• Korean Journal of Cognitive Science
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• v.24 no.1
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• pp.25-47
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• 2013

We conducted a psycholinguistic experiment in which participants orally produced sentences using a subject, a dative object, an accusative object, and a verb, provided just before the production. Results of the experiment are twofold: (i) Korean speakers basically produce the dative object earlier than the accusative one if the lengths of the objects are identical. (ii) If there is a length difference between the two objects, though, the longer one strongly tends to be placed before the shorter one, overriding the preference for 'dative-accusative' order. This 'long before short' preference which is generally observed in head-final languages appears to reflect the underlying tendency of the processing mechanism to put the heads of arguments and the predicate as closely as possible, thereby minimizing the cost for the processing of verb-argument structure.

• Journal of Korean Society of Transportation
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• v.29 no.3
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• pp.41-48
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• 2011

In order to detect driver's state in a driver safety system, both overt and covert measures such as driving performance, visual attention, physiological arousal and traffic situation should be collected and interpreted in the driving context. In this paper, we suggest a vehicle monitoring system that provides multimodal information on a broad set of measures simultaneously collected from multiple domains including driver, vehicle and road environment using an elaborate timer equipped as a soft synchronization mechanism. Using a master timer that records key values from various modules with the same master time of short and precise interval, the monitoring system provides more accurate context awareness through synchronized data at any given time. This paper also discusses the data collected from nine young drivers performing a cognitive secondary task through this system while driving.

• Journal of the Korea Convergence Society
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• v.9 no.1
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• pp.405-418
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• 2018

This paper was carried out to provide basic data for career search of the free school system. Putting the goal of career education into cultivating expertise, the review was made on the results of the previous studies on the requirements of professional practice. However, As the controversy over the requirements of professional practice has not been solved, so the core elements related to expert performance were examined as a whole through a fundamental cognitive mechanism from which diverse human cognitive characteristics appear. The results show that expert domains consists of content and representation that can exist in an integrated to a great variety of combinations between the two or independent manner, and each domain or field expert performance require different levels of the elements such as intelligence, internal thinking, curiosity (motivation), and obsession (task commitment); and the birth of 1% experts in a domain or field is determined by the obsession. Based on the results, this paper discusses issues related to professionalism and provides a concrete approach to career search during the free semester.

• Journal of Physiology & Pathology in Korean Medicine
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• v.34 no.2
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• pp.81-87
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• 2020

Cognitive impairment is symptoms of dementia, a degenerative brain disease that is drawing attention in a rapidly aging society. This study was conducted to investigate the improvement of cognitive function of Leonurus japonicus on scopolamine-induced memory impairment in mice and the effect and mechanism of memory recovery. In vivo studies were conducted on mice orally pretreated with L. japonicus in doses of 50, 100 and 200 mg/kg (p.o.) and scopolamine (1 mg/kg, i.p.) were injected 30 min before the behavioral task. Antioxidant activity was assessed by 2,2-diphenyl-1-picryl hydrazyl (DPPH) assay and 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay, and acetylcholinesterase (AChE) inhibition activity evaluated by Ellman's method. In behavior studies showed that L. japonicus has an improved the memory of scopolamine-treated mice in Y-maze, passive avoidance and Morris water maze test. In addition, L. japonicus was also exerted free radical scavenging activity and inhibited acetyl cholinesterase activity. These results suggest that L. japonicus improves short-term and long-term memory in scopolamine-induced memory decline model and prevents scopolamine-induced memory impairments through in reduced oxidative stress and acetyl cholinesterase inhibition effect. Thus, L. japonicus is related to functional medicinal materials for prevention and treatment of human dementia patients.

• Parasites, Hosts and Diseases
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• v.55 no.3
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• pp.267-285
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• 2017

Angiostrongylus cantonensis invades the central nervous system (CNS) of humans to induce eosinophilic meningitis and meningoencephalitis and leads to persistent headache, cognitive dysfunction, and ataxic gait. Infected mice (nonpermissive host), admittedly, suffer more serious pathological injuries than rats (permissive host). However, the pathological basis of these manifestations is incompletely elucidated. In this study, the behavioral test, histological and immunohistochemical techniques, and analysis of apoptotic gene expression, especially caspase-3, were conducted. The movement and motor coordination were investigated at week 2 post infection (PI) and week 3 PI in mice and rats, respectively. The cognitive impairs could be found in mice at week 2 PI but not in rats. The plaque-like lesion, perivascular cuffing of inflammatory cells, and dilated vessels within the cerebral cortex and hippocampus were more serious in mice than in rats at week 3 PI. Transcriptomic analysis showed activated extrinsic apoptotic pathway through increased expression of TNFR1 and caspase-8 in mice CNS. Immunohistochemical and double-labeling for NeuN and caspase-3 indicated the dramatically increased expression of caspase-3 in neuron of the cerebral cortex and hippocampus in mice but not in rats. Furthermore, western-blotting results showed high expression of cleaved caspase-3 proteins in mice but relatively low expression in rats. Thus, extrinsic apoptotic pathway participated in neuronal apoptosis might be the pathological basis of distinct behavioral dysfunctions in rodents with A. cantonensis infection. It provides the evidences of a primary molecular mechanism for the behavioral dysfunction and paves the ways to clinical diagnosis and therapy for A. cantonensis infection.

