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Surgical Outcome of Tetralogy of Fallot in Adolt -Implication of Preoperative Cyanosis- (수술 전 청색증 정도에 따른 성인 활로씨 4징증의 임상 양상)

  • Kim Sang-hwa;Park Soon-Ik;Park Jung-Jun;Song Hyun;Lee Jae-Won;Seo Dong-Man;Song Meong-Gun;Song Jong-Min;Kang Duck-Hyun;Song Jae-Kwan;Jang Wan-Sook;Kim Young-Hwue;Yun Tae-Jin
    • Journal of Chest Surgery
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    • v.38 no.4 s.249
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    • pp.271-276
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    • 2005
  • We analysed differences in operative methods and postoperative outcome according to the severity of preoperative cyanosis in adult ToF (Tetralogy of Fallot) patients. Material and Method: From August 1989 to June 2001, thirty three adult patients, 18 females and 15 males, underwent total correction for ToF. Their age ranged from 15 years to 54 years (median: 34). Patients were divided into 2 groups by preoperative $SaO_2$ (arterial oxygen saturation): group I$(n=cyanotic,\;SaO_2\;\geq94\%)$ and group II $(acyanotic,\; SaO_2\geq95%)$. Preoperative median hemoglobin level was higher in group I compared to group II (17.5 g/dl vs 15 g/dl). Postoperative follow-up duration ranged from 1 to 94 months (670 patient-month, median: 14 months), and 63 two-dimensional echocardiographic examinations were done during this period. Result: There were no early or late mortality. With regard to RVOT (right ventricular outflow tract) reconstruction, trans-annular patch and RV-PA extracardiac conduit were used in 7 and 3 patients respectively, and all of them belonged to group I. In group I, cardiopulmonary bypass time, aortic cross-clamping time, ICU day, hospital day were significantly longer than in group II, and postoperative inotropic support was significantly greater than in group II. There was no ventricular arrhythmia in both groups, and one patient in group I suffered from atrial arrhythmia, which was resolved spontaneously after tricuspid and pulmonary valve replacement. During follow-up periods, functional class, residual RVOT stenosis and pulmonary regurgitation, tricuspid regurgitation, occurrence of ventricular and atrial arrhythmias were comparable between two groups. Conclusion: In adult ToF patients with severe preoperative cyanosis, more aggressive RVOT reconstruction and careful postoperative care are mandatory. However intermediate-term outcome of this group of patients is comparable to the patients with minimal or no preoperative cyanosis.

The Effect of Hydrology on Phytoplankton Assemblages and Its Adaptive Strategies in Lake Hwaseong, Estuarine Reservoir with Seawater Exchange, Korea (해수유통 중인 간척담수호 화성호에서 식물플랑크톤의 군집과 적응전략에 대한 수문학적 영향)

  • Song, Tae Yoon;Yoo, Man Ho;Lee, In Ho;Kang, Eue-Tae;Kim, Mi Ok;Choi, Joong Ki
    • Korean Journal of Ecology and Environment
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    • v.47 no.2
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    • pp.71-81
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    • 2014
  • A survey was carried out to understand the influence of hydrology on the composition, abundance and adaptive strategies of phytoplankton in artificial Lake Hwaseong, an estuarine reservoir with seawater exchange through a sluice. Samples were collected seven times from May to October 2012. Hydrological events (seawater exchange, rainfall) resulted in a wide variation in salinity along with nutrients and turbidity. Shifts in the dominant phytoplankton composition occurred on every survey. Chlorophyll-a ranged from 9.7 to $104.1{\mu}g\;L^{-1}$. Multivariate analysis allowed us to identify the four phases on phytoplankton community change. Phase I (May~June) was characterized by small-sized Gymnodinium sp. and Heterosigma akashiwo dominated in warm temperature and high salinity derived from seawater exchange, and followed by Cylindrotheca closterium blooms due to rainfall and winds during phase II (July and September). During phase III (August), the dominance of Oscillatoria spp. was correlated with high temperature and low salinity. Abundant cryptomonads were associated with lower temperature during phase IV (October). Adaptive strategies were identified in the phytoplankton as morphological and physiological characteristics. These strategies identified small-sized flagellates as CR-strategists, fast-growing opportunistic species, which might favor the weak stratification of lake due to the seawater exchange during phase I and IV. Dominant species during phase II and III were characterized with R-strategists, medium-sized stress-tolerant species, which might favor turbulence by river flow. The results indicate that stronger stratification following the termination of seawater exchange for the freshening might intensify the predominance of smaller flagellates. In conclusion, this study suggests that hydrology may drive phytoplankton community change and blooms through the controls of salinity, turbulence and nutrients.

