• 산업공학
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• 제23권1호
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• pp.12-23
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• 2010

A semiconductor market is one of the most competitive markets in the world. To survive this competition, important targets for production planning are on-time delivery and profit maximization. In our research, we modify the linear programming model for the current production planning by adding new objective functions that maximize the profit. In addition, we propose a production planning process that gives a priority to new products, reflecting daily fluctuations in demand to weekly production planning. We validate our model with real data sets obtained from a major company semiconductor manufacturer and performed the paired t-test to verify the results. The results showed that our model forecasted profit and loss with 93.2% accuracy and improved the due date satisfaction by 10%.

• Journal of Microbiology
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• 제43권spc1호
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• pp.101-109
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• 2005

To gain maximal benefit in a competitive environment, single-celled bacteria have adopted a community genetic regulatory mechanism, known as quorum sensing (QS). Many bacteria use QS signaling systems to synchronize target gene expression and coordinate biological activities among a local population. N-acylhomoserine lactones (AHLs) are one family of the well-characterized QS signals in Gram-negative bacteria, which regulate a range of important biological functions, including virulence and biofilm formation. Several groups of AHL-degradation enzymes have recently been identified in a range of living organisms, including bacteria and eukaryotes. Expression of these enzymes in AHL-dependent pathogens and transgenic plants efficiently quenches the microbial QS signaling and blocks pathogenic infections. Discovery of these novel quorum quenching enzymes has not only provided a promising means to control bacterial infections, but also presents new challenges to investigate their roles in host organisms and their potential impacts on ecosystems.

• Molecules and Cells
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• 제39권1호
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• pp.26-30
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• 2016

Peroxiredoxins are ubiquitous thiol proteins that catalyse the breakdown of peroxides and regulate redox activity in the cell. Kinetic analysis of their reactions is required in order to identify substrate preferences, to understand how molecular structure affects activity and to establish their physiological functions. Various approaches can be taken, including the measurement of rates of individual steps in the reaction pathway by stopped flow or competitive kinetics, classical enzymatic analysis and measurement of peroxidase activity. Each methodology has its strengths and they can often give complementary information. However, it is important to understand the experimental conditions of the assay so as to interpret correctly what parameter is being measured. This brief review discusses different kinetic approaches and the information that can be obtained from them.

• Nuclear Engineering and Technology
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• 제53권11호
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• pp.3772-3783
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• 2021

This work proposes a new efficient meta-heuristic optimization algorithm called Gamma Ray Interactions Based Optimization (GRIBO). The algorithm mimics different energy loss processes of a gamma-ray photon during its passage through a matter. The proposed novel algorithm has been applied to search for the global minima of 30 standard benchmark functions. The paper also considers solving real optimization problem in the field of nuclear engineering, radioisotope identification. The results are compared with those obtained by the Particle Swarm Optimization, Genetic Algorithm, Gravitational Search Algorithm and Grey Wolf Optimizer algorithms. The comparisons indicate that the GRIBO algorithm is able to provide very competitive results compared to other well-known meta-heuristics.

• 인터넷정보학회논문지
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• 제22권2호
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• pp.19-27
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• 2021

Fireworks Algorithm (FWA) is a new heuristic swarm intelligent algorithm inspired by the natural phenomenon of the fireworks explosion. Though it is an effective algorithm for solving optimization problems, FWA has a slow convergence rate and less information sharing between individuals. In this paper, we improve the FWA. Firstly, explosion operator and explosion amplitude are analyzed in detail. The coefficient of explosion amplitude and explosion operator change dynamically with iteration to balance the exploitation and exploration. The convergence performance of FWA is improved. Secondly, differential evolution and commensal learning (CDE) significantly increase the information sharing between individuals, and the diversity of fireworks is enhanced. Comprehensive experiment and comparison with CDE, FWA, and VACUFWA for the 13 benchmark functions show that the improved algorithm was highly competitive.

• Tuberculosis and Respiratory Diseases
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• 제42권6호
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• pp.801-812
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• 1995

CR asthma is associated with disease chronicity, a positive family history of asthma and in vitro and in vivo defects in mononuclear cell function. The HPA axis in CR asthmatics is suppressed normally by dexamethasone and the pharmacokinetic profile of an oral dose of prednisolone is similar to that found in CS subjects. In addition, competitive binding studies have shown that the ligand binding and nuclear translocation functions of the GR are similar in the two groups. Studies using gel retardation assay have indicated a defect in DNA binding in CR subjects. Chemical mutational analysis of the GR has shown that is not due to a defect in its structure at the cDNA level. Scatchard analysis of the GR/DNA and GR/ligand interactions suggests that there may be transcriptional interference of the GR with other transcriptionally active molecules leading to defective gene transcription.

