• Clinics in Shoulder and Elbow
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• 제25권1호
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• pp.5-14
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• 2022

Background: The purpose of this study was to verify the effect of protocatechuic acid (PCA) on tendon healing and fatty degeneration in a chronic rotator cuff model. Methods: Twenty-eight Sprague-Dawley male rats were randomly allocated into two groups: Saline+repair (SR) and PCA+repair (PR). The right shoulder was used for experimental interventions, and the left served as a control. PCA (30 mg/kg/day) was administered intraperitoneally at the site of infraspinatus tendon detachment in rats in the PR group, and the same volume of saline was administered to the same site in the SR group. The torn tendon was repaired 4 weeks after infraspinatus detachment. Four weeks after repair, hematoxylin and eosin (H&E), S100, and CD68 stains were performed to evaluate the degree of fatty degeneration and H&E and Masson trichrome stains were performed to assess tendon healing. Superoxide dismutase (SOD) was measured to test the efficacy of PCA as an antioxidant. Results: Results from histological evaluation indicated that SOD and CD68 levels at the musculotendinous region and collagen fiber parallel to the orientation at the tendon-to-bone junction were not significantly different between the SR and PR groups. The mean load-to-failure of the PR group (20.32±9.37 N) was higher than that of the SR group (16.44±6.90 N), although this difference was not statistically significant (p=0.395). The SOD activity in the operative side infraspinatus muscle of the PR group was higher than that of the SR group, but the difference was not statistically significant (p=0.053). Conclusions: The use of PCA could improve tendon healing and decrease fatty degeneration after rotator cuff repair.

• 동서간호학연구지
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• 제27권2호
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• pp.185-194
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• 2021

Purpose: This study aimed to investigate the effects of fatigue, anxiety, depression, and cognitive function on the quality of life of gastrointestinal cancer patients receiving chemotherapy. Methods: Data were collected from a total of 141 participants. The measurements used were Functional Assessment of Chronic Illness Therapy for fatigue (FACIT-F), Hospital Anxiety and Depression Scale (HADS) and Functional Assessment of Cancer Therapy for cognitive function (FACT-Cog). Results: Significant correlations were found among fatigue, anxiety, depression, cognitive function, and quality of life. The mean score of quality of life was 59.60 out of 108, and 68% of the variance in QOL was explained by fatigue, anxiety, depression, and cognitive function. Cognitive function was the most influential factor (β=.30), followed by anxiety (β=-.27), depression (β=-.24), and fatigue (β=-.18). We found that the better the cognitive function, the lower the anxiety and depression, and the lower the degree of fatigue, the higher the quality of life. Conclusion: A nursing program for managing the changes in fatigue, anxiety, depression, and cognitive function should be provided to enhance maintenance and the improvement of the quality of life for gastrointestinal cancer patients who receive chemotherapy.

• 디지털산업정보학회논문지
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• 제19권4호
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• pp.97-115
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• 2023

In South Korea, chronic kidney disease(CKD) impacts around 4.6 million adults, leading to a high reliance on hemodialysis. For effective dialysis, vascular access is crucial, with decisions about vascular surgeries often made during dialysis sessions. Anticipating these needs could improve dialysis quality and patient comfort. This study investigates the use of Artificial Intelligence(AI) to predict the timing of surgeries for dialysis vessels, an area not extensively researched. We've developed an AI algorithm using predictive maintenance methods, transitioning from machine learning to a more advanced deep learning approach with Long Short-Term Memory(LSTM) models. The algorithm processes variables such as venous pressure, blood flow, and patient age, demonstrating high effectiveness with metrics exceeding 0.91. By shortening the data collection intervals, a more refined model can be obtained. Implementing this AI in clinical practice could notably enhance patient experience and the quality of medical services in dialysis, marking a significant advancement in the treatment of CKD.

