• BMB Reports
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• v.42 no.7
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• pp.401-410
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• 2009

We have developed a targeted lipidomics approach that makes it possible to directly analyze chiral eicosanoid lipids generated in cellular systems. The eicosanoids, including prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs) and alcohols (HETEs), have been implicated as potent lipid mediators of various biological processes. Enzymatic formations of eicosanoids are regioselective and enantioselective, whereas reactive oxygen species (ROS)-mediated formation proceeds with no stereo-selectivity. To distinguish between enzymatic and non-enzymatic pathways of eicosanoid formation, it is necessary to resolve enantiomeric forms as well as regioisomers. High sensitivity is also required to analyze the eicosanoid lipids that are usually present as trace amounts (pM level) in biological fluids. A discovery of liquid chromatography-electron capture atmospheric pressure chemical ionization/mass spectrometry (LC-ECAPCI/MS) allows us to couple normal phase chiral chromatography without loss of sensitivity. Analytical specificity was obtained by the use of collision-induced dissociation (CID) and tandem MS (MS/MS). With combination of stable isotope dilution methodology, complex mixtures of regioisomeric and enantiomeric eicosanoids have been resolved and quantified in biological samples with high sensitivity and specificity. Targeted chiral lipidomics profiles of bioactive eicosanoid lipids obtained from various cell systems and their biological implications have been discussed.

• Economic and Environmental Geology
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• v.27 no.1
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• pp.11-28
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• 1994

The Anyang Feldspar Mine is located in Seoksu Dong, Anyang City, Kyeonggi Do, Korea and has a long exploitation record that is once produced high grade sodium feldspars, for glaze. Geologically, This area is mainly composed of Mesozoic Jurassic biotite granite (Anyang granite) which intruded Precambrian Kyeonggi Gneiss Complex outcroped near the mining area. The deposit is localized on the southwest hill side of Anyang granite batholith and is confined in hydrothemal alteration zone formed by sodium-rich alkali hydrothermal fluids along the fractures of leucocratic granite showing later differentiation facies in the biotite granite. The hydrothermal alteration is characterized by albitization, sericitization, and desilication. The microscopic observation and EPMA, XRD analysis of the feldspar ores show that major minerals are albite and quartz and accessory minerals are orthoclase and sericite, and they are rarely associated with perthite, fluorite, zircon, kaolinite, molybdenite, microcline and iron-oxide. In the REE pattern, the strong negative Eu anomalies of the feldspar ores indicate the influence of feldspar fractionation and show similiar pattern of the host leucocratic granite. The filling temperature of quartz crystals in ore zone ranges from $276^{\circ}C$ to $342^{\circ}C$, and it is inferred that the alteration occurred by the hypothermal solution.

• 한국전산유체공학회:학술대회논문집
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• 2000.05a
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• pp.159-165
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• 2000

In this paper, numerical study has been done for the improvement of the superdetonative ram accelerator performance and for the design optimization of the system. The objective function to optimize the premixture composition is the ram tube length required to accelerate projectile from initial velocity $V_o$ to target velocity $V_e$. The premixture is composed of $H_2,\;O_2,\;N_2$ and the mole numbers of these species are selected at design variables. RSM(Response Surface Methodology) which is widely used for the complex optimization problems is selected as the optimization technique. In particular, to improve the non-linearity of the response and to consider the accuracy and efficiency of the solution, design space stretching technique has been applied. Separate sub-optimization routine is introduced to determine the stretching position and clustering parameters which construct the optimum regression model. Two step optimization technique has been applied to obtain the optimal system. With the application of stretching technique, we can perform system optimization with a small number of experimental points, and construct precise regression model for highly non-linear domain. The error to compared with analysis result is only $0.01\%$ and it is demonstrated that present method can be applied more practical design optimization problems with many design variables.

• Bulletin of the Korean Chemical Society
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• v.34 no.12
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• pp.3703-3708
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• 2013

The scaling relationship of the longest relaxation time of a single chain of semiflexible biological polyelectrolyte has been investigated by performing well-established coarse-grained Brownian dynamics simulations. Two kinds of longest relaxation times were estimated from time-sequences of chain trajectories, and their behaviors were interpreted by applying the scaling law for different molecular weights of polyelectrolyte and Debye lengths. The scaling exponents for longest stress relaxation and rotational relaxation are found in the ranges of 1.67-1.79 and 1.65-1.81, respectively, depending on the physicochemical interaction of electrostatic Debye screening. The scaling exponent increases with decreasing screening effect, which is a special feature of polyelectrolytes differing from neutral polymers. It revealed that the weak screening allows a polyelectrolyte chain to follow the behavior in good solvent due to the strong electrostatic repulsion between beads.

• Korean Journal of Clinical Pharmacy
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• v.26 no.3
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• pp.264-266
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• 2016

A 21-year-old healthy Korean man worked on a building construction site every day for almost 2 months and exercised every day for 1 or 2 hours after working hard. He felt dizziness, nausea, and experienced vomiting and body aches immediately after exercise and immediately took cold medicines including acetaminophen, cimetidine, bepotastine, and Codenal? complex for the common cold symptoms for 2 days because he was scheduled to participate in navy training at that time. He complained of severe trapezius pain and aches in his left calf 3 days after joining the Navy training. Testing revealed creatine phosphokinase (CPK) 6260 U/L, myogloblin 176 mcg/L in the urine, liver enzymes increased, and oliguria, suggesting rhabdomyolysis. He recovered with intravenous fluids without any complications.

