• Journal of Periodontal and Implant Science
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• 제49권1호
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• pp.2-13
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• 2019

Purpose: The aim of this study was to conduct a histologic evaluation of irradiated calvarial defects in rats 4 weeks after applying fibroblast growth factor-2 (FGF-2) with hyaluronan or biphasic calcium phosphate (BCP) block in the presence or absence of adjunctive hyperbaric oxygen (HBO) therapy. Methods: Twenty rats were divided into HBO and non-HBO (NHBO) groups, each of which was divided into FGF-2 and BCP-block subgroups according to the grafted material. Localized radiation with a single 12-Gy dose was applied to the calvaria of rats to simulate radiotherapy. Four weeks after applying this radiation, 2 symmetrical circular defects with a diameter of 6 mm were created in the parietal bones of each animal. The right-side defect was filled with the materials mentioned above and the left-side defect was not filled (as a control). All defects were covered with a resorbable barrier membrane. During 4 weeks of healing, 1 hour of HBO therapy was applied to the rats in the HBO groups 5 times a week. The rats were then killed, and the calvarial specimens were harvested for radiographic and histologic analyses. Results: New bone formation was greatest in the FGF-2 subgroup, and improvement was not found in the BCP subgroup. HBO seemed to have a minimal effect on new bone formation. There was tendency for more angiogenesis in the HBO groups than the NHBO groups, but the group with HBO and FGF-2 did not show significantly better outcomes than the HBO-only group or the NHBO group with FGF-2. Conclusions: HBO exerted beneficial effects on angiogenesis in calvarial defects of irradiated rats over a 4-week healing period, but it appeared to have minimal effects on bone regeneration. FGF-2 seemed to enhance new bone formation and angiogenesis, but its efficacy appeared to be reduced when HBO was applied.

• 한국균학회지
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• 제42권1호
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• pp.91-94
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• 2014

2013년 6월, 경기도 여주시에서 저장 중인 고구마 괴근 표면에 갈색의 썩음 증상이 관찰되었다. 병징은 둥글고, 옅은 갈색 내지 진한 갈색이며, 단단하고 건조한 편으로 표피에 한하여 얄팍하게 나타났다. 병반 부위는 오래된 부위에서 움푹 패이고, 괴근의 내부로 깊게 썩히지 않았다. 병든 고구마에서 7개의 Fusarium균을 분리하였고, CLA 배지에서 균학적 특징을 조사한 결과 F. oxysporum으로 동정되었다. 이러한 결과를 확인하기 위하여 elongation factor 1 ${\alpha}$ 유전자 부위의 염기서열을 분석하였다. 그 결과, 7개 균주 중 4개는 F. commune으로, 3개는 F. oxysporum으로 확인되었다. 고구마 괴근을 상처구와 무상처구로 구분하고, 균사절편을 접종하여 병원성을 확인한 결과, 접종 7일 후 F. commune을 접종한 상처구에서만 병징이 관찰되었다. 따라서 본 병을 Fusarium commune에 의한 고구마 표피썩음병으로 명명하며, 국내에서 최초로 보고한다.

• Journal of Information Processing Systems
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• 제14권2호
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• pp.469-486
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• 2018

We propose an enhanced version of the local binary pattern (LBP) operator for texture extraction in images in the context of image retrieval. The novelty of our proposal is based on the observation that the LBP exploits only the lowest kind of local information through the global histogram. However, such global Histograms reflect only the statistical distribution of the various LBP codes in the image. The block based LBP, which uses local histograms of the LBP, was one of few tentative to catch higher level textural information. We believe that important local and useful information in between the two levels is just ignored by the two schemas. The newly developed method: gradual locality integration of binary patterns (GLIBP) is a novel attempt to catch as much local information as possible, in a gradual fashion. Indeed, GLIBP aggregates the texture features present in grayscale images extracted by LBP through a complex structure. The used framework is comprised of a multitude of ellipse-shaped regions that are arranged in circular-concentric forms of increasing size. The framework of ellipses is in fact derived from a simple parameterized generator. In addition, the elliptic forms allow targeting texture directionality, which is a very useful property in texture characterization. In addition, the general framework of ellipses allows for taking into account the spatial information (specifically rotation). The effectiveness of GLIBP was investigated on the Corel-1K (Wang) dataset. It was also compared to published works including the very effective DLEP. Results show significant higher or comparable performance of GLIBP with regard to the other methods, which qualifies it as a good tool for scene images retrieval.

