• Asian Journal of Atmospheric Environment
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• v.9 no.4
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• pp.280-287
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• 2015

The high time-resolution monitoring data are essential to estimate rapid changes in chemical compositions, concentrations, formation mechanisms, and likely sources of atmospheric particulate matter (PM). In this study, $PM_{2.5}$ sulfate, $PM_{2.5}$, $PM_{10}$, and the number concentration of size-resolved PMs were monitored in Fukuoka, Japan by good time-resolved methods during the springtime. The highest monthly average $PM_{2.5}$ sulfate was found in May ($8.85{\mu}g\;m^{-3}$), followed by April ($8.36{\mu}g\;m^{-3}$), March ($8.13{\mu}g\;m^{-3}$), and June ($7.22{\mu}g\;m^{-3}$). The cases exceed the Japanese central government's safety standard for $PM_{2.5}$ ($35{\mu}g\;m^{-3}$) reached 10.11% during four months campaign. The fraction of $PM_{2.5}$ sulfate to $PM_{2.5}$ varied from 12.05% to 68.11% with average value of 35.49% throughout the entire period of monitoring. This high proportion of sulfate in $PM_{2.5}$ is an obvious characteristic of the ambient $PM_{2.5}$ in Fukuoka during the springtime. However, the average fraction of $PM_{2.5}$ sulfate to $PM_{2.5}$ in three rain events occurred during our intensive campaign fell right down to 15.53%. Unusually high $PM_{2.5}$ sulfate (> $30{\mu}g\;m^{-3}$) marked on three days were probably affected by the air parcels coming from the Chinese continent, the natural sulfur in the remote marine atmosphere, and a large number of ships sailing on the nearby sea. The theoretical number concentration of $(NH_4)_2SO_4$ in $PM_{0.5-0.3}$ was originally calculated and then compared to $PM_{2.5}$ sulfate. A close resemblance between the diurnal variations of the theoretically calculated number concentration of $(NH_4)_2SO_4$ in $PM_{0.5-0.3}$ and $PM_{2.5}$ sulfate concentration indicates that the secondary formed $(NH_4)_2SO_4$ was the primary form of sulfate in $PM_{2.5}$ during our monitoring period.

• The Journal of Korean Medicine
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• v.35 no.1
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• pp.157-170
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• 2014

Objectives: The purpose of this study was to develop a standard instrument of diagnosis and assessment for spleen qi deficiency pattern. Methods: Reports published in Korea and China related to spleen qi deficiency pattern were selected. Assessments of selected references were performed to select major symptoms of spleen qi deficiency pattern. Korean translation and review by a Korean linguist were performed to create a draft of [Standard instrument of diagnosis and assessment for spleen qi deficiency (for subject)]. The final [Standard instrument of diagnosis and assessment for spleen qi deficiency (for subject)] was completed after assessment on inclusion or exclusion, on importance of items and on validity of translation by an expert committee, consisting of professors from the National College of Korean Medicine. Results & Conclusions: 1. 14 major symptoms were selected by frequency from 45 references which were related to standard identification of spleen qi deficiency pattern, translated into Korean and reviewed by a Korean linguist. 2. 11 symptoms were selected after assessment on inclusion yes or no by the expert group. Items were listed in order of importance: tiredness of extremities (肢体倦怠), sallow complexion (面色萎黃), reduced appetite (食欲减退), abdominal distension after eating (腹胀食後尤甚), inability to eat (納少), pale tongue and white fur (舌淡苔白), lethargy (神疲), emaciation (消瘦), loose stool (大便溏薄), shortness of breath and reluctance to speak (少氣懶言), and weak pulse (脈緩弱). 3. Final [Standard instrument of diagnosis and assessment for spleen qi deficiency (for subject)] was completed after assessment of translation validity, reflection of individual opinions by the expert committee, and application of weighted value computed from assessment on importance of items.