• 한국해양생명과학회지
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• 제9권1호
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• pp.1-8
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• 2024

Over the past decade, there has been global expansion in the advancement of underwater cleaning technology for ship hulls. This methodology ensures both diver safety and operational efficiency. However, recent attention has been drawn to the harmful effects of ship hull-cleaning wastewater on marine animals. It is anticipated that this wastewater may have various impacts on a wide range of organisms, potentially leading to populationand ecosystem-relevant alterations. This concern is especially significant when the wastewater affects functionally important species, such as aquaculture animals and habitat-forming species living in coastal regions, where underwater cleaning platforms are commonly established. Despite this, information on the ecotoxicological effects of this wastewater remains limited. In this mini review, we discuss the adverse effects of wastewater from in-water cleaning processes, as well as the current challenges and limitations in regulating and mitigating its potential toxicity. Overall, recent findings underscore the detrimental effects posed by sublethal levels of wastewater to the health status of aquatic animals under both acute and chronic exposure.

• Journal of Korean Neurosurgical Society
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• 제66권6호
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• pp.726-734
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• 2023

Objective : Chronic subdural hematoma (CSDH) patients using antithrombotic agents (AT) at high risk for cardiovascular disease are increasing. The authors aimed to analyze the factors influencing outcome by targeting patients using AT and to establish a desirable treatment strategy. Methods : A retrospective analysis was performed on data from 462 patients who underwent burr hole trephination (BHT) surgery for CSDH at five hospitals from March 2010 to June 2021. Outcomes included incidence of postoperative acute bleeding, recurrence rate, and morbidity or mortality rate. Patients were divided into the following four groups based on their history of AT use : no AT. Only antiplatelet agents (AP), only anticoagulants (AC), both of AP and AC. In addition, a concurrent literature review was conducted alongside our cohort study. Results : Of 462 patients, 119 (119/462, 25.76%) were using AT. AP prescription did not significantly delay surgery (p=0.318), but AC prescription led to a significant increase in the time interval from admission to operation (p=0.048). After BHT, AP or AC intake significantly increased the period required for an in-dwelling drain (p=0.026 and p=0.037). The use of AC was significantly related to acute bleeding (p=0.044), while the use of AP was not (p=0.808). Use of AP or AC had no significant effect on CSDH recurrence (p=0.517 and p=1.000) or reoperation (p=0.924 and p=1.000). Morbidity was not statistically correlated with use of either AP or AC (p=0.795 and p=0.557, respectively), and there was no significant correlation with mortality for use of these medications (p=0.470 and p=1.000). Conclusion : Elderly CSDH patients may benefit from maintenance of AT therapy during BHT due to reduced thromboembolic risk. However, the use of AC necessitates individualized due to potential postoperative bleeding. Careful post-operative monitoring could mitigate prognosis and recurrence impacts.

• 한국산림과학회지
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• 제85권1호
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• pp.84-95
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• 1996

최근 우리 나라 대도시와 공업지역의 환경오염은 주변 자연생태계의 만성적 피해에 대한 우려를 일으키고 있다. 본 연구는 오염지역 주변의 산림생태계내 물질유입과 환경오염이 토양환경의 변화에 미치는 영향을 구명하기 위하여 이루어졌다. 오염지역으로 서울, 울산, 여천 및 서산을 선정하였고 청정지역으로 평창을 선정하여 이들 지역의 산림에 유입되는 대기강하물을 강우와 임내우(수관통과수, 수간수)를 통하여 측정하였고 각 지역 토양의 화학적 특성을 조사하여 비교하였다. 대도시와 공업지역의 평균 강우 pH는 4.5에서 5.5사이에 분포하여 산악지역의 pH 5.8에 비하여 낮은 수준에 머물렀다. 강우 는 임분을 통과하면서 이온농도가 최고 4배까지 증가했으며 대도시와 공업지역에서 임내우 이온농도가 현저하게 증가한 것으로 나다났다. 임내우에서 나타난 물질유입 총량도 대도시와 공업지역이 산악지역에 비하여 2-3배 정도 높았다. 산성강하물의 영향으로 토양산성화가 진행되는 과정에서 가장 많은 영향을 받은 것으로 보이는 대도시의 토양은 산악지역에 비하여 pH 1정도 낮은 것으로 나타났다. 토양의 양이온 함량은 대도시와 공업지역에서 높게 나타나 양이온 유실은 심하게 이루어지지 않은 것으로 보이지만 산성물질 유입에 의한 토양산성화의 진행은 계속되고 있는 것으로 보인다. 대도시와 공업지대에서 배출되는 오염물질에 의해 주변 산림생태계내 물질유입과 토양환경의 변화가 관측되었으며 앞으로의 생태계의 변화 과정과 식물생육에 미치는 영향은 계속적인 연구를 통하여 밝혀져야할 과제이다.

