• Journal of Korean society of Dental Hygiene
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• v.20 no.2
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• pp.167-174
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• 2020

Objectives: The aim of this study was to identify causal factors for continuous innovative behavior and devise a plan for effective member management by improving continuous innovative behavior. Methods: A self-reported questionnaire was filled out by 190 clinical dental hygienists from June 1 to July 31, 2019. Data were analyzed using SPSS 22.0. The independent t-test, one-way analysis of variance, Scheffe's post-hoc test, and Pearson's correlation coefficient analysis were performed, and a stepwise multiple regression analysis was conducted. Results: Dental hygienists scored 3.43 points in innovative behavior. Variables influencing innovative behavior were emotional intelligence, self-efficacy, and educational level. These factors had a variance of 47.5% among clinical dental hygienists. Conclusions: It is necessary to develop a regular program aimed at improving the emotional intelligence and self-efficacy of clinical dental hygienists to exert a positive work effect and improve their innovative behavior rather than assigning them simple tasks.

• Korean Journal of Occupational Health Nursing
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• v.24 no.4
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• pp.302-312
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• 2015

Purpose: This study was conducted to identify the influencing factors of job stress, self-efficacy, and organizational culture to presenteeism in clinical nurses. Methods: A descriptive correlation research design was used for the this study. The subjects were 245 nurses working at the hospital in S, A and C City, from August $1^{st}$ to October $30^{th}$ 2014. Data were analyzed using t-test, ANOVA, $Scheff{\acute{e}}^{\prime}s$ test, stepwise multiple regression by SPSS 21.0 program. Results: Job impairment indicated a significant positive relationship to job stress (p=.009), health problem (p<.001), and indicated significant negative relationship to self-efficacy (p<.001), innovative-oriented (p<.001), affiliative-oriented (p=.002), task-oriented (p=.026) in organizational culture. Significant factors of influencing to presenteeism were self-efficacy (p<.001, ${\beta}=-.363$), culture of task-oriented (p<.001, ${\beta}=-.248$) in organizational culture, and health problem (p=.002, ${\beta}=.187$). Conclusion: Self-efficacy was defined as a variable to influence on presenteeism, and developing of strategies and program to strengthen self-efficacy and task-oriented of organizational culture in nursing is helpful to reduce the presenteeism of clinical nurses.

• Journal of Ginseng Research
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• v.44 no.2
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• pp.179-193
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• 2020

Ginseng products on the market show high variability in their composition and overall quality. This becomes a challenge for both consumers and health-care professionals who are in search of high-quality, reliable ginseng products that have a proven safety and efficacy profile. The botanical extract standardization is of crucial importance in this context as it determines the reproducibility of the quality of the product that is essential for the evaluation of effectiveness and safety. This review focuses on the well-characterized and standardized ginseng extract, G115, which represents an excellent example of an herbal drug preparation with constant safety and efficacy within the herbal medicinal products. Over the many decades, extensive preclinical and clinical research has been conducted to evaluate the efficacy and safety of G115. In vitro and in vivo studies of G115 have shown pharmacological effects on physical performance, cognitive function, metabolism, and the immune system. Furthermore, a significant number of G115 clinical studies, most of them double-blind placebo-controlled, have reinforced the findings of preclinical evidence and proved the efficacy of this extract on blood glucose and lipid regulation, chronic obstructive pulmonary disease, energy, physical performance, and immune and cognitive functions. Clinical trials and 50 years of presence on the market are proof of a good safety profile of G115.

• Journal of Korean Clinical Nursing Research
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• v.23 no.2
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• pp.170-178
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• 2017

Purpose: This study was done to investigate the correlation among symptom experience, self-efficacy, depression, and medication adherence in patients with chronic obstructive pulmonary disease (COPD). Methods: Participants were 100 patients with COPD recruited in one general hospital in Seoul. A structured questionnaire was used to measure the study variables. Data were analyzed using descriptive statistics, t-test, ANOVA, and Spearman correlation coefficient. Results: Symptom experience and depression were positively correlated (r=.41, p<.001), symptom experience and self-efficacy were negatively correlated (r=-.21, p=.035). Depression was negatively correlated with self-efficacy (r=-.60, p<.001) and medication adherence (r=-.48, p<.001). Self-efficacy and medication adherence were positively correlated(r=.76 p<.001). Conclusion: Findings from this study indicate that depression and self-efficacy are important variables related to medication adherence in patients with chronic obstructive pulmonary disease. Therefore, depression and self-efficacy should be assessed, and customized nursing interventions should be provided in order to increase medication adherence.

