• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2000.10a
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• pp.86-89
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• 2000

In cold forging by multi stage former, crowing process is important process for the high production rate and automation of forging process. But various cropping defects occur in cropping process such as orthogonality, ovality and unevenness, etc. These defects have harmful effects on the dimensional tolerance of products and tool life. So in this study, the cropping experiment is performed to examine influence of cropping process variables(clearance, cutting velocity, H/D) on occurrence of crowing defects and optimum process variables are selected, and then FE analysis is performed to verify influence of these defects on dimensional tolerance and tool life.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2021.05a
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• pp.12-13
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• 2021

Methods for the manufacture, erection, and assembly of heavy frame modules were proposed. Interferences among precast members were prevented by using bolted metal plates for dry precast beam-to-column joints during assembly with a clearance for tolerance implementing grouted concrete filler plates instead of metal filler plates. Clearances for tolerances were provided to avoid conflictions among components during erection phases. These gaps were, then, grouted by high-strength mortar. The constructability of new connections of a beam-to-column joint using bolted metal plates for precast structures was examined using a full-scale assembly test in which practical observations indicated that members could be aligned and placed accurately in both horizontal and vertical directions, leading to a fast and convenient assembling. Bolt holes of the endplate were properly aligned using couplers with 30 mm fastened length embedded in the columns. The assembly test demonstrated the erection safety and structural stability of the proposed joints that were without filler plates when they were subjected to heavy loads at the time of their erection. The facile and rapid assembly of precast beam-to-column connections with a 30 mm tolerance was observed. The proposed assembly method is rapid, sustainable, and resilient, replacing the conventional methods of concrete frame construction, offering a connection that can be used in constructing infrastructure, such as buildings and pipe-rack frames.

• BMB Reports
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• v.50 no.10
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• pp.496-503
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• 2017

The human body loses several billions of cells daily. When cells die in vivo, the corpse of each dead cell is immediately cleared. Specifically, dead cells are efficiently recognized and cleared by multiple types of neighboring phagocytes. Early research on cell death focused more on molecular mechanisms of cell death regulation while the cellular corpses were merely considered cellular debris. However, it has come to light that various biological stimuli following cell death are important for immune regulation. Clearance of normal dead cells occurs silently in immune tolerance. Exogenous or mutated antigens of malignant or infected cells can initiate adaptive immunity, thereby inducing immunogenicity by adjuvant signals. Several pathogens and cancer cells have strategies to limit the adjuvant signals and escape immune surveillance. In this review, we present an overview of the mechanisms of dead cell clearance and its immune regulations.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2011.06a
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• pp.571-572
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• 2011

• CELLMED
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• v.7 no.1
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• pp.3.1-3.2
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• 2017

The efficient removal of dead cells is an evolutionarily conserved process essential for homeostasis in multicellular organisms. The phagocytosis involves a series of steps that ultimately leads the detection of apoptotic cell by the phagocytes and the subsequent engulfment and degradation of corpse. The uptake of apoptotic cells by phagocytes not only removes debris from tissues but also generates an anti-inflammatory signal that blocks tissue inflammation. Conversely, impaired clearance of dead cells can cause loss of immune tolerance and the development of various inflammation-associated diseases such as autoimmunity, but can also affect cancer development. This review will discuss current understanding of the molecular mechanism of apoptotic cell phagocytosis and how they may be related to human diseases.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.36 no.4
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• pp.361-371
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• 2012

In order to improve the efficiency of the branch-and-bound method for mixed-discrete nonlinear programming, a nonuniform convergence tolerance scheme is proposed for the continuous subproblem optimizations. The suggested scheme assigns the convergence tolerances for each continuous subproblem optimization according to the maximum constraint violation obtained from the first iteration of each subproblem optimization in order to reduce the total number of function evaluations needed to reach the discrete optimal solution. The proposed tolerance scheme is integrated with five branching order options. The comparative performance test results using the ten combinations of the five branching orders and two convergence tolerance schemes show that the suggested non-uniform convergence tolerance scheme is obviously superior to the uniform one. The results also show that the branching order option using the minimum clearance difference method performed best among the five branching order options. Therefore, we recommend using the "minimum clearance difference method" for branching and the "non-uniform convergence tolerance scheme" for solving discrete optimization problems.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.20 no.5
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• pp.1508-1515
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• 1996