• Tuberculosis and Respiratory Diseases
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• 제61권2호
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• pp.121-128
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• 2006

연구배경: 만성폐질환 환자에서 삶의 질을 측정하는 도구로서 세인트조지 호흡기 설문(St George's Respiratory Questionnaire;SGRQ)이 개발되어 치료효과를 판정하는 측정지표로 널리 사용되고 있으나 영어권국가에서 만들어 졌기 때문에 우리나라에서 동일하게 사용하는데 제한점을 가지고 있다. 따라서 이의 정확한 적용을 위해서 언어, 기술, 개념적인 관점을 고려하여 한국어 설문지를 만들고 이들의 타당도와 신뢰도를 평가하였다. 방 법: 한국판 세인트조지 호흡기 설문은 번역, 역번역, 전문가 패널의 수정을 통해 완성되었고, 세브란스병원 호흡기내과를 방문한 환자를 대상으로 하여 이 설문을 시행하였다. 신뢰도 검정은 Cronbach's $\alpha$를 구하여 측정하였고 타당도는 폐기능검사, 6분보행검사, 호흡곤란지수와 산소포화도 검사를 동시에 시행하여 설문 검사결과와의 상관관계를 알아보았다. 결 과: 74명의 환자를 대상으로 시행하였으며, 남녀 비는 2.2:1, 평균연령은 $63.8{\pm}10.3$세였다. 이 중 천식환자는 27명(36.5%), 만성폐쇄성폐질환 환자는 39명 (52.7%)이었고, 결핵에 의한 파괴 폐환자는 8명(10.8%)이었다. Cronbach's ${\alpha}$ 값은 증상영역, 활동영역, 영향영역 및 총 점수에서 각각 0.63, 0.87, 0.89, 0.92 이였다. 총점수와 $FEV_1$, FVC, 6분보행거리, 산소포화도, 호흡곤란지수와 유의한 상관관계를 보였다. 결 론: 한국어판 세인트조지 호흡기 설문은 만성폐질환 및 천식과 같은 만성폐질환 환자에서 신뢰도가 높았고 총점수와의 상관관계는 6분보행검사 및 산소포화도에서 높음을 알수 있었고 폐기능 검사와의 상관계수는 원저인 세인트조지 호흡기설문 및 타 국가의 번역본 호흡기설문에서와 같이 높지 않음을 알 수 있었다. 따라서 우리나라에서도 호흡기질환의 삶의 질에 대한 치료효과 판정에 활용할 수 있을 것으로 기대된다.

