• KIISE Transactions on Computing Practices
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• 제23권5호
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• pp.304-309
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• 2017

Programmers use multiple languages to reuse legacy code best suited to their problems. However, it is quite challenging to develop error-free multilingual programs because new types of bugs occur since misunderstanding about language interfaces such as Java Native Interface (JNI) and Python/C. There is a considerable amount of research to overcome multilingual program bugs and errors but these researches have less consideration about substantiality of programming languages, language interfaces, and bugs to evaluate their analyses and tools. In this paper, we have identified and establish substantiality of multilingual programming research with empirical study about diversity and interoperability of programming languages in Ubuntu software ecosystem based on real-world statistical data.

• Structural Engineering and Mechanics
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• 제64권6권
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• pp.803-817
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• 2017

Structural health monitoring has increasingly been a focus within the civil engineering research community over the last few decades. With increasing application of sensor networks in large structures and infrastructure systems, effective use and development of robust algorithms to analyze large volumes of data and to extract the desired features has become a challenging problem. In this paper, we grasp some precautions and key points of the signal processing approach, wavelet, establish a relative reliable framework, and analyze three problems that require attention when applying wavelet based damage detection approach. The cases studies how to use optimal scales for extracting mode shapes and modal curvatures in a reinforced concrete beam and how to effectively identify damages using maximum curves of wavelet coefficient differences. Moreover, how to make a recognition based on the wavelet multi-resolution analysis, wavelet packet energy, and fuzzy sets is a meaningful topic that has been addressed in this work. The relative systematic work that compasses algorithms, structures and evaluation paves a way to a framework regarding effective structural health monitoring, orientation, decision and action.

• Korean Journal of Bronchoesophagology
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• 제9권1호
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• pp.30-38
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• 2003

Cancers of the cervical esophagus occur uncommonly, but treatment is remaining a challenging problem and surgery demands special knowledge of abdominal, thoracic, and neck surgery. The primary risk factor is chronic heartburn, leading to a sequence of esophagitis, Barrett's esophagus, reflux esophagitis and etc. Among the various treatment modalities, Surgery is still a mainstay of treatment. The main aim of surgery is not only oncologically adequate resection but also preservation or restoration of physiologic functions, such as deglutition and phonation. Surgical treatment of cervical esophageal cancer is influenced by special problems arising from tumor factors, patient factors and surgeon factors. Complete clearance of loco-regional disease and prevention of postoperative complications are of particular importance for the improvement of long-term survival in patients with these cancers. So the cervical and thoracic extension of these tumors usually required an extensive lymphadenectomy with primary resection. Radical resection of the primary site almostly include sacrifice of the larynx, but the voice could be rehabilitated with various methods, such as tracheoesophageal prosthesis or tracheoesophageal shunts, etc. Restoration of the esophageal conduit can be performed using gastric or colon interposition, radial forearm free flap or jejunum free flap, etc. Recently, the advances of radiation therapy and chemotherapy will enable less extended resections with greater rates of laryngeal preservation. At initial presentation, up to 50％ to 70％ of patients will have advanced locoregional or distant disease with virtually no chance for cure. Patients with advanced but potentially resectable esophageal cancer are generally treated by surgery with some form of neoadjuvant chemotherapy, radiotherapy, or both, with 5-year survivals in the 20％ to 30％ range. So the significant adverse factors affecting survival should be taken into account to select the candidates for surgery.

• Journal of the Korean Wood Science and Technology
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• 제46권4호
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• pp.402-414
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• 2018

Species identification of wood provides important information for archaeology, restoration of cultural assets, preventing illegal logging, and more. Wood species are usually identified based on their anatomical features with the use of a microscope. However, this method may not be able to distinguish between anatomically similar species or subspecies. To overcome this problem, wood species need to be identified at the molecular level using DNA sequencing. However, unlike living plant cells, wood is difficult to pulverize using a mortar, and DNA extraction from dried wood is challenging. To solve these problems, we propose a pretreatment method in which wood is pulverized using 60-grit sandpaper and hydrated with water for 2 days. Using this method, we were able to stably amplify the rpoB gene from the extracted DNA of Pinus rigida. In addition, sequence analysis of the rpoB gene revealed six single nucleotide polymorphisms (SNPs), which classified the rpoB sequences in the genus Pinus into five groups. Our data indicate that although these SNPs were not suitable for species identification, they can potentially be used to determine the origin of different wood subspecies or individual samples of wood.

• International Journal of Control, Automation, and Systems
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• 제5권5호
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• pp.547-558
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• 2007

This paper proposes a simpler solution to the stabilization problem of a special class of nonlinear underactuated mechanical systems which includes widely studied benchmark systems like Inertia Wheel Pendulum, TORA and Acrobot. Complex internal dynamics and lack of exact feedback linearizibility of these systems makes design of control law a challenging task. Stabilization of these systems has been achieved using Energy Shaping and damping injection and Backstepping technique. Former results in hybrid or switching architectures that make stability analysis complicated whereas use of backstepping some times requires closed form explicit solutions of highly nonlinear equations resulting from partial feedback linearization. It also exhibits the phenomenon of explosions of terms resulting in a highly complicated control law. Exploiting recently introduced Dynamic Surface Control technique and using control Lyapunov function method, a novel nonlinear controller design is presented as a solution to these problems. The stability of the closed loop system is analyzed by exploiting its two-time scale nature and applying concepts from Singular Perturbation Theory. The design procedure is shown to be simpler and more intuitive than existing designs. Design has been applied to important benchmark systems belonging to the class demonstrating controller design simplicity. Advantages over conventional Energy Shaping and Backstepping controllers are analyzed theoretically and performance is verified using numerical simulations.