• Journal of Physiology & Pathology in Korean Medicine
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• v.26 no.3
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• pp.320-324
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• 2012

Osteoporosis is an important public health issue in postmenopausal women. It is a major public health concern and is widely believed that osteoporosis results from imbalance between bone resorption and bone formation. Recently natural products from plants have been extensively studied as therapeutic drugs to treat and prevent various diseases. Hoelen (scientific name, Poria cocos) is a mushroom that is used in traditional Chinese medicine. Hoelen exhibits anti-inflammatory activity and has a protective effect on tumor progression. However, the effect of hoelen in osteoclast differentiation remains unknown. Thus, we examined the effect of hoelen in receptor activator of nuclear factor-${\kappa}B$ ligand (RANKL)-induced osteoclast differentiation. Hoelen significantly inhibited RANKL-induced osteoclast differentiation in bone marrow-derived macrophages (BMMs) in dose dependent manner without toxicity. Also, we showed that hoelen significantly inhibited the mRNA expression of tartrate-resistant acid phophatase (TRAP) and nuclear factor of activated T cells 1 (NFATc1) in BMMs treated with RANKL. In Particular, hoelen greatly inhibited the protein expression of NFATc1. Ectopic expression of NFATc1 partially reverses hoelen-mediated inhibition of osteoclast differentiation. Taken together, our results demonstrated that hoelen may be useful treatment option of bone-related disease such as osteoporosis, reumatoid arthritis, and periodontitis.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.16 no.3
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• pp.39-46
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• 2016

For several decades, Korean corporations have achieved remarkable success in the world market pursuing a quantitative growing strategy by benchmarking developed countries such as the United States, Japan and European Union. Recently, however, since not only the world economy enters into low growth age of New Normal, but the continuously increasing pressure of emerging countries like China and India, the global position of Korean corporations has ruffled. For these reason, the purpose of the study based on searching the strategy for Korean corporations to promote sustainable growth while gaining a competitive advantage in the world market. The study uses two analytical tools, Porter's Diamond Model and Productivity Frontier by analyzing the smart phone industry where Korea, the United States and China are competing desperately. The study is aimed at analyzing and comparing the global competitiveness among Apple as a leader, Samsung Electronics as a follower and Chinese corporations as newcomers in the smart phone industry. Based on the analysis and comparison, the study focuses on searching the strategic decision of Samsung Electronics, and suggests the future strategic positioning of major corporations in different industries in the world market.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.3
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• pp.540-547
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• 2009

There needs disease-predictable signs in order to enable preventive diagnosis and therapy. Then traditional Chinese medicine applies various medical diagnostic equipments used in western medicine to diagnosing sub-healthy state. But such data are not originated from inherent oriental medicine, and not obtained easily in ordinary clinical practice. This paper is to provide synopsis of the ante-disease diagno-therapeutics partly and to show predictable data based on the facial shapes and signs, especially of gall bladder's versus bladder's body and masculine versus feminine shape. Ante-disease means not only the complete healthy state, but also the state unseen any symptoms in macrographically in the course of outbreak of disease. It contains two stages, first one is the former state of disease and second one is untransmitted state of disease. The patterns of ante-disease consist of latent disease, pre-disease, transmission type like senescent syndrome, abnormal reactive syndrome(變證), syndrome of transmission and transmutation. The classification with gall bladder and bladder type manifests the differences of shape, color and size of each organ in comparison of the universal and standard figures of the human being. On the other hand, the classification with masculine and feminine shape contrasts the innate sexual difference and the shape, characteristics originated from in itself. These two classification theories have their own pathologic types and syndrome types with each disease so that disease-predictable data can be constructed based on such a relationship. In addition, this diagnostic method by facial shapes and signs is able to be applied to whole stages from prenatal to present state of disease even if the cause and inducement are not clear. Ante-disease diagno-theraputic system by Gall Bladder's versus Bladder's Body and Masculine versus Feminine Shape is getting more important in the chronic and internal disease in comparison of the acute and traumatic disease. So this study is able to make up for the limit of diagnosis on ante-disease in the field of oriental medicine clinic.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.5
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• pp.1062-1070
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• 2008

