• Journal of Microbiology and Biotechnology
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• 제29권9호
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• pp.1478-1487
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• 2019

Ulcerative colitis (UC), a chronic inflammatory bowel disease, substantially impacts patients' health-related quality of life. In this study, an effective strategy for discovering high-efficiency probiotics has been developed. First, in order to survive in the conditions of the stomach and intestine, high bile salt-resistant and strong acid-resistant strains were screened out from the fecal flora of healthy adults. Next, the probiotic candidates were rescreened by examining the induction ability of IL-10 (anti-inflammatory factor) production in dextran sodium sulfate (DSS)-induced colitis mice, and Lactobacillus sakei 07 (L07) was identified and selected as probiotic P. In the end, fourteen bifidobacterium strains isolated from stools of healthy males were examined for their antimicrobial activity. Bifidobacterium bifidum B10 (73.75% inhibition rate) was selected as probiotic B. Moreover, the colonic IL-6 and $TNF-{\alpha}$ expression of the DSS-induced colitis mice treated with L. sakei 07 (L07) - B. bifidum B10 combination (PB) significantly decreased and the IL-10 expression was up-regulated by PB compared to the DSS group. Furthermore, Bacteroidetes and Actinobacteria decreased and Firmicutes increased in the DSS group mice, significantly. More interestingly, the intestinal flora biodiversity of DSS colitis mice was increased by PB. Of those, the level of B. bifidum increased significantly. The Bacteriodetes/Firmicutes (B/F) ratio increased, and the concentration of homocysteine and LPS in plasma was down-regulated by PB in the DSS-induced colitis mice. Upon administration of PB, the intestinal permeability of the the DSS-induced colitis mice was decreased by approximately 2.01-fold. This method is expected to be used in high-throughput screening of the probiotics against colitis. In addition, the L. sakei 07 - B. bifidum B10 combination holds potential in UC remission by immunomodulatory and gut microbiota modulation.

• 농업과학연구
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• 제48권1호
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• pp.33-43
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• 2021

Along with the widespread use of pesticides in the world, concerns over human health impacts are rapidly growing. There is a large body of evidence on the relationship between the exposure to pesticides and the elevated rate of chronic diseases such as different types of cancers, diabetes, neurodegenerative disorders like Parkinson, Alzheimer, and amyotrophic lateral sclerosis (ALS), birth defects, and reproductive disorders. This research assessed the health risk of pesticide residues by the dietary intake of vegetables collected from the agro-based markets of Dhaka, Bangladesh. As some of the banned pesticides were also found in vegetable samples, they may pose a higher risk because of cheaper availability and hence the government of Bangladesh should take strong measures to control these banned pesticides. Five organo phosphorus (chlorpyrifos, parathion, ethion, acephate, fenthion) and two carbamate (carbaryl and carbofuran) pesticide residues were identified in twenty four samples of two common vegetables (tomato and brinjal). The pesticide residues ranged from below a detectable limit (< 0.01) to 0.36 mg·kg^-1. Acephate, chlorpyrifos, ethion, and carbaryl were detected in only one sample, while co-occurrence occurred twice for parathion. Continuous monitoring and strict regulation should be enforced regarding the control of pesticide residues in fresh vegetables and other food commodities in Bangladesh.

• The Korean Journal of Pain
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• 제34권1호
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• pp.72-81
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• 2021

Background: In the literature, there have been debates as to whether smartphone use has negative effects on physical and mental health. The present study investigated the extent to which smartphone addiction impacts on musculoskeletal pain prevalence among university students. Methods: The questionnaire consisted of three sections: demographic information, the Smartphone Addiction Scale (SAS), and the modified Nordic Musculoskeletal Questionnaire. Results: A total of 249 participants were included in this cross-sectional study. The body parts that were reported with highest prevalence of musculoskeletal pain were the upper back (70.3%), neck (65.9%), and wrists/hands (68.7%). The SAS scores were correlated with duration of smartphone use on a typical day (P = 0.001), duration of owning a smartphone (P = 0.027), and musculoskeletal pain prevalence in the neck (P = 0.001), wrists/hands (P = 0.001), shoulders (P = 0.025), and upper back (P = 0.023). The SAS score was significantly associated with prevalence of musculoskeletal pain in the neck (odd ratio [OR], 1.08; 95% confidence interval [CI], 0.98-1.10; P = 0.002), wrists/hands (OR, 1.07; 95% CI, 0.97-1.09; P = 0.001), and upper back (OR, 1.10; 95% CI, 0.98-1.11; P = 0.033). Conclusions: The findings indicated that the upper back, neck, and wrists/hands have a higher prevalence of musculoskeletal pain among smartphone users, particularly those with a smartphone addiction. Smartphone addiction scores were correlated with duration of smartphone use on a typical day, duration of owning smartphone, and musculoskeletal pain prevalence in the neck, wrists/hands, shoulders, and upper back.

