• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.5
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• pp.1185-1193
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• 2007

Ginsing polysaccharide, known to have an immune regulating effect, was administered to 23 randomly selected healthy male subjects with a mean age of 23 years in accordance with an IRB approval. Then, these subjects underwent physico-chemical tests and serum proteome was analyzed from the blood sample taken from these subjects. Analyses of proteome involved image analysis, protein sections and protein identification in sequence after two-dimensional electrophoresis was carried out. During the physico-chemical test, 4 subjects were excluded from the study. In the proteome analysis, identified were 5 spots such as SP40, 40, Cytokeratin 9, hypothetical protein LOC544932, Apolipoprotein E ,similar to Human albumin, which showed differences in the amount of protein expression. In conclusion, changes of 5 proteins were remarkable before and after administration of ginsing polysaccharides. In certain cases, hepatic and renal slight injury occurred. Thus, further clinical study on dosage regimen would be necessary for securing the basis for concentration-dependent effectiveness and safety.

• Journal of Physiology & Pathology in Korean Medicine
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• v.27 no.1
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• pp.92-98
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• 2013

Bee Venom(below BV) has been used in alternative medicine to treat the diseases, such as pain diseases. BV contains a variety of peptides, including melittin, apamin, adolapin, MCD peptide, enzymes(i.e. PLA2), amines(i.e. histamine and epinephrine), and nonpeptide components. The two main components of BV are melittin and PLA2. The cell cytotoxic effects through the activation of PLA2 by melittin have been suggested to be the critical mechanism for the depress of cancer cell. Melittin and PLA2 have been reported to induce apoptosis and to possess anti-cancer effects and neurite outgrowth in PC12 cells. Analysis of proliferation was confirmed by MTT assay. BV decreased cell number through dose- and duration-dependent manner and these effects are apparent at a concentration of 3 ${\mu}g/ml$. To observe which signaling molecules will be activated by BV, phosphorylation of ERK, p38 MAPK, JNK and ERM were examined by Western blot analysis. To study the long term effect of BV in human gastric adenocarcinoma cell lines, the image of cells treated with BV for 4 days were obtained. BV was shown to exhibit anti-cancer activity in human gastric adenocarcinoma cell lines at a broad range of concentrations of 3 ${\mu}g/ml$. ERK, p38 MAPK and JNK were found to increase in BV treated cells. However, ERM which known to be involved in the cell death, was gradually decreased to 30minutes after addition 3 ${\mu}g/ml$ of BV. These results provide a possible BV-induced inhibitory signal for cancer proliferation that is initiated by the decrease in ERM activity. Moreover, it is likely that the activation of ERK, p38 MAPK and JNK are required for the BV-induced inhibition of cancer proliferation.

• Proceedings of the KSRS Conference
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• 2005.10a
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• pp.441-444
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• 2005

The goal of this study is to investigate the relationship between microphytobenthic biomass and normalized vegetation index obtained from Landsat TM images. Monitoring a seasonal change of microphytobenthic biomass in the sand bar is specifically focused. Since the study area, Hampyeong Bay, was difficult to approach, we failed to obtain ground truths simultaneously on satellite image acquisition. Instead, chlorophyll-a concentration in surface top layer was measured on different dates for microphytobenthic biomass. Although data were acquired on different dates, a correlation between the field and satellite images was calculated for investigating general trends of seasonal change. NDVI and tasseled cap transformed images were also used to review the variation of microphytobenthic biomass by using Landsat TM and ETM+ images. Atmosphere effects were corrected by applying COST model. Seaweeds were also flouring in the same season of microphytobentic blooming. Songseok-ri area was minimally affected by seaweeds from February to May, and selected as a test site. NDVI value was classified into high-, moderate-, and low-grade. It was well developed over fme-grained sediments and rapidly reduced from May to November over sand bar. In this bay, correlation between grain size and microphytobenthic biomass was clearly seen. From the classified NDVI and tasseled cap transformed data, we finally constructed spatial distribution and seasonal variation maps of microphytobenthic biomass.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.287-287
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• 1994

