• Journal of Haehwa Medicine
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• v.21 no.1
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• pp.65-78
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• 2012

Found on the 19th century, GuiLinGuBon can have more several unique features than the other extinguish editions. GuiLinGuBon has been Receiving attention, because it contains both and 's contents, as well as it consistt of 16 books to the same as the preperce, and then it analyzed the chapter on Wending Disease(溫病) and Liuyin Disease(六淫病) in detail which is not written in current book, and gives several clues to solve many questions that caused the controversy. This thesis is the study the GuiLinGuBon on the overall composition and the prescriptions for the overall analysis to book configuration, herbs configuration, 8 method(八法) according to the prescribed frequency, SinNongBonChoGyong(神农本草经) according to the herbs of the SamPum(三品) classification and statistical processing GuiLinGuBon the specific features were analyzed.

• Journal of Korean Medicine for Obesity Research
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• v.1 no.1
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• pp.77-83
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• 2001

We wanted to study the effect of Taeyeumjowee-tang and electroacupunctre combined-therapy on obese patients. From 1 March, 2000 to 30, September, 2000 we studied 33 out-ward patients who clinically diagnosed obesity and classified Tae-Em-In by QSCC(Questionnaire of Sasang Constitution Classification). We treated the patients by electroacupuncture therapy and taeyeumjowee-tang for 6 weeks, We investigated the change of mean body weight, mean body mass index, mean obesity degree, percent body fat and waist-hip circumference ratio. To analyze the results we used repeat measure method by SPSS ver 7.5. The results were as follows: 1. From $70.4{\pm}11.4\;to\;64.9{\pm}8.7$, mean body weight was significantly decreased according to combined-therapy. 2. From $27.2{\pm}3.2\;to\;24.6{\pm}2.7$, mean BMI was significantly decreased according to combined-therapy. 3. From $116.7{\pm}13.9\;to\;104.4{\pm}12.1$, mean obesity degree was significantly decreased according to combined-therapy. 4. From $32.1{\pm}6.8\;to\;27.4{\pm}7.5$, percent body fat was significantly decreased according to combined-therapy. 5. From $0.90{\pm}0.06\;to\;$0.86{\pm}0.06$, waist-hip circumference ratio was significantly decreased according to combined-therapy. In this study we knew the combined-therapy of electroacupuncture and taeyeumjowee-tang is very efficient in obese patient.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.5
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• pp.1102-1110
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• 2006

Sambyun(三變) is standard classification for nine palace. Through sambyun you can define new meaning of 'self' in three perspective ways. First 'self' could mean desire, emotion and memory which are ontological values. second, 'self' could mean id, ego, and superego which are practical values. Third 'self' could mean unconscious, preconscious and conscious which are epistemological values. Samjae(三才) is method that analyze things base on common features. Sa sang is method that analyze things base on difference. They both are device that searching for reason. If you put one's mind in center to observe the universe creativity of great absolute and symmetry distinction of yingyang produces jeung(情), supreme intelligence(神), and soul(魂魄). With these facts identity of the heaven(天), earth(地) and man(人) which is named samjae(三才) generates symbols of independent sasang(四象). And also, sasang generates relations between five element(五行), six energy(六氣). From ten shen(十神) relation comes seven feelings(七情) of man which creates a category of the eight trigrams(八卦) for divination and unification of nine palace(九宮). All these process are united.

• Journal of Sasang Constitutional Medicine
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• v.8 no.2
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• pp.239-255
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• 1996

The study was conducted for the purpose of finding out an objective classification method for the Sasang Constitutional medicine, which divides people into 4 groups of constitution and presents comprehensively physiology, pathology, diagnosis, theraphy and recuperation fit to each constitution. Questionnaire of Sasang Constitution collected during 9 months from March 1995 to November 1995. For the purposes of this study, the collected data were analyzed by crosstabs, variation analysis, discrimination analysis. The analyzing program was SPSS PC+V4.0. The results were as follows : 1. QSCC consists of the authorized questions studied by te oriental medicine specialists based on "four groups" given the diagnosis of Sasang Constitution Classification and variation analysis by scores of body constitution. 2. When human's body constitution is classified on the basis of QSCC scores of body constitutions and classified by the absolute size, group cases correctly classified was So-Yang-In 17.3%, Tae-Em-In 26.4%, So-Em-In 74.2%, Tae-Yang-In 100%. However, the number of examples are rare. Average percent of "group" cases correctly classified was 39.3%. 3. When human's body constitution is classified on the basis of QSCC scores of body constitutions and clasified by the relative size, group cases correctly classified was So-Yang-In 40.5%, Tae-Em-In 29.1%, So-Em-In 49.2%, Tae-Yang-In 100%. However, the number of examples are rare. Average percent of "group" cases correctly classified was 39.6%. 4. If the diagnosis of body constitution applies to the people after discrimination formula applies to them before the scores of body constitution is correctly analyzed, group cases correctly classified was So-Yang-in 50.5%, Tae-Em-In 36.9%, So-Em-In 55.9%, Tae-Yang-In 100%. However, the number of examples are rare. Average percent of "group" cases correctly classified was 44.03%. 5. As discrimination formula is applied and analyzed based on the questions of higher percent of reaction freqency, So-Yang-in 61.4%, Tae-Em-In 48.8%, So-Em-In 62.0%. Average percent of group cases correctly classified was 54.91% and it was percent increased compared to chance probability. 6. Therefore, it comes to the conclusion if we utilize QSCC, we are able to predict Sasang Constitution.