• Journal of Oral Medicine and Pain
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• 제39권2호
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• pp.35-45
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• 2014

Many therapeutic modalities including continuous positive airway pressure, surgery, and oral appliances are used to treat patients with sleep-disordered breathing. However, there are no definitive treatment modalities for individual patients due to various causes of sleep-disordered breathing. Clinicians should have select best options for individual patients and it is quite challenging process. Oral appliances attracted clinical attention for its convenience and safety. Several designs of oral appliances are introduces such as soft palate lifter, tongue retaining device, and various appliances which aimed to mandibular advancement. Among these oral appliances, mandibular advancement devices (MADs) are considered the most excellent based on their effectiveness and patient tolerance. Although MADs are not guarantee dramatic outcome and less consistent than continuous positive airway pressure, they offer several advantages over continuous positive airway pressure and surgical methods, including non-invasiveness, silence, portability, and tolerability, simplicity. Therefore, general dental practitioner who had passed sleep dental curriculum or coursework can treat the patients with sleep problems. This article reviews the history, clinical indications, suggested mechanism of actions, various positive effects and several side effects, factors predicting a favorable outcome, determining amounts of mandibular advancement, compliance and long-term efficacy of MADs use.

• Journal of Computational Design and Engineering
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• 제3권1호
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• pp.14-23
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• 2016

The problem of fitting B-spline curves to planar point clouds is studied in this paper. A novel method is proposed to deal with the most challenging case where multiple intersecting curves or curves with self-intersection are necessary for shape representation. A method based on Delauney Triangulation of data points is developed to identify connected components which is also capable of removing outliers. A skeleton representation is utilized to represent the topological structure which is further used to create a weighted graph for deciding the merging of curve segments. Different to existing approaches which utilize local shape information near intersections, our method considers shape characteristics of curve segments in a larger scope and is thus capable of giving more satisfactory results. By fitting each group of data points with a B-spline curve, we solve the problems of curve structure reconstruction from point clouds, as well as the vectorization of simple line drawing images by drawing lines reconstruction.

• Journal of Radiopharmaceuticals and Molecular Probes
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• 제6권1호
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• pp.27-38
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• 2020

Alzheimer's disease (AD) is one of the challenging conditions that have no cure, yet early diagnosis can help to control the disease. PET imaging of tau has several advantages, such as being a noninvasive, safe diagnostic technique that correlates directly with the disease progression. Many tau tracers have been reported to date; however, the chemical scaffolds of them fall in a narrow chemical window, and none was approved yet as none is entirely selective and sensitive to tau. These problems are being solved as new tracers emerge constantly. In this report, the first-generation tau tracers such as [¹¹C]PBB3, 2-arylquinoline (THK) series, [¹⁸F]T808, and [¹⁸F]AV-1451 ([¹⁸F]T807) are reviewed from an organic and radiochemistry perspective; thus the most effective chemical approach to synthesize these tracers is discussed. This would help to design novel tracers which can meet the challenges faced by the current tracers.

• Proceedings of the Korean Geotechical Society Conference
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• 한국지반공학회 1993년도 지하공간 건설기술에 관한 서울 심포지움 논문집
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• pp.235-247
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• 1993

The 62 m span Olympic lee Hockey cavern in Gjovik, Norway, is located in jointed gneiss of average RaD = 70% and has a rock cover of only 25 to 50m, thus posing challenging design p problems. The investigations prior to construction included two types of stress measurements, cross-hole seismic tomography, special coe logging, Q-system classification and numerical modelling with UDEC-BB. Predicted maximum deformations were 4 to 8 mm; surprisingly small due to the high horizontal stresses recorded. Extensometer (MPBX) installations from the surface prior to construction, precision surface levelling and MPBX installed from inside the cavern give a combined measure of maximum deformations in the range 7 to 8 mm with the 62 m span fully e excavated, and three adjacent caverns for the Postal Services also completed.

• The Journal of Korean Institute of Communications and Information Sciences
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• 제18권3호
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• pp.372-384
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• 1993

The inverted pendulum system has interesting and challenging problems related to robotics and rocket attitude control view of both control theory and applications. Generally approximately linearized plant models are employed to control the system. In this paper a recently developed control theory based on differentiable manifold theory is used to control the inverted pendulum system which is typically nonlinear. First, the nonlinear model is transformed into the approximate feedback linearized system by nonlinear state feedback. Secondly, the linear controller is designed using the pole-placement method for the approximate feedback linearized plant model, the output of which are finally inverse-transformed to yield the control input to the actual system of the inverted pendulum. The proposed method is evaluated by the computer simulation to compare with the 3rd order linearization model.