• BMB Reports
• /
• v.57 no.3
• /
• pp.125-134
• /
• 2024

Whole-genome doubling (WGD), characterized by the duplication of an entire set of chromosomes, is commonly observed in various tumors, occurring in approximately 30-40% of patients with different cancer types. The effect of WGD on tumorigenesis varies depending on the context, either promoting or suppressing tumor progression. Recent advances in genomic technologies and large-scale clinical investigations have led to the identification of the complex patterns of genomic alterations underlying WGD and their functional consequences on tumorigenesis progression and prognosis. Our comprehensive review aims to summarize the causes and effects of WGD on tumorigenesis, highlighting its dualistic influence on cancer cells. We then introduce recent findings on WGD-associated molecular signatures and genetic aberrations and a novel subtype related to WGD. Finally, we discuss the clinical implications of WGD in cancer subtype classification and future therapeutic interventions. Overall, a comprehensive understanding of WGD in cancer biology is crucial to unraveling its complex role in tumorigenesis and identifying novel therapeutic strategies.

• Korean Journal of Environmental Biology
• /
• v.41 no.4
• /
• pp.550-556
• /
• 2023

Henricia specimens were collected using a dual approach of trimix scuba diving and fishing nets. This inclusive collection encompasses the discovery of two species highlighted in this study and introduces and provides comprehensive descriptions for Henricia kinkasana and Henricia longispina aleutica. The descriptions offered in this study were derived from the thorough examinations of external morphological characteristics. The documentation provides detailed insight into key traits related to the abactinal and actinal skeletons and spines of these newly recorded species in Korea. This comprehensive examination contributes to our understanding of the distinct morphological characteristics defining each species within the genus Henricia.

• The Korean Journal of Medicine
• /
• v.99 no.2
• /
• pp.61-68
• /
• 2024

Chronic Kidney Disease (CKD) is a major global health burden. Sodium-glucose cotransporter-2 (SGLT2) inhibitors have demonstrated potential in slowing CKD progression. We evaluated the expanding role of SGLT2 inhibitors, emphasizing their renoprotective benefits in diabetic and non-diabetic CKD patients. We also investigated the underlying mechanisms, including the reduction of glomerular hypertension via modulation of tubuloglomerular feedback. Our study critically analyzed current indications for SGLT2 inhibitor therapy based on recent clinical trial data. To optimize patient outcomes, we present a comprehensive analysis of practical considerations for the prescription of SGLT2 inhibitors, including the potential initial decline in the estimated glomerular filtration rate and a review of adverse events.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• v.18 no.7
• /
• pp.1953-1967
• /
• 2024

Lately, there has been a notable surge in the defense industry's efforts to develop highly advanced intelligent systems. These systems encompass sophisticated computing platforms that boast an impressive level of autonomy. However, it's important to acknowledge that these very systems are not impervious to vulnerabilities stemming from both hardware and software tampering. Within the context of this discourse, our focus of the survey is directed towards the hardware security module. This component stands out for its capability to offer a significantly heightened level of protection when compared to conventional software-based techniques. Through the lens of this paper, we embark on a comprehensive survey of Trusted Platform Module (TPM), a hardware security module, shedding light on its potential to fortify the defense against threats that emerge from various vectors of attack.

• Anatomy and Cell Biology
• /
• v.55 no.2
• /
• pp.251-254
• /
• 2022

Variations of the ovarian veins can impact imaging diagnosis, surgical procedures of the region, and can be related to clinical findings such as compression of the ureter. Therefore, a good working knowledge of such variants is important to the clinician who interprets imaging of the posterior abdominopelvic region of women and surgeons who operate in this region. Herein, we present a comprehensive review of duplicated ovarian veins and provide a case illustration.

• Korea Journal of Hospital Management
• /
• v.19 no.3
• /
• pp.70-78
• /
• 2014

• Journal of the korean Society of Automotive Engineers
• /
• v.31 no.3
• /
• pp.76-80
• /
• 2009

• Journal of Korean Society of Environmental Engineers
• /
• v.29 no.3
• /
• pp.262-270
• /
• 2007

• Korean Journal of Rural Living Science
• /
• v.3
• /
• pp.63-83
• /
• 1992

• 대한예방의학회:학술대회논문집
• /
• 1995.10a
• /
• pp.239-240
• /
• 1995