• Proceedings of the Korean Journal of Food and Nutrition Conference
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• 1997.06b
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• pp.15-17
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• 1997

암 발생의 원인 중 80% 이상이 식사습관과 환경오염에 있는 것으로 인정되고 있다. 음식물, 담배, 술, 대기오염, 스트레스, 자외선이 그 대표적인 원인물질로 꼽을 수 있으며 그 중에서도 매일 섭취하는 음식물이 가장 중요한 발암요인으로 지적되고 있다. 대장암과 유방암의 발생에 대한 Wynder 등의 역학조사에서도 식사습관이 암 발생에 중요함을 시사 하고 있다. 동물성 단백질과 지방의 다량 섭취가 대장암과 유방암의 발생을 증가 시키고 섬유질이 풍부한 곡류와 야채의 섭취는 대장암 발생을 억제한다는 상관관계가 밝혀졌다. 그러나 우리가 늘 섭취하는 음식물 자체는 대장암과 유방암을 유발하는 기능이 거의 없다. 섭취된 음식물이 암을 일으키려면 장내 부패 미생물의 분해작용에 의하여 발암물질로 변환되는 과정이 필요하다. 그 발암물질들이 장관으로 흡수 자극함으로써 암을 유발할 수 있다. 반대로 일부장내 미생물들은 장내 발암물질들을 무독화 하거나 숙주의 면역기능을 증강 시킴으로써 암 발생을 억제할 수도 있다는 사실을 간과해서는 안 될 것이다. Mitsuoka는 장내 미생물이 암을 유발하는 중요한 요인이라고 강조하였다. Veer 등은 유산균 발효유를 많이 섭취하면 유방암 발생이 억제됨을, 국제암연구위원회는 섬유질을 많이 섭취하고 있는 핀란드 쿠피오의 거주자들에게는 덴마크의 코펜하겐에 거주하는 사람들에 비하여 대장암 발생율이 1/4에 불과하고 분변내 유산간균수는 100배 높은 사실을 역학조사에서 밝혔다. 이 외에 유산균과 발효유제품의 항암효과에 대한 실험결과들이 많이 발표되었다. 여기에서는 유산균의 항암효과에 대한 지금까지의 관련 자료들을 요약, 정리하여 고찰하고자 한다.높은 당 함량을 나타냈으며, T-AS는 70.3%의 당과 7.8%의 단백질로 구성 되었다. GLG 대부분의 분획들은 60~93%의 glucose로 구성된 다당류 이었으며, 주로 $\beta$-glucose로 구성된 다당류 이었다. 아미노산은 Asp 및 Glu의 산성 아미노산과 Ala, Leu 등의 함량이 높게 나타났으며, 비알칼리 추출물에서 Ser과 Thr의 함량이 높게 나타났다. 다당류 T-AS는 평균 분자량이 2,000 kD와 12kD에서 주 peak를 나타냈으며, 수용성 분획의 평균 분자량은 12kD이고 비수용성 분획은 36~2,000 kD의 평균 분자량 분포를 갖는 것으로 나타났다. IR과 NMR 분석 결과 890 cm-1에서 흡수 peak를 나타내어 $\beta$-(1,3)0glucan과 $\beta$-(1,6)-glucan의 구조를 갖는 다당류로 확인 되었다. T-AS 분획은 C:H:O:N의 함량비가 38.9:5.7:49.6:1.84%이며, 이 물질의 융점은 163 $^{\circ}C$로 연한 갈색을 나타낸다. 분리된 GLG의 항암활성 기전 규명을 위해, in vivo 항암실험, 항보체 활성능, 항체 생성능, serum protein 분비능, 대식세포의 탐식능과 활성능 및 세포간 물질 분비 등의 상관관계를 조사하였다. 다당류 GLG 분획물들 가운데 항보체의 활성이 높았던 분획은 sarcome 180에 대한 항암 활성이 높게 나타났다. 다당류 T-AS의 보체 활성화 기작은 classical과 alternative complement pathway의 양 경로를 통해 활성화 되었다.

