• Transactions of the Korean Society of Mechanical Engineers A
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• v.28 no.6
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• pp.799-806
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• 2004

This paper presents a scheme for finding an optimal combination of design parameters affecting on the handling performance of a large truck using design of experiments. The average of the sum of peak-to-peak roll angles at the first and second part of the double lane is used as an objective function for design of experiments. Six design parameters are selected from all possible parameters affecting on the handling performance. The table of orthogonal arrays is made by 27 times simulations. A computational model of a large truck is developed by MSC/NASTRAN and MSC/ADAMS, and verified the reliability of it with the results of vehicle tests performed in a double lane change course. It is used for the simulations. Analyses of variance and factor effect of the table of orthogonal arrays are performed. This paper proposes an optimal combination of those six design parameters for improving the handling performance of the large truck.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.28 no.2
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• pp.158-164
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• 2004

Steam generator tubes experience widespread degradations such as stress corrosion cracking, wear, tube rupture, denting, fatigue and so on. The resulting damages can cause tube bursting or leak of the primary water which contains radioactivity Therefore the allowable size of the damage is required to be determined on the maintenance purpose. The burst pressure of a tube with a T-type combination crack consisting of longitudinal and circumferential cracks is obtained experimentally and analytically. Fracture parameters such as stress intensity factor and crack opening angle are investigated. Also the burst pressure for a T-type combination crack is compared with that of a single longitudinal crack to develop a length-based criteria.

• Journal of Periodontal and Implant Science
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• v.26 no.2
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• pp.396-413
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• 1996

Current acceptable methods for promoting periodontal regeneration are based on removal of diseased soft tissue. root treatment, guided tissue regeneration, introduction of new graft materials and biological mediators. Insulin-like growth factor-I(IGF-I) and Platelet-derived growth factor-BB(PDGF-BB), the members of the polypeptuyde growth factor family have been reported as the biological mediators which regulate a variety cellular matrix biologic activities of wound healing process including the cell proliferation, migration and extracellular matrix synthesis.The purposes of this study is to evaluate the combination effects of IGF-I and PDGF-BB on the cellular activity of the periodontal ligament cells to act as a regeneration promoting agent of periodontal tissue. Human periodontal ligament cells were prepared from the first premolar tooth extracted for the orthodontic treatment and were cultured in DMEM containing 10% FBS at the $37^{\circ}C$, 5% CO2 incubator. Author measured the DNA synthetic activity, and total protein, collagen and noncollagenous protein synthetic activities according to the concentration of 10,100ng/ml IGF-I and1,10 ng/ml PDGF-BB in combination. The results were as follows: Significantly increased in the 1 ng/ml PDGF-BB alone compared to the 10 ng/ml PDGF-BB alone(P<0.01) and in the 1 ng/ml PDGF-BB and 10, 100ng/ml IGF-I in combination compared to the 1 ng/ml PDGF-BB alone(P<0.05, P<0.0l). The synthetic activity of the total protein and collagen is significantly increased like to the synthetic activity of the DNA(P<0.05). The synthetic activity of the noncollagenous protein is increased according to the concentration of IGF_I, but not statistically statistically significant(P>0.05). The percent of the collagen is significantly in the 1ng/ml PDGF-BB and 10ng/ml IGF-I in combination compared to the 1ng/ml PDGF-BB alone(P<0.05) and in the 10ng/ml IGF-I in combination compared to the 10ng/ml PDGF-BB alone(P<0.05). The synthetic activity of the DNA is In conclusions, the percent study shows that PDGF-BB and IGF-I in combination have a potentiality to enhance the DNA synthesis and the total protein and collagen synthesis of The periodontal ligament cells, especially it is more significant in the low concentration of PDGF-BB compared to the high one. Thus, the PDGF-BB and IGF-I in combination may have important roles in promotion of periodontal litgment healing, and consequently, may useful for clinical application in periodontal regenerative procedures.

