• Title/Summary/Keyword: chemical defense

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Cloning and characterization of a novel gene with alternative splicing in murine mesenchymal stem cell line C3H/10T1/2 by gene trap screening

  • Wang, Mingke;Sun, Huiqin;Jiang, Fan;Han, Jing;Ye, Feng;Wang, Tao;Su, Yongping;Zou, Zhongmin
    • BMB Reports
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    • v.43 no.12
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    • pp.789-794
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    • 2010
  • A novel gene, designated mgt-6, containing four splicing variants, was isolated from a gene trap clone library of C3H/10T1/2 cells transfected with retroviral promoterless gene-trap vector, ROSAFARY. The transcript variants were differentially expressed in murine tissues and cell lines and differentially responded to diverse stimuli including TGF-${\beta}1$ and mitogen-activated protein kinase (MAPK) inhibitors. The mgt-6 gene encoded a protein of 37 or 11 amino acid residuals with cytoplasmic distribution. However, when C3H/10T1/2 cells were treated with 5-azacytidine, the protein translocated into cell nucleus as indicated by fused LacZ or C-terminally tagged EGFP. Our preliminary results suggest that further study on the role of mgt-6 gene in cell transformation and differentiation may be of significance.

A study on the fabrication of polymer-coated SAW sensors and their sensing properties for some toxic chemical compounds (SAW 센서의 제작 및 독성화학물질 감도특성 연구)

  • Lim, Y.R.;Park, B.H.;Choi, S.K.;Song, K.D;Lee, D.D.
    • Journal of Sensor Science and Technology
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    • v.17 no.2
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    • pp.143-146
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    • 2008
  • Polymer-coated film SAW sensors have been fabricated and their sensing properties for toxic chemicals have been extensively investigated. Four types of the toxic chemical compounds of hydrogen cyanide(AC), carbonyl dichloride(CG), pinacolyl methylfluorophosphonate(GD), 2,2'-dichlorodiethylthio ether(HD) were used as target gases. SAW sensors using five different kinds of polymers were used to detect toxic chemicals and their gas sensing characteristics were investigated. The polymers used as the sensing materials were polyisobutylene(PIB), polyepichlorohydrin(PECH), polydimethylsiloxane(PDMS), polybutadiene(PBD) and polyisoprene(PIP). The recommendable mixing ratio of PIB, PECH, PDMS, PBD and PIP to solvents were 1:30, 1:40, 1:10, 1:30 and 1:30, respectively. The sensing characteristics of the SAW sensors were measured by using E-5061A network analyzer.

Mass Spectrometric Analysis of Eight Common Chemical Explosives Using Ion Trap Mass Spectrometer

  • Park, Sehwan;Lee, Jihyeon;Cho, Soo Gyeong;Goh, Eun Mee;Lee, Sungman;Koh, Sung-Suk;Kim, Jeongkwon
    • Bulletin of the Korean Chemical Society
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    • v.34 no.12
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    • pp.3659-3664
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    • 2013
  • Eight representative explosives (ammonium perchlorate (AP), ammonium nitrate (AN), trinitrotoluene (TNT), 2,4-dinitrotoluene (DNT), cyclonite (RDX), cyclotetramethylenetetranitramine (HMX), pentaerythritol tetranitrate (PETN), and hexanitrostilbene (HNS)) were comprehensively analyzed with an ion trap mass spectrometer in negative ion mode using direct infusion electrospray ionization. MS/MS experiments were performed to generate fragment ions from the major parent ion of each explosive. Explosives in salt forms such as AP or AN provided cluster parent ions with their own anions. Explosives with an aromatic ring were observed as either $[M-H]^-$ for TNT and DNT or $[M]^{{\cdot}-}$ for HNS, while explosives without an aromatic ring such as RDX, HMX, and PETN were detected as an adduct ion with a formate anion, i.e., $[M+HCOO]^-$. These findings provide a guideline for the rapid and accurate detection of explosives once portable MS instruments become more readily available.

Study on the Deactivation Trends of Liquid Fuel According to the Types of Endothermic Catalyst in Flow Reactor (흐름형 반응기 내에서 액체연료의 흡열반응촉매 종류에 따른 비활성화 정도에 대한 연구)

  • Lee, Tae Ho;Jeon, Sunbin;Kim, Sung Hyun;Jeong, Byung Hun;Han, Jeong Sik
    • Journal of the Korean Society of Propulsion Engineers
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    • v.22 no.5
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    • pp.81-87
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    • 2018
  • In hypersonic aircraft, increase of aerodynamic and engine heat lead thermal load in airframe. It could lead structural change of aircraft's component and malfunctioning. Endothermic fuels are liquid hydrocarbon fuels which absorb the heat load by undergoing endothermic reactions. In this study, we investigated the relationship between product, coke formation and catalytic properites of endothermic catalysts by using exo-tetrahydrodicyclopentadiene as a fuel in a fixed bed flow reactor similar to the actual reaction conditions.

Numerical Simulation of Diffusion and Flow in Fabrication of Carbon/Carbon Composite Using Chemical Vapor Infiltration (다단계 화학반응과 밀도화 모델을 이용한 탄소/탄소 복합재 화학기상침투 공정의 확산 및 유동 수치해석)

  • Kim, Hye-gyu;Ji, Wooseok;Jo, Namchun;Park, Jonggyu
    • Composites Research
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    • v.32 no.1
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    • pp.56-64
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    • 2019
  • In this paper, a model is developed to simulate carbon/carbon composite fabrication using chemical vapor infiltration, considering density and porosity change in the preform and multi-step hydrocarbons reactions. The model considers the preform as a porous medium whose diffusion and flow properties changes due to the porosity. To verify the theoretical model, two numerical analyses were performed for the case that the flow inside the preform is zero and the case that the flow inside the preform is calculated by fluid mechanics. The numerical results showed good agreement with the experimental data.

