• Journal of Life Science
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• v.31 no.2
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• pp.183-191
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• 2021

Euglena gracilis is a microalga of great biotechnological interest that can create high levels of bioactive compounds, such as tocopherol, paramylon, and folic acid. The objective of this study was to investigate the biological activities of extracts from E. gracilis, especially those focused on immunological activity. E. gracilis biomass was extracted with hot water (HWE) and the remaining pellet was continuously extracted with methanol (HWME). First, we examined the effect of two extracts from E. gracilis on the production of nitric oxide (NO) and the expression of pro-inflammation cytokines, including IL-1β, IL-6, and TNF-α in murine macrophage RAW 264.7 cells. HWE treatment dose-dependently increased the production of IL-1β and TNF-α. On the other hand, treatment with HWME significantly decreased the generation of NO and pro-inflammatory cytokines (IL-6 and TNF-α) in lipopolysaccharide (LPS)-stimulated macrophage cells. In addition, other biological activities of the extracts were further analyzed: α-glucosidase inhibition, protein tyrosine phosphatase (PTP1B) inhibition, tyrosinase inhibition, xanthine oxidase (XO) inhibition, and angiotensin-converting enzyme (ACE) inhibition. Analysis of these biological activities showed that HWE has more inhibitory effects than HWME against α-glucosidase, tyrosinase, and XO agents. However, the inhibition of PTP1B and ACE with HWME were higher than with HWE. Taken together, the results suggested that E. gracilis possesses various biological activities―especially immunological capabilities―through regulation of cytokine production. Therefore, E. gracilis extract may be potentially useful for food material with immune-regulating effects.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.49 no.1
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• pp.75-84
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• 2021

The authors had presented two previous papers[1,2] on Helicopter/Rotorcraft develoment in Europe and US. Meanwhile, the next generation rotorcrafts, currently under development in US and Europe, have new configurations (tilt-rotor, coaxial, compound) of rotor-type vertical takeoff/landing rotorcrafts to overcome the disadvantages of traditional helicopters. For developing these new types of rotorcrafts, the upgraded conceptual design/comprehensive programs are required. In US and Europe, they are already developing new program tools with their technologies and database obtained during more than last half centuries. For us, many academia, research institutes and industrial engineers have experienced and developed core technologies on rotorcrafts (aerodynamics, structural analysis, flight dynamics, and noise analysis etc.) comparable to US and Europe during last couple of decades of developing helicopters and various configurations of rotorcrafts. In this paper, the pros and cons of conceptual design/comprehensive tools currently used in US and Europe have been summarized. Furthermore, the possibilities and problems to develope our own design and analysis tools have been studied.

• The Korean Journal of Zoology
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• v.15 no.3
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• pp.111-131
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• 1972

Fine structures of retina of an ommatidium in dragonfly, having eyes of closed rhabdom type, were studied under light and electron microscopes. The ommatidia consisted of eight retinular cells distributed in a circular pattern and the retinular layer in turn can be divided into three sublayers according to the number of cells in the retina. Each retinular cell has different starting points in the retina and the length of retinular cells is varied greatly; the length of one distal retinular cell shows one half of that of others. In the middle layer, three proximal retinular cells interconnect the adjacent two rhabdoms which are triangular in the appearence of the cross section which in turn consisted of tubular, parallel and lamellated microvilli. The rhabdom is formed by three rhabdomeres, each of which is separated by $120^{\circ}$ between them, but they can be distinguished into two parts according to electron density. Around the outer part of microvilli composing rhabdom, electron density was much less than the inner part of the structure. The microvilli of the inner part appear to be connected to the cytoplasm of retinular cells. Rough endoplsmic reticulum with enlarged cisternae runs through the vacuoles in the outer part of distal retinular cells. Abundant mitochondria concentrated in the vicinity of rhabdom are found at the central part of the retinular cells, while in the area of immediate vicinity of the rhabdom, prominent vacuoles are observed. Above the rhabdom of an ommtidium stands a crystalline cone which is consisted of four cone cells arranged radially along the axis. The crystalline cone is surrounded by cells containing pigment granules. The outermost photoreceptor element of an ommatidium is corneal lens.