Preservation of Subvalvular Apparatus During Mitral Valve Replacement (판막하부 구조물을 보존하는 인공 승모판막 치환술)

  • 임창영;임정철
    • Journal of Chest Surgery
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    • v.29 no.12
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    • pp.1329-1336
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    • 1996
  • From January, 1994 to January. 1996, mitral valve replacement was performed in 27 patients. Among these, 17 patients underwent mitral valve replacement(MVR) with preservation of the annulo-papillary continuity(PAPCMVR) (-Group I), and 10 patients underwent conventional methods of excision of all the chordae(Group II). The operative technique for PAPCM VR consists of the division of the anterior leaflet into anterior and posterior segments, shifting and reattachment of the divided segments to the mitral ring of the respective commissural areas. This retrospective study has been designed to evalute the postoperative left ventricular function in the two groups. In the group 1, LVEF(Left Vnetricular Ejection Fraction : %) was 52 $\pm$ 3 preoperatively And 50$\pm$3 postoperatively, LVESI Vent icular End Systolic Volume Index/mL/m2) wIns 59 :6 and 51 $\pm$ 7, LVEDI Ventricular End Diastolic Volume Index/mL/m2) was 124$\pm$ 11 and 91 :8. In the group II, LVEF was 56$\pm$1 and 47:), LVESVI 62$\pm$12 and 61$\pm$15, LVEDVI 133$\pm$27 and 104$\pm$17. : the variation of the LVEF in these two group was statistically different(p(0.05). A comparison of left ventricular function data between Group I(n: 17) and Group II(n: 10) revealed better results in echocardiographic LVEF(p<0.05), LVEDVI(p<0.01) in the former group. The mean functional class(UYHA) was 2.6 preoperative and improved to 1.0 postoperatively In group 1, and 2.8 and to 1.0 in group II. We conclude that maintenance of continuity between the mitral annulus and papillary muscles is expected to have a beneficial effect on postoperative left ventricular performance.

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A Nursing College Women's Meaning of Labor and Delivery : Phenomenological Method (간호학 전공 여대생이 인지한 분만의 의미에 대한 연구)

  • Yeo, Jung-Hee
    • Women's Health Nursing
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    • v.7 no.2
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    • pp.203-211
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    • 2001
  • A women's meaning about labor and delivery may influence the process of childbirth and performance of the maternal role. Therefore, negative meaning about the birth experience may have a negative impact on the childrearing. The purpose of this study is to explore the meaning of labor and delivery for the strategies of nursing intervention in positive childbirth experience. The data were collected through the in-depth interviews of 10 nursing college women on Jeju Island from October 2000 to January 2001. The interviews were conducted by investigator in the class room after school hours. Each interview lasted for about 30 minutes on average. Subjects were interviewed one at a time. The interviews were recorded with the consent of the subject. The data were analyzed by means of Giorgi's phenomenological analysis methods and catagorized according to the similarities of its contents. The investigator read the data repeatedly to identify the themes and the main meanings. Eight main meanings were identified as follows : 1)pain 2) shame and disgust 3)load 4)naturality 5)unreality 6)happiness 7)anxiety 8)maturity. Under these main meanings there were seventeen themes. I. Pain : (a) It's too painful (b) I don't want to deliver II. Shame and Disgust : (a) I am shameful (b) I am hateful III. Load : (a) I don't feel free (b) I have responsibility IV. Naturality : (a) It's in order to obtain a child (b) It's natural for women (c) It's a destiny of women V. Unreality : I don't feel real VI. Happiness : (a) I am glad (b) I am happy (c) It's miraculous VII. Anxiety : (a) I am anxious (b) I am worried VIII. Maturity : (a) I understand parents (b) I feel great. The results of the study will provide basic data for positive childbirth experience.