Nanoporous Organo-functional Silica Synthesis Based on a Purely Inorganic Precursor

  • Oh, Chang-Sup;Koo, Kyung-Wan;Han, Chang-Suk;Kim, Jang-Woo;Kim, Heon-Chang;Lee, Yong-Sang;Choi, Young-Tai;Kim, Yong-Ha
    • Korean Journal of Metals and Materials
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    • v.47 no.8
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    • pp.516-521
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    • 2009
  • In this study we report a rapid synthesis of nanoporous organo-functional silica (OFS) with unimodal and bimodal pore structures encompassing pores ranging from meso-to macroscale. The problems of tediousness and high production cost in the conventional syntheses are overcome by co-condensation of an inexpensive inorganic precursor, sodium silicate with an organosilane containing trimethyl groups. The insitu covalent anchoring of the non-polar trimethyl groups to the inner pore walls prohibits irreversible shrinkage of the wet-gel during microwave drying at ambient pressure and thus larger size pores (from ca. 20 to ca. 100 nm) can be retained in the dried silica. The drying process of the silylated wet-gels at an ambient pressure can be greatly accelerated upon microwave exposure instead of drying in an oven or furnace. Using this approach, anoporous and superhydrophobic silicas showing a wide variation in texture and morphology can be readily synthesized in roughly two hours. The effects of various sol-gel parameters solely on the textural properties of the organo-functional silica (OFS) have been investigated and discussed.

Decontamination of Chemical Warfare Agent Simulants using Vapor-phase Hydrogen Peroxide (과산화수소 증기를 이용한 유사화학작용제의 제독)

  • Kim, Yun-Ki;Yoo, Hyun-Sang;Kim, Min-Cheol;Hwang, Hyun-Chul;Ryu, Sam-Gon;Lee, Hae-Wan
    • Korean Chemical Engineering Research
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    • v.52 no.3
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    • pp.360-365
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    • 2014
  • Vapor-phase hydrogen peroxide(VPHP) has been used as a sterilant in the field of medical and pharmaceutical application due to low corrosive than chlorine contained sterilant. In addition, it is well known that VPHP is effective for decontamination of chemical warfare agents by adding ammonia gas. In this study, the decontamination efficiency was confirmed about CEPS, DFP and dimethoate as simulants of HD, GD and VX using VPHP respectively. For this purpose, VPHP generated from self configured device was injected into decontamination chamber and maintained for reaction time. After the decontamination, the residues are analyzed by GC/MS and decontamination efficiency was calculated. Through by-product for each simulants, the similarities in reaction mechanism of chemical warfare agents were confirmed. CEPS was completely decontaminated at 30% relative humidity within 60 min. By adding ammonia gas, DFP and dimethoate were completely decontaminated within 30 and 150 min respectively.

Effects of Sheet Thickness on the Electromagnetic Wave Absorbing Characterization of Li0.375Ni0.375Zn0.25-Ferrite Composite as a Radiation Absorbent Material

  • Kim, Dong-Young;Yoon, Young-Ho;Jo, Kwan-Jun;Jung, Gil-Bong;An, Chong-Chul
    • Journal of electromagnetic engineering and science
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    • v.16 no.3
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    • pp.150-158
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    • 2016
  • This paper reports on a study of LiNiZn-ferrite composite as a radiation absorbent material (RAM). The electromagnetic (EM) wave absorbers are composed of an EM wave absorbing material and a polymeric binder. The surface morphology, chemical composition, weight percent of the ferrite composite of the toroid sample, magnetic properties, and return loss are investigated using field emission scanning electron microscopy (FE-SEM), energy dispersive X-ray spectroscopy (EDX), X-ray photoelectron spectroscopy (XPS), thermogravimetric analysis (TGA), vibrating sample magnetometer (VSM), and network analyzer. For preparing the absorbing sheet, chlorinated polyethylene (CPE) is used as a polymeric binder. The EM wave absorption properties of the prepared samples were studied at 4 - 8 GHz. We can confirm the effects of the thickness of the samples for absorption properties. An absorption bandwidth of more than a 10-dB return loss shifts toward a lower frequency range along with an increase in the thickness of the absorber.

Preparation of Selectively Permeable Membrane Materials with Enhanced Protective Capability against Blister Agents (수포작용제 방호성능이 향상된 선택투과막 제조)

  • Kwon, Tae-Geun;Kim, Jin-Won;Kang, Jae-Sung;Park, Hyen-Bae;Lee, Hae-Wan;Seo, Hyeon-Kwan
    • Membrane Journal
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    • v.24 no.2
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    • pp.167-175
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    • 2014
  • For selectively permeable membrane based on cellulose acetate butyrate (CAB) and polyethyleneimine (PEI) with water vapor transportability and DMMP protective performance, we intended to improve protective performance of the membrane against CEES using several additives. Results showed that CAB/PEI membranes possessed performance with good water vapor permeation (${\geq}1,800g/m^2/day$) and enhanced protective capability against CEES contamination ($7.1{\sim}11.5{\mu}g/cm^2{\cdot}day$). Of these membranes, the membrane containing $Ag^+$ ion and ionic exchange resin showed the best protective performance. And, we identified that the CAB/PEI membranes show excellent protection against aerosols with various particle sizes ($0.005{\sim}3{\mu}m$) simulating biological agents.