• Korean Journal of Cognitive Science
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• v.13 no.2
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• pp.37-45
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• 2002

Despite dynamical retinal image changes caused by pursuit eye movements, we usually perceive the stable spatial properties of the environment suite successfully Helmholtz and his followers have suggested that the visual system coordinates the retinal and extraretinal eye position information to represent the spatial properties of the environment. However. there have been a significant amount of researches showing that this kind of mechanism may not operate perfectly, and the pursuit eye movement employed in those researches were limited to conjugate eye movements. When an observer tracks an object moving away from the observer with his/her eyes. the two eyes rotate in opposite direction. and this kind of disjunctive eye movement may produce undesirable binocular disparities for the objects in the background. The present study examined whether the visual system compensated for the undesirable binocular disparities caused by disjunctive eye movements with extraretinal eye position information. Although the target object was presented frontoparellely to the subjects. the subjects reported that the object was slanted toward (or alway from) them in consistent with the undesirable binocular disparities produced by the disjunctive eye movements. These results imply that the visual system may not perfectly compensate for the undesirable binocular disparities with extraretinal eye position information.

• Korean Journal of Cognitive Science
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• v.17 no.1
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• pp.1-13
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• 2006

We applied fMRI to examine brain activation at intentionality detection (ID) task. The main purpose of this study was to explore whether brain activation regions involved in intentionality detection (known as the basic mechanism of theory of mind) differ or not, according to prior instruction. Left uncus, superior temporal gyrus and right inferior occipital gyrus, supramarginal gyrus, inferior parietal lobule, thalamus (medial dorsal nucleus), and precuneus were activated with prior instruction. In contrast, ID task with no instruction activated merely inferior parietal lobule and superior parietal lobule. Common activated area between the two instruction conditions was inferiordparietal lobule. Our results suggest thar prior instruction activated ID-related brain regions more explicitly. furtherdinvestigations would be loused on spontaneity of intentionality detector and characteristic of participants.

• Korean Journal of Cognitive Science
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• v.10 no.3
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• pp.39-49
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• 1999

The space of IID([ndependently, Identically Distributed) textures was built with axes of mean luminance and contrast, and studied on what kind of mechanisms were required to mediate texture segregation in this space. The conjecture was tested that one of these mechanisms is sensitive to the differences between the means of textures to be discriminated, whereas the other is sensitive to the differences between variances. The probability of discrimination was measured for various pairs of textures in the lID space The data were well fit by a model in which discrimination depends on two mechanisms whose responses are combined by probability summation. The conjecture was rejected that two mechanisms respectively tuned to mean and variance of texture function in segregation. Discrimination within space is mediated by 2 independent channels however: the 2 independent channels are not exactly tuned to texture mean and variance. One m mechanism was primarily sensitive to texture mean, whereas the other was sensitive to b both texture mean and variance.

• Animal cells and systems
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• v.16 no.4
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• pp.302-312
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• 2012

The purpose of this study was to examine whether Phellodendri Cortex extract (PCE) could improve learning and memory impairments caused by lipopolysaccharide (LPS)-induced inflammation in the rat brain. The effect of PCE on modulating pro-inflammatory mediators in the hippocampus and its underlying mechanism were investigated. Injection of LPS into the lateral ventricle caused acute regional inflammation and subsequent deficits in spatial learning ability in the rats. Daily administration of PCE (50, 100, and 200 mg/kg, i.p.) for 21 days markedly improved the LPS-induced learning and memory disabilities in the Morris water maze and passive avoidance test. PCE administration significantly decreased the expression of pro-inflammatory mediators such as tumor necrosis factor-${\alpha}$, interleukin-$1{\beta}$, and cyclooxygenase-2 mRNA in the hippocampus, as assessed by RT-PCR analysis and immunohistochemistry. Together, these findings suggest that PCE significantly attenuated LPS-induced spatial cognitive impairment through inhibiting the expression of pro-inflammatory mediators in the rat brain. These results suggested that PCE may be effective in preventing or slowing the development of neurological disorders, including Alzheimer's disease, by improving cognitive and memory function because of its anti-inflammation activity in the brain.

• Science of Emotion and Sensibility
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• v.21 no.4
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• pp.77-90
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• 2018

Behavioral studies of emotion recognition in autism spectrum disorders (ASD) have yielded mixed results. Most of the studies focused on emotion recognition abilities with regard to ASD using stimuli with unisensory modality, making it difficult to determine difficulties in real life emotion perception in ASD. Herein, we review the recent behavioral and cognitive neuroscience studies on emotion recognition functions in ASD, including both unisensory and multisensory emotional information, to elucidate the possible difficulties in emotion recognition in ASD. In our study, we discovered that people with ASD have problems in the process of integrating emotional information during emotion recognition tasks. The following four points are discussed: (1) The restrictions of previous studies, (2) deficits in emotion recognition in ASD especially in recognizing multisensory information, (3) possible compensation mechanisms for emotion recognition in ASD, and (4) the possible roles of attention and language functions in emotion recognition in ASD. The compensatory mechanisms proposed herein for ASD with regard to emotion recognition abilities could contribute to a therapeutic approach for improving emotion recognition functions in ASD.