• Journal of Korean Society of Transportation
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• v.21 no.1
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• pp.127-136
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• 2003

Road safety is defined under the minimum design standard and design examination process is consisted of the standard according to current road design. However, road safety in practical way is correlative to not only all element of roads but also road shape, such as, between straight line and curved line and between curved lines. Also. it is related to alignments such as horizontal alignment and vertical alignment, and cross section. That is, the practical road design should be examined in both sides of 3 dimension and consecutiveness (consistency) as the actual road is a 3 - dimensional successive object. The paper presents a concept for acceleration to evaluate consistency of road considering actual road shape on 3-dimension. Acceleration of vehicle is influential to road consistency based on running state of vehicles and state of drivers. The magnitude of acceleration. especially, is a quite influential element to drivers. Based on above, the acceleration on each point on 3-D road can be calculated and then displacement can be done. Computation of acceleration means total calculation on each axis. Speed profile refers to “Development of a safety evaluation model for highway horizontal alignment based on running speed(Jeong, Jun-Hwa, 2001)” and then acceleration can be calculated by using the speed pronto. According to literature review, definition of acceleration on 3-D and g-g-g diagram are established. For example, as a result of the evaluation, if the acceleration is out of range, the road is out of consistency. The paper shows calculation for change of acceleration on imaginary road under minimum design standard and the change tried to be applied to consistency. However accurate acceleration is not shown because the speed forecasting model is limited and the paper did not consider state of vehicles (suspension, tires and model of vehicles). If speed pronto is defined exactly, acceleration is calculated on all road shapes, such as. compound curve and clothoid curve. and then it is appled to consistency evaluation. Unfortunately, speed forecasting model on 3 -D road and on compound curves have rarely presented. Speed forecasting model and speed profile model need to be established and standard of consistency evaluation need to developed and verified by experimental vehicles.

• Journal of Korean Society of Forest Science
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• v.86 no.1
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• pp.69-79
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• 1997

The purpose of this study is to acquire essential data to reduce the amount of woody debris resulted from the debris flow. This research examined topographic characteristics of the channelbed affecting generation, movement and storage of woody debris and woody characteristics related to number, sizes, shapes, decay, storage direction to mountainous stream. 1. The number of woody debris had a tendency to increase in proportion to stream width, but it was hardly affected by longitudinal gradient of stream. Especially, the greater amount of woody debris was stored at wide section of the stream with compound channel, and it was found in deposits of channelbed rather than in the present channel. 2. Total woody debris over 10cm in diameter and over 2m in length was 402 units and storage number was 35.3 units per 100m of stream. Average diameter of breast height and length were 14cm and 4m, respectively. The woody debris appeared shorter in length and greater in diameter at down-stream than up-stream. 3. Since woody debris met sediments and bed-materials of great roughness in moving, the greater amount of woody debris without root was found in up-stream and down-stream, but deformed woody debris was discovered in upper stream. Decay of woody debris was more severe in down-stream and woody debris on rotting process was found down-stream. 4. Storage direction of woody debris was mainly parallel to center line of stream, and rate of parallel and perpendicularity was 276 and 126 units, respectively. But, as woody debris storing to the perpendicular direction was unstable, the traveling debris could easily be stored. Therefore, some counterplan was required to prevent the traveling woody debris. 5. Tree species of woody debris was mainly larch, which occupied about two third of total woody debris(256 units). The woody debris of larch is easy to move due to hitting of channelbed materials or lower channelbed fluctuation because the lower part of larch is weaker than its upper part. Therefore, the section of the tree species planting in the riparian vegetation needs much more carefulness.