• Asian Pacific Journal of Cancer Prevention
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• 제16권18호
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• pp.8431-8438
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• 2016

Doxorubicin (DOX) was introduced as an effective chemotherapeutic for a wide range of cancers but with some severe side effects especially on myocardia. 2-Deoxy-D-glucose (2DG) enhances the damage caused by chemotherapeutics and ionizing radiation (IR) selectively in cancer cells. We have studied the effects of $1{\mu}M$ DOX and $500{\mu}M$ 2DG on radiation induced cell death, apoptosis and also on the expression levels of p53 and PTEN genes in T47D and SKBR3 breast cancer cells irradiated with 100, 150 and 200 cGy x-rays. DOX and 2DG treatments resulted in altered radiation-induced expression levels of p53 and PTEN genes in T47D as well as SKBR3 cells. In addition, the combination along with IR decreased the viability of both cell lines. The radiobiological parameter (D0) of T47D cells treated with 2DG/DOX and IR was 140 cGy compared to 160 cGy obtained with IR alone. The same parameters for SKBR3 cell lines were calculated as 120 and 140 cGy, respectively. The sensitivity enhancement ratios (SERs) for the combined chemo-radiotherapy on T47D and SKBR3 cell lines were 1.14 and 1.16, respectively. According to the obtained results, the combination treatment may use as an effective targeted treatment of breast cancer either by reducing the single modality treatment side effects.

• Radiation Oncology Journal
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• 제12권1호
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• pp.81-90
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• 1994

Purpose : The aim of this study is to analyze the clinical results of thermo-irradiation treatment for surgically unresectable advanced hepatoma with or without hepatic arterial chemo-embolization (HACE), chemotherapy (CT) and interferon (IFN) therapy. Materials and Methods : Between February 1990 and December 1992, 45 Patients with surgically unresectable advanced hepatomas were treated by thermo-irradiation with or without hepatic arterial chemo-embolization and other treatment modalities. Among them, We analyzed retrospectively 25 patients who received more than three times of hyperthermias. Mean age was 50 years (range : 18-71 years) and male to female ratio was 20 : 5. In the study, treatment was administered as follows : 3 patients received radiation therapy(RT) and hyperthermia (HT). 3 received RT+HT+CT. 3 received RT+HT+HACE. 1 received RT+HT+CT+HACE. 2 received RT+HT+CT+IFN. 10 received RT+HT+HACE+IFN. 3 received RT+HT+CT+HACE+IFN. Radiation therapy was done by a 6 MV linear accelerator Patients were treated with daily fractions of 180 cGy to doses of 11Gy-50Gy (median 30Gy). Local hyperthermia was done by HEH-500C(Omron Co. Japan), 30-45 min/session, 2 sessions/wk and the number of HT sessions ranged from 3 to 17 (median 7 times). 15 patients of 25 were followed by abdominal CT scan or abdominal ultra-sonogram. The following factors were analyzed :Age, histologic grade, sex. number of hyperthermia, total RT dose, hepatic arterial chemo-embolization. Results : Of 25 patients. there were observed tumor regression (partial response and minimal response) in 6 (24$ \% $), no response in 8 (32$ \% $), progression in 1 (4$ \% $) and not evaluable ones in 10 (40$ \% $) radiographically. The over all 1-year survival was 25$ \% $, with a mean survival of 33 weeks. The treatment modes of partial and minimal responsive patients (PR+MR)were as follows : Two were treated with RT+HT+HACE, 2 were done with RT+HT+HACE+IFN Remaining 2 were treated with RT+HT+CT+HACE+IFN. The significant factor affecting the survival rate were RT dose (more than 25 Gy), HACE, number of HT (above 6 times), responsiveness after treatment (PR + MR). Age, sex, histologic differentiation, chemotherapy, interferon therapy were not statistically significant factors affecting the survival rate. Conclusion : Although follow-up duration was short, the thermo-irr3diBtion with/without hepatic arterial chemo-embolization was well tolerated and there were no serious complicatons. In future, it is considered the longer follow up and prospective, well controlled trials should be followed to evaluate the efficacies of survival advantage.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.409-412
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• 2013

Curcumin (Cum) has been reported to have potential chemo-preventive and chemotherapeutic activity through influencing various processes, inducing cell cycle arrest, differentiation and apoptosis in a series of cancers. However, the poor solubility of Cum limits its further applications in the treatment of cancer. We have previously reported Cum-loaded nanoparticles (Cum-NPs) prepared with amphilic methoxy poly(ethylene glycol)-polycaprolactone (mPEG-PCL) block copolymers. The current study demonstrated superior antitumor efficacy of Cum-NPs over free Cum in the treatment of lung cancer. In vivo evaluation further demonstrated superior anticancer effects of Cum-NPs by delaying tumor growth compared to free Cum in an established A549 transplanted mice model. Moreover, Cum-NPs showed little toxicity to normal tissues including bone marrow, liver and kidney at a therapeutic dose. These results suggest that Cum-NPs are effective to inhibit the growth of human lung cancer with little toxicity to normal tissues, and could provide a clinically useful therapeutic regimen. They thus merit more research to evaluate the feasibility of clinical application.