• Journal of Nutrition and Health
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• v.36 no.9
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• pp.908-917
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• 2003

It has been proposed that oxidative modification of LDL (oxLDL) plays a significant role in the pathogenicity of atherogenesis. We tested the hypothesis that chitin and chitosan may function as antioxidants with respect to 0.1 mg cholesterol/ml LDL incubated with 5 $\mu$ M Cu$^2$$^{+}$alone or in the P338Dl mouse macrophage system using L-ascorbic acid as a standard classical antioxidant. The degree of oxLDL formation was ascertained by the relative electrophoretic mobility (rEM) in the combination of thiobarbituric acid reactive substances (TBARS) levels, and the cytotoxicity of oxLDL was detected by macrophage viability. The oxLDL uptake and foam cell formation of macrophages were measured by Oil Red O staining. Incubation with Cu$^2$$^{+}$and macrophages increased rEM of LDL and stimulated TBARS formation. Culture of macrophages with LDL in the presence 5 $\mu$ M Cu$^2$$^{+}$induced macrophage death. In cell-free system 200 $\mu$g/ml water-soluble chitosan and chitosan-oligosaccharide blocked oxLDL formation. Water-soluble chitosan and chitosan-oligosaccharide blocked oxLDL formation near-completely relative to L-ascorbic acid, whereas water-soluble chitin and chitin-oligosaccharide had no measurable antioxidant effect. In macrophage system water-soluble chitosan and chitosan-oligosaccharide blocked oxidation of LDL with a significant increase in cell viability, and decreased TBARS in medium. As for the inhibitory effect on macrophage foam cell formation, chitosan and its oligosaccharide, but not watersoluble chitin, revealed the effectiveness. The endothelial expression of lectin-like oxLDL receptor-1 (LOX-1) was tested by Western blot analysis, and chitosan, chitosan-oligosaccharide and chitin-oligosaccharide blocked LOX-1 expression. These results indicate that water-soluble chitosan and its oligosaccharide showed the inhibitory effect on Cu$^2$$^{+}$-induced LDL oxidation of macrophages, and chitosan, chitosan-oligosaccharide and chitin-oligosaccharide had blocking effect on oxLDL receptor expression in the human umbilical vein endothelial system. Thus, water-soluble chitosan and its oligosaccharides possess anti-atherogenic potentials possibly through the inhibition of macrophage LDL oxidation or endothelial oxLDL receptor expression depending on chemical types.l types.

• Korean Journal of Cognitive Science
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• v.24 no.3
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• pp.203-235
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• 2013

The goal of this paper is to test the findings about English-speaking children's acquisition of inflectional morphemes in the literature using a large-scale database. For this, we obtained a 4.7-million-word corpus from the CHILDES (Child Language Data Exchange System) database, and analyzed 1,630 British and American children's uses of English derivational morphemes up to age 7. We analyzed the type and token frequencies, type per token ratio (TTR), and the lexical diversity (D) for such inflectional morphemes as the present progressive -ing, the past tense -(e)d, the comparative and superlative -er/est with reference to children's nationality and age groups. To sum up our findings, the correlations between the D value and children's age varied from morpheme to morpheme; e.g. we found no correlation for -ing, a marginal correlation for -ed, and a strong correlation for -er/-est. Our findings are consistent with Brown's (1973) classical observation that children learn progressive forms earlier than the past tense marker. In addition, overgeneralization errors were frequently found for -ed, but rarely for -ing, showing a U-shaped developmental pattern at ages 2-3. Finally, American children showed higher D scores than British children, which showed that American children used inflectional morphemes for more word types compared with British children. The present study has its significance in testing the earlier findings in the literature by setting up well-defined methodology for analyzing the entire CHILDES database.

• The Journal of Korea Assosiation for Disability and Oral Health
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• v.4 no.2
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• pp.82-87
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• 2008

Cleidocranial dysplasia (CCD) is an autosomal dominant skeletal dysplasia and is caused by mutation in the CBAFA1 gene of 6p21 chromosome band. Patients with CCD express skeletal dysplasia such as hypoplastic/aplastic clavicle, brachycephalic skull, midface hypoplasia and moderate short stature. In addition to skeletal dysplasia, specific symptoms may appear in respiratory organs, auditory area, and the more distinguished, dentition. Dental findings include: delayed eruption of permanent tooth, multiple supernumerary tooth more than five, malocclusion, etc. In Patients presenting excessive SNT, complications of SNT could be prevented and will be managed through pertinently timed treatment such as tooth extraction, using space maintainer, and orthodontic management after early diagnosis. This case is about the treatment of eruption disorders in permanent teeth owing to SNT in CCD patients, who are three family members in the $3^{rd}$ generation inherited from maternal grandfather through atavism. We performed the extraction of numerous SNT and orthodontic treatment on them in this case. On evaluating panoramic and cephalometric views, some classical signs of skeletal dysplasia due to CCD were recognized in a pool of three patients, the clavicle was distinctively displayed in all patients.