The human body and nature respond to each other. The change of nature influences to directly human body. One of the change is the weather change. and there is order in the change. The order is twelve months. To explain the weather change of the cold, hot. dry and wet. we can use Four seasons, The twenty-four seasons, or The twelve month. To explain the five elements of the chinese cosmogony, The four season is useful, and the change of weather, the twenty-four seasons is good. But, the viscera is explained by the ten celestial stems and the twelve horary sings. Thus the twelve horary sings is most useful to explain, because one year is composed by twelve months. The twelve season and fancy of the ten celestial stems is explained fully by Diao-hou-yong-shen. Diao-hou-yong-shen is expressed by the zodiac signs, and explained by the disposition of the zodiac sings. In addition to the oriental medical science is also explained and expressed by the zodiac signs. Therefore, I think that the change of viscera, according to weather, is based on the Diao-hou-yong-shen, and I get some results. In the acting of viscera, there are some relationship between organs. The relationship is not influenced directly by the weather of four seasons, unless there are some special details. If the energy of the month, which rules one specific organ, is weak, doctor should fill up the organ. If not, the organ tends to get sick. According to the full or weak of the five elements which is under the month, the useless or harmful elements should be taken off, and useful and needful elements should be serviced. The balance between cold, hot, dry and wet should be maintained. However, the fancy of the viscera is very different. So, doctor should be careful to maintain balance. The full and weak between Yin and Yang should be considered when doctor think about cold and hot in the month.

• Food Science and Preservation
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• v.12 no.1
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• pp.80-85
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• 2005

The effect of 12 edible mushroom species on the antioxidant and cytotoxicity on cancer cells were studied Methanol extract of Lyophyllum ulmarium, Cordyceps militaris and Sarcodon aspratus showed $30\~60\%$ DPPH radical scavenging activity and $39\~53\%$ protective effects against the cytotoxicity of $B_2O_2$. Methanol extracts of Sarcodon aspratus, Lyophyllum ulmarium, Cordyceps militaris, Agaricus blazei and Ganoderma lucidum revealed high inhibitive activities in cytotoxicity on human leukemia tells such as promyelocytic leukemia cell (HL60) and histiocytic lymphoma cell (U937). Highest toxicity was observed against HL60 cells in Sarcodon aspratus methanol extract showing $70.5\%$ inhibition at 1mg/mL whereas Cordyceps militaris methanol extract showed $81.5\%$ inhibition against U937 cells. Most water extracts of edible mushrooms exhibited the lowest effect against HL60 and U937 cells compared to methanol extract. These extract did not show cytotoxic effects against human lymphocyte. Results revealed 5 kinds of edible murshroom (Cordyceps militaris, Agaricus blaxei, Lyophyllum ulmarium, Ganoderma lucidum and Sarcodon aspratus) have strong antioxidative and in vitro anticancer efforts.

• Journal of Ginseng Research
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• v.24 no.2
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• pp.99-105
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• 2000

Ginsenf Radix (Panax ginseng C. A. Meyer) has been traditionally used as a herbal medicine for many therapeutic or prophylactic purposes in the oriental countries such as Korea, Japan and China for at least two thousand years and also extensively studied in the modern scientific field of chemistry, biochemistry and pharmacology. The herb is now also indicated for use as tonic or a prophylactic and restorative agent for enhancement of mental and physical capacities, in case of weahess exhaustion tiredness loss of concentration, impotence, cold limbs, during illiness anuor convalescence. Ginseng is commonly used in the form of detections, extract and powderl and ginseng products, in the form of capsules tablets and drinks. And also ginseng radix has been widely traditionally prescribed as an important comuonents of manny Chinese prescriptions or alone in various diseases and for health with its different dosages. Nowadays since rinsenf can be generally classified into food or medicine in many nations, it is very difficult to give any exact desnition on the dosage, which may be of particular importance in clinical applications. In addition, the establishment of the reasonable dosage is currently of great significance to meet the demand for such wide applications. Accordingly in this review paper we summarized the dosage of ginseng on the basis of oriental medical books oriental and western pharmacopeias and modern scientific clinical data. The recent survey demonstrated that the averare dosare of finsenf is considered to be three to four grams per day unless prescribed apart, while one to two grams per day in western countries from the western viewpoint of classification of ginseng as a medicine, surrorted by the dosage of not more than one gram per day in most clinical studies. For that reason, it seems likely that the dosage in western countries is ascribed to the safety of ginseng considering side or unwanted effects. Consequently whether the differences of dosage between oriental and western countries depend on dietary habits and races should be closely investigated. Besides, further studies on the pharmacokinetics and bioavailability of ginseng components in clinical trials need to be done to decide optimum dosage of ginseng.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.18 no.4
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• pp.191-203
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• 2018

