• 제목/요약/키워드: column design

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Analytical Quality by Design Methodology Approach for Simultaneous Quantitation of Paeoniflorin and Decursin in Herbal Medicine by RP-HPLC Analysis

  • Kim, Min Kyoung;Park, Geonha;Hong, Seon-Pyo;Jang, Young Pyo
    • Natural Product Sciences
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    • 제27권4호
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    • pp.264-273
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    • 2021
  • Simultaneous quantification of multiple marker compounds in herbal medicine by high performance liquid chromatography (HPLC) analysis is still a challenge due to the complexity in various parameters to be considered and co-existing multi-components. As a case study, a reliable HPLC method for simultaneous quantification of paeoniflorin from Paeoniae Radix and decursin from Angelicae Gigantis Radix in various commercial herbal medicine was developed based on analytical quality by design (AQbD) strategy. As a first step, risk assessment was performed to select the critical method parameters (CMPs) which were decided as organic mobile phase ratio and column oven temperature. In order to evaluate the effect of the CMPs on critical method attributes (CMAs) of peak resolution and tailing, central composite design (CCD) was employed. The final chromatographic conditions were optimized as follows: column- C18, 4.6 × 250 mm, 5 ㎛ particle size; mobile phase- A: acetonitrile, B: 0.1% acetic acid water; detection wavelength- 235 nm for paeoniflorin, 325 nm for decursin; column oven temperature- 25℃; flow rate- 1.0 mL/min; gradient mobile phase system as Time (min) : % A, 0:14, 25:14, 30:50, 60:50, 61:100, 65:100, 66:14, 75:14. The method was successfully validated according to the International Conference on Harmonization (ICH) guidelines and piloted for ten commercial herbal medicines.

원형단면 멀티기둥 풍력타워 적용 T형 강관조인트 강도 평가 (Strength Evaluation of T-type Tubular Joints for Circular Section Multi-Column Wind Towers)

  • 김경식;박현용;서동혁
    • 한국강구조학회 논문집
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    • 제27권1호
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    • pp.119-129
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    • 2015
  • 강재량을 줄이면서도 풍하중의 영향을 완화시킬 수 있는 장점으로, 수평재로 서로 연결된 다수의 수직 원형강관으로 구성된 멀티기둥 풍력타워 시스템은 기존의 단일 실린더형 타워구조에 대한 대안으로 고려될 수 있다. 멀티기둥 타워를 하나의 타워구조로 거동하게 하기 위해서는 수직 강관과 수평 강관의 연결부인 강관조인트의 강도 확보가 중요하다. 본 연구에서는 멀티기둥에 적용될 수 있는 T 조인트의 강도평가를 수행하였다. AISC, Eurocode3, ISO 19902, CIDECT의 4가지 강관조인트 설계기준을 검토하고, 조인트에서 주강관과 지강관의 세장비에 대한 매개변수해석을 통하여 설계기준에서 제공되는 강도산정식의 타당성을 검토하였다.

Rocking behavior of bridge piers with spread footings under cyclic loading and earthquake excitation

  • Hung, Hsiao-Hui;Liu, Kuang-Yen;Chang, Kuo-Chun
    • Earthquakes and Structures
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    • 제7권6호
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    • pp.1001-1024
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    • 2014
  • The size of spread footings was found to be unnecessarily large from some actual engineering practices constructed in Taiwan, due to the strict design provisions related to footing uplift. According to the earlier design code in Taiwan, the footing uplift involving separation of footing from subsoil was permitted to be only up to one-half of the foundation base area, as the applied moment reaches the value of plastic moment capacity of the column. The reason for this provision was that rocking of spread footings was not a favorable mechanism. However, recent research has indicated that rocking itself may not be detrimental to seismic performance and, in fact, may act as a form of seismic isolation mechanism. In order to clarify the effects of the relative strength between column and foundation on the rocking behavior of a column, six circular reinforced concrete (RC) columns were designed and constructed and a series of rocking experiments were performed. During the tests, columns rested on a rubber pad to allow rocking to take place. Experimental variables included the dimensions of the footings, the strength and ductility capacity of the columns and the intensity of the applied earthquake. Experimental data for the six circular RC columns subjected to quasi-static and pseudo-dynamic loading are presented. Results of each cyclic loading test are compared against the benchmark test with fixed-base conditions. By comparing the experimental responses of the specimens with different design details, a key parameter of rocking behavior related to footing size and column strength is identified. For a properly designed column with the parameter higher than 1, the beneficial effects of rocking in reducing ductility and the strength demand of columns is verified.

