• Proceedings of the CALSEC Conference
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• 2002.01a
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• pp.340-342
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• 2002

ASP Value Chain Modeling ㆍ The Value Chain of ASP Player ㆍ The Value Chain of ASP Customer Successful ASP Delivering Model ㆍ Enterprise ASP Remodeling ㆍ ASP Market Prediction(omitted)

• BMB Reports
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• v.33 no.2
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• pp.120-125
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• 2000

M2PI is an active single chain mini-proinsulin with a 9-residue linker containing the turn-forming sequence 'YPGDV' between the B- and A-chains, but which retains about 50% of native insulin receptor binding activity. The refolding efficiency of M2PI is higher than proinsulin by 20-40% at alkaline pH, and native insulin is generated by the enzymatic conversion of M2PI. The solution structure of M2PI was determined by NMR spectroscopy. The global structure of M2PI is similar to that of native insulin, but the flexible linker between the B- and A-chains perturbed the N-terminal A-chain and C-terminal B-chain. The helix in the N-terminal A-chain is partly perturbed and the ${\beta}$-turn in the B-chain is disrupted in M2PI. However, the linker between the two chains was completely disordered indicating that the designed turn was not formed under the experimental conditions (20% acetic acid). Considering the fact that an insulin analogue, directly cross-linked between the C-terminus of the B-chain and the N-terminus of the A-chain, has negligible binding activity, a flexible linker between the two chains is sufficient to keep binding activity of M2PI, but the perturbed secondary structures are detrimental to receptor binding.

• Korean Journal of Food Science and Technology
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• v.43 no.2
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• pp.220-223
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• 2011

Human basophilic KU812F cells express a high affinity for IgE receptor, $Fc{\varepsilon}RI$, which plays an important role in immunoglobulin E (IgE)-mediated allergic reactions. Using the human basophilic KU812F cells, we assessed the inhibitory effects of the ethanolic extract from Chrysanthemum zawadsaki(CZ) on $Fc{\varepsilon}RI$ ${\alpha}$ chain expression. Flow cytometric analysis showed that cell surface $Fc{\varepsilon}RI$ ${\alpha}$ chain expression was suppressed when the cells were cultured with CZ extract. RT-PCR analysis showed that the mRNAs for $Fc{\varepsilon}RI$ ${\alpha}$ chain decreased by the treatment of CZ extract. Moreover, CZ extract was also observed to result in a reduction in the release of histamine from anti-$Fc{\varepsilon}RI$ antibody (CRA-1)-stimulated cells. These results suggest that CZ extract may exert anti-allergic activity through down-regulation of $Fc{\varepsilon}RI$ ${\alpha}$ chain expression and a subsequent decrease in histamine release.

• Journal of the Korean Operations Research and Management Science Society
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• v.41 no.2
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• pp.101-127
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• 2016

Irrational ordering decisions of supply chain members have been gaining growing importance in the area of supply chain management. Irrational ordering behaviors that deviate from the profit maximizing decisions in the newsvendor settings have observed with human experiments in recent research. These behaviors can be modeled with several typical decision bias elements. This bias in ordering decisions affects the performance of supply chain contracts designed based on the assumption that the supply chain members make optimal decisions, making it necessary to design supply chain contracts by considering the irrationality. The purpose of this research is to derive a method to design the revenue sharing contract that considers human irrationality in ordering decisions. This research considers a simple two-echelon supply chain consisting of one supplier and one retailer, where the supplier is assumed to be perfectly rational while the retailer making newsvendor type ordering decisions displays irrational ordering behaviors. Under this environment, this research analytically models the revenue sharing contract to maximize the total supply chain profit or the supplier's own profits while considering the three decision bias patterns of the retailer, which include the pull-to-center effect, the prospect theory, and the increased subjective sensitivity to the revenue sharing ratio. Irrationality parameters are measured through human experiments based on which and through numerical simulations, we showed that significant improvements in the supply chain performance can be achieved.

• The Journal of Information Systems
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• v.12 no.2
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• pp.57-72
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• 2003

The purpose of this paper is to propose the modeling of multiagent based SCM and implement the prototype in the Internet environment. SCM process follows the supply chain operations reference (SCOR) model which has been suggested by Supply Chain Counsil. SCOR model has been positioned to become the industry standard for describing and improving operational process in SCM. Five basic processes, plan, source, matte, deliver and return are defined in the SCOR model, through which a company establishes its supply chain competitive objectives. A supply chain is a world wide network of suppliers, factories, warehouses, distribution centers and retailers through which raw materials are acquired, transformed or manufactured and delivered to customers by autonomous or semiautonomous process. With the pressure from the higher standard of customer compliance, a frequent model change, product complexity and globalization, the combination of supply chain process with an advanced infrastructure in terms of multiagent systems have been highly required. Since SCM is fundamentally concerned with coherence among multiple decision makers, a multiagent framework based on explicit communication between constituent agents such as suppliers, manufacturers, and distributors is a natural choice. Multiagent framework is defined to perform different activities within a supply chain. Dynamic and changing functions of supply chain can be dealt with multi-agent by cooperating with other agents. In the areas of inventory management, remote diagnostics, communications with field workers, order fulfillment including tracking and monitoring, stock visibility, real-time shop floor data collection, asset tracking and warehousing, customer-centric supply chain can be applied and implemented utilizing multiagent. In this paper, for the order processing event between the buyer and seller relationship, multiagent were defined corresponding to the SCOR process. A prototype system was developed and implemented on the actual TCP/IP environment for the purchase order processing event. The implementation result assures that multiagent based SCM enhances the speed, visibility, proactiveness and responsiveness of activities in the supply chain.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.15 no.1
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• pp.22-31
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• 2009

