• Proceedings of the Korean Society of Applied Pharmacology
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• 1995.04a
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• pp.45-46
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• 1995

Alzheimer's disease is believed to be associated with the loss of cholinergic activity in the cortex and hippocampus. In addition, it has been reported that the monoaminergic systems which also controls brain functions are disturbed in Alzheimer's patients. Based on these neurochemical background, a number of cholinesterase inhibitors including tacrine and its analogues and some monoamine oxidase inhibitors such as L-deprenyl and monoamine reuptake inhibitors have been developed for the treatment of dementia, but all of the known drugs are not truly effective. We thought that a drug that activates only one neurotransmitter system is not effective enough for the treatment of the symptoms associated with Alzheimer's disease and vascular dementia, and we conceived that an agent enhancing both central cholinergic and monoaminergic functions would be useful for the treatment of dementia

• Bulletin of the Korean Chemical Society
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• v.20 no.11
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• pp.1329-1334
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• 1999

The curing characteristics of diglycidyl ether of bisphenol A (DGEBA) with diaminodiphenylmethane (DDM) as a curing agent were studied using differential scanning calorimetry (DSC), rheometrics mechanical spectrometry (RMS), and dielectric analysis (DEA). The isothermal curing kinetics measured by DSC were well represented with the generalized auto-catalytic reaction model. With the temperature sweep, the inverse relationship between complex viscosity measured by RMS and ionic conductivity obtained from DEA was established indicating that the mobility of free ions represented by the ionic conductivity in DEA measurement and the chain segment motion as revealed by the complex viscosity measured from RMS are equivalent. From isothermal curing measurements at several different temperatures, the ionic conductivity contribution was shown to be dominant in the dielectric loss factor at the early stage of cure. The contribution of the dipole relaxation in dielectric loss factor became larger as the curing further proceeded. The critical degrees of cure, at which the dipolar contribution in the dielectric loss factor starts to appear, increases as isothermal curing temperature is increased. The dielectric relaxation time at the same degree of cure was shorter for a sample cured at higher curing temperature.

• Applied Chemistry for Engineering
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• v.33 no.1
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• pp.113-118
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• 2022

Multifunctional nanomaterials based on mesoporous silica nanoparticles (MSN) and metal oxide nanocrystals are among the most promising materials for theragnosis because of their ease of modification and high biocompatibility. However, the preparation of multifunctional nanoparticles requires time-consuming multistep processes. Herein, we report a simple one-pot synthesis of multifunctional Mn₃O₄/mesoporous silica core/shell nanoparticles (Mn₃O₄@mSiO₂) involving the temporal separation of core formation and shell growth. This simple procedure greatly reduces the time and effort required to prepare multifunctional nanoparticles. Despite the simplicity of the process, the properties of nanoparticles are not markedly different from those of core/shell nanoparticles synthesized by a previously reported multistep process. The Mn₃O₄@mSiO₂ nanoparticles are biocompatible and have potential for use in optical imaging and magnetic resonance imaging.

• Journal of the Korean Applied Science and Technology
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• v.36 no.2
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• pp.645-655
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• 2019

In this study, colloidal microgel with viscoelasticity were prepared by using dispersion containing physical crosslinking agents and microgels with various strengths depending on the degree of cross-links.As the chemical crosslinking agent PEGDA400 content increased, hydrogels have various physical properties the swelling ratio decreased from $2.0{\times}10^4%$ to $6.0{\times}10^3%$ and increased viscosity by about 60%. The colloidal microgel was prepared with micro hydrogel grinded to $100{\mu}m$ size and the rheological behavior was confirmed with physical cross linking agent. A colloidal microgel having various viscosities was prepared by controlling starch and alginate based on micro-hydrogel containing 0.75% (w/v) of PEGDA400. In conclusion, these results would be highly useful for applying as a product that can give various physical properties to the colloidal suspensions, cosmetics, paint, and food industry.

• The Plant Pathology Journal
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• v.21 no.4
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• pp.328-333
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• 2005

Paenibacillus elgii SD17 (KCTC $10016BP^T$=NBRC $100335^T$) was recently reported as a new species. Based on its inhibitory activity to Thanatephorus cucumeris AG1-1, strain SD17 was further evaluated for its potential as a biocontrol agent against soil-borne diseases of turf grasses in Korea. P. elgii SD17 showed a broad spectrum of antimicrobial activity in vitro test and suppressed development of turf grass diseases; Pythium blight caused by Pythium aphanidermatum and brown patch caused by T. cucumeris AG1-1 on creeping bentgrass (Agrostis palustris) in the growth chamber tests. Under a condition for massive culture in a 5,000 L fermenter, P. elgii SD17 reached $6.4{\times}10^8$ spores/ml that resulted in approximately $1.0{\times}10^7$ cfu/g when formulated into a granule formulation (GR) using the whole culture broth instead of water. Using the GR formulation, biocontrol activity of P. elgii SD17 was confirmed. In the growth chamber tests, the GR formulation was effective against brown patch and Pythium blight with similar level of disease severity compared to each of the standard fungicides at the application rates of 10 g/$m^2$ or above. In the field tests, compared to each untreated control, the GR formulation also effectively controlled Pythium blight, brown patch and large patch at all the application rates of 5, 10 and 20 g/$m^2$, respectively, without significant response by the application rates. However its performance was inferior to each of the standard chemical fungicides. Based on these results, we consider this GR formulation of P. elgii SD17 as an effective biocontol agent to suppress Pythium blight, brown patch and large patch of turf grasses in Korea.