• International Journal of Computer Science & Network Security
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• 제23권8호
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• pp.17-25
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• 2023

The alarming global prevalence of Type 2 Diabetes Mellitus (T2DM) has catalyzed an urgent need for robust, early diagnostic methodologies. This study unveils a pioneering approach to predicting T2DM, employing the Extreme Gradient Boosting (XGBoost) algorithm, renowned for its predictive accuracy and computational efficiency. The investigation harnesses a meticulously curated dataset of 4303 samples, extracted from a comprehensive Chinese research study, scrupulously aligned with the World Health Organization's indicators and standards. The dataset encapsulates a multifaceted spectrum of clinical, demographic, and lifestyle attributes. Through an intricate process of hyperparameter optimization, the XGBoost model exhibited an unparalleled best score, elucidating a distinctive combination of parameters such as a learning rate of 0.1, max depth of 3, 150 estimators, and specific colsample strategies. The model's validation accuracy of 0.957, coupled with a sensitivity of 0.9898 and specificity of 0.8897, underlines its robustness in classifying T2DM. A detailed analysis of the confusion matrix further substantiated the model's diagnostic prowess, with an F1-score of 0.9308, illustrating its balanced performance in true positive and negative classifications. The precision and recall metrics provided nuanced insights into the model's ability to minimize false predictions, thereby enhancing its clinical applicability. The research findings not only underline the remarkable efficacy of XGBoost in T2DM prediction but also contribute to the burgeoning field of machine learning applications in personalized healthcare. By elucidating a novel paradigm that accentuates the synergistic integration of multifaceted clinical parameters, this study fosters a promising avenue for precise early detection, risk stratification, and patient-centric intervention in diabetes care. The research serves as a beacon, inspiring further exploration and innovation in leveraging advanced analytical techniques for transformative impacts on predictive diagnostics and chronic disease management.

• 생명과학회지
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• 제34권3호
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• pp.208-213
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• 2024

본 연구는 노인의 우울증 예방 및 치료를 위해 신체활동과 운동이 어떠한 효과가 있는지를 확인하는 것이다. 전 세계적으로 우울증은 지속적으로 증가하는 추세이며 특히 가속화되어 가는 고령화 사회에서 노인의 우울증은 더욱 심각한 문제라고 볼 수 있다. 노인의 우울증은 젊은 층에 비해 예후가 좋지 않으며 노화로 인한 신체적 질병의 증가와 신체적 장애에 의한 자존감 저하로 더욱 취약하다고 할 수 있다. 그러나 노인들의 우울증 관리, 노쇠로 인한 우울증 등의 문제에도 불구하고 지금까지 예방 및 치료에 관한 연구는 미미하다고 판단된다. 따라서 본 연구는 중요한 매개 변인인 수면장애와 우울증, 우울증에 대한 운동과 해마의 연관성, 우울증 관리를 위한 신체활동 및 운동의 과학적 효과를 분석하였다. 추후 노인의 우울증 개선과 자살예방에 관한 다양한 연구들이 수행되어져야 할 것으로 여겨진다.

• 한국농림기상학회지
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• 제16권4호
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• pp.403-417
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• 2014