In the present study, it was aimed to asses the possibility that calcitonin gene-related peptide (CGRP) released in response to transient hypotension may contribute to the reflex autoregulation of cerebral blood flow as a putative modulator. Changes in pial arterial diameter (mean, 33.0 ${\pm}$ 1.1 $\mu\textrm{m}$) with changes in systemic arterial blood pressure (mean, 101.9 ${\pm}$ 2.7 mmHg) were observed directly through a closed cranial window in anesthetized normotensive rats. Image of the pial vessels was captured with a stereoscope connected to a CCD video camera and the diameter was measured with a microscaler. In the capsaicin-treated rats (one day prior to experiment, 50 nmol capsaicin injected intracisternally), both vasodilater and vasoconstrictor responses evoked by a transient hypotension and the reverse of blood pressure were markedly attenuated or almost abolished. When changes in pial arterial diameter were plotted as a function of changes in blood pressure, the slopes of both regression lines (for vasodilators and vasoconstrictors ) were markedly reduced. Similar reductions were evidenced under treatment wi th the CGRP antibody serum (1:1,000) and following CGRP receptor desensitization. However, the autoregulatory mechanics were neither affected by treatment wi th spantide (1 ${\mu}$M), substance P antagonist, nor by substance P receptor desensitization. Suffusion wi th mock cerebrospinal fluid containing CGRP and cromakalim caused a vasodilatation in a concentration-dependent manner, respectively and their effects were antagonized by glibenclamide. Substance P produced a vasodilatation, which was, however, little affected by glibenclamide. These observations indicate that the CGRP released from the perivascular sensory fibers in response to a hypotension is implicated in the modulation of the autoregulation of cerebral blood flow.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.24 no.5
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• pp.566-573
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• 2013

Inverse synthetic aperture radar(ISAR) images have been widely used in non-cooperative target recognition(NCTR). One of the most important issues in ISAR imaging is the improvement of the image smeared by target motion. In this paper, we propose the discrete Gabor representation(DGR) in an oversampling scheme for efficient acquisition of high-quality ISAR images. The DGR compartmentally assigns the Gabor coefficients to unit cells of the time-frequency grid related to the given Gabor logons. Thus, it can show an excellent time-frequency concentration and effectively discriminates the Doppler components from point-scatterers. The simulation results demonstrated that the DGR not only obtained high-quality ISAR images but also retained computational efficiency.

• Journal of the Korean Society of Safety
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• v.32 no.6
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• pp.61-67
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• 2017

Suspended sediment transport plays principal roles in morphological process of natural coastals. It is needed to understand the reason why interaction characteristics of solitary wave and suspended sediment. The present study shows that suspended sediment pickup derived on solitary wave celerity. The 2D prismatic open channel length is 12 m, width is 0.8 m, height is 0.75 m and slope is 1/6. Generation of solitary wave is used by rapidly opening the sluice gate. Bottom surface sediments are laid movable slope section by 0.03 m thickness and experimental sediments are used anathracite and jumoonjin sand. Techniques of suspended sediment pickup rate are designed equipment ASC(Absorptive Suspended sediment Collector). It could directly absorb 5 points suspended sediment by channel water depth. Solitary wave celerity is measued by ADV(Acoustic Doppler Velocimeter). Mounted two video cameras(Model No. : Sony, HDR-XR550) are used to image processing of suspended sediment concentration and turbidity. Suspended sediment pikcup rate(Einstein, 1950) is analyzed to nondimensionalization based on solitary wave celerity. The suspended sediment pickup rate is suggested that more effective plunging breaking type than spilling. The results indicates fundamental suspended sediment transport mechanism between solitary wave celerity and suspended sediment pickup based on laboratory experiments. Finally, the present study suggests that suspended sediment pickup rate by solitary wave is used only characteristics of sediment and solitary wave celerity.

• Ocean and Polar Research
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• v.30 no.4
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• pp.407-418
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• 2008

Seawater samples were collected at discrete depths from five stations across the polar front in the Drake Passage (Antarctic Ocean) by the $20^{th}$ Korea Antarctic Research Program in December, 2006. Nitrate concentrations of seawater increase with depth within the photic zone above the depth of Upper Circumpolar Deep Water (UCDW). In contrast, ${\delta}^{15}N$ values of seawater nitrate decrease with depth, showing a mirror image to the nitrate variation. Such a distinct vertical variation is mainly attributed to the degree of nitrate assimilation by phytoplankton as well as organic matter degradation of sinking particles within the surface layer. The preferential $^{14}{NO_3}^-$ assimilation by the phytoplankton causes $^{15}{NO_3}^-$ concentration to become high in a closedsystem surface-water environment during the primary production, whereas more $^{14}{NO_3}^-$ is added to the seawater during the degradation of sinking organic particles. The water-mass mixing seems to play an important role in the alteration of ${\delta}^{15}N$ values in the deep layer below the UCDW. Across the polar front, nitrate concentrations of surface seawater decrease and corresponding ${\delta}^{15}N$ values increase northward, which is likely due to the degree of nitrate utilization during the primary production. Based on the Rayleigh model, the calculated ${\varepsilon}$ (isotope effect of nitrate uptake) values between 4.0%o and 5.8%o were validated by the previously reported data, although the preformed ${\delta}^{15}{{NO_3}^-}_{initial}$ value of UCDW is important in the calculation of ${\varepsilon}$ values.