고강도 RC 보-기둥 접합부의 비탄성 거동에 대한 슬래브의 영향 (Slab Effect on Inelastic Behaviors of High Strength RC Beam-Column Joints)

  • 장극관;김윤일;오영훈
    • 콘크리트학회지
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    • 제9권2호
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    • pp.167-177
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    • 1997
  • 모멘트 연성골조의 접합부와 기둥은 적절한 에너지흡수 능력과 구조물의 횡붕괴를 방지하기 위하여 탄성적으로 거동해야 하며, "강한 기둥-약한 보"의 설계개념을 채택하고 있다. 접합부는 골조구조의 취약부분으로 인정되고 있지만 부재설계에서는 접합부를 구성하는 보와 기둥에 의해서 접합부의 치수가 결정되기 때문에 접합부가 부담해야 하는 하중조건과 보강방법을 결정하는데에 어려움이 있다. 또한 콘크리트의 고강도화, 경량화에 의해 부재단면은 작아지게 되고 상대적으로 철근량은 늘어나게 되므로 접합부 영역의 응력부담은 이전보다 훨씬 높아지게 되었다. 따라서 접합부의 적절한 구조성능 확보 및 시공상의 문제점을 개선하기 위하여 접합부의 설계 및 상세에 특별한 주의가 필요하다고 할 수 있다. 이에 본 연구에서는 슬래브의 기여도를 고려한 접합부의 적절한 보강방법을 제시하기 위한 기초자료로서 $\frac{2}{3}$의 실물크기로 4개의 고강도 콘크리트 보-기둥 접합부를 제작하고, 반복하중 실험을 수행하였다.실험을 수행하였다.

Finite element simulations on the ultimate response of extended stiffened end-plate joints

  • Tartaglia, Roberto;D'Aniello, Mario;Zimbru, Mariana;Landolfo, Raffaele
    • Steel and Composite Structures
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    • 제27권6호
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    • pp.727-745
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    • 2018
  • The design criteria and the corresponding performance levels characterize the response of extended stiffened end-plate beam-to-column joints. In order to guarantee a ductile behavior, hierarchy criteria should be adopted to enforce the plastic deformations in the ductile components of the joint. However, the effectiveness of thesecriteria can be impaired if the actual resistance of the end-plate material largely differs from the design value due to the potential activation of brittle failure modes of the bolt rows (e.g., occurrence of failure mode 3 in the place of mode 1 per bolt row). Also the number and the position of bolt rows directly affect the joint response. The presence of a bolt row in the center of the connection does not improve the strength of the joint under both gravity, wind and seismic loading, but it can modify the damage pattern of ductile connections, reducing the gap opening between the end-plate and the column face. On the other hand, the presence of a central bolt row can influence the capacity of the joint to resist the catenary actions developing under a column loss scenario, thus improving the joint robustness. Aiming at investigating the influence of these features on both the cyclic behavior and the response under column loss, a wide range of finite element analyses (FEAs) were performed and the main results are described and discussed in this paper.

Stiffener configurations of beam to concrete-filled tube column connections

  • Dessouki, Abdelrahim K.;Yousef, Ahmed H.;Fawzy, Mona M.
    • Steel and Composite Structures
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    • 제17권1호
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    • pp.83-103
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    • 2014
  • The objective of this research is to study the ultimate moment capacity of the connections between steel I-beams and concrete-filled steel tube columns using different stiffener configurations. The main parameters considered are column cross section shape, square or circular, and filling the column with concrete. This analytical study includes finite element models using ANSYS program taking geometric and material nonlinearities into consideration. These models are verified against the experimental results obtained from previous researches and current design guides. The results show that using proper stiffener configuration affects the stress distribution through the connection and increases the ultimate moment capacity of the connections. Also, circular column is advantageous than the square column for all stiffener configurations and dimensions.