• Journal of Periodontal and Implant Science
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• 제45권4호
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• pp.136-144
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• 2015

Purpose: The objective of this study was to comparatively assess the bone regenerative capacity of absorbable collagen sponge (ACS), biphasic calcium phosphate block (BCP) and collagenated biphasic calcium phosphate (CBCP) loaded with a low dose of recombinant human bone morphogenetic protein-2 (rhBMP-2). Methods: The CBCP was characterized by X-ray diffraction and scanning electron microscopy. In rabbit calvaria, four circular 8-mm-diameter defects were created and assigned to one of four groups: (1) blood-filled group (control), (2) rhBMP-2-soaked absorbable collagen sponge (0.05 mg/mL, 0.1 mL; CS group), (3) rhBMP-2-loaded BCP (BCP group), or (4) rhBMP-2-loaded CBCP (CBCP group). The animals were sacrificed either 2 weeks or 8 weeks postoperatively. Histological and histomorphometric analyses were performed. Results: The CBCP showed web-like collagen fibrils on and between particles. Greater dimensional stability was observed in the BCP and CBCP groups than in the control and the CS groups at 2 and 8 weeks. The new bone formation was significantly greater in the BCP and CBCP groups than in the control and CS groups at 2 weeks, but did not significantly differ among the four groups at 8 week. The CBCP group exhibited more new bone formation in the intergranular space and in the center of the defect compared to the BCP group at 2 weeks, but a similar histologic appearance was observed in both groups at 8 weeks. Conclusions: The dose of rhBMP-2 in the present study enhanced bone regeneration in the early healing period when loaded on BCP and CBCP in rabbit calvarial defects.

• 한국농공학회지
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• 제30권1호
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• pp.38-49
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• 1988

This paper presented as follows results of laboratory model tests with various shaped footings on soil bed reinforced with the strips on the base of behaviour of soil structure according to the loads and triaxial test results reinforced with geotextiles. Their parameters studied were the effects on the bearing capacity of a footing of the first layer of reinforcement, horizontal and vertical spacing of layers, number of layers, tensile strength of reinforcement and iclination load to the vertical 1.Depending on the strip arrangement, ultimate bearing capacity values could be more improved than urreinforced soil and the failure of soil was that the soil structure was transfered from the macrospace to microspase and its arrangement, from edge to edge to face to face. 2.The reinforcement was produced the reinforcing effects due to controlling the value of factor of one and permeable reinforcement was never a barrier of drainage condition. 3.Strength ratio was decreased as a linear shape according to increment of saturation degree of soil used even though at the lower strength ratio, the value of M-factor was rot influenced on the strength ratio but impermeable reinforcement decreased the strength of bearing capacity. 4.Ultimate bearing capacity under the plane-strain condition was appeared a little larger than triaxial or the other theoretical formulars and the circular footing more effective. 5.The maximum reinforcing effects were obtained at U I B=o.5, B / B=3 and N=3, when over that limit only acting as a anchor, and same strength of fabric appeared larger reinforcing effects compared to the thinner one. 6.As the LDR increased, more and more BCR occurred and there was appeared a block action below Z / B=O.5, but over the value, decrement of BCR was shown linear relation, and no effects above one. 7.The coefficient of the inclination was shown of minimum at the three layers of fabrics, but the value of H / B related to the ultimate load was decreased as increment of inclination degree, even though over the value of 4.5 there wasn't expected to the reinforcing effects As a consequence of the effects on load inclination, the degree of inclination of 15 per cent was decreased the bearing capacity of 70 per cent but irnproved the effects of 45 per cent through the insertion of geotextile.

• 한국항공우주학회지
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• 제33권9호
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• pp.34-40
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• 2005

본 연구에서는 비정상 유동해석을 위한 CFD 코드의 개발을 위해 대각화 ADI 기법을 적용한 정상 해석기법과 내재적 이중시간 전진기법을 도입하였다. 정상상태 Navier-Stokes 방정식의 Jacobian 행렬은 비점성항에 대해서만 적용하였고 여기에 내재적 인공점성 연산자를 첨가하여 블록 5대각 행렬을 유도하였다. 시간단축을 위해 스칼라 5대각 행렬로 대체하였다. 가상시간에 대한 정상상태기법에 실시간에 대한 미분항이 포함된 새로운 잔류항을 정의하였다. 가상시간에 대해 수렴된 해로부터 실시간 해를 구하고 시간에 대해 적분을 수행하는 내재적 이중시간 전진기법을 이용한 비정상 Navier-Stokes 코드를 개발하였다. 이에 대한 검증으로 정지한 유체속에 진동하는 평판문제, 원기둥 후방의 주기적인 Karman 와류생성, 이중원호 익형주위의 충격파 진동문제등을 수치해석하여 이론치, 실험치, 타연구자의 계산결과와 비교, 분석하였다.