• 대한치과의사협회지
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• 제49권9호
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• pp.527-534
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• 2011

Microvascular reconstruction of maxillary composite defect after oncologic resection has improved both esthetic and functional aspect of quality of life of the cancer patients. However, a lot of patients had prior surgery with radiation and/or chemotherapy as a part of comprehensive cancer treatment. Sometimes it is nearly impossible to find out adequate recipient vessel for maxillary reconstruction with microvascular anastomosis. Therefore long pedicle of the flap is needed to use distant neck vessels located far from the reconstruction site such as ipsilateral transverse cervical artery or a branch of contralateral external carotid artery. For this reason, although we know the treatment of the choice is osteocutaneous flap, it is difficult to use this flap when we need long pedicle with complex three dimensional osseous defect. Vascular option for these vessel-depleted neck patients can be managed by a soft tissue reconstruction with long vascular pedicle and additional free non-vascularized flap that is rigidly fixed to remaining skeletal structures. For this reason, maxillofacial reconstruction by vascularized soft tissue flap with or without the secondary restoration of maxillary bone with non-vascularized iliac bone can be regarded as one of options for reconstruction of profound maxillofacial composite defect resulted from previous oncological resection with chemo-radiotherapy.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제37권1호
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• pp.67-71
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• 2011

Myxofibrosarcoma, also known as a myxoid variant of a malignant fibrous histiocytoma (MFH), is one of the most common sarcomas in the extremities of elderly people. The lesion is characterized by a high frequency of local recurrence but is uncommon in the head and neck regions. Low-grade myxofibrosarcoma, which is commonly misinterpreted as being benign, has a tendency for histological and biological progression in local recurrences, highlighting the importance of an accurate diagnosis and wide surgical excision of the primary lesion. We report a rare case of low-grade myxofibrosarcoma of the mandible located in the left mandibular body and angle area. The tumor was first diagnosed as a myxofibroma and was resected initially. After the final biopsy the patient underwent combined chemo-radiotherapy. The progress of the patent was uneventful until the one year follow up.

• 대한세포병리학회지
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• 제13권1호
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• pp.33-37
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• 2002

We report two different types of thyroid lymphoma associated with Hashimoto's thyroiditis. Both showed autoantibodies and were compatible with Hashimoto's thyroiditis according to their clinical backgrounds. A 76-year-old female noted a painless, rapidly growing mass in her neck which was diagnosed as diffuse non-Hodgkin's lymphoma, large cell type, after the fine needle aspiration cytology of the thyroid. She underwent chemo-radiotherapy and is free of the disease 10 months after diagnosis. The other patient, a 73-year-old female with a diffuse golfer, was diagnosed on fine needle aspiration cytology as having Hashimoto's thyroiditis. Three years later she developed a hard nodular growth in the both lobes of the thyroid. This was subjected to fine needle aspiration cytology and needle biopsy and was diagnosed as a MALT lymphoma. She refused any treatment and died 12 months after the diagnosis.

• 대한두경부종양학회지
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• 제25권1호
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• pp.43-46
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• 2009

Nasopharyngeal carcinomas are epithelial neoplasm derived from nasopharyngeal mucosa. Nasopharyngeal carcinoma involved cervical lymph nodes frequently. However, nasopharyngeal carcinoma with metastatic axillary node after concurrent chemoradiotherapy was reported rarely. We report the patients who was a 34-year-old man diagnosed as nasopharyngeal carcinoma. He was treated by concurrent chemo-radiotherapy. But axillary node metastasis was found after treatment in 2 years. After surgical resection of axillary lymph node, there is no evidence of disease.