• Archives of design research
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• v.20
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• pp.219-229
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• 1997

Today seafoods, such as fisheries and clams, have become an important part of our diet. But processing and storing these perishable seafoods for a long period of time present a serious problem. Only a few years ago, the seafood consumption was minimal. However, an improvement in our diet has enabled us to enjoy seafoods more often than before. Moreover, the recent trend toward the concentration of the popuration to the metropolitan area and the improvement in the standards of living have accelerated a change in our food consumption pattern-preference for the convenient foods over time consuming cooking. Judging from these changes, we can easily predict that the demand for the covenient, dried seafoods will rise sharply in the coming days. The development for an innovative and attractive way to package and market these products are on the way. Research and development of the distribution channel and package design of the dried seafoods will offer a wide array of opportunities to increase the sales volume of the dried seafoods. In addition, by associating the image of Pusan, as a prime oceanic city, with the dried seafoods on the package will certainly draw the attention of many prospective consumers. Consequently it will make the dried seafoods special products of Pusan, and eventually contribute to the prosperity of the city.

• Journal of Advanced Navigation Technology
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• v.17 no.2
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• pp.234-239
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• 2013

Learning a lesson about poor concentration and problems of the existing content, the system of language which could not be determined, Many teachers' assessment decision was made. As a result, voice recording based on the combination of ubiquitous technology and virtual reality technology, and install the projector in a classroom Through the learning content corresponding grade English student ID card attached RFID reader in each classroom, and students of RFID tags attached. In reality of the virtual three-dimensional image content foreigners and question-and-answer using the voice recording technology at the same time check the pronunciation and intonation level passes or level failure judged. Student education data to a central server system is configured to do so after saving to the DB through a feedback process, which provides information. Analysis of the issues that can have a common language content in the present study and Problem for voice recording technology to solve the problem and did not solve the existing language in the content level based classes.

• Clinical and Experimental Reproductive Medicine
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• v.20 no.2
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• pp.117-123
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• 1993

The condition of the endometrium is an important factor which may influence the success or failure in IVF-ET. This study was undertaken for evaluation of the value of endometrial growth as an early predictor for the success of IVF. Ultrasonographic endometrial measurement were performed in 43 IVF cycles that conceived, 101 cycles that did not with an IVF-ET There was no significant difference in the endometrial thickness and the serum concentration of estradiol in the pregnant versus nonpregnant group(10.4 vs. 9.9 mm: 2348 vs. 2017 pg/ml no hCG administration day). No correlation was found between the ultrasound image and serum estradiol levels around the time of hCG administration(r=0.54, p=0.13 no Day 2; r=0.45, p=0.14 no Day 1). The duration of gonadotropin treatment, number of follicles, number of oocytes retrieved, and fertilization rate were not statistically different in the two groups, however, there was a significant difference in the number of embryos in the pregnant versus nonpregnant group)p< 0.05). A higher pregnancy rate and ongoing pregnancy rate occured with an endometrial thickness over 11 mm compared with below 7mm(p< 0.05, p< 0.005). however, no significant differences were noted in the implantation rate and abortion rate among the groups that classified according to their endmetrial thickness. The endometrial growth(${\Delta}$) from hCG administration day(DO) to D6 was greater in the women who achieved pregnancy than in the nonpregnant group(p< 0.01). There were no significant differences in serum estradiol levels, implantation rate, pregnancy rate, and abortion rate among the groups that classified according to the pattern of echogenesity of endometrium, however, significantly higher ongoing pregnancy rate was noted in group A, B compared with group C.(p< 0.0001, p< 0.001) These results suggest that there were no ultrasonographically detectable differences in the patterns of endometrial growth and development around the time of hCG administration in patients who conceive versus those that do not in IVF-ET.