• 한국치위생학회지
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• 제2권1호
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• pp.43-61
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• 2002

The purpose of this study was focus on development of educational objectives by using oral health education in the elementary school from now on. Based on the results of analysis compared with a model of educational objectives and contents by reflecting the programs for analysis were the oral health education programs of the Ministry of health and social Affairs in Korea, and the programs of two states in u.s. in order to construct goals and contents of oral health education in school. The results in this study can be arranged as follows: First, an analysis on the educational objectives of dental health education program resulted that, from a viewpoint of Bloom's taxonomy of educational objectives, in case of domestic, most learning objectives expressed in the handbook of Ministry of Health and social Welfare were given too much emphasis to the cognitive domain of 37 an items in all. Affective domain were appeared the lack of balance of the development domain. Second, the result of analysis for the programs of two states of America, the cognitive domain were the most abundant of 48 an items in all, and were not significantly different to those of Korea in the form of objectives domain or statement. However a big different was shown that they organized the same objectives domain as a pattern of repeating and deepening at every grade. Third, in this study, 10 educational objectives of dental health education were established, based on the result of analyzing those existing educational programs as central figure. Those are oral cavity, brushing, nutrition of teeth, fluoride, flossing, teeth injury, dental decay, periodontal disease, malocclusion, routine dental visits. And general objectives and specific objectives of each learning area were stated and arranged grade by grade.

• 생물정신의학
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• 제15권2호
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• pp.92-100
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• 2008

Objectives : The purpose of this study was to investigate 1) the neuropsychological deficits with major depressive disorder(MDD) in depressed state and 2) the changes of neuropsychological dysfunctions during depressed episodes and remitted periods in the MDD group. Methods : 12 patients with MDD and 70 normal controls who were diagnosed and classified by DSM-IV and SCID-IV interview participated in this study. The psychopathology was measured using the Hamilton rating scale for depression(HAM-D) and Brief Psychiatric Rating Scale(BPRS). The memory function, executive function, and sustained attention were measured by a trained psychologist using the Korean version of Memory Assessment Scale(K-MAS), Wisconsin Card Sorting Test(WCST), and Vigilance(VIG) and Cognitrone (COG) in Vienna Test System. After 6 weeks of treatment, we retested the cognitive tests in order to measure the cognitive functions in remitted states. Results : Patients with MDD achieved significantly lower score in sentence immediately recall, verbal memory score and total memory score of the K-MAS, total errors of the WCST, response time of Vigilance and response time at "Yes" response of Cognitrone than normal controls at baseline. After 6 weeks of medication, the psychiatric symptoms in the patient group were attenuated, and most of the neuropsychological functions including attention, memory, and frontal/executive function were improved except for response time of Cognitrone. Conclusions : This study provides evidence for distinct neuropsychological deficits in patients with MDD on their depressed states and remitted periods. The impairment on response time remains after remission, and this would be a trait marker of major depressive disorder.

• 대한간호학회지
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• 제22권2호
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• pp.238-247
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• 1992

Immigration of Koreans to the United States has increased since the 1960's. Adjusting to life in the United States produces a great deal of stress for immigrants. Despite better economic opportunites, many see the U.S. culture as threatening to their family and cultural values. Differences in culture, language, expectations and social behavior can lead to misunderstandings between health care providers and clients. These misunderstanding can leaf to frustration on the part of each. The ultimate result of this is that often Korean-immigrants do not get their health care needs met and stress response symptoms can lead to disease if there is no appropriate care. To determine the health care needs and concerns of Korean-Americans, a health needs assessment is needed. Appropriate and adequate information about the health care needs of these individuals is important as it relates to American policy changes allowing greater numbers of immigrants to enter the U.S. The purpose of this prospective study was to describe Korean-American stress response. This study focused on the primary presenting problems for which subjects reported having sought care. These included a variety of stress-related symptoms, including peripheral manifestations, cardiopulmonary symptoms, central-neurological symptoms, gastrointestinal symptoms, muscle tension, habitual patterns, depression, anxiety, emotional irritability and cognitive disorganization. Of the 300 subjects who entered the study, 80% (N＝223) completed the questionnaire in full. Demographically, the percentage of females and males was 50% each and they ranged in age from 20 to 69 years. Ninety percent of the subjects were highly educated, 25% owners of business, 25% white collar professionals, 15% employed in sales or as skilled /unskilled labor, 30% had no occupation : and 5% were housewives or students. The SOS inventory is designed to quantify self-perception of behavioral, cognitive, and physiological components of the stress response. It consisted of 94 items divided into 10 subscales. The result of this study are as follows : The total mean 505 of all subjects (N＝223 was .8129 ; the mean 505 for male(N＝114) was .7665 and for females, (N＝108) .8594. The level of symptoms for central-neurologic and muscle tension was higher for than for males. The highest stress response of all subjects was emotional irritability symptoms(1.0644) : the lowest stress response of all subjects was peripheral manifestation symptoms.