• The Microorganisms and Industry
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• v.16 no.3
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• pp.2-5
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• 1990

IgA is the predominant immunoglobulin isotype in mucosal secretions(1). It has been reported that a population of Peyer's patch T cells can selectively induce IgM bearing B cells to switch to surface IgA bearing B cells(2,3). Further, IL-4, IL-5, and IL-6 alone and in combination, can significantly influence murine IgA B cell differentiation in vitro(4-7). However, it remains an open question which cytokines have a major role in class switching to the IgA isotype. Recently, it has been reported that transforming growth factor .betha.1(TGF .betha.1) alone, or in combination with IL-2 increases IgA secretion by LPS-activated surface IgA negative (sIgA$\^$-/) murine spleen B cells while concurrently downregulating IgM and IgG secretion by such cells(8-11). In the present study, limiting dilution analysis was used to demonstrate, at the clonal level, that TGF .betha.1 has siginificant activity as an IgA isotype switch factor.

• Journal of Periodontal and Implant Science
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• v.24 no.3
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• pp.572-580
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• 1994

The purpose of the present study was to evaluate the effect of platelet - derived growth factor(PDGF) - BB and insulin - like growth factor(IGF) - 1, Centella Asiatica, and Zea Mays L. on the mitogenic activity of PDL cells from healthy and RPP patients. Combination of PDGF - BB and IGF - 1, Centella Asiatica, and Zea Mays L. were treated on PDL cells and the mitogenic effects were meaured by quantitative assay of methyl - $^3H$ - thymidine incorporation during DNA synthesis. Combination of PDGF - BB and IGF - 1 enhenced the mitogenic effects of both healthy and RPP PDL cells, however, the effect was less pronounced on RPP PDL cells. In cases of Centella Asiatica and Zea Mays L., no mitogenic effect on healthy PDL cells could be noticed.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 1999.05a
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• pp.317-320
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• 1999

In this study, the piezoelectric ceramics PZT powder was synthesized by Wet-Dry combination method. And the flexible 1-3-0 type composites were fabricated with piezoceramic PZT and Eccogel polymer matrix embedded 3rd phase. Dielectric constant of 1-3-0 type composites was lower than that of single phase PZT ceramics. Thickness mode coupling factor k/sub t/ which was comparable with single phase PZT ceramics and mechanical quality factor Qm were about 0.65 and 6, respectively. These composites are considered as a good candidates for broad-band type transducer applications. The acoustic impedance of 1-3-0 type composites was lower than that of single phase PZT ceramics. Therefore, these composites would be better used for hydrophone applications.

• Journal of the Korea Safety Management & Science
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• v.14 no.1
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• pp.155-165
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• 2012

This essay talks about research of robust design for quality improvement of production procedure of Wet Etchant. It suggested the optimum design method in consideration of specific capability value that is the way to maximize the quality of product in the production system by using Daguchi parameter design method while finding factors affecting product quality with analysis of production system of product A from producer D. Also, it set long term of 6months as noise factor and let it to be the robust design that can find the optimum condition of control factor that is dull to the changes of each month, that is the change in noise factor. The control factor which affects the product quality is decided as combination method, temperature of raw material, combination time and as there are too many possibilities for combination methods, we performed 4 methods first based on previous research data then derived three ways with product that passed SPEC and set as the factor. As a result of application of optimum production procedure suggested in this essay to the actual production process with its standardization, there was a effect of drop of more than 10particles in comparison to the particle number of previous product and also it brought the effect that resulted the stable number of particle of under 30 that is what the client company suggested.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.65 no.9
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• pp.1626-1631
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• 2016

Generally, the low-voltage customer has been used with a linear load and nonlinear load in the 3-phase 4-wire distribution system. Linear load has usually configured the resistance and inductance, current phase is slower than the voltage phase, so power factor is low. It is required for the power factor correction device prior to the phase of the current than the voltage. The capacitor is connected in parallel to the load in order to ensure a low power factor. Power converter such as an inverter is a typical non-linear load. Non-linear load generates harmonic currents in the energy conversion process. Many electrical equipment may be adversely affected by the harmonic current. There, passive or active filter have been used to reduce these harmonics current. Passive filter consisting of inductor and capacitor generates a reactive power. According to the combination of filter inductor and capacitor, reactive power can be adjusted. In this paper, we analyzed how the combination of inductor and capacitor affects the overall power factor by simulation and measurement.

