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Radiotracers for Functional Neuroimaging (기능성 신경영상화를 위한 방사성추적자)

  • Lee, Byung-Chul;Chi, Dae-Yoon
    • The Korean Journal of Nuclear Medicine
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    • v.37 no.1
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    • pp.53-62
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    • 2003
  • After the development of two major techniques - SPECT (Single Photon Emission Computed Tomography) and PET (Positron Emission Tomography) to image the human subjects in a three-dimensional direction in the 1980s, many radiotracers have been used for functional neuroimaging. Still it would be very important study to develop selective radiotracers for functional neuroimaging. New radiotracers will help to expand the knowledge of neurotransmitter systems and of the genetic contribution to receptor or transporter availability. Neurotransmitter depletion-restoration studies, the distribution of brain functions and their modulation by neurotransmitter system aid in better understanding and limiting the side effects of drugs used as well as newly developed. In audition, these radiotracers will be thus very useful to gain a better understanding in biochemical and pharmacological interactions in living human. This review mentions the introduction of radioligands for the functional neuroimaging. Although significant progress has been achieved in the development of new PET and SPECT ligands for in vivo imaging of those receptors and transporters, there are continuous needs of new diagnostic radioligands.

Composition Ratio Analysis of Transesterification Products of Olive Oil by Using Thin Layer Chromatography and Their Applicability to Cosmetics (올리브 오일의 에스터 교환반응 생성물의 TLC를 이용한 조성비 분석 및 화장품에의 응용가능성 평가)

  • Park, So Hyun;Shin, Hyuk Soo;Kim, A Rang;Jeong, Hyo Jin;Xuan, Song Hua;Hong, In Kee;Lee, Dae Bong;Park, Soo Nam
    • Applied Chemistry for Engineering
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    • v.29 no.3
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    • pp.342-349
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    • 2018
  • In this study, the physicochemical properties, emulsifying capacity, moisture content and cytotoxicity of the composite material produced by transesterification reactions of the olive oil (olive oil esters) were investigated for cosmetic applications. Olive oil esters with short (S) and long (L) reaction times were studied. From the TLC-image analysis, composition ratios of the olive oil esters S were found to be 5.2, 24.1, 46.4, and 21.9% for mono-, di-, tri-glyceride, and fatty acid ethyl ester, respectively. Those of the olive oil esters L were 4.1, 24.7, 40.6, and 28.8% for mono-, di-, tri-glyceride, and fatty acid ethyl ester, respectively. The iodine value, acid value, saponification value, unsaponified matter, refractive index, and specific gravity were determined and purity tests were also carried out and normalized to establish standards and testing methods for using olive oil esters in cosmetics. To evaluate their emulsifying capacities, the O/W emulsion was prepared without surfactants and the formation of the emulsified particles were confirmed. After 5 days of applying the olive oil esters to human skin, the skin moisture retention was improved by 13.1% from the initial state. For the evaluation of toxicity on human skin cells, the olive oil esters showed 90% or more of the cell viability at $0.2-200{\mu}g/mL$. These results suggested that olive oil esters can be applied as natural/non-toxic ingredients to cosmetics industries.

Chemical Imaging Analysis of the Micropatterns of Proteins and Cells Using Cluster Ion Beam-based Time-of-Flight Secondary Ion Mass Spectrometry and Principal Component Analysis

  • Shon, Hyun Kyong;Son, Jin Gyeong;Lee, Kyung-Bok;Kim, Jinmo;Kim, Myung Soo;Choi, Insung S.;Lee, Tae Geol
    • Bulletin of the Korean Chemical Society
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    • v.34 no.3
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    • pp.815-819
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    • 2013
  • Micropatterns of streptavidin and human epidermal carcinoma A431 cells were successfully imaged, as received and without any labeling, using cluster $Au_3{^+}$ ion beam-based time-of-flight secondary ion mass spectrometry (TOF-SIMS) together with a principal component analysis (PCA). Three different analysis ion beams ($Ga^+$, $Au^+$ and $Au_3{^+}$) were compared to obtain label-free TOF-SIMS chemical images of micropatterns of streptavidin, which were subsequently used for generating cell patterns. The image of the total positive ions obtained by the $Au_3{^+}$ primary ion beam corresponded to the actual image of micropatterns of streptavidin, whereas the total positive-ion images by $Ga^+$ or $Au^+$ primary ion beams did not. A PCA of the TOF-SIMS spectra was initially performed to identify characteristic secondary ions of streptavidin. Chemical images of each characteristic ion were reconstructed from the raw data and used in the second PCA run, which resulted in a contrasted - and corrected - image of the micropatterns of streptavidin by the $Ga^+$ and $Au^+$ ion beams. The findings herein suggest that using cluster-ion analysis beams and multivariate data analysis for TOF-SIMS chemical imaging would be an effectual method for producing label-free chemical images of micropatterns of biomolecules, including proteins and cells.