• 감성과학
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• 제4권2호
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• pp.69-77
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• 2001

인간의 적응적인 마음상태는 긍정적/부정적 사고의 상호작용에서 자기 고양적인 방향으로 편향된 비대칭성을 가정한다. 본 논문에서는 긍정적/부정적 인지, 정서의 균형에 대한 심리 수학적 모형인 SOM 모형을 감성판단 영역에 적용하여 보았다. ,iOM 모형은 개인이 긍정적, 부정적 감성의 이분법적 판단에 있어서 평균적으로 6B의 비율을 유지한다고 제안하며, 이러한 비율은 고대수학의 .6)0 ,.182의 황금분할비와 일치하는 것이다. 32명의 일반성인을 대상으로 한 분석결과, 긍정적/부정적 감성단어에 대한 자기 관련성 평정의 SOM 비율은 .62(SD=.On)로 나타났으며, 우연회상 과제수행의 SOM 비율은 .18(SD=.34)로 이론적 기준과 유사하게 나타났다. 또한 상관분석에서 개인의 10M 비율은 긍정적/부정적 감성단어에 대한 평정과도 유의미한 상관관계를 지니고 있는 것으로 나타났다. 이러한 결과를 바탕으로 인지적 균형비의 의미와 감성과학 분야의 적용 가능성에 대해 제안하였다.

• 대한수학교육학회지:학교수학
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• 제10권2호
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• pp.259-277
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• 2008

본 연구는 인지 진단 이론을 활용하여 수학 평가 결과를 분석하고 교수 학습에 활용하는 방안을 모색하고자 하였다. $2003{\sim}2006$년에 실시된 국가수준 학업성취도 평가의 중학교 3학년 수학 검사에서 30개의 선다형 문항을 선정하여 검사지를 재구성하고 검사를 실시하였고 인지 진단 이론의 한 모형인 Fusion Model을 적용하여 평가 결과를 분석하였다. 검사 문항을 통해 학생들이 숙달한 수학적 속성을 판별하고, 학생 전체와 성취수준별로 숙달한 속성과 그 속성의 개수를 분석하였다. 그리고 학생 개개인의 수학적 강점과 약점을 분석하여 교사들에게 학생 개개인의 수학적 능력에 대한 정보를 구체적으로 알려줄 수 있었다. 이 결과는 학생들의 수학 학습에 대한 진단과 처방, 추후 학습 지도에 유용한 정보로 활용될 수 있을 것이다.

• 디지털융복합연구
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• 제13권9호
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• pp.169-175
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• 2015

융복합 학문이 중요시 되는 21세기에 교수학습방법도 이론 중심의 강의보다 컴퓨터를 활용한 학습이 높은 학습 효과를 보이는 것으로 연구되고 있다. 본 연구는 경기지역 4년제 대학생 중 회계정보수업을 수강한 학습자를 대상으로 계획행동이론을 적용하여 회계정보수업에서 인식적 참여를 향상시키기 위하여 어떠한 요인이 영향을 미치는지를 실증 분석하였다. 분석결과는 첫째, 회계정보수업의 TPB 변수들은 인식적 참여에 있어서 본질적 호기심에 유의적으로 정(+)의 영향을 미치는 것으로 나타났다. 이는 신기술의 활용학습이 회계정보수업에서 학습 태도, 인지된 행위통제, 주관적 기준이 높을수록 인식적 참여 중 본질적 호기심이 향상된다는 것을 보여주는 결과이다. 둘째, 회계정보수업의 TPB 변수 중 주관적 기준이 즐거움에 정(+)영향을 주는 것으로 나타났다. 본 연구의 공헌점은 TPB가 인식적 참여에 미치는 영향을 분석함으로써 학습자의 심리상태를 실증적으로 검증하고, 회계교육 개선을 위한 시사점을 제공하였다는 것이다. 향후에는 연구의 한계점을 보완하여 인식적 참여에 대한 다양한 변수에 대한 연구가 이루어져야 할 것으로 생각한다.

• Biomolecules & Therapeutics
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• 제20권4호
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• pp.357-370
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• 2012

Radiation therapy, the most commonly used for the treatment of brain tumors, has been shown to be of major significance in tumor control and survival rate of brain tumor patients. About 200,000 patients with brain tumor are treated with either partial large field or whole brain radiation every year in the United States. The use of radiation therapy for treatment of brain tumors, however, may lead to devastating functional deficits in brain several months to years after treatment. In particular, whole brain radiation therapy results in a significant reduction in learning and memory in brain tumor patients as long-term consequences of treatment. Although a number of in vitro and in vivo studies have demonstrated the pathogenesis of radiation-mediated brain injury, the cellular and molecular mechanisms by which radiation induces damage to normal tissue in brain remain largely unknown. Therefore, this review focuses on the pathophysiological mechanisms of whole brain radiation-induced cognitive impairment and the identification of novel therapeutic targets. Specifically, we review the current knowledge about the effects of whole brain radiation on pro-oxidative and pro-inflammatory pathways, matrix metalloproteinases (MMPs)/tissue inhibitors of metalloproteinases (TIMPs) system and extracellular matrix (ECM), and physiological angiogenesis in brain. These studies may provide a foundation for defining a new cellular and molecular basis related to the etiology of cognitive impairment that occurs among patients in response to whole brain radiation therapy. It may also lead to new opportunities for therapeutic interventions for brain tumor patients who are undergoing whole brain radiation therapy.