• Journal of Veterinary Science
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• v.24 no.3
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• pp.37.1-37.14
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• 2023

Background: Toll-like receptor (TLR) agonists have been used as adjuvants to modulate immune responses in both animals and humans. Objectives: The objective of this study was to evaluate the combined effects of the TLR 4 agonist monophosphoryl lipid A (MPL) and the TLR 3 agonist polyinosinic:polycytidylic acid (Poly I:C) on equine peripheral blood mononuclear cells (PBMCs), monocyte-derived dendritic cells (MoDCs), and bone marrow-derived mesenchymal stromal cells (BM-MSCs). Methods: The PBMCs, MoDCs, and BM-MSCs collected from three mixed breed horses were treated with MPL, Poly I:C, and their combination. The mRNA expression of interferon gamma (IFN-γ), interleukin (IL)-1β, IL-4, IL-6, IL-8, IL-12p40, tumor necrosis factor alpha (TNF-α), vascular endothelial growth factor (VEGF), and monocyte chemoattractant protein-1 (MCP-1) was determined using real-time polymerase chain reaction. Results: The combination of MPL and Poly I:C significantly upregulated immunomodulatory responses in equine cells/ without cytotoxicity. The combination induced greater mRNA expression of pro-inflammatory cytokines IFN-γ and IL-6 than MPL or Poly I:C stimulation alone in PBMCs. In addition, the combination induced significantly higher mRNA expression of IL-1β, IL-6, and IL-12p40 in MoDCs, and IL-8, MCP-1, and VEGF in BM-MSCs compared to stimulation with a single TLR agonist. Conclusions: The combination of MPL and Poly I:C can be used as a potential adjuvant candidate for vaccines to aid in preventing infectious diseases in horses.

• Journal of Korean Neurosurgical Society
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• v.44 no.6
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• pp.375-381
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• 2008

Objective : The effects on neural proliferation and differentiation of neural stem cells (NSC) of basic fibroblast growth factor-2 (bFGF). insulin growth factor-I (IGF-I). brain-derived neurotrophic factor (BDNF). and nerve growth factor (NGF) were assessed. Also, following combinations of various factors were investigated : bFGF+IGF-I, bFGF+BDNF, bFGF+NGF, IGF-I+BDNF, IGF-I+NGF, and BDNF+NGF. Methods : Isolated NSC of Fisher 344 rats were cultured with individual growth factors, combinations of factors, and no growth factor (control) for 14 days. A proportion of neurons was analyzed using $\beta$-tubulin III and NeuN as neural markers. Results : Neural differentiations in the presence of individual growth factors for $\beta$-tubulin III-positive cells were : BDNF, 35.3%; IGF-I, 30.9%; bFGF, 18.1%; and NGF, 15.1%, and for NeuN-positive cells was : BDNF, 34.3%; bFGF, 32.2%; IGF-I, 26.6%; and NGF, 24.9%. However, neural differentiations in the absence of growth factor was only 2.6% for $\beta$-tubulin III and 3.1% for NeuN. For $\beta$-tubulin III-positive cells, neural differentiations were evident for the growth factor combinations as follows : bFGF+IGF-I, 73.1 %; bFGF+NGF, 65.4%; bFGF+BDNF, 58.7%; BDNF+IGF-I, 52.2%; NGF+IGF-I, 40.6%; and BDNF+NGF, 40.0%. For NeuN-positive cells : bFGF+IGF-I, 81.9%; bFGF+NGF, 63.5%; bFGF+BDNF, 62.8%; NGF+IGF-I, 62.3%; BDNF+NGF, 56.3%; and BDNF+IGF-I, 46.0%. Significant differences in neural differentiation were evident for single growth factor and combination of growth factors respectively (p<0.05). Conclusion : Combinations of growth factors have an additive effect on neural differentiation. The most prominent neural differentiation results from growth factor combinations involving bFGF and IGF-I. These findings suggest that the combination of a mitogenic action of bFGF and post-mitotic differentiation action of IGF-I synergistically affects neural proliferation and NSC differentiation.