• 생명과학회지
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• 제33권12호
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• pp.1046-1051
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• 2023

본 연구의 목적은 개인의 흡연여부와 다양한 사회경제적 변수 간 영향관계가 성별과 장애여부에 따라 구분된 하위집단에서 차별적으로 나타나는지를 확인하는데 있다. 특히 본 연구는 일반인의 흡연 여부가 아니라 장애인을 대상으로 흡연의 여부가 장애인의 건강에 미치는 영향을 분석한 연구로 연구의 의의가 있다고 볼 수 있다. 본 연구에서는 장애인의 흡연율과 흡연 요인을 분석하는데 목적이 있다. WHO에 따르면 담배로 인한 사망자는 매년 600만명에 이른다. 담배는 심혈관질환, 폐질환, 암 등 비전염성질환과 조기 사망에 매우 강한 인과관계를 갖는 것으로 알려져 있다. UN이 제시한 지속가능 발전목표(Sustainable Development Goals, 이하 SDGs)는 건강한 삶의 보장과 모든 세대의 복지 증진(Ensure healthy lives and promote well-being for all at all ages)을 위해 WHO의 담배규제기본협약(Framework Convention on Tobacco Control)을 이행할 것을 요구하고 있다. 이것은 흡연의 모든 과정에서 발생하는 다양한 위협요인이 흡연자뿐만 아니라 경제, 사회, 환경 등 다양한 영역에서 다차원적으로 작용하는 위협하기 때문이다. 본 연구목적의 달성을 위해 본 연구는 2013년 국민건강영양조사를 활용하여 흡연과 선행연구에서 확인된 흡연 영향요인 간 인과관계를 확인하였다. 본 연구를 위하여 특히 성별과 장애여부에 따라 구분된 4개의 하위집단을 독립적 모형으로 하여 분석하였으며 흡연여부를 종속변수로 하는 로지스틱회귀분석을 활용하였다. 본 연구 분석결과 독립변수의 영향력 여부는 성별과 장애유무에 따라 구분된 각 집단별로 뚜렷한 차이를 나타내는 것이 확인되었다. 상대적으로 비장애집단에서 독립변수의 영향이 유의한 반면 장애집단에서는 유의성이 상실되는 경향을 보였으며 이 같은 경향은 특히 장애여성집단에서 더욱 명백하게 확인되었다. 분석결과를 기반으로 장애집단의 특성을 고려하지 않은 기존의 선행연구가 가진 설명의 한계를 확인하였으며 장애의 물리적·심리적 특수성을 충분히 고려한 연구모형을 통해 흡연과의 상관관계를 재분석해야 함을 함의로 제시하였다. 추후 장애인의 건강한 삶의 질을 개선하기 위하여 건강증진 영향들을 분석한 이후 건강증진에 기여할 수 있는 대표적인 변인들을 고려하여 적용하는 다양한 연구들이 수행되어져야 할 것으로 여겨진다.

• 한국도서관정보학회지
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• 제20권
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• pp.317-349
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• 1993

The purpose of this study lies in identifying Korean scientists' dependency on foreign scientific and technical information (STI), with emphasis on investigating the causes and results. Especially, this study intends to investigate the impacts that a growing dependency on foreign STI might have brought and will bring about on the development of indigenous STI in ROK. To the end, the present discussion covers the following specific research questions: 1) what are the major information sources used by Korean scientists to locate STI necessary for research-related activities\ulcorner 2) to what extent do Korean scientists use foreign STI for research-related activates, as compared to the use of domestic STI\ulcorner 3) what are the major factors causing the information dependency among Korean scientists and what are the results of the growing information dependency\ulcorner And finally, 4) what suggestions can be made for ROK to further its indigenous STI development, while minimizing its dependency on foreign STI\ulcorner Survey method, together with citation analysis method, is employed as the major data collection technique. The survey sample consists of 167 most 'representative' Korean scientists selected on the basis of their research productivity. 167 specially-designed questionnaires were mailed and 104 out of 167 were responded. Follow-up interviews were carried out for 32 out of 104 respondents, who returned the questionnaire but did not answer some specific questions. The data collected from these 104 respondents were analyzed on the basis of two distinguished groups namely, junior and senior scientist groups. Among the 104 respondents, 58 a n.0, ppeared to belong to a group of senior scientists (older than age 45 and finished their final degrees since 1980), and 46 belonged to a group of junior scientists (younger than age 45 and finished their final degrees before 1980). The major findings of the present study include: 1) Korean scientists regard 'scientific and technical journals and books'as the most important information source to obtain the recent STI; 2) their dependency on foreign STI, for the purposes of research and teaching, is extremely high (information dependency for research activities is 88.5%, and that for teaching activities 91.2%); 3) the information dependency of junior scientists are higher than that of senior scientists; 4) Korean scientists' growing information dependency is closely related to both small quantity and low quality of domestically-produced STI, and has a statistically significant relationship with their educational background; and finally, 5) in order to theoretically explain the growing information dependency of Korean scientists, a hypothesis - 'chronic cycle of information dependency' was developed and introduced. The present study suggests the promotion of indigenous STI as a desirable alternative to escape from the 'chronic cycle of information dependency. Localization of the imported foreign STI is suggested as a good strategy for the indigenous STI development, and also suggested are STI policies for both success of localization process and promotion of more efficient STI flows at national and international level.