• Proceedings of the KAIS Fall Conference
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• 2010.11b
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• pp.878-881
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• 2010

For better diagnosis and prescription in Korean traditional medicine, Lee Je-Ma (1837-1900) created Sasang Constitution classification which was divided into four groups of Taeyangin, Soyangin, Taeumin and Soumin based on both body shape and natural disposition. The purpose of this study was to investigate the characteristics of facial skin parameters (hydration, lipid and pH) on forehead and cheek according to Sasang Constitution classifications of Taeumin, Soyangin and Soumin in Korean. Eighty-nine Korean female subjects were recruited for this study and the average age of them was 19.9${\pm}$0.84 years. The four groups by the Sasang Constitution were classified by questionnaire for the Sasang Constitution classification proposed by Kyung-Hee Oriental Medicine Hospital. Consequently, thirty-eight (42.7%) among the subjects were grouped into Soumin, twenty-nine (32.6%) into Taeumin, twenty (22.5%) into Soyangin and two (2%) into Taeyangin. Taeyangin group was excluded from statistical analysis due to small subjects. Hydration, lipid and pH parameters on forehead and cheek were measured by using non-invasive instruments of Corneometer (CM 825, Schwarzhaup, Germany), Sebumeter (SM 815, Schwarzhaup, Germany) and Skin-pH-meter (pH 905, Schwarzhaup, Germany), respectively. The measurements by the same investigator were performed under standardized condition with a room temperature of $21^{\circ}C$ and a humidity level of 40% to 50%. As a result, hydration (F=25.481, p=.000), lipid (F=5.753, p=.005) and pH (F=5.010, p=.009) of the forehead skin showed significant differences in the order of Taeumin, Soyangin and Soumin. Hydration (F=23.216, p=.000), lipid (F=6.898 p=.002) and pH (F=5.070, p=.008) of the cheek skin showed significant differences in the order of Taeumin, Soyangin and Soumin. In conclusion, facial skin surface seemed to be dependent on Sasang Constitution classification in Korean. These findings indicated that Sasang Constitution classification might be an useful esthetic treatment for caring facial skin in the future.

• The Korea Journal of Herbology
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• v.30 no.3
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• pp.41-47
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• 2015

Objectives : Due to the morphological similarity of the pericarp and description of multi-species in National Pharmacopoeia of Korea and China, the Zanthoxylum Pericarpium is difficult to authenticate adulterant in species levels. Therefore, we introduced the sequence analysis of DNA barcode and identification of single nucleotide polymorphism(SNP) to establish a reliable tool for the distinction of Zanthoxylum Pericarpium from its adulterants. Methods : To analyze DNA barcode region, genomic DNA was extracted from twenty-four specimens of authentic Zanthoxylum species and inauthentic adulterant and the individual internal transcribed spacer regions (rDNA-ITS and ITS2) of nuclear ribosomal RNA gene were amplified using ITS1, ITS2-S2F, and ITS4 primer. For identification of species-specific sequences, a comparative analysis was performed using entire DNA barcode sequences. Results : In comparison of four Zanthoxylum ITS2 sequences, we identified 16, 4, 6, and 4 distinct species-specific nucleotides enough to distinguish Z. schinifolium, Z. bungeanum, Z. piperitum, and Z. simulans, respectively. The sequence differences were available genetic marker to discriminate four species. Futhermore, phylogenetic relationship revealed a clear classification between different Zanthoxylum species showing 4 different clusters. These results indicated that comparative analysis of ITS2 DNA barcode was an useful genetic marker to authenticate Zanthoxylum Pericarpium in species levels. Conclusions : The marker nucleotides, enough to distinguish Z. schinifolium, Z. piperitum, Z. bungeanum, and Z. simulans, were obtained at 30 SNP marker nucleotides from ITS2 sequences. These differences could be used to authenticate official Zanthoxylum Pericarpium from its adulterants as well as discriminating each four species.