기상이변의 증가추세는 인류가 직면한 기후변화의 또 다른 속성이며 농업부문에서는 이미 심각한 재해로 이어지고 있다. 기상이변은 다양한 공간규모에 걸쳐 일어나지만 그 영향을 완화시킬 처방은 국지적인 규모에서만 가능하다. 따라서 기후변화 대응을 위한 조기경보체계는 반드시 '위치와 장소'를 기반으로 그곳의 영농정보를 바탕으로 할 때만 효율적이다. 기존 조기경보체계는 다양한 영농현장에 대한 구체적 위험을 알려주지 못하며, 농가의 개별적 상황이 대응조치에 반영되지 못하고, 악기상의 장기 누적효과에 의해 발생하는 '지발재해'나 둘 이상의 기상요소가 동시에 작용하는 '복합재해'에 대한 고려가 없다. 본 강좌에서는 선행연구들에 의해 확보된 '농가맞춤형 기상위험 관리기술'을 토대로, 필지단위 국지기상조건을 재배중인 작물의 종류와 발육단계에 맞춘 '재해위험지수'로 정량화하고, 이를 평년기준과 비교하여 재해발생 가능성을 판단하며, 적절한 대응방안과 함께 재배농가에게 일대일로 전달하는 '맞춤형 농업기상서비스' 구축에 관하여 논의한다. 이 서비스를 현업화하기 위한 1단계 4년의 조기경보체계 실증연구가 2014년에 시작되었고, 2017년까지는 남한 21개 대권역 가운데 하나인 유역면적 $4,914km^2$에 60,202호의 농가로 이루어진 섬진강권역을 대상으로 현업서비스를 구축하게 된다. 연구수행과정에서 얻어지는 경험은 2단계 전국 대상 사업으로 확대되어 기후변화와 기상이변 증가에 따른 농업부문 재해위험을 개별농가 차원에서 실질적으로 경감시키는 데 기여할 것이다. 금세기 농업분야 최대의 도전인 기후변화를 슬기롭게 극복하기 위해 '기후스마트농업'이 학계의 대안으로 자리 잡았지만, 국내 성공의 전제조건으로서 농업기상 조기경보체계의 지속적인 개발과 이를 토대로 한 맞춤형 농업기상서비스의 전국 확대가 필요하다.

• 한국학교ㆍ지역보건교육학회지
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• 제20권3호
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• pp.67-82
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• 2019

Objectives: The purpose of this study is to analyze how the different lifestyles between Koreans and Korean Americans have significant effects on their health. Despite being the same race, Koreans and Korean Americans have different health conditions and health attitudes due to the acquired environmental factors such as social-economic factors, lifestyle risk factors, healthcare systems, and medical utilization. It is crucial to examine how the different lifestyle habits between Koreans and Korean Americans lead to various health conditions for establishing an effective health promotion policy. Methods: In this study, a comparative analysis was conducted using the National Health and Nutrition Survey of Korea and CHIS data of the United States in 2005 and 2015 to provide valuable insights when establishing such a policy. Results: The specific research purpose is as follows: First, socioeconomic factors, such as (1)living habits risk factors, (2)health satisfaction levels, (3)disease outbreaks, and (4)medical uses, are analyzed to find the distinct characteristics among Koreans, Korean Americans, and Americans. Second, the three groups --Koreans, Korean Americans, and Americans-- were compared based on their exposure to disease-related lifestyle risk factors related to their body mass index and their general health condition. The research results are as follows: First, all three groups improved health conditions in 2015 better than in 2005. Koreans maintained relatively higher general health conditions compared to other groups: their prevalence rate of chronic diseases such as diabetes, high blood pressure, heart disease, and asthma was lower than that of U.S. residents. Second, in regards to health behavior factors, the lifetime smoking experience for Koreans and Americans both decreased in 2015 compared to 2005, while the lifetime smoking experience for Korean Americans increased slightly. The number of smokers for Koreans has greatly decreased over a decade while that of Americans has moderately increased. Third, according to the results of the multiple regression, the general health conditions, which is a dependent variable, suggests that the number of men who answered they are healthy is greater than that of women in Korea, compared to the United States. Conclusions: In conclusion, the acquired environmental factors had more significant impacts on health than the racial factors did. Compared to 2005, the health behaviors and health levels of Korean Americans in 2015 gradually became more similar to those of Americans.

• Journal of Chest Surgery
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• 제50권2호
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• pp.86-93
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• 2017

Background: The influence of lifestyle diseases on postoperative complications and long-term survival in patients with non-small cell lung cancer (NSCLC) is unclear. The aim of this study was to determine whether lifestyle diseases were significant risk factors of perioperative and long-term surgical outcomes in elderly patients with stage I NSCLC. Methods: Between December 1995 and November 2013, 110 patients aged 65 years or older who underwent surgical resection of stage I NSCLC at Dong-A University Hospital were retrospectively studied. We assessed the presence of the following lifestyle diseases as risk factors for postoperative complications and long-term mortality: diabetes, hypertension, chronic obstructive pulmonary disease, stroke, and ischemic heart disease. Results: The mean age of the patients was 71 years (range, 65 to 82 years). Forty-six patients (41.8%) had hypertension, making it the most common lifestyle disease, followed by diabetes (n=23, 20.9%). The in-hospital mortality rate was 0.9% (n=1). The 3-year and 5-year survival rates were 78% and 64%, respectively. Postoperative complications developed in 32 patients (29.1%), including 7 (6.4%) with prolonged air leakage, 6 (5.5%) with atrial fibrillation, 5 (4.5%) with delirium and atelectasis, and 3 (2.7%) with acute kidney injury and pneumonia. Univariate and multivariate analyses showed that the presence of a lifestyle disease was the only independent risk factor for postoperative complications. In survival analysis, univariate analysis showed that age, smoking, body mass index, extent of resection, and pathologic stage were associated with impaired survival. Multivariate analysis revealed that resection type (hazard ratio [HR], 2.20; 95% confidence interval [CI], 1.08 to 4.49; p=0.030) and pathologic stage (HR, 1.89; 95% CI, 1.02 to 3.49; p=0.043) had independent adverse impacts on survival. Conclusion: This study demonstrated that the presence of a lifestyle disease was a significant prognostic factor for postoperative complications, but not of survival, in elderly patients with stage I NSCLC. Therefore, postoperative complications may be influenced by the presence of a lifestyle disease.

