• 한국융합학회논문지
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• 제11권1호
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• pp.97-108
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• 2020

'1+N'은 현재 복합형 서점의 경영 모드이다. 본 연구는 우선 고객의 기본적 상황과 수요를 조사하였고, 서점 내의 10가지 공간 중 고객의 4가지 기본적 행위를 검토하였다. 다음 서비스 디자인의 3가지 연구 도구와 실내 디자인의 3가지 디자인 요소를 상대적으로 대응하여 '복합형 서점 실내 디자인 기본 분석 프레임'을 수립하였다. 그리고 사례와 '복합형 서점 실내 디자인 기본 분석 프레임'과 결합하여, 고객과 서점이 상호작용하는 자세한 프로세스, 터치포인트와 실내 디자인 프로젝트를 찾아냈다. 디자인 맹점을 찾아 상응하는 해결책을 추출하고 이를 바탕으로, '서비스 디자인 개념에 기초한 복합형 서점 실내 디자인 연구 모델'을 제안하였다. 여기에는 복잡한 공간의 실내를 디자인할 때 주목해야할 요소 및 각 요소 간의 뚜렷한 연관성을 포함하고 있으며, 복합형 서점 실내 기능 구역의 디자인 내용과 서비스 품질검사, 디자인의 공백점을 찾을 수 있다.

• Nuclear Engineering and Technology
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• 제50권1호
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• pp.18-24
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• 2018

This study proposes a new method of analyzing the burnup credit in boiling water reactor spent fuel assemblies against various operating parameters. The operating parameters under investigation include fuel temperature, axial burnup profile, axial moderator density profile, and control blade usage. In particular, the effects of variations in one and two operating parameters on the curve of effective multiplication factor ($k_{eff}$) versus burnup (B) are, respectively, the so-called single and compound effects. All the calculations were performed using SCALE 6.1 together with the Evaluated Nuclear Data Files, part B (ENDF/B)-VII238-neutron energy group data library. Furthermore, two geometrical models were established based on the General Electric (GE)14 $10{\times}10$ boiling water reactor fuel assembly and the Generic Burnup-Credit (GBC)-68 storage cask. The results revealed that the curves of $k_{eff}$ versus B, due to single and compound effects, can be approximated using a first degree polynomial of B. However, the reactivity deviation (or changes of $k_{eff}$, ${\Delta}k$) in some compound effects was not a summation of the all ${\Delta}k$ resulting from the two associated single effects. This phenomenon is undesirable because it may to some extent affect the precise assessment of burnup credit. In this study, a general formula was thus proposed to express the curves of $k_{eff}$ versus B for both single and compound effects.

• 생약학회지
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• 제41권1호
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• pp.48-53
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• 2010

GCSB-5 preparation is a purified extract from a mixture of 6 medicinal plants(Acanthopanacis Cortex, Achyranthis Radix, Saposhnikoviae Radix, Cibotii Rhizoma, Glycine Semen Nigra, Eucommiae Cortex) that have been widely used for the treatment of various bone disorders. The aim of this study was to investigate HPLC analysis method and screening of standard compound on Cibotii Rhizoma for quality standardization of a medicinal crude drug GCSB-5. Onitin-4-O-$\beta$-D-glucopyranoside was isolated from Cibotii Rhizoma as the standard compound and identified on the basis of spectroscopic data such as NMR. HPLC analysis method for the determination of onitin-4-O-$\beta$-D-glucopyranoside was established for the quality control of the medicinal plants of Cibotii Rhizoma species, GCSB-5 raw material and GCSB-5 preparation. And validation of HPLC analysis methods were conformed for verification of HPLC methods by check to specificity, linearity, intra-day precision, inter-day precision and accuracy following ICH guideline.

• 대한안전경영과학회:학술대회논문집
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• 대한안전경영과학회 2010년도 추계학술대회
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• pp.551-557
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• 2010

The research proposes the hypergeometric, binomial and Poisson yield models for defective and defect. The paper also presents the hypothesis test, confidence interval and control charts for DPU(Defect Per Unit) and DPO(Defect Per Opportunity). Especially the study considers the analysis of compound Poisson yield models using various DOU density distributions.

• 통합자연과학논문집
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• 제11권2호
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• pp.107-112
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• 2018

p38 MAP kinase belongs to the Mitogen-activated protein (MAP) kinase family; a serine/threonine kinase. It plays an important role in intracellular signal transduction pathways. It is associated with the development and progression of various cancer types making it a crucial drug target. Present study involves the HQSAR analysis of recently reported imidazo[1,2-b]pyridazine derivatives as p38 MAP kinase antagonists. The model was generated with Atom (A), bond (B), chirality (Ch), and hydrogen (H) parameters and with different set of atom counts to improve the model. An acceptable HQSAR model ($q^2=0.522$, SDEP=0.479, NOC=5, $r^2=0.703$, SEE=0.378, BHL=97) was developed which exhibits good predictive ability. A contribution map for the most active compound (compound 17) illustrated that hydrogen and nitrogen atoms in the ring A and ring B, as well as nitrogen atom in ring C and the hydrogen atom in the ring D provided positive activity in inhibitory effect while, the least active compound (compound 05) possessed negative contribution to inhibitory effect. Hence, analysis of produced HQSAR model can provide insights in the designing potent and selective p38 MAP kinase antagonists.