• Radiation Oncology Journal
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• 제18권4호
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• pp.244-250
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• 2000

목적 : 국소 진행된 하인두암에서 선행 항암화학요법과 방사선치료를 시행했을 때 결과와 각 치료법에 대한 반응이 생존율에 미치는 영향을 알아보고자 본 연구를 시행하였다. 대상 및 방법 :국소 진행된 하인두암으로 진단받고 선행 항암화학요법과 방사선치료를 받은 32명의 환자를 대상으로 후향적 분석을 실시하였다. 방사선치료는 일일 선량 1.75$\~$2.0 Gy를 하루 1회, 주 5회 조사하였다. 총 방사선량은 60.8$\~$73.8 Gy (평균선량 68.6 Gy) 이었다. 선행 항암화학요법은 29명의 환자에서 5-FU와 cisplatin을 병용했고 나머지 환자들에서는 cisplatin을 기본으로 하여 bleomycin또는 vinblastin을 병용 투여했다. 24명(75$\%$)의 환자에서 3주 간격으로 3회의 선행 항암화학요법을 모두 시행하였고, 6명에서 2회, 2명에서 1회의 항암화학요법을 시행하였다. 결과 : 추적관찰기간은 7개월에서 134개월이었고 중앙값은 28개월이었다. 전체 대상환자들의 2년 및 5년 생존율은 각각 66$\%$, 43$\%$였고, 5년 국소제어생존율은 34$\%$였다. 12명(38$\%$)의 환자에서 5년 이상 후두가 보존되었다. 전체32명의 환자 중 선행 항암화학요법 후에 5명(16$\%$)에서 완전관해를 보였고, 19명(59$\%$)에서 부분관해, 8명(25$\%$)의 환자에서 무반응을 보여 반응률은 75$\%$였다. 부분관해를 보인 19명 가운데 8명은 방사선치료 후에 완전관해를 보였다. 선행 항암화학요법에 대해 무반응이었던 8명 중 2명은 방사선치료 후에 완전관해를 보였고, 나머지 6명은 부분관해를 보였다. 모든 치료가 종료한 후 무반응인 환자는 한 명도 없었다. 선행 항암화학요법에 대해서 완전관해, 부분 관해, 무반응을 보인 환자군별로 5년 생존율은 각각 60$\%$, 35.1$\%$, 50$\%$였다. 세 군간에 5년 생존율을 비교했을 때 통계학적으로 유의한 차이는 없었다(p=0.93). 모든 치료가 끝난 후에 완전관해를 보인 환자군과 부분관해를 보인 환자군의 5년 생존율은 각각 73.3$\%$, 14.7$\%$로 통계학적으로 의미있는 차이를 보였다(p<0,01). 생존율에 영향을 미치는 예후인자에 대한 분석을 실시했을 때, 통계학적으로 유의성이 있었던 요인은 방사선 치료 후 최종 치료반응이었다(CR vs. PR, p<0.01). 결론 : 국소로 진행된 하인두암의 치료에 있어서 본 연구에서는 선행 항암화학요법에 대한 반응과 장기 생존율간에 관계가 없는 것으로 나타났고, 방사선치료 후 최종 치료 반응이 장기 생존율에 가장 중요한 예후 인자였다.

• Radiation Oncology Journal
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• 제17권3호
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• pp.195-202
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• 1999