• 설비공학논문집
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• 제18권12호
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• pp.1007-1016
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• 2006

Although the advance in electronic technology enables a large number of circuity to be packed in a small volume, it is simultaneously required to remove the high heat load produced by them. In this study, the heat transfer and pressure drop characteristics of a mini-channel heat exchanger, which is designed for liquid cooling of electronic components, are investigated by varying operating conditions. Water and FC-72 were used as working fluids. The mini-channel heat exchanger was made with circular shape channels having din-meters of 2, 3, and 4 mm in regular intervals, and the channel length was 100 mm. The header and inlet guide pathway to provide uniform inflow were attached at the inlet of the test section. Copper block including the heaters was attached at the sidewall of the test section as a heat source, which provided the heat flux from 5 to $15W/cm^2$. The entrance effects enhanced the heat transfer coefficient in the mini-channel significantly. In addition, the single-phase pressure drop in the mini-channel was very similar to that predicted by the laminar flow correlation except that the transition Re decreased due to flow instability in the entrance region.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2003년도 추계학술대회 논문집(III)
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• pp.236-246
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• 2003

This paper is implemented a control algorithm in order to be stable and minimized to entire train traffic system at delayed case. Signal ing system is described wi th algebraic equations given for train headway, Discrete-event simulation principles are reviewed and a demonstration block signaling model using the technique is implemented. Train congestion at station entrance for short headway operation is demonstrated and the propagation of delays along a platform of trains from any imposed delay to the leading train is also shown. A rail way signaling system is by nature a distributed operation with event triggered at discrete intervals. Although the train kinematic variables of position, velocity, and acceleration are continually changing, the changes are triggered when the trains pass over section boundaries and arrive at signals and route switches. This paper deals with linear-mode1ing, stability and optimal control for the traffic on such metro line of the model is reconstructed in order to adapt the circuits. This paper propose optimal control laws wi th state feedback ensuring the stability of the modeled system for circuits. Simulation results show the benefit to be expected from an efficient traffic control. The main results are summarized as follows: 1. In this paper we develop a linear model describing the traffic for both loop lines, two state space equations have been analyzed. The first one is adapted to the situation where a complete nominal time schedule is available while second one is adapted when only the nominal time interval between trains is known, in both cases we show the unstability of the traffic when the proceeding train is delayed following properties, - They are easily implemented at law cost on existing lines. - They ensure the exponetial stability of loop system. 2. These control laws have been tested on a traffic simulation software taking into the non-linearites and the physical constraints on a metro line. By means of simulation, the efficiency of the proposed optimal control laws are shown.

• 한국지반공학회논문집
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• 제23권5호
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• pp.43-51
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• 2007

동결작용은 빌딩, 구조물, 도로, 철도 그리고 공공시설관로에 엄청난 손상을 일으킬 것이다. 자연지반의 동상에 대한 연구는 과거에 많이 수행되었다. 근래에는 사회기반시설 유지의 발전과 함께 각종구조물의 복잡화로 인하여 동상대책에 대한 관심이 집중되고 있다. 본 연구에서는 구조물에 작용하는 자연지반의 동상력을 정량적으로 파악하는 것을 목적으로 하였다. 지표면에 설치한 원형강판에 작용하는 동상력이 현장시험에서 측정되었다. 동결면에서 발생하는 동상력은 동결된 토층을 거쳐 구조물에 전달된다. 또한 다단앵커로 보강된 옹벽이 현장에 설치되고 옹벽에 작용하는 동결선과 동상압 등이 측정되었다. 최종적으로 동결면의 위치와 형상이 수치해석수법을 이용하여 추정되었고 치환 범위를 결정하는 설계수법이 토질정보와 기상정보에 따라 제안되었다.

• The Korean Journal of Physiology and Pharmacology
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• 제16권5호
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• pp.297-303
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• 2012

This study was designed to elucidate high $K^+$-induced relaxation in the human gastric fundus. Circular smooth muscle from the human gastric fundus greater curvature showed stretch-dependent high $K^+$ (50 mM)-induced contractions. However, longitudinal smooth muscle produced stretch-dependent high $K^+$-induced relaxation. We investigated several relaxation mechanisms to understand the reason for the discrepancy. Protein kinase inhibitors such as KT 5823 (1 ${\mu}M$) and KT 5720 (1 ${\mu}M$) which block protein kinases (PKG and PKA) had no effect on high $K^+$-induced relaxation. $K^+$ channel blockers except 4-aminopyridine (4-AP), a voltage-dependent $K^+$ channel ($K_V$) blocker, did not affect high $K^+$ -induced relaxation. However, N(G)-nitro-L-arginine and 1H-(1,2,4)oxadiazolo (4,3-A)quinoxalin-1-one, an inhibitors of soluble guanylate cyclase (sGC) and 4-AP inhibited relaxation and reversed relaxation to contraction. High $K^+$-induced relaxation of the human gastric fundus was observed only in the longitudinal muscles from the greater curvature. These data suggest that the longitudinal muscle of the human gastric fundus greater curvature produced high $K^+$-induced relaxation that was activated by the nitric oxide/sGC pathway through a $K_V$ channel-dependent mechanism.