• Analytical Science and Technology
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• v.30 no.1
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• pp.10-19
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• 2017

Anabolic steroids have similar structures to testosterone, both of which promote the growth of muscle mass and increase strength. However, the side effects of anabolic steroid use may lead to heart attacks or strokes. Additionally, the excessive use of steroids inhibits the production of the sex hormones in the body via a negative feedback loop, which results in testicular atrophy in males and amenorrhea in females. Currently, the method of choice used to test for the presence of anabolic steroids is GC-MS. However, GC-MS methods require chemical derivatization of the steroid sample to ensure compatibility with the analytical method; therefore, analysis of many different samples is difficult and time consuming. Unlike GC-MS, the liquid chromatography-quadrupole-time of flight mass spectrometry (LC-Q-TOF-MS) method is suitable for many samples. Twenty-two different anabolic steroids were analyzed by LC-Q-TOF-MS with various collision energies (CE). Accurate mass spectral data were obtained using a Q-TOF-MS equipped with an electro-spray ionization source and operated in the positive MS/MS mode for several classes of steroids that are often the targets of testing. Based on the collected data, fragmentation pathways were carefully elucidated. The high selectivity and sensitivity of the LC-Q-TOF-MS instrument combined with these fragmentation pathways offers a new approach for the rapid and accurate screening of anabolic steroids. The obtained data from the 22 different anabolic steroids will be shared with the scientific community in order to establish a library to aid in the screening of illegal anabolic steroids.

• Journal of Wetlands Research
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• v.17 no.2
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• pp.130-138
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• 2015

According to the "Safety Evaluation Detailed Instructions (Dam)", a precise safety inspection is carried out for dams that exceed a certain scale. However, as the Hydrological Safety Evaluation from various evaluation standards is designed to evaluate the safety of existing dams considering PMF(Probable Maximum Flood), the evaluation is much less applicable for most agricultural reservoirs. Therefore, the Hydrological Safety Guidelines for agricultural reservoirs are expected to be re-evaluated considering the diverse risk factors with the coefficient model and AHP(Analytic Hierarchy Process) in this study. The coefficient model has been developed by selecting the hydrological safety superordinate subordinate evaluation factors to reflect diverse risk factors of agricultural reservoirs. This study indicated that in the short term, improving the safety check condition evaluation grade will be useful to improve the hydrological safety of the agricultural reservoir because it can be performed immediately.

• Safety and Health at Work
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• v.14 no.4
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• pp.406-414
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• 2023

Background: This study examined age-group differences in the rate, severity, and cost of injuries among construction workers to support evidence-based worker safety and health interventions in the construction industry. Methods: Ohio workers' compensation claims for construction workers were used to estimate claim rates and costs by age group. We analyzed claims data auto-coded into five event/exposure categories: transportation incidents; slips, trips, and falls (STFs); exposure to harmful substances and environments; contact with objects and equipment (COB); overexertion and bodily reaction. American Community Survey data were used to determine the percentage of workers in each age group. Results: From 2007-2017, among 72,416 accepted injury claims for ~166,000 construction full-time equivalent (FTE) per year, nearly half were caused by COB, followed by STFs (20%) and overexertion (20%). Claim rates related to COB and exposure to harmful substances and environments were highest among those 18-24 years old, with claim rates of 313.5 and 25.9 per 10,000 FTE, respectively. STFs increased with age, with the highest claim rates for those 55-64 years old (94.2 claims per 10,000 FTE). Overexertion claim rates increased and then declined with age, with the highest claim rate for those 35-44 years old (87.3 per 10,000 FTE). While younger workers had higher injury rates, older workers had higher proportions of lost-time claims and higher costs per claim. The total cost per FTE was highest for those 45-54 years old ($1,122 per FTE). Conclusion: The variation in rates of injury types by age suggests that age-specific prevention strategies may be useful.

• Geotechnical Engineering
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• v.12 no.3
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• pp.73-82
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• 1996

Limit state design(LSD) principles employing load and resistance factor design(LRFD) are coming into use in geotechnical engineering community around the world. Current working (allowable) stress design principles are expected to be replaced by LRFH method in the near future. North America has recently adopted LRFD principles, and European community has also developed its own code called "Eurocode" based on partial safety factor design which is essentially the same as LRFD. Relevant review and analysis of new global design codes are prerequisites to adopting these codes in the Korean construction industry and in the Korean foundation design prac titre. This paper reviews geotechnical aspects of LRFD and Eurocode, and analyzes the geomaterial resistance factors in LRFD for the design of axially-loaded driven piles.

• Journal of Korean Academy of Nursing
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• v.32 no.6
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• pp.855-866
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• 2002

The purpose of study is to develop a home nursing care project model suitable for Korea's heath care system and policy directions for expansion and establishment of home nursing care. Method: The first, status of home nursing care program in medical institution and public health center was evaluated respectively in view of structure, process and performance. And then, issues of the program were analyzed in view of accessibility, safety, and sufficient supply. The second, demand projection of home nursing care according to income level and technical level of service that is needed to the subject was tried. In addition, the level of supply for home nursing care at present was estimated. The third, home nursing care program in advanced countries (Japan and U.S.A.) was examined. Result and Conclusion: Community-based home nursing care program is developed into public-operation model and private-operation model from above the sub-subject result. Functional network for referral system among related institutions is built up to meet various needs, regardless of accessibility to distance and economy. And prior settlements and policy directions for expansion and establishment of home nursing care are suggested.