• Journal of Korea Entertainment Industry Association
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• v.14 no.8
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• pp.315-322
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• 2020

This study was carried out to provide basic data for prevention of burnout by measuring levels of self-efficacy, social support and burnout that nursing students experienced during clinical practice and identifying factors influencing burnout. This is a descriptive research targeting 173 junior- and senior-year nursing students in Y area, and data were collected from October 15^th to November 4^th 2019. For data analysis, frequencies and percentages were calculated, and t-test and ANOVA were conducted along with the Scheffé test as a post-test. In addition, Pearson's correlation coefficients and multiple regression analysis were employed. The study results are as follows. There were significant differences in self-efficacy, social support and burnout depending on grades(t= -2.20, p=.029) and major satisfaction(F=3.62, p=.029) among general characteristics of nursing students. When analyzing correlations among self-efficacy, social support and burnout of nursing students, there was a positive correlation between self-efficacy and social support(r=.214, p=.005), a negative correlation between burnout and self-efficacy(r=-.253, p<.001) and a negative correlation between burnout and social support(r=-.175, p=.021). Major satisfaction(β= -.21, p=.006) had the biggest influence on burnout, and it was followed by self-efficacy(β= -.16, p=.032) and social support(β= -.15, p=.047). The explanatory power of the model was 13.8 percent. In conclusion, it is required to improve university life satisfaction and clinical practice satisfaction and develop programs, which enhance social support and self-efficacy, for preventing burnout of nursing students during clinical practice.

• Tuberculosis and Respiratory Diseases
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• v.81 no.1
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• pp.6-12
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• 2018

The role of the treatment for latent tuberculosis infection (LTBI) has been underscored in the intermediate tuberculosis (TB) burden countries like South Korea. LTBI treatment is recommended only for patients at risk for progression to active TB-those with frequent exposure to active TB cases, and those with clinical risk factors (e.g., immunocompromised patients). Recently revised National Institute for Health and Care Excellence (NICE) guideline recommended that close contacts of individuals with active pulmonary or laryngeal TB, aged between 18 and 65 years, should undergo LTBI treatment. Various regimens for LTBI treatment were recommended in NICE, World Health Organization (WHO), and Centers for Disease Control and Prevention guidelines, and superiority of one recommended regimen over another was not yet established. Traditional 6 to 9 months of isoniazid (6H or 9H) regimen has an advantage of the most abundant evidence for clinical efficacy-60%-90% of estimated protective effect. However, 6H or 9H regimen is related with hepatotoxicity and low compliance. Four months of rifampin regimen is characterized by less hepatotoxicity and better compliance than 9H, but has few evidence of clinical efficacy. Three months of isoniazid plus rifampin was proved equivalence with 6H or 9H regimen in terms of efficacy and safety, which was recommended in NICE and WHO guidelines. The clinical efficacy of isoniazid plus rifapentine once-weekly regimen for 3 months was demonstrated recently, which is not yet introduced into South Korea.

• Korean Journal of Clinical Pharmacy
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• v.29 no.2
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• pp.71-78
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• 2019

Objective: This study aimed to provide efficacy and safety information on the use of erenumab for prevention of episodic and chronic migraines. Methods: The keywords "Erenumab and migraine" were used to search the PubMed database to then compile efficacy and safety data for erenumab. Data from relevant Phase 2 and Phase 3 clinical trials were analyzed, using RevMan for statistical analysis. Results: Three clinical trials (one Phase 2 and two Phase 3 studies) were retrieved. All three trials used the same primary endpoint (change from baseline in monthly migraine days (CBMD)) to evaluate efficacy and safety of erenumab use for prevention of episodic and chronic migraines. Subcutaneous doses of erenumab (70 or 140 mg) were administered monthly in each trial, for 3 months (Studies 2, and 3) or 6 months (Study 1). The mean differences in CBMD in the 70 mg and 140 mg erenumab arms were -1.36 and -1.98, respectively, compared to that in the placebo arm. Some adverse events, such as nasopharyngitis and upper respiratory tract infection, were reported, but no differences in safety between erenumab and placebo were found to be significant. Conclusions: Erenumab showed superior efficacy in prevention of migraines compared to placebo. However, additional information regarding the long-term safety of erenumab should be collected. Therefore, post-marketing surveillance for adverse events is needed.

