• 한국농공학회논문집
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• 제51권5호
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• pp.1-8
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• 2009

Photobioreactor (PBR) that houses and cultivates microalgae providing a suitable environment for its growth, such as light, nutrients, CO2, heat, etc. is now getting more popular in the last decade. Among the many types of PBRs, the bubble column type is very attractive because of its simple construction and easy operation. However, despite the availability of these PBRs, only a few of them can be practically used for mass production. Many limitations still holdback their use especially during their scale-up. To enlarge the culture volume and productivity while supplying optimum environmental conditions, various PBR structures and process control are needed to be investigated. In this study, computational fluid dynamics (CFD) was economically used to design a bubble-column type PBR taking the place of field experiments. CFD is a promising technique which can simulate the growth and production of microalgae in the PBR. To study bubble column PBR with CFD, the most important factor is the possibility of realizing bubble. In this study, multi-phase models which are generally used to realize bubbles were compared by theoretical approaches and comparing in a 2D simulation. As a result, the VOF (volume of fluid) model was found to be the most effective model to realize the bubbles shape as well as the flow inside PBR which may be induced by bubble injection. Considering the accuracy and economical efficiency, 0.005 second time step size was chosen for 2.5 mm mesh size. These results will be used as criteria for scale-up in the PBR simulation.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2003년도 생물공학의 동향(XIII)
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• pp.359-362
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• 2003

본 연구는 in vivo 와 유사한 환경을 조성하여 기존의 기관 배양기간인 7일보다 연장하려는 연구이며 세포가 있는 경우 세포가 없는 경우보다 morphology나 길이 성장 면에서도 모두 우수한 결과를 나타냈으며 minoxidil 첨가실험을 통해 DE를 이용한 모델이 단순 액침배양보다 한 단계 진보된 hair growth model 임을 확인할 수 있었다.

• Journal of Ginseng Research
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• 제31권3호
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• pp.159-174
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• 2007

Pharmacology of Korean Red ginseng gives us unique possibility to develop new class of antiepileptic drugs today and to improve one's biological activity. The chemical structures of ginsenosides (GS) have some principal differences from well-known antiepileptic new generation drugs. The antiepileptic effect of GS was also demonstrated in all models of epilepsy in rats (young and adult), which have studied, in all models of epilepsy including status epilepticus (SE), induced by lithium - pilocarpine. In our experiments in rats new evidences on protective effects were exerted as a result of premedication by GS. Pre-treatment of several GS could induce decrease of the seizures severity and brain structural damage (by MRI), neuronal degeneration in hippocampus. Wave nature of severity of motor seizures during convulsive SE was observed during lithium-pilocarpine model of SE in rats (the first increase of seizures was 30 min after the beginning of SE and the second - 90 min after. The efficacy of treatment on SE by ginsenoside as expected was observed after no less 3 weeks by daily GS i.p. administration. It is blocked SE or significantly decrease the severity of seizures during SE. The implication of presented data is that combination of ginsenosides from Korean Red ginseng and ginseng cell culture Dan25 that could be applied for prevention of epileptical status development. However, a development of optimal ratio of different ginsenosides $(Rb_1$ Rc, Rg, Rf,) should consummate in the new antiepileptic drug development.

• 문화기술의 융합
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• 제6권4호
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• pp.753-760
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• 2020

본 연구에서는 정밀 3차원 수치해석모델을 이용하여 수직하중(받침설계하중)과 수평하중(지진시 발생되는 수평력)을 적용하여 교량받침 교체시 보자리의 구조적 안전성에 대한 검토를 수행하였다. 기존 콘크리트와 교량받침 교체로 인해 새로 타설된 콘크리트의 응력 및 용접된 철근에 발생하는 응력 및 변위 결과를 수치해석적으로 확인하였다. 수치해석결과, 수평력 및 보자리 높이 증가는 신구콘크리트 경계면의 발생응력의 증가에 따른 콘크리트 균열(파괴) 및 내부 철근연결부의 응력증가를 초래하는 것으로 분석되었다. 따라서 보자리 높이 증가는 수평력의 크기와 직접적인 상관관계가 있으며 받침 용량에 적합한 보자리 높이 적용이 필요할 것으로 분석되었다. 본 연구에서는 보자리에 작용하는 수평력의 크기와 보자리 높이와의 상관관계를 변수로한 받침교체공사 가이드라인을 도표로 제시하여 교량받침 용량에 적합한 보자리 높이 설정 및 보강유무를 결정하는 방안을 제시하였다.