• 한국임상약학회지
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• 제33권4호
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• pp.290-304
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• 2023

Background: Innovative Alzheimer's disease drugs received approval in the United States in 2021 and 2023. This study aims to assess the safety and efficacy of these novel treatments, elucidate their mechanisms of action, and compare their impact on cognitive function improvement with approved drugs. Methods: We conducted a comprehensive search of pivotal clinical studies related to Alzheimer's disease treatments in PubMed/Medline, Embase, and the Cochrane Library databases from January 1st, 2020 to December 31st, 2022. Meta-analysis was performed using RevMan 5.4 software. Results: A total of 14 studies were included in this systematic review. When compared to the placebo, the new drugs did not exhibit a statistically significant effect on MMSE (Mini-Mental State Examination) (mean difference= -0.04, 95% confidence intervals [CIs]: -0.31, 0.23, N=3662, I²=0%). However, they demonstrated a significant impact on ADAS-cog (Alzheimer's Disease Assessment Scale-Cognitive Subscale) (standardized mean difference= -0.15, 95% CIs: -0.2, -0.1, N=6710, I²=17%). When compared to the approved drugs, the new drugs showed a statistically significantly lower effect on MMSE (test for subgroup difference Chi²=23.13, N = 5870, p<0.00001) but showed only a trend of decreased efficacy on ADAS-cog (Chi²=1.16, N = 8670, p=0.28). Conclusion: New drugs yielded diverse clinical endpoint results compared to the placebo, and in comparison to existing approved drugs, they exhibited lower efficacy in improving cognitive function. The safety profile of these new drugs, as reported in clinical trials, was generally well-tolerated.

• International Journal of Computer Science & Network Security
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• 제24권8호
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• pp.184-190
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• 2024

The research involved children and parents of primary school-aged children with cognitive development disorder, as well as scientific and pedagogical workers who organized the psychological and pedagogical principles for organizing distance learning. The purpose of the research lies in establishing how effectively children, parents and their teachers cope with online distance learning during the pandemic, as well as investigating the extent to which such educational technology affects the emotional and behavioural state of the child. The research methodology is based on complexity. In the course of the research, the method of pedagogical experiment was used; observation and questionnaire methods were also introduced; the descriptive method, analysis and synthesis were used to review the theoretical material. The hypothesis lies in the fact that distance online education increases academic difficulties, changes the behavioural and emotional picture of a child with cognitive development disorder; consequently, the behaviour and emotional background will be limited by certain parameters, and this requires the active involvement of parents and teachers in the distance work process. The results of the research have revealed that distance education causes a number of restrictions for children with cognitive development disorder, namely: concentration of attention has decreased, anxiety has increased, and sleep has worsened. Behavioural changes predicted increased restlessness and aggression. Parents and teachers have had methodological, academic and everyday difficulties; all participants in the educational process have been more limited in the conditions of online distance learning. difficulties and improving the behaviour and emotional states of all participants in the educational process.

• 대한의용생체공학회:의공학회지
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• 제33권1호
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• pp.15-24
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• 2012

Classification of human thought is an emerging research field that may allow us to understand human brain functions and further develop advanced brain-computer interface (BCI) systems. In the present study, we introduce a new approach to classify various mental states from noninvasive electrophysiological recordings of human brain activity. We utilized the full spatial and spectral information contained in the electroencephalography (EEG) signals recorded while a subject is performing a specific mental task. For this, the EEG data were converted into a 2D spatiospectral pattern map, of which each element was filled with 1, 0, and -1 reflecting the degrees of event-related synchronization (ERS) and event-related desynchronization (ERD). We evaluated the similarity between a current (input) 2D pattern map and the template pattern maps (database), by taking the inner-product of pattern matrices. Then, the current 2D pattern map was assigned to a class that demonstrated the highest similarity value. For the verification of our approach, eight participants took part in the present study; their EEG data were recorded while they performed four different cognitive imagery tasks. Consistent ERS/ERD patterns were observed more frequently between trials in the same class than those in different classes, indicating that these spatiospectral pattern maps could be used to classify different mental states. The classification accuracy was evaluated for each participant from both the proposed approach and a conventional mental state classification method based on the inter-hemispheric spectral power asymmetry, using the leave-one-out cross-validation (LOOCV). An average accuracy of 68.13% (${\pm}9.64%$) was attained for the proposed method; whereas an average accuracy of 57% (${\pm}5.68%$) was attained for the conventional method (significance was assessed by the one-tail paired $t$-test, $p$ < 0.01), showing that the proposed simple classification approach might be one of the promising methods in discriminating various mental states.