Synthesis and Characterization of Zn(1-x)NixAl2O4 Spinels as a New Heterogeneous Catalyst of Biginelli's Reaction

  • Akika, Fatima-Zohra;Kihal, Nadjib;Habila, Tahir;Avramova, Ivalina;Suzer, Sefik;Pirotte, Bernard;Khelili, Smail
    • Bulletin of the Korean Chemical Society
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    • v.34 no.5
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    • pp.1445-1453
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    • 2013
  • $Zn_{(1-x)}Ni_xAl_2O_4$ (x = 0.0-1.0) spinels were prepared at $800^{\circ}C$ by co-precipitation method and characterized by infrared spectroscopy, X-ray diffraction, scanning electron microscopy and X-ray photoelectron spectroscopy. The specific surface area was determined by BET. SEM image showed nano sized spherical particles. XPS confirmed the valence states of the metals, showing moderate Lewis character for the surface of materials. The powders were successfully used as new heterogeneous catalysts of Biginelli's reaction, a one-pot three-component reaction, leading to some dihydropyrimidinones (DHPMs). These new catalysts that produced good yields of DHPMs, were easily recovered by simple filtration and subsequently reused with persistent activity, and they are non-toxic and environmentally friendly. The optimum amount of catalyst is 20% by weight of benzaldehyde derivatives, while the doping amount has been found optimal for x = 0.1.

Preference of Bedding Fabric according to Size and Spacing of Dot Pattern (도트 무늬의 크기와 간격에 따른 침구류 직물 선호도에 대한 연구)

  • Sa, A-Na;Lee, Sun-Young;Kim, Jung-Hwa;Lee, Jung-Soon
    • Fashion & Textile Research Journal
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    • v.20 no.5
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    • pp.592-599
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    • 2018
  • The purpose of this study is to investigate consumer needs, image sensibility and preference of bedding fabric according to size and spacing of dot pattern. 18 kinds of dot pattern fabrics were designed with different diameters(6, 8, 10cm) and distances(4, 7, 10cm) in regular arrangement of diamond figure. The subjects were 162 male and female university students. The data were analyzed by SPSS 24.0. Fabrics were assessed subjectively using a 5-point scale 17 consumer needs and 33 sensory descriptors. The most consumer's needs for bedding fabric was shown to be functionality of bedding including hygiene, touch, warmth, ease of washing and management, air permeability, and hygroscopicity. The other parameters of consumer's needs were shown to be physical property and design parameter. The results of analysis of the dimension of image sensibility for fabrics with different size and spacing of dots are derived from six factors including joyfulness, coziness, uniqueness, charm, femininity, and complexity. As a result of analysis of preference with fabric kinds, there was a significant difference in preference with fabrics. The preferred fabrics were characterized by the pattern and the base fabric being striking three-dimensionally with 1/3 twill and 3/1 twill fabric. Sensory descriptors related to joyful image and unique image were analyzed as evaluation terms that can distinguish the preferences of fabrics. Correlation analysis showed the fabrics are preferred as the difference in luminance and reflectance between the base and pattern of the fabric become larger and the spacing of patterns become closer.

Evaluation of Selective Saturation and Refocousing Pulses in Chemical Shift NMR Imaging

  • Shin, Yong-Jin;Park, Young-Sik
    • Journal of the Korean Magnetic Resonance Society
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    • v.4 no.1
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    • pp.64-73
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    • 2000
  • There are several methods to achieve selective NMR image of differing chemical species with the three most popular methods of Dixon's, CHESS, and SECSI. A major problem common to all chemical shift imaging methods is the uniformity of the static magnetic field and distortions introduced when RF coils are loaded with a conducting specimen. Without magnetic field shimming, these methods cannot be used to acquire selectively image protons in fat and water which are separated by approximately 3.0ppm. Experiments with a phantom, with linewidths of 2.5 to 3.5ppm, were quantitatively evaluated for the three methods and a new chemical shift imaging method. In this study the new chemical shift imaging method (modified CHESS+SECSI technique) which included a selective saturation and refocusing pulse, was developed to determine the ratios of water and fat in different samples.