• 영어영문학
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• 제58권2호
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• pp.279-304
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• 2012

Since the publication of Foucault's Discipline and Punish, theatricality has become one of the key concepts in New Historicism. By defining theatricality as the most definitive feature of early modern society and culture, New Historicists have promoted the idea that theatrical practices in every day life were eventually replaced by textual practices as the western society started to undergo modernization with the advent of print culture and technologies. This paper questions this linear model of English literature, the shift of literary practices from theatricality to textuality in the event of modernization, by closely looking at the ways in which newsbooks and playlets during the English civil wars appealed to their target readers. The early print-based literary commodities during the English civil war (i.e. newsbooks and playlets) were able to win the attention of their audience not by breaking away from theatrical energy and creativity but instead by embracing and taking advantage of them through the use of dramatic conventions, dialogues, and many others. The newsbooks and the playlets during the time, however, did not simply replicate the dramatic forms and experiences of the previous generation. Instead, as the case study of Craftie Cromwell exemplifies, they went further to produce a different mode of theatricality by reshaping everyday lives into serialized drama, whose resolution is always already delayed and postponed into the ever-receding future. In conclusion, the study of the newsbook and playlets during the civil wars suggests that the textuality of modern times, materialized in print forms, have been co-evolved with the development of new theatricality, whose contents and forms are susceptible to the changes of everyday reality.

• 문화기술의 융합
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• 제9권3호
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• pp.727-730
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• 2023

전세계적으로 온실가스 및 미세먼지 저감을 위한 탄소중립 정책에 따라 전기차보급이 확대될 전망이다. 전기자동창의 운용은 열악한 환경에서 사용되고 충전과 방전 등을 거듭할수록 에너지밀도가 낮아지고 내부분리막의 손상등의 이유로 건전성이 떨어짐에 따라 차량의 주행거리가 줄고, 충전 속도가 느려지는 이유로 대략 5~10년 정도 사용한 배터리들은 폐배터리로 분류하며 이 같은 이유로 배터리 화재 및 폭발 등의 위험성이 높아 지게 됩에 따라 배터리의 진단 및 SOH의 추정이 필수적이라 할 수 있다. 배터리 SOH추정은 매우 중요한 요소로 현재는 배터리 충방전을 반복하면서 소요되는 시간, 온도, 전압을 측정하여 배터리의 상태를 평가하는데 정확도가 낮다. 불안정한 폐배터리를 다수의 반복적 충전과 방전을 통해 진단하는 과정에서 화재 및 폭발의 취약점을 보완하여 신뢰성이 높은 폐배터리의 상태데이터를 취득할 수 있는 기반을 마련하고 본 논문에서는 리튬이온 배터리의 SOH예측을 위해 테슬라 폐배터리를 이용한 방전 용량 측정을 바탕으로 획득한 데이터를 서포트 벡터 머신 기반으로 예측하고자 하였다.

• Molecules and Cells
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• 제38권9호
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• pp.806-813
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• 2015

Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by mutations in the glucocerebrosidase gene (GBA), which encodes the lysosomal enzyme glucosylceramidase (GCase). Deficiency in GCase leads to characteristic visceral pathology and lethal neurological manifestations in some patients. Investigations into neurogenesis have suggested that neurodegenerative disorders, such as GD, could be overcome or at least ameliorated by the generation of new neurons. Bone marrowderived mesenchymal stem cells (BM-MSCs) are potential candidates for use in the treatment of neurodegenerative disorders because of their ability to promote neurogenesis. Our objective was to examine the mechanism of neurogenesis by BM-MSCs in GD. We found that neural stem cells (NSCs) derived from a neuronopathic GD model exhibited decreased ability for self-renewal and neuronal differentiation. Co-culture of GBA-deficient NSCs with BM-MSCs resulted in an enhanced capacity for self-renewal, and an increased ability for differentiation into neurons or oligodendrocytes. Enhanced proliferation and neuronal differentiation of GBA-deficient NSCs was associated with elevated release of macrophage colony-stimulating factor (M-CSF) from BM-MSCs. Our findings suggest that soluble M-CSF derived from BM-MSCs can modulate GBA-deficient NSCs, resulting in their improved proliferation and neuronal differentiation.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2009년도 학술발표회 초록집
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• pp.2190-2199
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• 2009

Nihombashi is located in the central area of Tokyo, Japan. Tokyo has been the capital in Japan since the Edo period, which started approximately 400 years ago, and has accepted a variety of cultures, human resources, businesses for the last 400 years. This has resulted in building up the present prosperity. The Sumida River, one of the symbols of Tokyo and its tributaries including the Kanda River and the Nihombashi River, flows through the Nihombashi district. The river and tributaries used to benefit to the City of Edo. Due to the economic development and the industrial growth in Tokyo, however, they were polluted and lost their functions. In 1960s, approximately 40 years ago, the Sumida River became so dirty that local citizens kept away from it. The Nihombashi River was covered with an expressway, which was obscuring the river view. Since 1970s, local communities have proposed to rehabilitate rivers in Tokyo successively, and have proceeded with measures for river floods, improvement of sewage systems and construction of water purification facilities. Consequently, the quality of the river water was considerably improved in 1990. The stagnant rivers were turned into ones that local citizens were physically able to come close by. Today, restoring of the environment and the appearance of the city in the old days, Nihombashi district has been proposed as a model city of the future, which is alive with history and culture and harmonizing with rivers. The concept is "To Create, To Reserve, To Restore." This paper introduces a case study of the urban development, in which the local communities and public authorities collaborated with and proposed a brand-new style of the urban city harmonizing with the environment.

• 한국실내디자인학회논문집
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• 제24권3호
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• pp.104-112
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• 2015

This study purposes drawing changing tendency of apartment kitchen areas and character of that by figuring out type, form and per period cause of change of brand apartment kitchen areas. I adopted subject of study as the six leading construction companies considering the apartment rankings of brand and subcontract from 2001 to 2015 when brand apartment was activated(Samsung C&T corporation Raemian, Daelim Industrial Co., Ltd E-pyeonhansesang, Daewoo E&C Prugio, GS E&C XI, Posco E&C The sharp, Hyundai E&C Hillstate) and analyzed kitchen plane of $84m^2{\sim}102m^2$ housing units which were in great demand from apartment housing market. Also, I drew changing trends of kitchen areas by conducting a model house field survey. Through this study result, I will expect the utility of baseline data which is necessary for space development by figuring out kitchen culture, flows and cause of change.

• 한국미생물·생명공학회지
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• 제11권1호
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• pp.33-38
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• 1983

에타놀을 생산하는 Flocculent 균주는 균체순환을 위한 외부적인 장치 없이도 발효조 내부 자체에서 고농도의 균체를 유지시킬 수 있는 장점이 있다. 본 연구에서는 Flocculation 특성을 가지고 있는 Saccharomyces uvarum을 사용하여 Glucose 배지에서 회분식 및 연속식 발효특성을 고찰하였고 에타놀 발효의 수학적 모델을 만들었다. 이를 이용하여 여러 온도 및 pH에 따른 발효특성을 비교 검토한 결과 균체성장과 에탄올 생산의 최적온도는 33~35$^{\circ}C$ 이었고 pH 에 대한 영향은 그리 크지 않았으나 pH5가 최적 조건이었다. 이러한 환경적 최적 조건하에서 Semi-batch 발효에 의한 에타놀 최고 생산성은 12g/$\ell$/h이었다.