• 복식
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• 제58권6호
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• pp.54-68
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• 2008

The purpose of this study is to investigate the effect of dot pattern size(0.8, 1.8, 2.5, 5, 8), color combination(BG/R, Y/B), area-ratio on image formation. Sets of stimulus and response scales(7 point semantic) were used as experimental materials. The stimuli were 20 color pictures manipulated with the combination of dot pattern size, color combination, and area-ratio using computer simulation. The subjects were 240 female undergraduates living in Gyeongnam-do. Image factor of the stimulus was composed of 5 different components, visibility, attractiveness, cuteness, stability and high class image. In the cuteness, color combination, dot pattern size showed independent effect. In the stability, area-ratio, dot pattern size showed independent effect. Interaction effects of color and area-ratio combination was significant on cuteness. For visibility image 8cm yellow dot/blue background, for attractiveness image BG/R coloration, for cuteness image Y/B coloration and for stability image 0.8cm yellow dot/blue background were effective. According to the variation of dot pattern size, color combination and area-ratio, it was investigated that the images for a dress wearer were expressed diversely, were shown differently in image dimensions, and could be produced to different images.

• 생명과학회지
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• 제32권3호
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• pp.210-221
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• 2022

비스테로이드소염제(NSAID)와 γ-secretase 저해제(DAPT) 또는 SIRT1저해제(MHY2245)의 병용 효과를 인간 대장암(KM12) 및 간암(SNU475) 세포를 대상으로 조사한 결과, celecoxib (CCB) 및 2, 5-dimethyl celecoxib (DMC)를 포함하는 NSAID는 DAPT 또는 MHY2245와의 병용에 의하여 COX-2활성과 상관없이 NSAID의 암세포 증식 억제능이 현저히 증강되었다. DAPT와 MHY2245는 p62단백질 감소와 동시에 Notch1, CD44, CD133, octamer- binding transcription factor 4 (Oct4) 등의 다수의 종양 줄기세포 표지자 및 NICD1 발현 양을 감소시켰지만, activating transcription factor 4 (ATF4) 발현은 증강시켰다. 또한 NSAID 단독처리 보다 NSAID/DAPT 및 NSAID/MHY2245 병용 처리에 의하여 오토파지가 촉진되므로서 종양 줄기세포 표지자의 발현 및 단백질양의 감소가 가속화되고, 이에 따라 PARP 활성화 및 세포사멸이 현저히 증강 되었다. 결론적으로 NSAID/DAPT 및 NSAID/MHY2245의 병용 투여는 종양 줄기세포 표지자를 발현하는 인간 암세포의 증식 억제 및 제거에 효과적인 처리방법으로, 임상에 적용시킬 수 있는 학문적 근거로서 제공 될 수 있다.

• 대한음성학회지:말소리
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• 제67호
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• pp.79-102
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• 2008

In this paper, we investigate the relation between Bayes factor and likelihood ratio test (LRT) approaches and apply the neighborhood information of Bayes factor to building an alternate hypothesis model of the LRT system. To consider the neighborhood approaches, we contemplate a distance measure between models and algorithms to be applied. We also evaluate several methods to improve performance of utterance verification using neighborhood information. Among these methods, the system which adopts anti-models built by collecting mixtures of neighborhood models obtains maximum error rate reduction of 17% compared to the baseline, linear and weighted combination of neighborhood models.

• 감성과학
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• 제13권2호
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• pp.301-308
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• 2010

본 연구는 톤 인 톤 배색과 톤 온 톤 배색을 활용한 배색의 감성 효과에 관한 것이다. 톤 인 톤 배색 과 톤 온 톤 배색에 근거하여 제작한 24개 배색에 대하여 Osgood의 SD법(Semantic Differential Method)을 이용하여 10명 대학생에게 배색에 대한 인상 평가를 받았으며 자료 분석은 엑셀 통계 프로그램 2004를 사용하여 요인분석을 하였다. 연구결과, 톤 인 톤 배색에 근거한 배색과 톤 온 톤 배색에 근거한 배색의 인상이 매우 다르게 평가되는 것을 확인했다. 따라서 색채조화의 형식으로 제안되는 배색 기법이 배색의 감성 효과에 영향을 미칠 가능성을 확인하였다. 그리고 '좋다-싫다', '어린이답다-어른답다', '강하다-약하다', '따뜻하다-차갑다' 4개 이미지 차원이 도출되었으며 이러한 이미지에는 색상과 색조가 영향을 주는 요소로 작용한다는 것을 확인하였다. 제품의 사진배색과 거의 동일한 색종이 배색의 인상을 비교한 것으로 색표를 이용한 배색과 그 배색에 근거한 제품의 배색 인상에는 거의 차이가 없다는 것을 확인하였다. 그러나 제품이 가진 고유 특성이나 형태, 재질 등에 의해 인상이 크게 달라지는 것도 확인하였다. 이러한 연구 결과는 배색 이미지나 색채 디자인의 기초 자료로 활용 될 것이다.