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Effect of Aromatherapy according to the type of Sasang constitution (사상체질별(四象體質別) 향요법(香療法)의 효과(效果))

  • Lee, Sung-Hee
    • Women's Health Nursing
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    • v.6 no.3
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    • pp.372-382
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    • 2000
  • The purpose of this quasi-experimental study was to explore the differences in the effect of aromatherapy according to the type of Sasang constitution. The subjects were fifty-three nursing students experiencing clinical practice from March 10th. 2000 to April 22nd, 2000. For experiment, researcher used inhalation of 2% grape seed oil mixed with Rosemary oil for 2 minutes and massage with same oil for 20 minutes on the back of subjects in the speed of 20 strokes per minutes. The instruments used for this study were Questionnaire of Sasang Constitution Class II program for personal computer developed by Kim Sun Ho et al., (1996), and Mood Questionnaire developed by Ryman. Biersner, & Larocco (1974). The concentration of IgA within saliva was analyzed by immunoturbidimeter assay. The data were analyzed using SPSS and hypotheses were examined with paired t-test and ANCOVA. The results were as follows : 1) The mean score of mood was increased significantly after aromatherapy. 2) The mean concentration of salivary IgA was increased significantly after aroma therapy. 3) There was no significant difference in the mean score of mood after aromatherapy according to the type of Sasang constitution, 4) There was no significant difference in the mean concentration of salivary IgA after aromatherapy according to the type of Sasang constitution. In conclusion, the results suggest that aromatherapy with Rosemary oil have effect on the improvement of mood and IgA within saliva in the nursing students under stress caused by clinical practice regardless of the type of Sasang constitution.

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TREATMENT OF TRANSVERSE DEFICIENCY WITH SURGICALLY ASSISTED RAPID PALATAL EXPANSION IN AN OPEN BITE PATIENT SHOWING PSEUDOMACROGLOSSIA (상대적 거대설을 보이는 전치부 개방교합 환자의 외과적 급속 구개확장술을 통한 횡적 부조화의 치험례)

  • Kim, Yoon-Ji;Lee, Kyu-Hong;Park, Jun-Woo;Rhee, Gun-Joo;Cho, Hyung-Jun;Park, Yang-Ho
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.34 no.3
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    • pp.376-382
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    • 2008
  • Anterior open bite is a condition in which maxillary and mandibular incisors do not occlude at central occlusion. It is a vertical discrepancy of the jaws and dental arches that has many etiologic factors making it difficult in diagnosis, treatment and prediction of prognosis. One of the causes of open bite is abnormal size and shape of the tongue. Macroglossia, a condition in which tongue is oversized, is caused by several factors which are not clearly identifiable, and it may be a major factor of anterior and posterior open bite. Macroglossia is subdivided into true, functional and pseudomacroglossia depending on its relative size in the oral cavity. In this case report, a patient was diagnosed as skeletal Class II with pseudomacroglossia, and was treated with SARPE in order to expand the narrowed maxillary arch and Quad helix for the mandibular arch. As a result the transverse deficiency was treated. In the adult patients where no skeletal growth is expected, SARPE has shown to be effective in treating maxillomandibular transverse discrepancies in which macroglossia was accompanied as in this case.

Characterization of a Novel Gene in the Extended MHC Region of Mouse, NG29/Cd320, a Homolog of the Human CD320

  • Park, Hyo-Jin;Kim, Ji-Yeon;Jung, Kyung-In;Kim, Tae-Jin
    • IMMUNE NETWORK
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    • v.9 no.4
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    • pp.138-146
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    • 2009
  • Background: The MHC region of the chromosome contains a lot of genes involved in immune responses. Here we have investigated the mouse NG29/Cd320 gene in the centrometrically extended MHC region of chromosome 17. Methods: We cloned the NG29 gene by RT-PCR and confirmed the tissue distribution of its gene expression by northern blot hybridization. We generated the NG29 gene expression constructs and polyclonal antibody against the NG29 protein to perform the immunofluorescence, immunoprecipitation and flow cytometric analysis. Results: The murine NG29 gene and its human homologue, the CD320/8D6 gene, were similar in the gene structure and tissue expression patterns. We cloned the NG29 gene and confirmed its expression in plasma membrane and intracellular compartments by transfecting its expresssion constructs into HEK 293T cells. The immunoprecipitation studies with rabbit polyclonal antibody raised against the NG29-NusA fusion protein indicated that NG29 protein was a glycoprotein of about 45 kDa size. A flow cytometric analysis also showed the NG29 expression on the surface of Raw 264.7 macrophage cell line. Conclusion: These findings suggested that NG29 gene in mouse extended MHC class II region was the orthologue of human CD320 gene even though human CD320/8D6 gene was located in non-MHC region, chromosome 19p13.

