• 한국한의학연구원논문집
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• 제13권1호통권19호
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• pp.1-17
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• 2007

Dang jonghae had written five books on chinese medicine, ${\ulcorner}$Hyeoljeungron${\lrcorner}$ is his most important work. He wanted to correct the fallacies of the theory of Jang and Bu by comparing with Oriental and Western medicine. He distinguished Bi from Cheomyuk by comparing the spleen with the pancreas. He recognized Stomach as the warehouse of foods, and explained that Bi took charge of digestion actually. Bi charged the function of Transportation and Blood-govering in addition to plain digestion, he wrote. Dang jonghae regarded the metabolism of the human body as the interaction of Gi, Blood, Water and Fire. And he explained that Bi adjusted them. He classified Syndrome of Blood into five sorts of syndrome and presented four kinds of treatment. Especially he took a serious view of the treatment connected with Bi and Stomach. He set up the theory of Bi and Stomach practically on basis of anatomy, but he didn ' t assorted the physiology and pathology of each organ clearly. However he proved the importance of Bi and Stomach by treating Syndrome of Blood and provided with the foundation of merging chinese and western medicine.

• 대한예방한의학회지
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• 제24권2호
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• pp.1-15
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• 2020

Objectives : The objectives of this study were to investigate why and how China used traditional Chinese medicine as a response to COVID-19 and how its performance was achieved, and to explore ways to utilize traditional Korean medicine in Korea. Methods : We examined the information through government data and media articles. China's COVID-19 progress and policy response were reviewed and compared with Korea. Based on this, the characteristics of traditional Chinese medicine response in China were identified. Results : Based on legal basis, China makes the overall use of traditional Chinese medicines to respond to COVID-19. Traditional Chinese medicine has been applied to health insurance, the licensing regulations have been eased, and traditional Chinese medical specialists were dispatched. The medical care guidelines were developed and R&D were carried out. In addition, policies related to traditional Chinese medicine included policies for preventive treatment, the combination of Chinese and Western medicine, and telemedicine. Conclusions : Traditional Chinese medicine response to COVID-19 was included within the overall national quarantine policy, providing medical services for the mild stage. In addition, R&D was conducted to establish a basis for the utilization of traditional Chinese medicines. Traditional Korean medicine also needs to be prepared so that it can be used as a complement to the response of communicable diseases.

• 대한한방소아과학회지
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• 제21권1호
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• pp.1-9
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• 2007

Objectives : The purpose of this study is to investigate oriental medical treatment of pediatric bronchial asthma. Method : Chinese medical journals which is about pediatric bronchial asthma were analyzed for a reference. Result : Oriental medical treatment can be classified into three ways; internal treatment, external treatment, and combination treatment which means combining with Chinese and Western ways of treatments. Conclusion : Oriental medical treatment of pediatric bronchial asthma is more effective therapy than Western's.

• Journal of Ginseng Research
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• 제47권1호
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• pp.133-143
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• 2023

Background: Past studies suggested that ginseng extracts and ginseng-derived molecules exerted significant regulatory effects on skin. However, no reports have described the effects of ginseng-derived nanoparticles (GDNPs) on skin cell proliferation and wound healing. In this study, we investigated whether GDNPs regulate the proliferation of skin cells and promote wound healing in a mouse model. Methods: GDNPs were separated and purified via differential centrifugation and sucrose/D2O gradient ultracentrifugation. GDNP uptake, cell proliferation and cell cycle progression were measured by confocal microscopy, CCK-8 assay and flow cytometry, respectively. Cell migration and angiogenic effects were assessed by the wound scratch assay and tube formation assay, respectively. ELISA was used to detect extracellular matrix secretion. The relevant signaling pathway was confirmed by western blotting. The effects of GDNPs on skin wound healing were assessed by wound observation, HE staining, and western blotting. Results: GDNPs possessed the essential features of exosomes, and they were accumulated by skin cells. Treatment with GDNPs notably enhanced the proliferation of HaCaT, BJ and HUVECs. GDNPs also enhanced the migration in HaCaT cells and HUVECs and angiogenesis in HUVECs. GDNPs increased the secretion of MMP-1, fibronectin-1, elastin-1, and COL1A1 in all three cell lines. GDNPs regulated cell proliferation through the ERK and AKT/ mTOR pathways. Furthermore, GDNPs facilitated skin wound healing and decreased inflammation in a mouse skin wound model. Conclusion: GDNPs can promote skin wound healing through the ERK and AKT/mTOR pathways. GDNPs thus represent an alternative treatment for chronic skin wounds.