• Bulletin of the Korean Chemical Society
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• 제31권12호
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• pp.3553-3560
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• 2010

A new hydrazone derivative compound has been synthesized and characterized by IR, $^1H$-NMR, $^{13}C$-NMR and UV-vis. spectroscopy techniques, elemental analysis and single-crystal X-ray diffraction (XRD). The new compound crystallizes in monoclinic space group C2/c. In addition to the crystal structure from X-ray experiment, the molecular geometry, vibrational frequencies and frontier molecular orbitals analysis of the title compound in the ground state have been calculated by using the HF/6-31G(d, p), B3LYP/6-311G(d, p) and B3LYP/6-31G(d, p) methods. The computed vibrational frequencies are used to determine the types of molecular motions associated with each of the observed experimental bands. To determine conformational flexibility, molecular energy profile of (1) was obtained by semi-empirical (AM1) calculation with respect to a selected degree of torsional freedom, which was varied from $-180^{\circ}$ to $+180^{\circ}$ in steps of $10^{\circ}$. Molecular electrostatic potential of the compound was also performed by the theoretical method.

• Food Science and Biotechnology
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• 제27권6호
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• pp.1833-1842
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• 2018

The aim of this study was to identify sleep-promoting substance from Polygonatum sibiricum rhizome extract (PSE) with the regulation of sleep architecture. PSE showed a decrease in sleep latency time and an increase in the sleeping time. In the electroencephalography analysis of rats, PSE (150 mg/kg) showed an increase of non-rapid eye movement by 38% and a decrease of rapid eye movement by 31% compared to the control. This sleep-promoting activity was found to be involved in the $GABA_A$-BDZ receptor. The chemical structure of the pure compound was determined by the $^1H$ and $^{13}C$ nuclear magnetic resonance spectroscopy and gas chromatography mass spectrometry analysis; active compound was glyceryl-1-monolinoleate. The commercial standard glyceryl-1-monolinoleate showed a similar inhibitory concentration on [$^3H$]-flumazenil binding to $GABA_A$-BDZ receptors with final active fraction of PSE. The results indicate that glyceryl-1-monolinoleate is a major active compound responsible for the PSE-derived sleep promotion.

• Archives of Pharmacal Research
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• 제16권2호
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• pp.134-139
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• 1993

The molecular structure of acemetacin, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid carboxymethyl ester, was determined by single cystal X-ray diffraction analysis. The compound was recrystallized from a mixture of acetone and water in triclinic, space group P1, with a=7.796(1), b=10.245(2), c=13.542(3)$\AA,\;\alpha=97.35(1),\;\beta=96.34(1),\;\gamma=107.06(1)^\circ$, and Z=2. The calculated density is 1.422; the observed value is $1.42\;g/cm^3$. The structure was solved by the direct method and refined by full matrix least-squares procedure to the final R value of 0,037 for 2960 independent reflections. There are water molecules, which are thought to be co-crystallized during the evaporation procedure, with the ratio of one water per compound molecule in the crystal. The conformation of the compound is found to be very similar to that of indomethacin. The molecules are stabilized by three O-H.....O type intermolecular hydrogen bonds between the oxygen of water molecule and those of the compound.

• Elastomers and Composites
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• 제56권2호
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• pp.72-78
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• 2021

A phase-change material (PCM) is a material that has the ability to delay heat transfer by absorbing heat from its environment or releasing heat to its environment while its phase changes from solid to liquid or liquid to solid at a specific temperature. As it is applied, it can contribute to environmental conservation such as energy savings and carbon dioxide emission reduction. In order for a PCM to store and release heat, the volume change during its phase transition should be large, and thus a phase transition space is required. When a PCM is used as a polymer additive, it is confined within the polymer, and there is no phase transition space; thus, its ability to absorb and release heat is significantly reduced. Therefore, in this study, porous silica was used to provide EVA/PCM compounds with sufficient space for their phase transition, and to improve the compatibility between the EVA and PCM, modified silica is used: surface-modified 5 wt% silica with 3-methacryloxypropyltrimethoxysilane. The compound was prepared and compared with the silica compound. The presence or absence of the modified silica surface modification was confirmed using Fourier-transform infrared spectroscopy and thermogravimetric analysis, the heat capacity of the compound was evaluated based on a differential scanning calorimetry analysis, and its mechanical strength and morphology were determined using scanning electron microscopy.

• 생약학회지
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• 제48권1호
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• pp.46-50
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• 2017

This study was conducted to investigate the antioxidative activities and tyrosinase inhibition effects of fractions from the distilled water extract of Inonotus obliquus. Moreover, GC-MS based analysis with trimethylsilyl (TMS) derivatization was carried out for active compound in the extract of I. obliquus. In DPPH radical scavenging ability, $SC_{50}$ values of the ethyl acetate fraction was 0.393 mg/ml as a result of the most effective than other fractions. Meanwhile, aqueous fraction showed higher effect in tyrosinase inhibitoty activity. In GC-MS based analysis with TMS derivatization, 7 compounds including syringic acid, vanillic acid and protocatechuic acid were observed in ethyl acetate fraction, and oxalic acid is the main compound in aqueous fraction. As a result, it was confirmed that oxalic acid in aqueous fraction from the distilled water extract of I. obliquus was a compound showing tyrosinase inhibition effect.