• 한국습지학회지
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• 제9권1호
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• pp.79-89
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• 2007

This paper provides a comprehensive overview of the present status of several environmental problems caused by emerging toxic substances such as persistent organic pollutants (POPs), endocrine disrupting chemicals (EDCs), and arsenic in various environmental media in Vietnam. Monitoring data reported during the 1990s demonstrated elevated contamination of DDTs in most of these compartments in Vietnam. Studies in frame of the Asia-Pacific Mussel Watch Program revealed that fish, mussels and resident birds from Vietnam contained higher concentrations of DDTs as compared to other countries in region, suggesting the role of Vietnamese environment as a significant emission source of DDT in the Southeast Asian region. The estimated dietary intakes of PCBs and DDTs for Vietnamese were relatively high among Asian developing countries, suggesting potential risk for humans posed by thesechemicals. Widespread contamination of some endocrine active compounds such as alkylphenols and phthalates was observed at various sites along the coasts of northern and middle Vietnam. The presence of significant source of bisphenol-A along Red River estuary was revealed with the concentrations comparable to those reported for developed nations. A case study on seasonal variation of alkylphenols and phthalates in surface water of river delta and estuary of north and middle Vietnam indicated the differences in distribution of these compounds between dry and rainy seasons. Higher concentrations of alkylphenols and phthalates were found in dry season in estuary; while the contrasting pattern was observed in the river delta, showing elevated residues in rainy season. This result suggests the different behavior of alkylphenols and phthalates in river delta and coastal environment. From ecotoxicological perspectives, concentrations of bis-phenol A and di(2-ethylhexyl)phthalates [DEHP] in surface water from some locations in Vietnam exceeded the guideline values for Ecotoxicological Effects and the Environmental Risk Limit, respectively, suggesting potential for toxic implications on aquatic wildlife. Widespread and elevated arsenic contamination was discovered inour recent surveys in groundwater in a large area of suburban areas of Hanoi city, the capital of Vietnam. The most recent investigation in 4 villages showed about more than 50 % of groundwater samples contained As concentrations exceeding 50 g/L (the WHO and Vietnamese standard). In particular, in Son Dong villages, 58 % of samples analyzed contained As concentrations higher than 200 g/L. Good correlations were found in As concentrations in water and hair and urine of peoples in corresponding families, suggesting the chronic exposure to As by people living in As-contaminated ground water areas. In Son Dong village, As levels in hair (mean: 1.7 mg/kg dry wt) and urine (g/g creatinine) exceeding the reference values recommended by WHO, suggesting potential for human risk posed by long term accumulation of As in human body. Future studies should be focused on the time trends of POPs and EDCs in biota in Vietnam in order to predict future trend of contamination and to reveal new clues for understanding possible toxic impacts on aquatic organisms. The issues of arsenic contamination in groundwater and their chronic toxic implications on human health should be systematically investigated in the future.