• Title/Summary/Keyword: changwon

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Proteolysis of $\beta$-Catenin in Apoptotic Jurkat Cells

  • Hwang, Sang-Gu;Park, Jeong-Uck;Lee, Hyung-Chul;Joo, Woo-Hong;Cho, Yong-Kweon;Moon, Ja-Young
    • Journal of Life Science
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    • 제10권1호
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    • pp.57-63
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    • 2000
  • ${\beta}$-catenin, which plays a critical role in both the cytoskeleton and in transcriptional regulation in variousadherent cell types, undergoes degradation during adherent cell apoptosis. Although ${\beta}$-catenin has been reported to be present in Jurkat T-acute lymphoblastic leukemia cells, the regulation of ${\beta}$-catenin in hematologic malignancies have not been examined. The data presented here demonstrate that treatment of the T cell leukemia Jurkat iwht the apoptosis inducer anti-Fas induced proteolytic cleavage of ${\beta}$-catenin. ${\beta}$-catenin was cleaved at both the N- and C-terminus after anti-Fas treatment. Cleavage of intact ${\beta}$-catenin was completely inhibited by caspase selective protease inhibitors. These data demonstrate that ${\beta}$ -catenin proteolysis is triggered by the cross-linking of the Fas receptor on Jurkat cells and subsequent activation of caspase protease. There was a clear accumulatio of the large proteolytic fragment in Jurkat cells treated with lactacystin of ALLM. These are potent inhibitors of proteasome and calpain. these results suggest that both the proteasome and clapain may recognize the large ${\beta}$-catenin fragment as a substrate fot further degradation and that these pathewasy may act downstream of scapase in response to Fas receptor activation. Therefore, we suggest that ${\beta}$-catenin may play a role in promoting Jurkat survival.

창원시 아파트 공급량에 영향을 미치는 요인에 관한 연구 (A Study on Factors Affecting the Supply of Apartments in Changwon City)

  • 성주한
    • 토지주택연구
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    • 제11권4호
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    • pp.35-50
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    • 2020
  • The purpose of this study is to examine which factors are important in determining the amount of the apartment supply in Changwon City. Additionally, this study is to examine the changes in the determination of the amount of apartment supply in Changwon by dividing it into before and after 2016 as the city showed a large difference in apartment supply that caused structural changes during this time period. This study shows that the increase in the number of housing construction permits in Changwon before 2016 had a negative impact on the housing market as well as causing a decrease in the supply of apartments in Changwon after 2016. As a result of the shortsighted predictions on the housing market of Changwon from before 2016, it still affects the current housing market as of June 2020. The implication of this study is that through the housing market system of Changwon City, they can take the role as a control tower in Changwon City and propose principles and standards for supply control in order to better predict the demand of the housing market.

Synthesis of POSS Derived Organic-Inorganic Hybrid Esters for Insulating Oil Applications

  • Choi, Kyeong-Min;Harshavardhan, S.J.;Sridhar, Ch.;Vijaykumar, B.V.D.;Kumar, Deepak;Jang, Kiwan;Lee, Man-Sig;Shin, Dong-Soo
    • Bulletin of the Korean Chemical Society
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    • 제35권9호
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    • pp.2769-2773
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    • 2014
  • In this work, a new family of polyhedral oligomeric silsesquioxanes (POSS) based esters have been synthesized that consists eight ester functional groups. These are classified into Type-I and Type-II esters based on the starting materials, octakis(3-chloropropyl)silsesquioxane (Cl-POSS) and octakis(3-hydroxypropyldimethylsiloxy) octasilsesquioxane (OHPS) respectively. These new POSS type ester moieties can be used as insulating oils and oil additives in the transformers and also considered to be alternatives to mineral and vegetable oils that are presently used in the insulation system.