-intensive, digitization, high intellectualization due to technology combination according to IT convergence. This study, therefore, is to provide a golden opportunity to increase the direct and indirect expected effects in poor management activities of small businesses by actually implementing and managing the entire process of mold life cycle to information system from mold planning to mass production and preservation by building SME(small and medium-sized enterprises)-type mold life cycle management information system in the cloud computing environment and applying it to the production site.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2011년도 정기 학술대회
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• pp.531-538
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• 2011

멤브레인형 LNG 탱크의 구조적 안전성을 확보하기 위해서는 슬로싱에 의한 작용 압력과 구조응답을 정확히 평가할 수 있어야 한다. 탱크 방열구조에 작용하는 슬로싱 충격하중은 매우 불규칙적이며 이로 인한 구조 응답 역시 유탄성 거동을 포함하는 매우 복잡한 물리 현상이기 때문에 최신의 이론적 실험적 접근 방법을 동원하더라도 정확한 평가가 어렵다. 본 연구에서는 실험이나 수치해석으로부터 얻어진 슬로싱 압력 시계열을 이용하여 탱크 방열 구조의 구조응답을 간편하게 해석할 수 있는 방안을 제안하였다. 이 간이 해석법은 기본적인 삼각형 impulse 형태의 충격 압력에 대한 구조응답을 시간영역에서 과도응답해석법으로 계산한 후, 이렇게 구해진 구조물의 삼각형 응답함수를 조합하여 임의 형상의 압력 시계열에 대한 구조 응답을 구하는 방식이다. 여러 가지 예제 해석을 통하여 제안된 해석법의 타당성을 검토하였고, 이를 이용하여 실제 모형실험에서 얻어진 압력시계열을 바탕으로 구조응답을 계산하고 그 결과를 고찰하였다.

• 한국전자거래학회지
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• 제21권3호
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• pp.1-13
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• 2016

IoT 기술과 시맨틱 기술의 결합을 통한 상황인지 기반의 서비스를 제공하는 많은 연구가 활발하게 진행 중이다. 하지만 시맨틱 기술인 온톨로지를 이용한 서비스를 제공하는 선행 연구는 특정 서비스 시나리오를 도메인으로 선정하여 온톨로지를 구축했기 때문에 서비스 요구사항 등의 변경을 수용하기에는 한계를 가지고 있다. 이를 극복하기 위해 크로스 버티컬 온톨로지 개념이 등장하였지만 상황정보를 표현하기 위해 서비스 환경을 구성하는 요소 이외의 추가적인 요소를 필요로 하며, 환경구성요소의 상태정보를 표현하지 못하는 한계가 있다. 이와 같은 한계를 극복하기 위해 본 논문은 상황정보를 표현하기 위한 요소를 추가하지 않으면서, 환경구성요소의 상태표현이 가능한 SISO(Semantic-based IoT Service Ontology)를 제안한다. 이와 같은 SISO의 특징을 검증하기 위해 서비스 시나리오를 선정하고, 시나리오에 따라 적용한 결과를 제시하였다. 또한 서비스 시나리오 적용 결과를 기반으로 선행연구와의 정성적 비교결과를 제시하였다.

• 복식문화연구
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• 제28권5호
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• pp.573-590
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• 2020

The purpose of this study was to develop contemporary Qipao design that emphasized creative feminine beauty with a unique sense beyond the concept of traditional Qipao design. This would be achieved using the expressive technique of human liberation from the oppression of the unconscious world a supported by surrealism. Using existing literature and previous research, surrealist expression technique used in fashion were investigated and analyzed. The results are as follows. First, the possibility of new and original design beyond existing surrealistic Qipao design was demonstrated through various realistic surrealism expression techniques, such as dépaysement, objet, and trompe-l'œil techniques. This occurred by exploring various unconscious world out of fixed ideas and through expression techniques of surrealistic fashion such as imagery of body parts, metaphorical expression of objects, and position deformation and illusion. Second, Qipao design that combined objet and attempted ordinary escape by combining isolated body parts (such as hands, eyes, and lips) within the composition combine with surrealistic expression enabled various and fun surrealistic fashion designs to emerge. Third, the metaphor of surreal lips and eyes (mainly used in works of this study) presented a unique and extraordinary combination of images in accessories and partial design that used the dépaysement technique. Thus, it was possible to expand surrealistic expression by including LED wire.

• 대한토목학회논문집
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• 제34권6호
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• pp.1845-1850
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• 2014

철도 운영측면에서 비용을 최소화하는 최적노선을 설계하기 위해서는 다양한 지형 위에 설계기준에 맞는 노선을 배치하여야 하며, 절토량과 성토량을 최소화 하거나 이 둘의 합을 균형화 하여 공사비용을 최소화하고 있다. 열차의 효율적인 운행을 가능하게 하는 노선의 설계는 다양한 변수의 해 공간을 모두 고려하여야하기 때문에 조합최적화의 문제라고 할 수 있다. 본 연구에서는, 공사비를 최소화 하는 최적 철도 노선을 설정하기 위한 수리적 모형을 개발하였으며, Genetic Algorithm을 사용한 문제의 해석을 하였고, Algorithm과 결과를 활용한 철도 최적 노선 설계 개념을 정립하였다. 그리고 가상의 구간에 대한 사례적용을 통하여 본 연구에서 제시하고 있는 방법론에 대하여 평가하여 성토량과 절토량을 균형화 할 수 있음을 확인하였다. 이러한 결과는 실제적으로 수명 동안의 에너지 비용이 공사비보다 높은 현실에서 철도노선설계의 최적화 과정에서 중요하게 활용될 수 있을 것이다.

• Journal of Periodontal and Implant Science
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• 제50권4호
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• pp.268-277
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• 2020

Purpose: Many home care treatments can be used to promote the health and longevity of dental implants; however, few studies are available to support the concept that self-performed oral hygiene behaviors are an essential tool for improving and maintaining oral health. We investigated age-stratified associations between dental health behaviors related to tooth brushing (TB) and oral hygiene product use in Korean adults with implants. Methods: A total of 1,911 subjects over 19 years of age who had 1 or more implants and who participated in the 2013 to 2015 Korea National Health and Nutrition Examination Survey were reviewed. Periodontal status was assessed using Community Periodontal Index (CPI) scores, and periodontitis was defined as a CPI greater than or equal to 3. The complex sampling design of the survey was utilized to obtain the variance and individual weight of each analyzed factor. A high CPI was the outcome variable, and the main explanatory variables were oral hygiene behaviors, such as TB, dental floss (DF), interproximal brushing, and mouth rinsing. Results: Almost all individuals with a lower CPI brushed their teeth twice or more per day, in contrast to those with a higher CPI, and were likely to use DF. The adjusted odds ratio of not using DF for a higher CPI was 1.83 (95% confidence interval, 1.35-2.49). Conclusions: TB was implemented more than twice a day by patients with good oral health, and the combination of TB and DF significantly reduced the prevalence of a higher CPI. Self-performed oral hygiene practices combining TB and DF were significantly related to a low prevalence of periodontitis in implant patients.