• Journal of Oral Medicine and Pain
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• v.19 no.2
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• pp.181-192
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• 1994

There have been many different theories on the etiology of temporomandibular disorders(TMDs). The objective of the study was to investigate the effects of occlusal fctors and recent life event changes as prediposing fctor on the development of temporomandibjlar disorders. To evaluate the above predisposing factor, the author used T-scan system(Tekscan Co. U.S.A.) for quantitative occlusal analysis, clinical examination for occlusal state and Social Readjustment Rating Scale(SRRS) for recent life event change units (LCU). 63 patients with TMDs and 57 patients with malocclusion presented at Wonkwang University Dental Hospital participated in this study. The subjects were grouped by Angle's classification and presence of absence of TMDs and parafunctional oral habits. Data gained with regard to contact number, contact force, contact time, occlusal state(number of total teeth and occluding teeth, overjet, overbite) and occlusal interferences (protrusive posterior contact, nonworking side interference, and RCP-ICP slide) and recent life event changes. The data were processed and analysed by SAS statistical package program, The results of this study were as follows : 1. There were no significant differences on both quantitative occlusal contact analysis and occlusal state between TMDs group and Angle's malocclusion group. Also, there were no differences among the Angle's classifications. But amount of overjet in TMDs group were more greater than that of malocclusion group. 2. There was no difference on protrusive posterior contact, and balancing contact between TMDs group and Angle's malocclusion group. Premature contact was more frequent in malocclusion group, but RCP-ICP slide was more frequent in TMDs group. And RCP-ICP slide was more freqent in Angle's class II malocclusion than Angle's I or III malocclusion. 3. Life changes units in TMDs group were higher than those in malocclusion group. And recent life change units in group with parafunctional oral habit were higher than those in group without parafunctional oral habits. Clenching was the most common habit among parafunctional oral habits.

• The Journal of Korea Assosiation for Disability and Oral Health
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• v.6 no.1
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• pp.19-22
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• 2010

Cerebral palsy is an umbrella term encompassing a group of non-progressive non-contagious motor conditions that cause physical disability in human development. Motor disorder of cerebral palsy is often accompanied by disturbances of sensation, perception, cognition, communication, behavior and seizure disorder. Disharmony of motor function leads to frequent falling down. Moreover patients have high prevalence of class II malocclusion. Compared to normal patients, the patients with cerebral palsy tends to have high prevalence of recurrent trauma and bruxism which make restoration of the anterior tooth more difficult. This case report is consisted of three cases of cerebral palsy patients who have challenging problems with restoration of anterior teeth.

• Journal of the Korea Fashion and Costume Design Association
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• v.16 no.1
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• pp.27-39
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• 2014

The purpose of this study is to investigate the formative characteristics and the aesthetic values of denim dresses from the 19th century until the $20^{th}$ century and analyze those changes shown in Paris Milan London New York collections from 2001 S/S to 2013/14 F/W. The results of this study are as follows; 1) In the mid-$19^{th}$ century, the denim pants were working suits. In the 1920's, they started to be recognized as ordinary clothing and they were supplied to women in World War II. In the 1950's, denim pants stood for youth and resistance, and they became popular among teenagers. In the 1960's, hippies who protested against the Vietnamese War would wear worn-out denim pants symbolizing peace and freedom. As they became more common in the 1970's, people all around the world wore the clothes. In the 1980's~90's, the waves of high class brand fashions brought in sensualism, extravagance, reactionary tendency, and so forth. Consequently, the aesthetic values of denim dresses have connotations of practicality, resistibility, ornamentation and femininity. 2) Practicality in recent collections is represented in classic fashion which features typical details and raw denim and modern fashion which is made with glossy denim and minimized details. Resistibility is represented in avant-garde fashion which features deformed or over-layered jackets and pants with damaged denim and vintage fashion which is made with wash-out and wild stone denim. Ornamentation is represented in ethnic fashion which is made with wash-out denim and ethnic prints and romantic fashion which features details such as ruffle, frill and shirring as well as lace and flowery decorations. Femininity is represented in sexy fashion which designs to expose or to focus in women's body and elegant fashion which is made with soft and glossy denim and hourglass silhouette.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.42 no.2 s.332
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• pp.31-40
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• 2005

The Multi-Threshold CMOS (MTCMOS) technology provides a solution to the high performance and low power design requirements of mobile computing applications. In this paper, we (i) motivate the post-mask-tooling performance enhancement technique combined with the MTCMOS leakage current suppression technology, and (ii) develop a practical MTCMOS ASIC design methodology which fine-tunes and integrates best-in-class techniques and commercially available tools to fix the new design issues related to the MTCMOS technology. Towards validating the proposed techniques, a Personal Digital Assistant (PDA) processor has been implemented using the methodology, and a 0.18um Process. The fabricated PDA processor operates at 333MHz which has been improved about $23\%$ at no additional cost of redesign and masks, and consumes about 2uW of standby mode leakage power which could have been three orders of magnitude larger if the MTCMOS technology was not applied.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.38 no.5
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• pp.284-294
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• 2012

Objectives: The anterior open bite with temporomandibular disorders (TMD) is one of the most challenging cases both orthodontically and surgically. We introduce an intermaxillary traction treatment for patients with anterior open bite and TMD using a skeletal anchorage system (SAS). Materials and Methods: This study was comprised of 52 patients with anterior open bite and TMD. A total of four mini-screws were inserted, two screws each into the maxilla and mandible, to obtain a class II pattern of elastic application with 120-200 g force. Adjunctive muscle relaxation treatments, such as splint therapy, medication, and botulinum toxin injection were applied during or before intermaxillary traction. At least one treatment among adjunctive muscle relaxation treatment, mentioned above, was applied to 96.2% of patients. We evaluated the clinical characteristics of patients, TMD symptom changes, amount of open bite improved. The degree of open bite improvement was compared between the open bite-reduced group (21 patients) and not-reduced group (5 patients). Results: TMD symptoms (muscle/joint pain, joint sound, mouth opening) remained or improved in most patients, and worsened in about 10% of patients for each items. Anterior open bite was improved by a mean of 1.75 mm (P<0.01) during treatment. The open bite-reduced group exhibited a significant open bite improvement compared to the not-reduced group (P<0.05), with 37% of open bite improvement occurring during the first 3 months of treatment. Conclusion: The intermaxillary traction technique using SAS is a valid modality for correction of anterior open bite and improvement of TMD symptoms.