• 한국도로학회논문집
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• 제14권2호
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• pp.145-155
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• 2012

현재 서울시는 대중교통 활성화 정책에 따라 버스전용차로제도를 실시하고 있다. 과거 가로변버스전용차로 설치를 시작으로 현재에는 중앙버스전용차로 설치구간도 증가하고 있다. 본 연구의 목적은 이 중앙버스전용차로와 가로변버스전용차로에서 버스사고에 영향을 미치는 요인을 분석하는데 있다. 분석방법으로 교통사고가 확률적으로 극히 드물게 일어난다는 점을 생각하여 포아송 회귀모형과 음이항 회귀모형을 선택하였으며, 과산포 존재여부에 따라 음이항 회귀모형으로 최종모형을 정립하였다. 중앙버스전용차로구간은 버스노선수, 중앙차로 진출입 유형수, 중앙차로 정지선 후퇴유무, 중앙차로 정지선과 횡단보도 이격거리, 교통량, 가변차로 정류장 정차노선수 6개의 변수에서 버스사고에 유의한 영향을 미치는 것으로 나타났다. 가로변버스전용 차로구간은 우회전 버스노선수, 상습 불법주정차 유무, 보행신호시간, 토지이용형태 4개의 변수에서 버스사고에 유의한 영향을 미치는 것으로 나타났다.

• 한국농림기상학회:학술대회논문집
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• 한국농림기상학회 2014년도 추계 학술발표논문집
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• pp.25-48
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• 2014

기상이변의 증가추세는 인류가 직면한 기후변화의 또 다른 속성이며 농업부문에서는 이미 심각한 재해로 이어지고 있다. 기상이변은 다양한 공간규모에 걸쳐 일어나지만 그 영향을 완화시킬 처방은 국지적인 규모에서만 가능하다. 따라서 기후변화 대응을 위한 조기경보체계는 반드시 '위치와 장소'를 기반으로 그곳의 영농정보를 바탕으로 할 때만 효율적이다. 기존 조기경보체계는 다양한 영농현장에 대한 구체적 위험을 알려주지 못하며, 농가의 개별적 상황이 대응조치에 반영되지 못하고, 악기상의 장기 누적효과에 의해 발생하는 '지발재해'나 둘 이상의 기상요소가 동시에 작용하는 '복합재해'에 대한 고려가 없다. 본 강좌에서는 선행연구들에 의해 확보된 '농가맞춤형 기상위험 관리기술'을 토대로, 필지단위 국지기상조건을 재배중인 작물의 종류와 발육단계에 맞춘 '재해위험지수'로 정량화하고, 이를 평년기준과 비교하여 재해발생 가능성을 판단하며, 적절한 대응방안과 함께 재배농가에게 일대일로 전달하는 '맞춤형 농업기상서비스' 구축에 관하여 논의한다. 이 서비스를 현업화하기 위한 1단계 4년의 조기경보체계 실증연구가 2014년에 시작되었고, 2017년까지는 남한 21개 대권역 가운데 하나인 유역면적 4,914km2에 60,202호의 농가로 이루어진 섬진강권역을 대상으로 현업서비스를 구축하게 된다. 연구수행과정에서 얻어지는 경험은 2단계 전국 대상 사업으로 확대되어 기후변화와 기상이변 증가에 따른 농업부문 재해위험을 개별농가 차원에서 실질적으로 경감시키는 데 기여할 것이다. 금세기 농업분야 최대의 도전인 기후변화를 슬기롭게 극복하기 위해 '기후스마트농업'이 학계의 대안으로 자리 잡았지만, 국내 성공의 전제조건으로서 농업기상 조기경보체계의 지속적인 개발과 이를 토대로 한 맞춤형 농업기상서비스의 전국 확대가 필요하다.