A General Class of Estimators of the Population Mean in Survey Sampling Using Auxiliary Information with Sub Sampling the Non-Respondents

  • Singh, Housila P.;Kumar, Sunil
    • The Korean Journal of Applied Statistics
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    • v.22 no.2
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    • pp.387-402
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    • 2009
  • In this paper we have considered the problem of estimating the population mean $\bar{Y}$ of the study variable y using auxiliary information in presence of non-response. Classes of estimators for $\bar{Y}$ in the presence of non-response on the study variable y only and complete response on the auxiliary variable x is available, have been proposed in different situations viz., (i) population mean $\bar{X}$ is known, (ii) when population mean $\bar{X}$ and variance $S^2_x$ are known; (iii) when population mean $\bar{X}$ is not known: and (iv) when both population mean $\bar{X}$ and variance $S^2_x$ are not known: single and two-phase (or double) sampling. It has been shown that various estimators including usual unbiased estimator and the estimators reported by Rao (1986), Khare and Srivastava (1993, 1995) and Tabasum and Khan (2006) are members of the proposed classes of estimators. The optimum values of the first phase sample size n', second phase sample size n and the sub sampling fraction 1/k have been obtained for the fixed cost and the fixed precision. To illustrate foregoing, we have carried out an empirical investigation to reflect the relative performance of all the potentially competing estimators including the one due to Hansen and Hurwitz (1946) estimator, Rao (1986) estimator, Khare and Srivastava (1993, 1995) and Tabasum and Khan (2006) estimator.

Investigation of Scientific Argumentation in the Classes for Elementary Gifted Students (초등 단위 학교 영재 수업에서 나타나는 과학적 논증 과정에 대한 탐색)

  • Lim, Hyeon-Ju;Shin, Young-Joon
    • Journal of Korean Elementary Science Education
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    • v.31 no.4
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    • pp.513-531
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    • 2012
  • This study was to analyze the characteristic of scientific argumentation in the classes for the gifted of elementary school. The participants of this study were 5 fifth graders and 9 sixth graders, 14 in total, from the basic unit schools for gifted students of J elementary school in Incheon city. And it constituted small scale groups made up of 2~3 students with similar or identical ability in scientific reasoning. It had set up hypothesis for each group before the experiment, and students had a group discussion as a whole after the experiment. Classes were conducted 4 times, all courses were recorded as a sound/video. The ability in scientific reasoning of the students was inspected, making use of SRT II by means of pre-survey, and their argumentation levels were analyzed, utilizing 'Rubric for scientific argumentation course assessment.' As a result, argumentations did not incurred in every class. Analysis in argumentations of the students resulted in low level argumentation. This means argumentation cannot incur based on that with the limit in understanding the principle of experiments over the threshold of textbook no matter that he is an gifted student or not. The student both in formal operational period and transition period (2B/3A), the ability of scientific thinking in upper level, was improved of his argumentative ability in an overall aspect. However, a student of concrete operational period, the ability of scientific thinking in lower level, had argumentation with still lower level even after the experiment at the moment of discussing with the students on the upper level of scientific thinking ability.

Swine Leukocyte Antigen-DQA Gene Variation and Its Association with Piglet Diarrhea in Large White, Landrace and Duroc

  • Yang, Q.L.;Kong, J.J.;Wang, D.W.;Zhao, S.G.;Gun, S.B.
    • Asian-Australasian Journal of Animal Sciences
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    • v.26 no.8
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    • pp.1065-1071
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    • 2013
  • The swine leukocyte antigen class II molecules are possibly associated with the induction of protective immunity. The study described here was to investigate the relationship between polymorphisms in exon 2 of the swine DQA gene and piglet diarrhea. This study was carried out on 425 suckling piglets from three purebred pig strains (Large White, Landrace and Duroc). The genetic diversity of exon 2 in swine DQA was detected by PCR-SSCP and sequencing analysis, eight unique SSCP patterns (AB, BB, BC, CC, CD, BD, BE and DD) representing five specific allele (A to E) sequences were detected. Sequence analysis revealed 21 nucleotide variable sites and resulting in 12 amino acid substitutions in the populations. A moderate level polymorphism and significant deviations from Hardy-Weinberg equilibrium of the genotypes distribution were observed in the populations (p<0.01). The association analysis indicated that there was a statistically significant difference in the score of piglet diarrhea between different genotypes, individuals with genotype CC showed a lower diarrhea score than genotypes AB ($0.98{\pm}0.09$), BB ($0.85{\pm}0.77$) and BC ($1.25{\pm}0.23$) (p<0.05), and significantly low than genotype BE ($1.19{\pm}0.19$) (p<0.01), CC genotype may be a most resistance genotype for piglet diarrhea.