The method of utilizing sensitivity linkages for the analysis of mechanical errors are proposed. As sources of the mechanical error, tolerances in the link length and clearances in thejoints are considered. It is demonstrated that the problem of calculating mechanical errors of a 4-bar mechanism can be transformed into a problem of conventeional velocity analysis of a sensitivity linkage. As a result of the present study, it is found and proved that the mechanical error of the output angle in the 4-Bar mechaism is represented as a simple harmonic function with respect to the relative position of the pin on the clearance circle. Also the vector representing the mechanical error of a coupler point makes, in general, an ellipse as the relative angle varies on the clearance circle. With these results we can better identify the characteristic of the mechanical errors in linkages.

• Transactions of the Korean Society of Mechanical Engineers
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• v.18 no.9
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• pp.2257-2264
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• 1994

A method to evaluate the position performance for a stochastically defined planar robot manipulator is presented. Performance is defined as the operational reliability based upon the positional errors of the manipulator tip. An analytical method is developed and applied to a two-link robot manipulator through forward kinematics. This study includes uncertainties in the link length, pin center location and radial clearance. By virtue of the effective link length model, only the nominal manipulator model and statistical information on the uncertainties are required. The results from the analytical method is compared to those from the Monte Carlo simulation.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2014.10a
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• pp.402-403
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• 2014

Damping of multi-span tube with loose supports according to the finite support clearances is investigated through the experimental modal analysis. Loose intermediate support leads to strong nonlinearity in tube dynamics, provides statistical nature, and increases tube damping through impacting and friction at the supports. Fraction of critical damping was estimated by the modal curve fitting to parameter estimation from the measured frequency response functions. Magnitude of random excitation force, which can reproduce the in-situ excitation in operating environment, was maintained as constant value with a fine tolerance during vibration testing. Range of input force was carefully selected to cover from the low magnitude excitation for linearly behaved tube motion to high magnitude of force for nonlinearly-behaved tube motion. Estimated critical damping ratio shows scatters in data and tends to increase as the magnitude of rising force and decrease with upward frequency variation. Larger size of support gap increases multi-span tube damping for high magnitude of excitation.

• Genomics & Informatics
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• v.14 no.4
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• pp.181-186
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• 2016

Glucose tolerance tests have been devised to determine the speed of blood glucose clearance. Diabetes is often tested with the standard oral glucose tolerance test (OGTT), along with fasting glucose level. However, no single test may be sufficient for the diagnosis, and the World Health Organization (WHO)/International Diabetes Federation (IDF) has suggested composite criteria. Accordingly, a single multi-class trait was constructed with three of the fasting phenotypes and 1- and 2-hour OGTT phenotypes from the Korean Association Resource (KARE) project, and the genetic association was investigated. All of the 18 possible combinations made out of the 3 sets of classification for the individual phenotypes were taken into our analysis. These were possible due to a method that was recently developed by us for estimating genomic associations using a generalized index of dissimilarity. Eight single-nucleotide polymorphisms (SNPs) that were found to have the strongest main effect are reported with the corresponding genes. Four of them conform to previous reports, located in the CDKAL1 gene, while the other 4 SNPs are new findings. Two-order interacting SNP pairs of are also presented. One pair (rs2328549 and rs6486740) has a prominent association, where the two single-nucleotide polymorphism locations are CDKAL1 and GLT1D1. The latter has not been found to have a strong main effect. New findings may result from the proper construction and analysis of a composite trait.