• Journal of KIISE:Software and Applications
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• v.31 no.11
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• pp.1543-1550
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• 2004

Modeling from images is a cost-effective means of obtaining 3D geometric models. These models can be effectively constructed from classical Structure from Motion algorithm. However, it's too difficult to reconstruct whole scenes using SFM method since general sites contain a very complex shapes and brilliant colours. To overcome this difficulty, the current paper proposes a new reconstruction method based on a moving Planar mirror. We devise the mirror posture instead of scene itself as a cue for reconstructing the geometry That implies that the geometric cues are inserted into the scene by compulsion. With this method, we can obtain the geometric details regardless of the scene complexity. For this purpose, we first capture image sequences through the moving mirror containing the interested scene, and then calibrate the camera through the mirror's posture. Since the calibration results are still inaccurate due to the detection error, the camera pose is revised using frame-correspondence of the comer points that are easily obtained using the initial camera posture. Finally, 3D information is computed from a set of calibrated image sequences. We validate our approach with a set of experiments on some complex objects.

• Journal of KIISE:Software and Applications
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• v.29 no.12
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• pp.883-894
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• 2002

Classical deterministic testing controls the execution of concurrent programs based on the equivalence between specifications and programs. However, it is not directly applicable to a situation in which synchronization sequences, being valid but infeasible, are taken into account. To resolve this problem, we had proposed automata-based deterministic testing in our previous works, where a concurrent program is executed according to one of the sequences accepted by the automaton recognizing all sequences semantically equivalent to a given sequence. In this paper, we present the automata-based testing environment for Java multi-thread programs, and we design and implement "Deterministic Executor" in the testing environment. "Deterministic Executor" transforms a Java multi-thread program by applying automata-based deterministic testing, the transformed program presents testing results. "Deterministic Executor" uses "Automata Generator", which generates an equivalent automaton of a test sequence, and "Replay Controller", which controls the execution of programs according to the sequence accepted by the automaton. By illustrating automata-based testing procedures with a gas station example, we show how the proposed approach does works in a Java multi-threaded program.roach does works in a Java multi-threaded program.

• The Journal of Pediatrics of Korean Medicine
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• v.12 no.1
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• pp.133-143
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• 1998

Myofascial pain syndrome is one of the pain syndrome resulted from myofascia which covered muscles and clinically characteristic feature by sensitive trigger point in skeletal muscles and referred pain reactivated by stimulating each trigger point. The origin of headache are local lesion such as head, chest, abdominal organ, systemic lesion with fever or in toxic state. the other factors are consciousness, personality, anxiety, depression, which cause muscle strain in physiological environment. The Oriental Medical therapy for headache has herb medication and acupuncture. especially acupuncture therapy has not only classical systemic acupuncture(體鍼) but also neo-acupuncture(新鍼) such as commonly using auricular acupuncture(耳鍼) and manual acupuncture (手鍼), recently trigger point acupuncture is used. The author analyzed 27 cases of patient with headache treated by trigger point acupuncture therapy in Dong-yu Oriental Medical Hospital from March 1st 1997 to February 28th 1998. The following results were obtained. 1. The sex ratio of the female was 59.26%(16 cases) and male was 40.74%(11 cases), the ratio of high school student was 62.96%(17cases) as first. 2. The headache duration ratio of 2-3 years was 37.04%(10 cases) as first, 1-2 years was 25.93%(7 cases) as second. 3. The portion ratio of whole headache was 33.33%(9 cases) as first, lateral headache was 29.63%(8 cases) as second 4. The combined symptoms ratio of anorexia was 40.74%(11 cases) as first, fatigue was 33.33%(9 cases) as second, neck stiffness and dizziness was each 25.93%(7 cases) as third. 5. The therapeutic duration ratio of below 1 week was 29.63%(8 cases) as first, 2-3 weeks was 22.22%(6 cases) as second, 1-2 weeks and 3-4 weeks was each 18.52%(5 cases) as third. 6. The ratio of family history was 11 cases(40.74%). mother with headache was 6 cases, father was 3 cases, and brothers & sisters was 2 cases. 7. The herb medication ratio of Chungsanggyuntongtang(淸上?痛湯) was 37.04%(10 cases), Kamiondamtang(加味溫膽湯) was 22.22%(6 cases), Hyangsapyunguisan(香砂平胃散) was 18.25%(5 cases) etc. 8. The remedial effect ratio of good was 25.93%(7 cases), fair was 48.15%(13 cases), not improved was 7.41%(2 cases), side effect was 3.70%(1 cases), and unknown was 14.81%(4 cases).

