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A Case Series of Snake Venom Pharmacopuncture for Chemotherapy-Induced Peripheral Neuropathy: A Retrospective Observational Study

  • Song, Si Yeon;Bae, Kyeore;Shin, Kwhang Ho;Yoo, Hwa-Seung
    • Journal of Pharmacopuncture
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    • v.20 no.4
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    • pp.280-286
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    • 2017
  • Objective: This case series aims to report the efficacy and the safety of using snake venom pharmacopuncture (SVP) for chemotherapy-induced peripheral neuropathy (CIPN). Methods: Three heterogeneous cancer (1 endometrium, 1 cervix, and 1 prostate cancer) patients were referred to the East-West Cancer Center (EWCC), Dunsan Korean Medicine Hospital of Daejeon University, from August 02, 2017, to September 15, 2017, for treatment with SVP, and they were treated with SVP 4 times, 6 times, and 8 times, respectively. During the treatment period, the efficacy of SVP therapy was assessed by using the Numerical Rating Scale (NRS) and the Common Terminology Criteria for Adverse Events (CTCAE), and the stability was evaluated by using blood tests. Following each session, all patients were examined closely for any allergenic responses or adverse effects. Results: All patients showed noticeable improvements of their NRS and CTCAE scores. Except for bleeding and bruising at the SVP injection site, no major side effects were noted. One of the patients reported mild chilling and a sore throat after receiving the second treatment; those symptoms went away after a few hours. No hematologic toxicity, hepatotoxicity, or nephrotoxicity was found on the blood test. Conclusion: The results of this research suggest positive potential benefits of using SVP for treating patients with CIPN. Also, the excellent safety results of SVP seen in this research should lead to larger clinical trials aimed at developing SVP into a potential intervention for managing patients with the symptoms of CIPN.

A Study on the Whipping Phenomena Effect on the Structural Response of Large Container Ships (대형 컨테이너 선박의 구조 응답에 미치는 휘핑 영향도 분석)

  • Kim, Beom-Il;Kim, Min-Su;Seo, Sun-Kee;Park, Jae-Hong
    • Journal of the Society of Naval Architects of Korea
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    • v.55 no.4
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    • pp.341-349
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    • 2018
  • Recently, it has been reported that the whipping response, which is the elastic phenomenon of the ship, may be one of the causes of the ship accident. Unfortunately, the commonly used methodology for evaluating the whipping effect effectively has not been developed yet. In this study, we developed a procedure to estimate the whipping effect of hull in actual design stage. Fluid-structure interaction analysis was performed for a dominant short term sea state to obtain the time series data of vertical wave bending moment including the whipping response by slamming. In order to estimate the whipping effect by using the time series, some signal processing and statistical techniques such as low pass filtering, Weibull fitting and so on, were applied. the hydro-elasticity analysis was performed on container ships of various sizes to evaluate the whipping effect. The parameters that can affect the response of the hull vibration was selected and the effect of these parameters on whipping was analyzed.

An Analysis of Audiovisual Art Exhibition "lux et sonitus" - in the Context of Nam June Paik's Artworks (오디오비주얼아트전 분석 - 백남준의 예술 작품의 관점에서)

  • Yeo, Woon Seung;Yoon, Ji Won
    • Design Convergence Study
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    • v.19 no.2
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    • pp.107-122
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    • 2020
  • "lux et sonitus" is an audiovisual art exhibition series with an artistic combination of music and video at its center. Since its first introduction in 2013, the series have been held five times under the theme of "exhibition of music", presenting works featuring both audio and visual media in an effort to explore the key issues in the field of audiovisual art. In addition to the previous achievement of the exhibition, recent works from the series feature new concepts that explore the possibility of expanding the realm of synesthesia. In this paper, details of the entire series are summarized. In addition, theoretical background behind creative results of the series is analyzed in the context of music, synesthesia and space found in Nam June Paik's audiovisual artwork as a source of inspiration. This will contribute to establishing a vision for the creation/analysis of audiovisual art in the future.

Biomechanical Analysis of Human Stability According to Running Speed: A Comparative Analysis of Lyapunov Exponent and Coefficient of Variation Methods (달리기 속도에 따른 인체 안정성의 생체역학적 분석: 리아프노프 지수와 변이계수 방법의 비교 분석)

  • Ho-Jong Gil
    • Korean Journal of Applied Biomechanics
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    • v.33 no.1
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    • pp.34-44
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    • 2023
  • Objective: The purpose of this study was to examine the effects of increasing running speed on human stability by comparing the Lyapunov Exponent (LyE) and Coefficient of Variation (CV) methods, with the goal of identifying key variables and uncovering new insights. Method: Fourteen adult males (age: 24.7 ± 6.4 yrs, height: 176.9 ± 4.6 cm, weight: 74.7 ± 10.9 kg) participated in this study. Results: In the CV method, significant differences were observed in ankle (flexion-inversion/eversion; p < .05) and hip joint (internal-external rotation; p < .05) movements, while the center of mass (COM) variable in the coronal axis movements showed a significant difference at the p < .001 level. In the LyE method, statistical differences were observed at the p < .05 level in knee (flexion-extension), hip joint (internal-external rotation) movements, and COM across all three directions (sagittal, coronal, and transverse axis). Conclusion: Our results revealed that the stability of the human body is affected at faster running speeds. The movement of the COM and ankle joint were identified as the most critical factors influencing stability. This suggests that LyE, a nonlinear time series analysis, should be actively introduced to better understand human stabilization strategies.