Purpose The purpose of this study was to compare the effects of closed kinetic chain exercise and open kinetic chain exercise in improving the balance of patients with hemiplegia. Methods Ten patients with stroke were randomly allocated to either a closed kinetic chain exercise (CKC) group(n=5) or an open kinetic chain exercise(OKC) group(n=5). The subjects of each group followed the exercise regimen of their respective groups, and each exercise was performed for 50 mins per day, 3 days per week, for 4 weeks. Assessment was made using Berg Balance Scale (BBS), One Leg Standing(OLS) test, and Timed up and go(TUG) test. The 2 groups were assessed twice: before and after the intervention. Results The TUG test score was significantly different in the CKC group between before and after intervention (p<.05); however, there was no such deference in the OKC group (p>.05). Further, the scores of the BBS and OLS tests were not significantly different for the 2 groups between before and after intervention (p>.05). The hanges in these BBS and OLS score were not significantly different(p>.05); however, there was a significant difference in the change in the TUG scores (p<.05). Conclusion On the basis of the results of this study, we found that the closed kinetic chain exercise is more effective in improving the walking ability and dynamic balance in patients with stroke. Future studies are warranted in this regard.

• Journal of the Korea Safety Management & Science
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• v.13 no.3
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• pp.123-132
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• 2011

Supply chain for the economic development of East Asian economic development model, the study's purpose is to establish. Korea, Japan, China, Russia and Asia, including North Korea and get the status of economic development by focusing on key issues and proposed solutions, within a few years of the coming of a new East Asian economic integration of new supply chain would like to prepare for the era. Weight The weight of the center to the center of East Asia, looking for techniques to approach the supply chain scenario, the economic development strategies and measures were studied. East Asia's economic potential value of the supply chain, identify and recognize the importance and benefits should be Presents detailed country-specific development strategies and leading Asian economies will have to pay the supply chain. Republic of Korea's leading East Asian economies in order to supply the industry, industry development strategy as detailed in the running to move. North and South Korea for economic integration, the era of supply-chain economy, you need to prepare calmly.

• Management & Information Systems Review
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• v.32 no.5
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• pp.45-68
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• 2013

The goal of supply chain integration is to improve the effectiveness and efficiency of supply chain in order to deliver customer value. So, the fit of between supply chain integration strategy and customer value strategy is very important. Therefore, this study explores the different types of relationship between supply chain integration and customer value, as well as in the firm performances. Cluster analysis is used to develop the typology of supply chain integration, and five typology (High Internal Oriented Integration, Medium Oriented Internal Integration, High Supply Chain Integration, High Customer Oriented Integration, Medium Oriented External Integration) are identified. Analysis of variance is used to test the relationship between supply chain integration typology and customer value, and firm performances. The results show that there are statistically significant differences in customer value and firm performances.

• Korean Journal of Remote Sensing
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• v.23 no.5
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• pp.431-437
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• 2007

Multi-Spectral Camera(MSC) on the KOMPSAT-2 satellite was developed and launched as a main payload to provide 1m of GSD(Ground Sampling Distance) for one(1) channel panchromatic imaging and 4m of GSD for four(4) channel multi-spectral imaging at 685km altitude covering l5km of swath width. Since the compression on MSC image chain was required to overcome the mismatch between input data rate and output date rate JPEG-like method was selected and analyzed to check the influence on the performance. In normal operation the MSC data is being acquired and transmitted with lossy compression ratio to cover whole image channel and full swath width in real-time. In the other hand the MSC performance have carefully been handled to avoid or minimize any degradation so that it was analyzed and restored in KGS(KOMPSAT Ground Station) during LEOP(Launch and Early Operation Phase). While KOMPSAT-2 had been developed, new compression method based upon wavelet for space application was introduced and available for next satellite. The study on improvement of image chain including new compression method is asked for next KOMPSAT which requires better GSD and larger swath width In this paper, satellite image chain which consists of on-board image chain and on-ground image chain including general MSC description is briefly described. The performance influences on the image chain between two on-board compression methods which are or will be used for KOMPSAT are analyzed. The differences on performance between two methods are compared and the better solution for the performance improvement of image chain on KOMPSAT is suggested.

• Journal of Digital Convergence
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• v.17 no.5
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• pp.145-155
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• 2019

The Healthcare supply chain management has recently attracted attention as a critical tool to improve service quality and reduce healthcare operational cost. Improving large hospital supply chain performance has become increasingly important as healthcare organizations strive to improve the service quality, while reducing the ever-increasing healthcare cost. This paper explores the strategic areas where the traditional supply chain management may enhance the overall performance of the large hospitals. Based on the literature review and relevant case analysis, this paper argues that the visibility, information sharing and standardization are the critical factors for deploying the supply chain principles, and also proposes the supply chain framework for efficient planning and execution, the use of RFID-enabled system for the end-to-end traceability of medical products, and cross-docking system for minimizing the inventory level in the hospital supply chain. Implications of the study findings are discussed.