• 통합자연과학논문집
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• 제10권3호
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• pp.171-174
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• 2017

Non-hydrolyzable fluorinated organosilicon compounds as an eletrolyte for the application of lithium-ion batteries (LIB) are synthesized. New synthetic method for the perfluorinated organosilicon compound containing spacer such as ethyl and propyl group with cyano moiety instead of ethylene glycol to prevent hydrolysis and to promote conductivity are developed in one pot reaction with moderately high yield. Air-sensitive boron trifluoride etherate is no longer required in this reaction. The products are characterized by spectroscopic analysis.

• Bulletin of the Korean Chemical Society
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• 제11권3호
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• pp.245-248
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• 1990

A series of compounds were synthesized that contain varying number of mesogenic units, 4-n-butylazobenzene moiety, attached to the central benzene ring through ester bond. These compounds were subjected to thermal analysis on a differential scanning calorimeter (DSC) and also on a polarizing microscope. It was found from this study that the presence of mesogenic units in a multi-mesogenic compound does not guarantee for the compound to become mesomorphic and that the linear molecular shape is conducive to form a liquid crystalline phase.

• Journal of Ginseng Research
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• 제42권2호
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• pp.165-174
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• 2018

Background: Extended endoplasmic reticulum (ER) stress may initiate apoptotic pathways in cancer cells, and ER stress has been reported to possibly increase tumor death in cancer therapy. We previously reported that caspase-8 played an important role in compound K-induced apoptosis via activation of caspase-3 directly or indirectly through Bid cleavage, cytochrome c release, and caspase-9 activation in HL-60 human leukemia cells. The mechanisms leading to apoptosis in A549 and SK-MES-1 human lung cancer cells and the role of ER stress have not yet been understood. Methods: The apoptotic effects of compound K were analyzed using flow cytometry, and the changes in protein levels were determined using Western blot analysis. The intracellular calcium levels were monitored by staining with Fura-2/AM and Fluo-3/AM. Results: Compound K-induced ER stress was confirmed through increased phosphorylation of $eIF2{\alpha}$ and protein levels of GRP78/BiP, XBP-1S, and $IRE1{\alpha}$ in human lung cancer cells. Moreover, compound-K led to the accumulation of intracellular calcium and an increase in m-calpain activities that were both significantly inhibited by pretreatment either with BAPTA-AM (an intracellular $Ca^{2+}$ chelator) or dantrolene (an RyR channel antagonist). These results were correlated with the outcome that compound K induced ER stress-related apoptosis through caspase-12, as z-ATAD-fmk (a specific inhibitor of caspase-12) partially ameliorated this effect. Interestingly, 4-PBA (ER stress inhibitor) dramatically improved the compound K-induced apoptosis. Conclusion: Cell survival and intracellular $Ca^{2+}$ homeostasis during ER stress in human lung cancer cells are important factors in the induction of the compound K-induced apoptotic pathway.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 1996년도 춘계학술대회 논문집
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• pp.629-634
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• 1996

Heat generation in machine operating condition makes thermal deformation and thermalstress in the structure, which results in the change the contact characteristics of machine joint such s change of shrinkage fit, contact heat conductance and contact pressure. As the change of contact pressure is related to variation of static, dynamic and thermalcharacteristics, the prediction of transient contact perssure is strongly required. This paper presents some analytical results which will be effective to predict static and dynamic characteristics of the compound cylindrical structure.

• 대한기계학회논문집
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• 제19권8호
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• pp.1889-1900
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• 1995

In this study, a large deflection analysis of a plane frame composed of a thin-walled tube in investigated. When bent, a thin-walled tube is usually controlled by local buckling and subsequent bending collapse of the section. So load resistance reaches the yield level in a thin-walled rectangular tube. This relationship can be divided into three regimes : elastic, post-buckling and crippling. In this paper, this relationship is theoretically presented to be capable of describing nonlinearities and a stiffness matrix is derived by introducing a compound beam-spring element. A numerical analysis uses a constant incremental energy method and the solution is obtained by modifying stiffness matrix at elastic/inelastic stage. This analytical results, load-deflection paths show a good agreement with the test results.