• 동의신경정신과학회지
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• 제16권1호
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• pp.193-200
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• 2005

Objective : This study was carried out to investigate the differences of mental illness between Korea and China in oriental medicine Method : Several main texts in oriental medicine and articles related with topic were collected and inquired. Result : There are some differences of mental illness between Korea and China in oriental medicine. Brain is more important than heart in psychophysiology of chinese medicine, and blood stasis is a main pathologic factor of mental illness. They use not only Ohaeng(five elements) theory, but also Yin-yang theory in oriental psychotherapy. Conclusion : It seems that materialism and western medicine had some influences on modern chinese medicine. On the other hand, There are respect for traditional theory and creativity in Korean medicine represented by Dongeuibogam(東醫寶鑑) and Sasang constitutional medicine.

• Advances in nano research
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• 제12권5호
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• pp.501-514
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• 2022

This study aimed to investigate the effects and potential mechanisms of Chikusetsusaponin V (CsV) on endothelial nitric oxide synthase (eNOS) and vascular endothelial cell functions. Different concentrations of CsV were added to animal models, bovine aorta endothelial cells (BAECs) and human umbilical vein endothelial cells (HUVECs) cultured in vitro. qPCR, Western blotting (WB), and B ultrasound were performed to explore the effects of CsV on mouse endothelial cell functions, vascular stiffness and cellular eNOS mRNA, protein expression and NO release. Bioinformatics analysis, network pharmacology, molecular docking and protein mass spectrometry analysis were conducted to jointly predict the upstream transcription factors of eNOS. Furthermore, pulldown and ChIP and dual luciferase assays were employed for subsequent verification. At the presence or absence of CsV stimulation, either overexpression or knockdown of purine rich element binding protein A (PURA) was conducted, and PCR assay was employed to detect PURA and eNOS mRNA expressions, Western blot was used to detect PURA and eNOS protein expressions, cell NO release and serum NO levels. Tube formation experiment was conducted to detect the tube forming capability of HUVECs cells. The animal vasodilation function test detected the vasodilation functions. Ultrasonic detection was performed to determine the mouse aortic arch pulse wave velocity to identify aortic stiffness. CsV stimulus on bovine aortic cells revealed that CsV could upregulate eNOS protein levels in vascular endothelial cells in a concentration and time dependent manner. The expression levels of eNOS mRNA and phosphorylation sites Ser1177, Ser633 and Thr495 increased significantly after CsV stimulation. Meanwhile, CsV could also enhance the tube forming capability of HUVECs cells. Following the mice were gavaged using CsV, the eNOS protein level of mouse aortic endothelial cells was upregulated in a concentration- and time-dependent manner, and serum NO release and vasodilation ability were simultaneously elevated whereas arterial stiffness was alleviated. The pulldown, ChIP and dual luciferase assays demonstrated that PURA could bind to the eNOS promoter and facilitate the transcription of eNOS. Under the conditions of presence or absence of CsV stimulation, overexpression or knockdown of PURA indicated that the effect of CsV on vascular endothelial function and eNOS was weakened following PURA gene silence, whereas overexpression of PURA gene could enhance the effect of CsV upregulating eNOS expression. CsV could promote NO release from endothelial cells by upregulating the expression of PURA/eNOS pathway, improve endothelial cell functions, enhance vasodilation capability, and alleviate vessel stiffness. The present study plays a role in offering a theoretical basis for the development and application of CsV in vascular function improvement, and it also provides a more comprehensive understanding of the pharmacodynamics of CsV.