기둥지지-벽식구조에서 전이층의 구조해석모델링에 대한 연구 (Investigation of the Structural Modeling of Transfer Floor in Column-Supported Wall Structure)

  • 김영찬;이재준
    • 한국안전학회지
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    • 제20권2호
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    • pp.79-83
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    • 2005
  • Recently, column-supported wall structural system is frequently adopted in mixed-use high-rise buildings. Due to the sudden change of stiffness at the transfer floor proper load transfer and avoiding stress concentration are very important in column-supported wall structural system. It is revealed by many investigators that 2-dimensional analysis is not reliable and inappropriate selection of element for modeling may lead to erroneous result for gravitational loading. In this study, structural behavior of column-supported wall structure at transfer floor subject to lateral loading is compared by changing modeling methods.

충진층 흡착관 내에서 입상활성탄에 의한 페놀 제거 : 매개변수 감응도 해석 (Removal of Phenol by Granular Activated Carbon from Aqueous Solution in Fixed-Bed Adsorption Column : Parameter Sensitivity Analysis)

  • 윤영삼;황종연;권성헌;김인실;박판욱
    • 한국환경과학회지
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    • 제7권6호
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    • pp.773-782
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    • 1998
  • The adsorption experiment of phenol(Ph) from aqueous solution on granular activated carbon was studied in order to design the fixed-bed adsorption column. The experimental data were analyzed by unsteady-state, one-dimensional heterogeneous model. Finite element method(FEM) was applied to analyze the sensitivity of parameter and to predict the fixed-bed adsorption column performance on operation variable changes. The prediction model showed similar effect to mass transfer and intraparticle diffusion coefficient changes suggesting that both parameter present mass transfer rate limits for GAC-phenol system. The Freundlich constants had a greater effect than kinetic parameters for the performance of fixed-bed adsorption column. FEM solution facilitated prediction of concentration history in solution and within adsorbent particle.

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GAX 암모니아 흡수식 열폄프의 발생기 일체형 정류기의 열 및 물질전달 해석 (Heat and mass transfer characteristics of generator combined rectification system of the GAX ammonia absorption heat pump)

  • 윤상국
    • 설비공학논문집
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    • 제11권4호
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    • pp.431-439
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    • 1999
  • A generator-GAX combined rectification system of an ammonia absorption heat pump was investigated to get the optimum design values. The mass and heat transfer phenomena of the rectification system were analysed. The number of column plates, equilibrium temperature of solution on each plate and flow rates of solution and vapor generated were predicted. The characteristics of mass and heat transfer of the generator-GAX combined rectification system, i.e. concentration difference of leaving solution and vapor on each column plate, were found to be mainly governed by the pressure of generator, reflex ratio and temperature difference of analyser coolant. The number of rectification column plates for each different pressure in generator was obtained. The optimum locations for installing the feeder from solution-cooled absorber and GAX desorber in generator were predicted. The improvement of COP was followed by the increase of the rectifier efficiency and the number of column plate, and the decrease of reflex ratio.

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플랫 플레이트 구조의 기둥.슬래브 접합부 연성에 관한 연구 (Ductility of Column-Slab eoint in R/C Flat Plate System)

  • 김형기;박복만
    • 콘크리트학회논문집
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    • 제12권4호
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    • pp.113-119
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    • 2000
  • The R/C flat plate system provides architectural flexibility, clear space, reduced building height, simple formwork, which consequently enhance constructibility. One of the serious problems in the flat plate system is brittle punching shear failure due to transfer of shear force and unbalanced moments in column-slab joint. Recently, the flat plate system accompanied with shear walls to resist the lateral loads is applied to high-rise buidings. Although the flat plate system is not considered in design as part of the lateral load-resisting system, it is required that this system keeps the ductile behavior for the lateral displacement of the building. However, it is unclear whether the column-slab joint possesses ductility enough to survive the lateral deformation. The objective of this paper is to investigate the major parameters that influence the ductility of R/C flat plate system by examining the existing experiments on column-slab joint. The effects of gravity load and shear reinforcement on the ductility of the flat plate system are presented.