• Applied Chemistry for Engineering
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• v.9 no.4
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• pp.608-613
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• 1998

The purpose of this experiment was the physical properties of rubber compounds with DPCB and pure carbon black. Si-O peak in the silcia surface was observed at the range of wavenumber from 1,100 to 1,200 in the DPCB by FT-IR analysis. Cure rate of rubber compounds containing DPCB and organic silane coupling agent were (Si69) delayed compared with those containing pure carbon black. 300% modulus and interaction coefficient of DPCB with silane coupling agent were higher than those of pure carbon black and PICO weight loss amount showed constant value. It was found that $0^{\circ}C$ tan$\delta$ of rubber compounds with DPCB was larger than those of pure carbon black at 2.0% silane coupling agent based on 50 phr DPCB and $60^{\circ}C$ tan$\delta$ of rubber compounds with DPCB decreased as increasing the usage coupling agent. Consequently, it is postulated that DPCB is strong candidate material for lowering rolling resistance under constant abrasion resistance.

• Environmental Engineering Research
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• v.23 no.4
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• pp.474-484
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• 2018

The cleaning efficiency of reverse osmosis (RO) membranes inevitably fouled by organic foulants depends upon both chemical (type of cleaning agent, concentration of cleaning solution) and physical (cleaning time, flowrate, temperature) parameters. In attempting to determine the optimal procedures for chemical cleaning organic-fouled RO membranes, the design of experiments concept was employed to evaluate key factors and to predict the flux recovery rate (FRR) after chemical cleaning. From experimental results and based on the predicted FRR of cleaning obtained using the Central Composite Design of Minitab 17, a modified regression model equation was established to explain the chemical cleaning efficiency; the resultant regression coefficient ($R^2$) and adjusted $R^2$ were 83.95% and 76.82%, respectively. Then, using the optimized conditions of chemical cleaning derived from the response optimizer tool (cleaning with 0.68 wt% disodium ethylenediaminetetraacetic acid for 20 min at $20^{\circ}C$ with a flowrate of 409 mL/min), a flux recovery of 86.6% was expected. Overall, the results obtained by these experiments confirmed that the equation was adequate for predicting the chemical cleaning efficiency with regards to organic membrane fouling.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2015.11a
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• pp.103-104
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• 2015

This study is an experiment about what affects the compressive strength by using a reducing agent (PNS based admixtures) to play cement using the cement paste based Waste Concrete Powder of waste concrete, which accounts for more than 60% of construction waste around the latest domestic and international It was. Securing the replacement of cement with Waste Concrete Powder and, by varying the admixture was to compensate for the low absorption of liquidity and obtain a fine powder. And the experiment was conducted with a constant water cement ratio and aggregate usage for the purpose of lowering the water cement ratio promoting strength development. When substituted with the experimental results of 0.3% based on 3 ~ 28 days as strength 36Mpa exhibited the highest strength.

• Nuclear Engineering and Technology
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• v.31 no.6
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• pp.541-547
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• 1999

Corrosion control, in the end-shield cooling system of Wolsung Nuclear Power Plant, is directly related to the control of dissolved oxygen (DO). The current method, being used to deoxygenate the end-shield cooling water, is a chemical treatment by addition of reducing agent, hydrazine, to react with DO. This method has several limitations including high reaction temperature of hydrazine , unwanted explosive hydrogen gas production, and its intrinsic harmful property. A new approach to remove DO using a membrane-based oxygen removal system (MORS) was tried to overcome limitations of the hydrazine treatment. The DO removal efficiency of the MORS was found to be in the range 87% to 98%: The higher vacuum, the lower water flow rate and the higher water temperature tend to increase the DO removal efficiency.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.47 no.6
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• pp.81-88
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• 2015

The molecular weight (MW) and crystallinity of cotton linter need to be controlled to be dissolved well in N-methylmorpholine N-oxide (NMMO) solvent for manufacturing regenerated fibers of clothing fabrics. Electron beam irradiation or sulfuric acid pre-treatment followed by alkaline peroxide bleaching has been used to control MW effectively and to improve brightness of cotton linter. Auto-hydrolysis of cotton linter without electron beam irradiation or chemical pre-treatment was found to be effective as an alternative pre-treatment method. Removal of metal ions, that hampered dissolution of cotton linter by NMMO, was also investigated when the auto-hydrolysis was accompanied with ionic polymers and chelating agent.