• 대한한방부인과학회지
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• 제27권4호
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• pp.43-56
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• 2014

Objectives: The purpose of this study is to review the trend of chinese clinical studies of herbal treatment for infertility caused by Polycystic Ovary Syndrome (PCOS). Methods: We searched the clinical studies published from 1979 to 2013 through CAJ (Chinese Academic Journal) with keywords of "PCOS and 不孕" or "多囊卵 巢綜合證 and 不孕". We analyzed the intervention type of clinical studies. In addition, We researched randomized controlled trials (RCTs) published from 2009 to 2013, assessed the quality of RCTs using the Jadad Scale and reanalyzed the intervention type of RCTs. Results: One hundred and seventeen clinical studies were finally selected. Clinical studies of herbal treatment for infertility caused by PCOS increased remarkably after the 2000s in China. Combined herbal medicine and western medicine was used the most frequently. RCTs published from 2009 to 2013 were fifty. Average of Jadad score of RCTs was 1.2. Combined herbal medicine and western medicine was also the most frequently used as intervention in RCTs. Conclusions: Clinical studies on effect of combined herbal medicine and western medicine for infertility caused by PCOS were mostly published in China. But Quality of studies was generally low. Further research on effect of herbal treatment for infertility caused by PCOS is needed.

• 동의신경정신과학회지
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• 제24권4호
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• pp.343-352
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• 2013

Objectives: This study was performed to review the research trends in treatment for REM sleep behavior disorder (RBD) in Traditional Chinese Medicine (TCM) and Kampo in Japan. Methods: We searched articles in CNKI (China National Knowledge Infrastructure) under the key words, "RBD", and Chinese words related with it in Traditional Chinese Medicine, Traditional Chinese Medicinal Herbs and Combination of Traditional Chinese Medicine With Western Medicine' field, and also in CiNii (Citation Information by NII); we also searched articles in Kampo Square in Japan under the key words, "RBD" and Japanese words related with it. We found 10 papers, and then selected 6 of them except the non-clinical and unrelated studies. We then analyzed their way of diagnosis, treatments, study type and etc.. Results: 6 studies were divided into 4 case reports, one control study, and one literature review study. All of the studies reported that Herbal medicine for RBD was effective as much as Western medicine like clonazepam and paroxetine. However, the quality and the quantity of these clinical studies were not enough. Conclusions: It seems that the researches for RBD have gradually been performed in TCM and Kampo. We hope that our study can activate/push forward clinical research for this disorder in Korean traditional medicine.

• 동의생리병리학회지
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• 제18권2호
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• pp.359-370
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• 2004

Before the current western medicine was spreaded out in the world as the main stream, each country had treated diseases with the medicine of their own and the traditional medical books, which are so characteristic, are handed down. Considering the earnest assignment to do in Korean medical of this age and one of the tendencies of medical circles in the world is putting together the current medicine with the traditional medicine, the production and spread of the classification system for the technical books which is contained the characteristic of traditional chinese medicine, the present condition of modern chinese medicine, and the future of it, must be settled without delay. The classification system for oriental medicine section developed in the range of the simple system before the time of flowering, since then the western medicine had grew as the main current in medicine in Korea. But until now the rational and realistic classification system based on the changeable time isn't be established, so setting up one of the classification systems for medicine section, it is classified according to the principle of classification system for medicine section. Hereupon, the result was made after researching the changes of modern classification system for korean and studying on the changes of classification system for oriental medicine section of the Korean decimal classification.

• 셀메드
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• 제2권1호
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• pp.5.1-5.3
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• 2012