목적 : 국소 진행된 비소세포성 폐암의 치료에 있어서 예후 인자를 분석하고, 유도 화학요법이 생존율 및 치료 실패양상에 미치는 영향을 알아 보고자 본 연구를 시행하였다. 대상 및 방법 : 1986년 1월부터 1996년 10월까지 국소 진행된 비소세포성 폐암으로 진단받고 근치적 목적으로 방사선치료 혹은 병합요법(유도 화학요법 및 방사선치료)을 받은 130명의 환자를 대상으로 후향적 분석을 시행하였다. 방사선치료 단독군이 85명, 병합요법군이 45명이었다. 연령, 성별, 전신 수행능력, 병리조직학적 유형, 그리고 병기 등은 양군에서 고르게 분포하였다. 방사선치료는 6 MV 혹은 10 MV 선형가속기를 사용하였고, 일일 선량 $1.8\~2.0$ Gy를 주 5회 조사하였다. 총 방사선량은 129명에서 59.6 Gy 이상($56\~66$ Gy, 중앙값 60 Gy) 조사되었다. 유도 화학요법은 $2\~5$회(중앙값 2회) 시행하였다. 사용된 약제는 CAP (Cyclophosphamide, Adriamycin, Cisplatin)가 6명, MVP (Mitomycin, Vinblastine, Cisplatin)가 9명, MIC (Mitomycin, ifosfamide Cisplatin)이 13례, 그리고 EP (Etoposide, Cisplatin)가 17명에서 시행되었으며, 모든 요법이 Cis-platinum을 포함하였다. 결과 : 전체 환자의 생존율은 1, 2, 3 년 전체 생존율이 각각 41.5, 13.7, $7\%$였고, 중앙 생존기간은 11개월이었다. 치료 방법별 1, 2, 3 년 전체 생존율, 그리고 중앙 생존기간은, 방사선치료 단독군의 경우 각각 32.9, 10.5, $6\%$, 9개월이었으며, 병합요법군의 경우는 각각 57.8, 20, $7.6\%$, 14 개월이었다(p=0.0005). 최종 치료반응을 관찰할 수 있었던 126명 중 38명($30.2\%$)에서 완전관해를 보였고, 치료 방법별로 나누어 분석하였을 경우, 방사선치료 단독군에서 완전관해가 $25\%$ (21/84), 병합요법군의 경우는 $40.5\%$, (17/42)에서 완전관해를 보였다(p=0.09). 생존율에 영향을 미치는 예후인자는 혈색소치(p=0.04), NSE (neuron-specific enolase)치(p=0.004), 그리고 최종 치료반응(p=0.004)등이었다. 치료 방법별로 나누어서 분석한 결과, 방사선치료 단독군의 경우는 WSE치(p=0.006)와 최종 치료반응(p=0.003), 병합요법군의 경우는 최종 치료반응(p=0.007)이 예후인자였다. 치료 실패양상은 추적 관찰이 가능했고 치료에 대한 반응을 알 수 있었던 120명을 대상으로 분석한 결과, 양 군간에 특이한 차이를 보이지 않았다. 그러나, 치료에 완전관해를 보인 환자들을 대상으로 살펴보면 병합요법 군에서 원격전이가 감소하는 경향을 보였는데, 방사선치료 단독군은 19명중 11명에서, 병합요법군은 13명중 3명에서 원격전이가 발견되었다(p=0.07). 국소 실패는 완전관해를 보인 환자에서도 양 군에서 차이가 없었다(10/19 vs 6/13). 결론 : 국소 진행된 비소세포성 폐암의 경우 유도 화학요법을 시행함으로써, 방사선치료 단독보다 2년 생존율이 향상 되었고, 적어도 완전관해를 보인 경우는 원격전이가 감소하는 경향을 보였다. 그러나, 국소 실패양상 및 장기생존율에는 유도 화학요법이 도움이 되지 않았다. 따라서, 국소 제어율을 높이기 위한 다각적인 노력이 요구된다.

• 대한두경부종양학회지
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• 제17권1호
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• pp.26-31
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• 2001

Background: Primary malignant lymphoma of the parotid gland is a rare disease and defined as any malignant lymphoma that first manifests in the parotid gland, regardless of the subsequent stage of the diseases, whether it arises in the parenchyma or intraglandular lymph nodes. This study was performed to review the clinicopathological characteristics of primary parotid lymphoma and identify its optimal treatment modality. Materials and Methods: Six cases with parotid mass as first presentation of malignant lymphoma between 1988 and 2000, were studied on the basis of clinical features, diagnostic tools, treatment modality, treatment outcomes, and clinical stage by Ann Arbor Criteria. All were microscopically reevaluated and classified by NCI working formulation. Results: All patients were males and mean age was 36.7 years (2-66 years). Rapid growing non-tender mass was presented in all the cases and cervical lymphnodes were palpated in 4 cases. However, there was not any evidence of concurrent autoimmune disease such as Sjogren's syndrom or Rheumatoid arthritis. One case was confirmed by surgical specimen after superficial parotidectomy, 2 by excisional biopsy, and 3 by incisional biopsy. The stage of disease by NCI working formulation was IE in 1 patient, IIE in 4 and IV in 1. All were classified into non-Hodgkin' lymphoma, of which there were 5 cases of B-cell type and 1 case of T-cell type. There were 3 diffuse large cell lymphomas, 1 Burkitt lymphoma, 1 MALT lymphoma and 1 T-lymphoblastic lymphoma. Three cases were treated by chemotherapy only, 2 by radiotherapy only and 1 by chemo-radiotherapy. One case with Burkitt lymphoma was died from the disease and one case was lost to follow-up. The others are alive with no evidence of recurrence. Conclusions: Although primary parotid lymphoma is rare and difficult to diagnose preoperatively, most were detected in early stage and showed a relatively good response to the chemotherapy or radiotherapy like other types of extranodal malignant lymphoma.