• 한국전산유체공학회:학술대회논문집
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• 2003.10a
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• pp.294-298
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• 2003

The complex, unsteady, self-sustained pressure oscillations induced by supersonic flow past a rectangular cavity is investigated using numerical simulations. The present numerical study is performed using a parallel, multiblock solver for the two-dimensional, compressible Navier­Stokes equations. Open cavities with length-to-depth (L / D) ratio in the range 0.5 - 3.3 are considered. This paper sheds light on the cavity physics, cavity oscillatory mechanism, and the organisation of vortical structures inside the cavity. The vortex shedding phenomenon, the shear layer impingement event at the aft wall and the movement of the acoustic/compression wave within the cavity are well predicted. The vortical structures· and the source of the acoustic disturbances are found to be located near the aft wall of the cavity. With the increase in the cavity length, strong recompression of the flow near the aft wall leading to a sudden jump in the cavity form drag is observed. The estimated cavity tones are in good agreement with the available semi­empirical relation. Multiple peaks are noticed in deep and long cavities. For the present free­stream Mach number 1.71, it is observed that around L/D=2.0, the cavity oscillatory mechanism changes from the transverse to longitudinal oscillatory mode. The effects of this transition on various fluid dynamics and acoustic properties are also discussed.

• 한국전산유체공학회:학술대회논문집
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• 2010.05a
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• pp.155-162
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• 2010

Recently, due to high oil prices and environmental pollution issues, interest of alternative energy development increases and the related research is widely conducted. Among those research activities the tidal stream power generation utilizes the tidal flow as its mechanical power resource and less depends on the environmental condition for installation and operation than other renewable energy resources. Therefore the amount of power generated is quite consistent and straightforward to predict. However, research on the tidal stream energy conversion turbine is rarely found. In the present study, two numerical methods were developed and compared for the open water Momentum Theory, which is widely used for wind turbines, was adopted. The moving reference frame method for Computational Fluid Dynamis solver were also used. Hybrid meshing was used for the complex geometry of turbines. The analysis results using each method were compared to figure out a better method for the performance prediction.

• 한국전산유체공학회:학술대회논문집
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• 2010.05a
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• pp.247-251
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• 2010

It is very difficult to understand and estimate the heat transfer and flow characteristics in the combustor, which is one of main components in the Auxiliary Power Unit (APU), because its flow filed has very complex structure. In this paper, specified is characteristics of injection and flow through different air goles in the liner, which consist of large circular holes film cooling holes, and tangential air swirl holes. The durability of the liner depends on whether the surface of the liner is exposed to the hot gas over 1000 $^{\circ}C$ of a temperature or net. It is proved that the locations of hot spots estimated from the calculation using CFD are matched well with that from the test. In this study, CFD simulations were performed to examine the heat transfer and temperature distributions in and about a liner wall with film cooling on the wall. This computational study is based on the ensemble average continuity, compressible Navier-Stokes, energy, and PDF combustion equations closed by the standard $k-{\varepsilon}$ turbulence model with standard wall functions for the gas phase and the Fourier equations for conduction in the solid phase.

• 한국전산유체공학회:학술대회논문집
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• 2008.03a
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• pp.125-130
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• 2008

The present study numerically simulates the flow and heat transfer characteristics of rib-induced secondary flow in a cooling channel with staggered V-shaped ribs, extruded on both walls. The rib pitch-to-height ratio (p/h) varies from 2.8 to 10 with the rib-height-to-hydraulic diameter ration ($h/D_h$) of 0.07 and the Reynolds number of 50,000. Shear stress transport (SST) turbulence model is used as a turbulence model. Computational results show that complex secondary flow patterns are generated in the duct due to the snaking flow in the streamwise direction for all tested cases. In the range of p/h=5 to 10 the staggered V-shaped rib gives about 3 times higher heat transfer augmentation than the reference smooth channel with high heat transfer on both front side and the area around the leading edge of the ribs, while the former cases give about 2.5 times higher streamwise pressure drop than the latter ones. Consequently, for the thermal performances, based on the equal pumping power condition, the staggered ones give about 2 times higher values than the latter ones with more uniform heat transfer distribution.

• Journal of Mechanical Science and Technology
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• v.17 no.2
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• pp.296-309
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• 2003

The periodicity of the physiological flow has been the major interest of analytic research in this field up to now Among the mechanical forces stimulating the biochemical reaction of endothelial cells on the wall, the wall shear stresses show the strongest effect to the biochemical product. The objective of present study is to find the effects of velocity waveform on the wall shear stresses and pressure distribution along the artery and to present some correlation of the velocity waveform with the clinical observations. In order to investigate the complex flow phenomena in the bifurcated tube, constitutive equations, which are suitable to describe the rheological properties of the non-Newtonian fluids, are determined, and pulsatile momemtum equations are solved by the finite volume prediction. The results show that pressure and wall shear stresses are related to the velocity waveform of the physiological flow and the blood viscosity. And the variational tendency of the wall shear stresses along the flow direction is very similar to the applied sinusoidal and physiological velocity waveforms, but the stress values are quite different depending on the local region. Under the sinusoidal velocity waveform, a Newtonian fluid and blood show big differences in velocity. pressure, and wall shear stress as a function of time, but the differences under the physiological velocity waveform are negligibly small.