• The Korea Journal of Herbology
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• v.33 no.3
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• pp.25-35
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• 2018

Objectives : Lepidii seu Descurainiae Semen has been frequently adulterated with the seeds of several inauthentic plant species. However, the accurate identification of these plant seeds is very difficult. To develop a reliable genetic authentication tool for Lepidii seu Descurainiae Semen, we analyzed matK sequence. Methods : To obtain the matK sequences of plant materials, genomic DNA was extracted from 24 samples and PCR amplification was carried out using matK-AF/matK-8R universal primer set and matK-LDSF/matK-LDSR primer set. For identifying species-specific nucleotides and phylogenetic analysis, matK regions were sequenced and comparatively analyzed by the ClustalW and Maximum Likelihood method. Results : We developed a new primer set to amplify matK region in Lepidii seu Descurainiae Semen and closely related plant samples. From the comparative analysis of matK sequences, we identified species-specific marker nucleotides for D. sophia, L. apetalum, L. latifolium, E. cheiranthoides, E. macilentum, and D. nemorosa, respectively. Furthermore, phylogenetic analysis revealed clear classification depending on the species. These results indicated that the matK sequence obtained a new primer set in this study was useful to identify Lepidii seu Descurainiae Semen in species level. Conclusions : We developed a primer set and identified species-specific marker nucleotides enough to distinguish authentic Lepidii seu Descurainiae Semen and adulterants at the species level based on the matK sequences. These genetic tool will be useful to prevent adulteration and to standardize the quality of Lepidii seu Descurainiae Semen.

• Korean Journal of Adult Nursing
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• v.15 no.2
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• pp.173-182
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• 2003

Purpose: This study was founded to identify perception and ways of coping with stress according to classification of Sasangin(4 constitutions). Method: The subjects were 258 regular students who majored in oriental medicine in Jechon and Seoul. Data was collected by 3 types of questionnaires for 3 months; Perceived stess, ways of coping, Questionnaires of Sasang Constitution Classification (QSCCII). Data analysis was conducted by SPSS version 10. Result: 1) Difference of perceived stress in Sasangin: Perceived stress by the Sasangin indicated that Soeumin perceived more stress than Soyangin and Taeumin(P=.013). 2) Different method in coping with stress of Sasangin: It was found that Soeumin didn't make use of emotional coping way according to the analysis(P=.040). 3) Relationship between ways of coping for stress and perceived stress in Sasangin: It was shown that as Soeumin perceived stress so higher than Soyangin and Taeumin, they tended to use the solving problem-method therefore it was shown to have a negative correlation(P=.044). Conclusion: In conclusion, it was found that there were differences of Sasangin in perceived stress and ways to cope with it. The dose relationship between the perception and coping method of stress was found.

• Herbal Formula Science
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• v.19 no.2
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• pp.119-133
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• 2011

Objectives : This study aimed to reveal the characteristics of formulas in "Key to Therapeutics of Children's Diseases" by analysis of crude drugs that constitute formulas. Methods : To analyze the formulas, We classified the formulas to presenting symptom classification. And within that categories, the crude drugs in formulas were diagrammatized. Results : After those analyses, we brought a conclusion as like these. 1. The formulas classified into some categories that include chronic consumption disease, parasitization, digestive system disease, febricity, infectious disease, respiratory disease, skin disease, infirmity and etc. 2. We analyzed the characteristic of formulas by categorization of crude drug combination. In this way, we recognized that Qian Yi(錢乙) frequently used cold crude drugs unlike the trend of S$\grave{o}$ng(宋) dynasty doctors. 3. The prescription that described in "Key to Therapeutics of Children's Diseases" can be found in "Treasured Mirror of Eastern Medicine(東醫寶鑑)" and the other books on posterity. Conclusions : Through these researches, we verified that Qian Yi affect cold herbal and mineral drugs. This tendency of Qian Yi have an effect on the Nourish yin school. And several decades of formulas of "Key to Therapeutics of Children's Diseases" contain in part of pediatrics on "Treasured Mirror of Eastern Medicine". We reconfirmed that Qian Yi affected profound influence on the development of pediatrics and Nourish yin school.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.20 no.2 s.33
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• pp.151-160
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• 2007

Objective : This study was performed to examine the patterns of skin disease in patients that had visited Dept. of Dermatology Hospital of Oriental Medicine, Dongguk University. We also compared on disease, age and treatment. Methods : We analysed statistic study in 505 patients, who had visited to our hospital from July, 2005 to February, 2007. Results : The results were as follows; 1. Distribution of dermatology classification was 40.6%, males were 41 % and females were 59%. 2. Distribution of aging was 18.2% in 0-9 years old and 18.8% in 10-19 years old and 17.4% in 20-29 years old. 3. Common disease group were Atopic dermatitis (24.55%); Acne (10.89%); Eczema (10.89%); Urticaria (10.30%). 4. Distribution of treatment according to diagnosis were external preparation in atopic dermatitis, acne, eczema, dermatitis seborrheica ; herbal-medication in urticaria ; herbal-medication and external preparation in facial redness. 5. Distribution of treatment according to aging were external preparation in all group except 50-59 years old; acupuncture treatment in 20-29 years old; herbal-medication in 10-19 years old; consultation in 70-79 years old. Conclusion : This study suggests that oriental medical treatments is popular in dermatologic diseases, especially atopic dermatitis and acne. We have to take steps for effective management and treatment for special diseases and ages.