• 한국자기공명학회논문지
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• 제27권4호
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• pp.35-41
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• 2023

From a marine sponge Dysidea species, four new furanosesquiterterpenoids were isolated and characterized. Their structural elucidation was achieved through an extensive analysis employing NMR, MS data, and DFT method. Notably, all compounds shared as identical molecular formula. Compound 2 was identified as a derivative of compound 1, while compounds 3 and 4 exhibited an identical planar structure. Determination of the configurations of chiral centers in compounds 1 and 2 involved a comparative analysis between measured and calculated ECD spectra, along with the application of DP4+ probability analysis. Distinctly, the configurations of isomers 3 and 4 were established by scrutinizing proton chemical shifts based on the NOE correlation.

• 한국문헌정보학회지
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• 제38권4호
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• pp.179-192
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• 2004

본 논문에서는 복합명사에 대한 색인 방법을 다각적으로 적용하여 계층적 결합 문서 클러스터링 시스템의 결과를 분석한다. 우선 한글 색인 엔진과 HAC(Hierarchical Agglomerative Clustering) 엔진에 대해서 설명하고 한글 색인 엔진에서 제공되는 3가지 복합명사 분석 모드에 대해서 기술한다. 또한 구현된 클러스터링 엔진의 특징과 속도 향상을 위한 기법 등을 예시한다. 실험에서는 3가지 복합명사 색인 방법을 기준으로 문서 클러스터링을 수행하고, 실험 결과에 대한 분석에서 복합명사에 대한 색인 방법이 문서 클러스터링의 결과에 직접적인 영향을 준다는 것을 보여준다.

• 대한기계학회논문집A
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• 제20권2호
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• pp.488-499
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• 1996

SMC(Sheet molding compound) is a thermosetting material reinforced with chopped fiberglass. The compression molding of SMC was analyzed based on a rigid thermo-viscoplastic approach using a three dimensional finite element program coupled with temperatures. Only the temperature analysis part was tested in this paper by solving one-dimensional heat transfer problem and comparing with the exact solutions available in the literature. Based on this comparison the program was proved to be valid and was further applied in solving compression molding of SMC between flat dies. To investigate the usefulness of a rigid thermo-viscoplastic approach in the compression molding analysis of SMC charge, compression of rectangular shaped SMC charge at plane strain and three dimensionalde formation condition was analyzed under the same condition as given in the literature. From this comparison it was found out that the rigid thermo-viscoplastic approach was useful in analyzing SMC compression molding between flat dies.

• Journal of Microbiology and Biotechnology
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• 제19권10호
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• pp.1139-1141
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• 2009

Clitocybin D, a novel human neutrophil elastase inhibitor, was isolated from the culture broth of Clitocybe aurantiaca. This compound was purified by solvent extraction, silica gel column chromatography, Sephadex LH-20 column chromatography, and preparative HPLC. The compound was determined to be 4-(4,6-dihydroxy-3-methoxy-3H-isoindol-1-yl)-benzoic acid on the basis of 1D and 2D NMRs and MS spectroscopic analysis. Analysis of the human neutrophil elastase (HNE) inhibitory activity of the isolated compound revealed that it showed significant HNE inhibitory activity with an $IC_{50}$ value of $17.8{\mu}M$.

• 생약학회지
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• 제45권2호
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• pp.141-146
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• 2014

In this study, we investigated on antioxidative activities and tyrosinase inhibitory activities of methanol extract and its fractions from roots of Arctium lappa. The total phenolic compound and flavonoid content of the ethylacetate fraction was found to be 818.29 mg/g and 360.59 mg/g as the highest content. In the measurement of DPPH radical scavenging ability and tyrosinase inhibitory activity, the ethylacetate fraction was higher than the other fractions and the extract. In addition, comparative analysis of phenolic compounds by liquid chromatography-mass spectrometry (MS)/MS system under the multiple-reaction monitoring (MRM) with negative-ion electrospray ionization mode. The main phenolic compounds in the extract and fractions of roots from Arctium lappa were cynarin and chlorogenic acid. The main phenolic compound of the ethylacetate fraction was cynarin. n-Butanol fraction had a significantly higher chlorogenic acid content than other samples. In conclusion, DPPH radical scavenging ability and tyrosinase inhibitory activity of the cynarin-riched ethylacetate fraction showed the highest activity.