• Journal of the Korean Society for Advanced Composite Structures
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• v.3 no.1
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• pp.29-34
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• 2012

Even though the longitudinally stiffened laminated composite plates with closed section ribs should be an effective system for axially compressed members, the existing researches on the applications of closed-section ribs, especially for the laminated composite plates, are not sufficient. This study is aimed to examine the influence of the sectional stiffness of U-shaped ribs on the buckling modes and strengths of laminated composite plates. Applying the orthotropic plates with eight layers of the layup $[(0^{\circ})_4]_s$ and $[(0^{\circ}/90^{\circ})_2]_s$, 3-dimensional finite element models for the U-rib stiffened plates were setup by using ABAQUS and then a series of eigenvalue analyses were conducted. From the parametric studies, the minimum required ply thicknesses as well as the buckling strengths were presented for the analysis models. The buckling strengths were compared with the theoretical critical stress equation for simply supported plates based on the Classical laminated plate theory. This study will contribute to the future study for evaluating the minimum required stiffness and optimum design of U-rib stiffened plates.

• Korean Institute of Interior Design Journal
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• v.24 no.1
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• pp.178-188
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• 2015

This study has the main objective of being of help as a reference data for the application of the finishing materials when designing the interior of the chapel of the church space through analysis of the finishing materials against the chapels of church space which has complex function. As precedent studies for this, the composition of the function and concept of the church space was surveyed and the complex function of the church space was surveyed. The theoretical surveyed was performed according to the casual composition, behavior of the community and role and location of the duties of the church members. The case objects were 10 chapels constructed by 5 professional interior design companies. The content of the analysis was the finishing materials in the chapels and their application characteristics. The detailed considerations to be referred to when designing the interior of the chapels of church space in the future were proposed. The analysis result of the application of the finishing materials according to the locational function of the chapels of church space can be explained as follows. First, the platform area was the characteristic of applying finishing materials which induce visual immersion. As for the floor materials in the platform, in order to minimize the floor sound and vibration phenomenon occurring during movements, noise insulation and dust protection rubber sheet was place and on top of it the floor or the carpet was placed. Second, the Choir area had the difficult problem of having to consider the appropriate sound absorption occurring due to the proliferation of sound and performance of classical instruments at the same time. However, in the case, this problem was solved through the sculptures of convex shape. Third, since the scheelite is a space where many people move around, the finishing material which absorbs sound was mainly used. Fourth, the entrance area was composed of thick wall materials compared to other walls, and the sound absorption character was most significantly considered when applying the finishing material. Fifth, the broadcasting room was composed either in independent type or an open type and performed its function and the main finishing materials was transparent glass which was highest use frequency.

• Journal of Korean Society of Steel Construction
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• v.15 no.1
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• pp.77-85
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• 2003

The lifting and lowering supports method makes up for the weak points in the classical method and provides makes construction economical effect to construction. The application of pre-compression to continuous steel box girder bridges makes it possible to reduce the amount of steel, the height of girders and consequently, the cost consequentlyof the bridges' construction by through the process of concrete filling- up and the lifting-lowering of the inner supports. The lifting and lowering supports method is apt to cause local buckling in the lower flange and web plates by due to the process of the lifting of the inner supports. Therefore iln this study, therefore, the possibility of local buckling could be decreased, in consideration of the lifting force and the buckling strength of stiffened plates, by increasing the number of longitudinal stiffeners and the installation of extended longitudinal stiffeners on the lower flange and the web plates in the range of positive moment.