• The Korean Journal of Physiology and Pharmacology
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• 제23권5호
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• pp.419-426
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• 2019

Mosapride accelerates gastric emptying by acting on 5-hydroxytryptamine type 4 ($5-HT_4$) receptor and is frequently used in the treatment of gastrointestinal (GI) disorders requiring gastroprokinetic efficacy. We tested the effect of mosapride on 5-hydroxytryptamine type 3 ($5-HT_3$) receptor currents because the $5-HT_3$ receptors are also known to be expressed in the GI system and have an important role in the regulation of GI functions. Using the whole-cell voltage clamp method, we compared the currents of the $5-HT_3$ receptors when 5-HT was applied alone or was co-applied with mosapride in cultured NCB-20 cells known to express $5-HT_3$ receptors. The $5-HT_3$ receptor current amplitudes were inhibited by mosapride in a concentration-dependent manner. Mosapride blocked the peak currents evoked by the application of 5-HT in a competitive manner because the $EC_{50}$ shifted to the right without changing the maximal effect. The rise slopes of $5-HT_3$ receptor currents were decreased by mosapride. Pre-application of mosapride before co-application, augmented the inhibitory effect of mosapride, which suggests a closed channel blocking mechanism. Mosapride also blocked the opened $5-HT_3$ receptor because it inhibited the $5-HT_3$ receptor current in the middle of the application of 5-HT. It accelerated desensitization of the $5-HT_3$ receptor but did not change the recovery process from the receptor desensitization. There were no voltage-, or use-dependency in its blocking effects. These results suggest that mosapride inhibited the $5-HT_3$ receptor through a competitive blocking mechanism probably by binding to the receptor in closed state, which could be involved in the pharmacological effects of mosapride to treat GI disorders.

• 통상정보연구
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• 제17권2호
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• pp.253-284
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• 2015

오늘날 화주기업들이 자사의 물류경쟁력을 확보하고자 물류전문기업을 활용하는 비중은 점차 증가되고 있다. 본 연구의 목적은 화주기업이 3자물류를 활용함에 있어 기대하는 서비스의 수준과 제공받은 이후의 인지 수준에 대한 차이를 확인하여 3자 물류서비스의 확대에 기여하기 위함이다. 이러한 차원에서 SERVQUAL의 모형을 활용하여 물류서비스 품질을 측정하기 위한 새로운 모델을 설계하였으며, 현재 3자물류를 활용하고 있는 178개의 화주기업을 대상으로 물류 기능별(보관, 운송, 국제운송) 설문을 진행한 후 물류서비스 품질 수준을 측정하였다. 분석 결과 화주기업들의 물류서비스에 대한 기대수준과 인지수준에 차이가 평균 8% 발생됨을 알 수 있었다. 본 연구의 결과는 현재 국내에서 물류서비스를 제공하고 있는 물류기업들의 물류서비스 품질 수준을 확인할 수 있었을 뿐 아니라 물류 경쟁력 확보하고 경쟁우위를 선점하기 위해 필요한 역량이 무엇인지를 제시했다는 점에서 큰 의의가 있다 하겠다.

• 한국언론정보학보
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• 제19권
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• pp.7-36
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• 2002

본 논문의 목적은 인터넷방송 콘텐츠의 산업적 가능성을 모색해 보기 위해서 기존의 텔레비전 프로그램과 비교하여 어떠한 특성이 나타나는지를 살펴보고자 한다. 본 논문에서는 두 매체의 프로그램간 유사성과 차이점을 분명하게 나타내 보기 위하여 층족적소이론(Niche theory)을 적용하여 보고자 한다. 연구결과, 첫째, 대부분의 장르에서 인터넷방송이 텔레비전보다 적소폭이 좁다는 결과가 도출되었다. 둘째, 교육 장르의 중복값 평균이 가장 높았고, 그 다음은 교양, 오락 순이어서 비교적 다른 장르에 비해서 경쟁적인 관계가 아닌 것으로 나타났다. 반면, 이상의 새 장르를 제외한 6개는 비슷한 정도의 경쟁관자로 형성하고 있는 것으로 나타났다. 셋째, 경쟁적 우위성 분석 결과에서는 인터넷방송이 우위성을 확보하고 있는 기능은 유일하게 음악의 개인적 정보습득 기능이었다. 전체적으로 아직까지는 텔레비전이 인터넷방송에 비해서 경쟁적인 매체가 아니라는 것을 알 수 있었다. 그러므로 인터넷방송은 텔레비전과는 다른 새로운 포맷 개발이 필요하다고 할 수 있겠다.

• 한국콘텐츠학회논문지
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• 제10권6호
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• pp.213-221
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• 2010

최근 문화콘텐츠 시장의 규모가 커짐에 따라 한국의 소리문화의 경쟁력을 갖추고 세계에 알릴 수 있는 독창적인 콘텐츠 개발이 요구되고 있다. 이러한 흐름에 따라 본 논문에서는 한국 전통음악인 사물놀이를 터치 인터페이스를 이용하여 연주하는 '사물놀이 협주 시스템'을 제안한다. 본 시스템은 터치기능을 지원하는 '콘트롤 디바이스'와 콘트롤 디바이스에서 입력한 터치 신호를 감지하여 연주음을 재생하는 '연주관리자', 다른 디바이스와 협주를 가능하게 하는 '통신 관리자', 협주시 시간 동기화 프로토콜을 활용하여 속도의 차이가 있는 통신환경에서도 연주의 순서를 유지할 수 있도록 하는 '동기화 관리자'로 구성 하여 설계하였다. 또한 사물놀이의 재미를 느낄 수 있도록 멀티터치를 활용한 조작방법을 고려했고, 여러 사람이 함께 연주할 수 있는 협주 기능을 구현하여, 사물놀이의 관심이 부족한 사람들에게 흥미를 끌어낼 수 있도록 하였다.