Identify the effects of ISO quality management system on the durability of the enterprise by applying it to early startups and small - and medium-sized enterprises. In particular, the quality management system of a technology start-up small and medium sized companies is important in applying the management system to the financial, management and quality control services rather than to research and development. The quality management system is applied to the medical equipment manufacturers, mobile phone brokers, foreign Chinese companies, and components manufacturers for diesel engines.Try it. Check the case where the quality management system has been applied to the company concerned and the nonconformities have been improved. In addition, the success of the project was determined by applying the quality control system to maintain the stability and perpetuation of the company through the case of the failed selection. The company explains that recently, it must appoint internal auditors to carry out continuous improvement activities and that those who want the development and continuity of the company must reflect the quality management system.

• Journal of Sasang Constitutional Medicine
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• v.8 no.2
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• pp.69-94
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• 1996

The main purpose of this work is comparing the difference between Soumin Bojungyikgitang of constitutional medicine and Li Dongyuan's Bojungyikgitang Bojungyikgitang, the prescription originated from the Pi-Wei theory(脾胃論) of Li Dongyuan who was a medical man in the Jin Yuan dynasty, had been used widely for many kinds of disease caused by the singking of the qi of middle energizer due to the weakness of the spleen and stomach. But in the singking of the qi of middle energizer due to the weakness of the spleen and stomach. But in the end of Choseon dynasty Li Je Ma, the creator of the constitutional medicine, modified the Bojungyikgitang and applied to Soumin's disease. In this paper, the difference between the two prescription were investigated from the viewpoint of chinese herb pharmacology and purpose of prescription. Additionally the problems which could be brought out by applying Bojungyikgitang to the Soyangin and the Taeumin were studied. And the conclusion could be summarized as follows: 1. The prescription of the Li Dongyuan's Bojungyikgitang is based on the deficiency of vital energy due to internal damage and the Soumin Bojungyikgitang is useful to only a certain stage of progressing disease on the basis of Shanghanlun(傷寒論). 2. In the Li Dongyuan's Bojungyikgitang, Cimicifugae Rhizoma and Bupleuri Radix were used for emphasizing the ascending action and have the antipyretic action and the effect of elavating of yangqi as they are bitter in taste and cold in nature. 3. In the Soumin Bojungyikgitang, Pogostemonis Herba and Perillae Folium have the ascending-descending action and strengthen the stomach with the effect of mild sweating by pungent taste and warm nature. 4. The effect of elavating of yangqi in the Li Dongyuan's Bojungyikgitang offers the pathway where vital qi go up by eleminating the pathogenic fire with the action of Cimicifugae Rhizoma and Bupleuri Radix in the triple energizer and yangming muscular striae. On the other hand, the Soumin Bojungyikgitang depends on the effect of reinforcing qi and elavating yangqi by Astrgalli Radix entirely and supply vital qi by reinforcing yangqi with Ginseng Rsdix. 5. The exahausion of yin(亡陰證) in the Soyangin exterior syndrome and cold limbs(寒厥證) in Taeumin exterior syndrome are similar to the indication of Li Dongyuan's Bojungyikgitang. As the causes of the disease are fundamentally different in the view of constitutional medicine, the diseases could be aggravated by applying Li's Bojungyikgitang. These results suggest that Li Dongyuan's Bojungyikgitang is proper to the exterior syndrome of Soumin and Soumin Bojungyikgitang seems to be appropriate to the Soumin's disease.