• The Journal of Korean Academy of Prosthodontics
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• v.58 no.2
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• pp.110-120
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• 2020

Although not all kinds of deep bite occlusions are considered pathological states, they can cause persistent wear and eruption of the anterior mandibular teeth if the anterior occlusal contact is unstable or accompanied by an occlusal disharmony. The patient was a 72-year-old man with no occlusal contact of the remaining anterior teeth in the centric relation position because of a skeletal class II malocclusion and loss of occlusal support. If the vertical dimension needs to be increased for prosthetic restoration in a patient with a deep bite, the amount of vertical dimension increase must be determined through precise diagnosis. This is because the overjet may increase and cause an unstable occlusion. In this review, we report the case of a patient with a stable occlusion and good treatment results achieved by using a removable partial denture prosthesis and applying the Dahl concept.

• Journal of the korean academy of Pediatric Dentistry
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• v.35 no.3
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• pp.523-531
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• 2008

Maxillary molar distalization is a treatment approach for patients with Class II malocclusions who do not require extractions and mesial movements of mandibular molars. The pendulum appliance is effective for distalization of the maxillary molars and independent of patient cooperation. This appliance can stabilize the maxillary premolars and use the palatal rugae area as an additional anchorage. However, caution is needed to control collateral effects, including increase of lower facial height, incisor protrusion and damage to the rugae area. This article reports the cases in which maxillary molar distalization achieved by pendulum appliance resolves the space problems and corrects the molar relationships.

• Tuberculosis and Respiratory Diseases
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• v.41 no.5
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• pp.579-583
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• 1994

A 22-year old female visited CNUH due to palpable neck mass. Cytologic examination of a fine needle aspiration was performed and the result was Pap class II. Routine chest x-ray shows solitary pulmonary nodule. For rule-out malignancy, FNA at neck mass was repeated and pathologic finding was dysplasia. She was admitted to MI department for evaluation of solitary pulmonary nodule and percutaneous needle aspiration was done. Pathologic diagnosis was adenoid cystic carcinoma. Thereafter, the lesions were treated by excisional biopsy of submandibular gland mass with left supraomohyoid neck dissection and wedge resection of right lower lobe at ENT department and thoracic and cardiovascular surgery department, respectively. Final diagnosis was adenoid cystic carcinoma arising in submandibular gland with solitary lung metastasis. According to TMN staging system, surgical staging is stage IV of T2N0M1. Clinical follow-up to postoperative 13 months in this case showed that she is alive and well without evidence of recurrence.

• Journal of Genetic Medicine
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• v.1 no.1
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• pp.27-31
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• 1997

Steroid 21 hydroxylase deficiency is a major cause of congenital adrenal hyperplasia (CAH) and is caused by genetic impairment of the gene (CYP21B). In the human genome, CYP21B is located within the MHC class III region on the short arm of chromosome 6. Most of the genes in this region are highly polymorphic and crowded. Also the CYP21B gene is accompanied by its pseudogene (CYP21A) and tandemly arranged with two genes of fourth component of complement. This highly complex gene cluster in this area may predispose genetic instability of CYP21, i.e. mutations. In this study, tried to investigate the frequency of duplication and deletion of CYP21 and patterns of the genetic alterations of these genes.We also compared the genetic alteration in normal subjects with those of the CAH patients. The results showed that 15% of the normal korean population have duplication or deletion of CYP21. There was one normal subject with heterozygous deletion of CYP21B. Of the 5 CAH patients examined, 2 were found to show abnormal patterns. One was a large-scale gene conversion and the other a gene conversion associated with deletion involving both CYP21B and C4 locus II gene. Through this study, we carne to the conclusion that the duplication or even deletion of CYP21 and C4 might be quite a common event in the Korean population and these rearrangements must be regarded as polymorphisms. It could contribute to a high incidencs of CAH by providing a genetic pool of instable CYP21.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.4
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• pp.1739-1743
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• 2014

MicroRNAs are a class of small noncoding RNA which play important regulatory roles in a variety of cancers. MiRNA-specific expression profiles have been reported for several pathological conditions. In this study, we combined large scale parallel Solexa sequencing to identify 11 up-regulated miRNAs and 19 down-regulated miRNAs with computational techniques in the sera of ovarian cancer patients while using healthy serum as the control. Among the above, four miRNAs (miR-22, miR-93, miR-106b, miR-451) were validated by quantitative RT-PCR and found to be significantly aberrantly expressed in the serum of ovarian cancer patients (P<0.05). There were no significant differences between samples from cancer stage I/II and III/IV. However, the levels of miR-106b (p=0.003) and miR-451 (p=0.007) were significantly different in those patients under and over 51 yearsof age. MiR-451 and miR-93 were also specific when analyzed with reference to different levels of CA125. This study shows that Solexa sequencing provides a promising method for cancer-related miRNA profiling, and selectively expressed miRNAs could be used as potential serum-based biomarkers for ovarian cancer diagnosis.