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Fast and Efficient Method for Fire Detection Using Image Processing

  • Celik, Turgay
    • ETRI Journal
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    • v.32 no.6
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    • pp.881-890
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    • 2010
  • Conventional fire detection systems use physical sensors to detect fire. Chemical properties of particles in the air are acquired by sensors and are used by conventional fire detection systems to raise an alarm. However, this can also cause false alarms; for example, a person smoking in a room may trigger a typical fire alarm system. In order to manage false alarms of conventional fire detection systems, a computer vision-based fire detection algorithm is proposed in this paper. The proposed fire detection algorithm consists of two main parts: fire color modeling and motion detection. The algorithm can be used in parallel with conventional fire detection systems to reduce false alarms. It can also be deployed as a stand-alone system to detect fire by using video frames acquired through a video acquisition device. A novel fire color model is developed in CIE $L^*a^*b^*$ color space to identify fire pixels. The proposed fire color model is tested with ten diverse video sequences including different types of fire. The experimental results are quite encouraging in terms of correctly classifying fire pixels according to color information only. The overall fire detection system's performance is tested over a benchmark fire video database, and its performance is compared with the state-of-the-art fire detection method.

The Study of New Image Enhancement Algorithm (새로운 이미지 개선 알고리즘에 관한 연구)

  • Yu, Sung-Jae;Shin, Ho-Chul;Kim, Young-Sup;Rhew, Sang-Burm;Jang, Ji-Geun;Gong, Myung-Seon;Chang, Ho-Jung;Lee, Jun-Young;Lee, Young-Kwan
    • Journal of the Semiconductor & Display Technology
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    • v.5 no.2 s.15
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    • pp.15-18
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    • 2006
  • This paper presents a optimizing algorithm getting through analyzing a image improvement algorithm using retinex theory. Improving a existing retinex theory's slow process speed, our proposal is that it controls a small filter size of surrounding function by comparing with original algorithm. So slow process speed decreased drastically. For filling a short of lighting information by small filter, we also selected gray image as a forth channel. Using the color constancy, we got fast process time like linear color correction and could do comfortable auto color rectification according to other images.

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Synthesis and Biodistribution of Cat's Eye-shaped [57Co]CoO@SiO2 Nanoshell Aqueous Colloids for Single Photon Emission Computed Tomography (SPECT) Imaging Agent

  • Kwon, Minjae;Park, Jeong Hoon;Jang, Beom-Su;Jung, Hyun
    • Bulletin of the Korean Chemical Society
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    • v.35 no.8
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    • pp.2367-2370
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    • 2014
  • "Cat's eye"-shaped $[^{57}Co]CoO@SiO_2$ core-shell nanostructure was prepared by the reverse microemulsion method combined with radioisotope technique to investigate a potential imaging agent for a single photon emission computed tomography (SPECT) in nuclear medicine. The core cobalt oxide nanorods were obtained by thermal decomposition of $Co-(oleate)_2$ precursor from radio isotope Co-57 containing cobalt chloride and sodium oleate. The $SiO_2$ coating on the surface of the core cobalt oxide nanorods was produced by hydrolysis and a condensation reaction of tetraethylorthosilicate (TEOS) in the water phase of the reverse microemulsion system. In vivo test, micro SPECT image was acquired with nude mice after 30 min of intravenous injection of $[^{57}Co]CoO@SiO_2$ core-shell nanostructure.

Distinction of Internal Tissue of Red Ginseng Using Magnetic Resonance Image (MRI을 이용한 홍삼 내부조직 판별)

  • Kim, Chun-Suk;Jung, In-Chan;Kim, Se-Bong
    • Journal of Ginseng Research
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    • v.32 no.4
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    • pp.332-336
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    • 2008
  • Red ginseng is classified according to outer form and the quality of internal tissue, and red ginseng below third grade can't be sold. Also there are many differences in price according to grade. So if inferior Red ginseng is sold, economic loss and claim take place. This research is done conducted to investigate the possibility of the non-destruction internal tissue investigation of red ginseng. It is observed and compared that MR image after getting MR image agrees with real cutting side in 10-13% water content of red ginseng. The MR image can be obtained to see the internal section of red ginseng with equal condition of time, temperature and slice thickness in spin echo pulse sequence. The MR signal of red ginseng is very weak, because it contains low water density. So it takes about 30 minutes with the measurement of single point image (SPI). But the suitable time to distinguish internal tissues is about 9 seconds in TE (Echo Time) 2.23 ms, TR (Repetition Time) 150ms. The image to discriminate internal tissues in 9 seconds can be obtained when slice thickness is 10 mm with changes of 3, 5, 10 mm. The image obtained after 30 minutes' boiling of 55 degrees has clearer image than that of normal temperature. It is thought that MR signal is stronger through active motion of water particles as temperature increases. With this method MR image of red ginseng can be obtained and characteristics of internal tissues can be observed in such a short time.