• Asian-Australasian Journal of Animal Sciences
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• 제23권11호
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• pp.1412-1420
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• 2010

In this study, changes in testicular tissues of rats subjected to xylene and formaldehyde inhalation were evaluated. Three experimental groups were included in the study. Each group of rats was exposed to formaldehyde (6 ppm), technical xylene (300 ppm) or a combination of these two agents (150 ppm+3 ppm) for 8 weeks (8 h/d). Control groups were maintained for a period of eight weeks under the same conditions. Staining methods (triple staining, strep ABC method) were applied to examine histometric changes and relaxin like factor (RLF) expression in the testicular tissue. Immunostaining for RLF showed that density of staining for RLF decreased in rats exposed to formaldehyde. Formaldehyde or a combination of formaldehyde and xylene led to a decrease in seminiferous epithelial height. In conclusion, exposure of rats to formaldehyde and xylene-formaldehyde combinations adversely affects Leydig cells (RLF) and seminiferous epithelium of testicular tissue.

• 대한기계학회논문집
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• 제7권3호
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• pp.270-277
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• 1983

Plastic plane stress solutions are given for a center cracked strip, characterized by the Ramberg-Osgood plastic index, under bi-axial tension. Using a power law hardening stress-strain relation, an incremental plasticity finite element formulation is developed, and simple formulation is given for computing J-integral with nodal displacements. The near tip angular distribution of von Mises effective stress doesn't differ significantly in magnitude according to the change of loading stress and bi-axial load combination factor. But, for smaller plastic index, the location of its maximum value moves vertically at a head of crack. J-integral value, in the plastic zone near crack tip, decreases with load combination factor for large and small plastic index.

• 생명과학회지
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• 제9권5호
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• pp.504-509
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• 1999

The trend of organogenesis in Xenopus presumptive ectoderm was studied by combined dose of activin A and IGF-1(insulin-like growth factor-1). In reference study of Asashima and his colleagues, the inductive patterns of various organs were reported with activin, the potent mesoderm inducing factor. In present study, the inducing pattern was cleared with combined-dose of concentration 1-100 ng/ml activin A and IGF-1. In addition, the result from single treatment of activin A was compared with former study. As a result, eye was differentiated in 5-20% of explants at 10 and 50 ng/ml concentrative combination of activin A. Otic vesicle was appeared in the entire concentrative combination of IGF-1. Pronephric duct was induced 19-38% of explants at the concentration of activin A 100 ng/ml by adding IGF-1. The comparison of single treatment of activin A was showed some difference in dose-dependent inducing pattern.

• 해양환경안전학회지
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• 제23권3호
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• pp.217-223
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• 2017

In order to assess risk as a basic step for securing safety, it requires to select risk factors and determine the frequency and the severity of the consequence of each risk factor. This research adopted common risk factors among well-known maritime risk assessment models, and proposed objective criteria to gauge the risk level of each risk factor. The starting points of risk evolution were chosen for criteria according to related studies and seafarers' experience. The rate of risk appearance over the criteria is named as the incidence of risk factor. Therefore, the total risk level is expressed as the combination of incidence of each risk factor and severity. This quantitative method would be applied to measuring and comparing the risk level of target maritime zones, and it would also be useful to survey which risk factor be focused for reducing the total risk of a certain maritime zone.

• Kyungpook Mathematical Journal
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• 제50권2호
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• pp.281-288
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• 2010

By introducing some parameters and using the way of weight function and the technic of real analysis and complex analysis, a new Hilbert-type integral inequality with a best constant factor and a combination kernel involving two mean values is given, which is an extension of Hilbert's integral inequality. As applications, the equivalent form and the reverse forms are considered.

• Biomolecules & Therapeutics
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• 제28권5호
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• pp.473-481
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• 2020

Axl receptor tyrosine kinase has been implicated in cancer progression, invasion, and metastasis in various cancer types. Axl overexpression has been observed in many cancers, and selective inhibitors of Axl, including R428, may be promising therapeutic agents for several human cancers, such as breast, lung, and pancreatic cancers. Here, we examined the cell growth inhibition mediated by R428 and auranofin individually as well as in combination in the human breast cancer cell lines MCF-7 and MDA-MB-231 to identify new advanced combination treatments for human breast cancer. Our data showed that combination therapy with R428 and auranofin markedly inhibited cancer cell proliferation. Isobologram analyses of these cells indicated a clear synergism between R428 and auranofin with a combination index value of 0.73. The combination treatment promoted apoptosis as indicated by caspase 3 activation and poly (ADP-ribose) polymerase cleavage. Cancer cell migration was also significantly inhibited by this combination treatment. Moreover, we found that combination therapy significantly increased the expression level of Bax, a mitochondrial proapoptotic factor, but decreased that of the X-linked inhibitor of apoptosis protein. Furthermore, the suppression of cell viability and induction of Bax expression by the combination treatment were recovered by treatment with N-acetylcysteine. In conclusion, our data demonstrated that combined treatment with R428 and auranofin synergistically induced apoptosis in human breast cancer cells and may thus serve as a novel and valuable approach for cancer therapy.