• Journal of the Korean Institute of Educational Facilities
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• v.23 no.2
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• pp.19-29
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• 2016

In the context of lifelong education program for an aging society and information age, elementary school facilities are expected to accommodate various people in diverse age group and diverse physical abilities. Introduction of the 'Universal Design' concept seems inevitable in school environment in terms of public infra structure for community. However, in architectural point of view, unlike foreign examples, simply applied barrier-free and safety standards of domestic guidelines based on dimensional data does not function enough to achieve universal design in authentic manner. This study is focused on this issue and suggests the direction of improvement for architectural design guidelines. Through the comparative analysis of foreign and domestic design guidelines, two principles of universal design-'Flexibility in Use', 'Perceptile Information'- are found to be lacking in the domestic design guidelines for elementary school facilities. It is expected for government authority to develop more concrete guidelines to achieve universal design for school as a basic public space in the community.

• The Korean Journal of Community Living Science
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• v.28 no.3
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• pp.391-401
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• 2017

This study was conducted to evaluate the relationships between exposure level to pyrethroid pesticide and wearing of protective equipment in 194 Chung-nam orchard male farmers. The urinary metabolites of pyrethroid pesticides, including Cis, Trans, DBCA, and 3-PBA, were analyzed by GC/MSD. As a result of this study, the detection rate and exposure level of 3-PBA was the highest among pyrethroid metabolites discovered by orchard farmers. As a result of analyzing the actual conditions of wearing protective equipment by the subjects of this study, the rate of agricultural farmers who wore four pieces of protective equipment compared to agricultural farmers wearing a single piece of protective clothing was as high as 35.1%. Pyrethroid exposure levels were low when farmers wore more personal protective equipment (PPE). In conclusion, training with regards to pesticide hazards and protective equipment for farmers who spray pesticides will help reduce pesticide exposure levels.

• Journal of the Korean housing association
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• v.27 no.6
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• pp.1-8
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• 2016

This study is focusing on Territoriality which is supposed to be one of the most important elements to activate open spaces in apartment communities. Case analysis with onsite visit is selected as the research method of this study targeting 6 apartment complexes in Bukgu and Gwangsangu, Gwangju city which accommodate over 500 households up to 800 households, which show high occupancy ratio and which were built after 2006 to minimize the physical environment variable. The result of this study is concluded as follows. First, we need the elements which can induce various action and the use of floor surface in color, pattern, and material should be considered in the stance of pedestrian for easy recognition of Territoriality change. Second, To secure the view, we should consider to plant shrubs or to plant trees wider apart. In most cases, enclosure is secured by using trees of Vertical Boundary for safety and comfort, but overuse in some cases make residents feel fear of enclosed spaces and insecurity. Third, Various and harmonious design elements can be recommended to increase aesthetic impression, to induce positive response for design, and to be used consistently. Finally, Unique space using notable landmark or design elements should be considered.

• Proceedings of the Korean Society of Food Science and Nutrition Conference
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• 2004.11a
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• pp.17-23
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• 2004

Not all individuals respond identically, or at times in the same direction, to dietary interventions. These inconsistencies likely arise because of diet and genomic interactions (nutrigenomics effects). A host of factors may influence the response to bioactive food components including specific polymorphisms (nutrigenetic effect), DNA methylation patterns and other epigenomic factors (nutritional epigenomic effects), capacity to induce anuo. suppress specific mRNA expression and patterns (nutritional transcriptomics), the occurrence and activity of proteins (proteomic effects), and/or the dose and temporal changes in cellular small molecular weight compounds will not only provide clues about specificity in response to food components, but assist in the identification of surrogate tissues and biomarkers that can predict a response. While this 'discovery' phase is critical for defining mechanisms and targets, and thus those who will benefit most from intervention, its true usefulness depends on moving this understanding into 'development' (interventions for better prevention, detection, diagnosis, and treatment) and a 'delivery' phase where information is provided to those most in need. It is incumbent on those involved with food and nutrition to embrace the 'omics' that relate to nutrition when considering not only the nutritional value of foods and their food components, but also when addressing acceptability and safety. The future of 'Nutrigenomics and Health Promotion' depends on the ability of the scientific community to identity appropriate biomarkers and susceptibility variants, effective communications about the merits of such undertakings with the health care community and with consumers, and doing all of this within a responsible bioethical framework.

• The Korean Journal of Community Living Science
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• v.15 no.4
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• pp.11-16
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• 2004

This study was conducted to find the powerful free radical scavenging effect in methanol extracts from 35 kinds of Korean medicinal plants obtained from the Plant Extract Bank as natural plant products. Antioxidant activity of the plant extracts was determined by measuring the scavenging effect of 1,1-diphenyl-2-picryl hydrazyl radical (DPPH). In the screening of plant extracts tested, at 200 ppm level, almost all plantex tracts showed significantly high antionidant activity. In the reinvestigation of 15 kinds of Korean medicinal plants at 50 ppm level selected as good sources with good free radical scavenging effect at 200 ppm level, the DPPH scavenging effects were similar to those of L-ascorbic acid in whole plant extract of Fragaria yezoensis (90.4％), in the plant stems and roots extract of Gingko biloba, and the leaves extract of Rhododendron mucronulatum var. ciliatum (90％). The fruits extract of Cornus officinalis showed the strongest antioxidant activity (95％). These results suggest that the methanol extracts from Korean medicinal plants can be a potential source of antioxidants that can be used to control oxidative stress in the body, But further study is needed to measure their safety for consumption