• Translational and Clinical Pharmacology
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• v.26 no.3
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• pp.118-127
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• 2018

The safety and efficacy of fimasartan have been evaluated through post-marketing surveillance in real world clinical practice. The multi-center, prospective, open-label and non-interventional study. A total of 3,945 patients (3,729 patients for safety assessment and 3,473 patients for efficacy assessment) were screened in patients with essential hypertension in 89 study centers from 9 September 2010 through 8 September 2016. Among the total patients, 2,893 patients (77.6%) were administered fimasartan for 24 weeks or longer and were classified as 'patients with long-term follow-up', and the additional safety and efficacy analysis were performed. The improvement was defined as systolic blood pressure (SBP) controlled to ${\leq}140mmHg$ or decreased SBP differences ${\geq}20mmHg$ after treatment or diastolic blood pressure (DBP) controlled to ${\leq}90mmHg$ or decreased DBP differences ${\geq}10mmHg$ after treatment. Adverse drug reactions (ADRs) were reported in 3.8% patients; dizziness, and hypotension were the most frequently reported ADRs in total patients. The results of patients with long-term follow-up were comparable with total patients. The overall improvement rate in all efficacy assessment at the last visit was 87.1% (3,025/3,473 patients). The overall improvement rate of the patients with long-term follow-up was 88.9%. Fimasartan was well tolerated, with no new safety concerns identified and an effective treatment in the real world clinical practice for Korean patients with hypertension.

• Journal of Korean Clinical Health Science
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• v.5 no.2
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• pp.850-863
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• 2017

Purpose. The purpose of this study was to investigate effects of preclinical OSCE(Objective Structured Clinical Evaluation) on knowledge, confidence in their Core fundamental nursing skills and self-efficacy in nursing students. Method. The research design was a one group pretest-posttest design and it was done to assess changes in knowledge, confidence in core fundamental nursing skills and self-efficacy from pre to the post-test which was given after the OSCE. Data were collected from March 5 to April 7, 2016 from 37 nursing students who were taking the 15-hours using OSCE learning module at one Gyeongbuk-do, P-city. This practicum was composed of 4 core fundamental nursing skills and 5 other fundamental nursing skills. The knowledge consisted of a 10-item by researchers and the confidence of core fundamental nursing skills consisted of an 9-item NRS and the self-efficacy consisted of a 17-item 5-point scale and measured in both the pretest and posttest. The collected data were analyzed with SPSS IBM 20.0 program for the frequency, percentage, x2-test, and paired t-test. Rusult. The results showed that although scores of knowledge of OSCE learning module were significanlty increased from 5.22 to 7.03(t=5.30, p<.001). There were significantly increased in scores of confidence in core fundamental nursing skills from 5.13 to 7.27(t=10.01, p<.001), In the sub-scales of each core fundamental nursing skills was scored the highest. otherwise, there was no significant difference in self-efficacy(t=1.42, p=.161). Conclusions. Based on the results, this study suggests that OSCE module development activities for nursing students in nursing education-learning in order to improve nursing skills.

• The Korean Journal of Pain
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• v.34 no.2
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• pp.156-164
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• 2021

Several types of pain occur following spinal cord injury (SCI); however, neuropathic pain (NP) is one of the most intractable. Invasive and non-invasive brain stimulation techniques have been studied in clinical trials to treat chronic NP following SCI. The evidence for invasive stimulation including motor cortex and deep brain stimulation via the use of implanted electrodes to reduce SCI-related NP remains limited, due to the small scale of existing studies. The lower risk of complications associated with non-invasive stimulation, including transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS), provide potentially attractive alternative central neuromodulation techniques. Compared to rTMS, tDCS is technically easier to apply, more affordable, available, and potentially feasible for home use. Accordingly, several new studies have investigated the efficacy of tDCS to treat NP after SCI. In this review, articles relating to the mechanisms, clinical efficacy and safety of tDCS on SCI-related NP were searched from inception to December 2019. Six clinical trials, including five randomized placebo-controlled trials and one prospective controlled trial, were included for evidence specific to the efficacy of tDCS for treating SCI-related NP. The mechanisms of action of tDCS are complex and not fully understood. Several factors including stimulation parameters and individual patient characteristics may affect the efficacy of tDCS intervention. Current evidence to support the efficacy of utilizing tDCS for relieving chronic NP after SCI remains limited. Further strong evidence is needed to confirm the efficacy of tDCS intervention for treating SCI-related NP.