High voltage driver circuit for CNT Field Emission Lamp (CNT(Carbon Nano Tube) FEL(Field Emission Lamp)용 고전압 구동 회로)

  • Kim, Heon-Kyu;Roh, Chung-Wook;Han, Sang-Kyoo;Hong, Sung-Soo;SaKong, Sug-Chin
    • Proceedings of the KIPE Conference
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    • 2007.07a
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    • pp.359-361
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    • 2007
  • 본 논문은 CNT(Carbon Nano Tube) FEL(Field Emission Lamp)에서 애노드(Anode)-캐소드(Cathode) 구동용 고전압 구동 회로 구현에 관한 것이다. 본 논문에서 제안하는 고전압 DC 전원 회로는 턴비가 높은 고전압 트랜스포머의 Leakage 인덕턴스를 이용하는 Series-Resonant 형태의 Full Bridge 컨버터를 적용하고 고전압 트랜스포머와 Voltage Multiplier를 이용한다. 고전압 트랜스의 절연전압을 줄이기 위해서 두개의 트랜스포머와 Voltage Multiplier를 이용하여 애노드 전극에는 Positive 고전압, 캐소드 전극에는 Negative 고전압을 인가한다. 이 경우 애노드와 캐소드 사이의 아크 방전 시에도 구동 IC 및 스위칭 소자를 보호할 수 있는 장점이 있다.

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A Single-Ended Transmitter with Variable Parallel Termination (가변 병렬 터미네이션을 가진 단일 출력 송신단)

  • Kim, Sang-Hun;Uh, Ji-Hun;Jang, Young-Chan
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2010.05a
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    • pp.490-492
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    • 2010
  • A swing level controlled voltage-mode transmitter is proposed to support a stub series-terminated logic channel with center-tapped termination. This transmitter provides a swing level control to support the diagnostic mode and improve the signal integrity in the absence of the destination termination. By using the variable parallel termination, the proposed transmitter maintains the constant output impedance of the source termination while the swing level is controlled. Also, the series termination using an external resistor is used to reduce the impedance mismatch effect due to the parasitic components of the capacitor and inductor. To verify the proposed transmitter, the voltage-mode driver, which provides eight swing levels with the constant output impedance of about $50{\Omega}$, was implemented using a 70nm 1-poly 3-metal DRAM process with a 1.5V supply. The jitter reduction of 54% was measured with the swing level controlled voltage-mode driver in the absence of the destination termination at 1.6-Gb/s.

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A Study on the Confining Effect Due to Geosynthetics Wrapping Compacted Soil Specimen (토목섬유로 보강된 다짐토 공시체의 구속효과 관한 연구)

  • Kim, Eun Ra;Iizuka, Atsushi;Kim, You-Seong;Park, Hong
    • Journal of the Korean Geotechnical Society
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    • v.20 no.5
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    • pp.5-16
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    • 2004
  • This paper presents the modeling of geosynthetic-reinforced compacted soils and discusses the reinforcement effect arising from confining the dilatancy deformation of the soil by geosynthetics. A series of compressive shear tests for compacted sandy soil specimens wrapped by geosynthetics are carried out by quantitatively examining the geosynthetic-reinforcement effect, occurring from a confinement of the dilative deformation in compacted soils during shearing. In the test, the initial degree of compaction is changed for each series of sandy soil specimens so that each series has different degree of dilatancy characteristics. Herein, the axial forces working on the geosynthetics so as to prevent dilative deformation of compacted soils during shearing are measured. Furthermore, the elasto-plastic modeling of compacted soils and a rational determination procedure for input parameters needed in the elasto-plastic modeling are presented. And to describe the irreversible deformation characteristics of compacted soils during shearing, the subloading yielding surface (Hashiguchi (1989)) to the elasto-plastic modeling is introduced. Finally, the elasto-plastic finite element simulation is carried out and the geosynthetic-reinforcement effect is discussed.

Colorectal Cancer Trends in Kerman Province, the Largest Province in Iran, with Forecasting until 2016

  • Roya, Nikbakht;Abbas, Bahrampour
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.2
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    • pp.791-793
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    • 2013
  • Colorectal cancer is one of the most common cancers. The aim of this study is determination its trends in Kerman province and individual cities separately until year 2016. This analytical and modeling study was based of cancer registry data of Kerman University of Medical Sciences, collected during 2001-2010. Among 20,351 cancer case, 792 were colorectal cancer cases in age group 18-93 years with a mean of 59.4 and standard deviation of 15.1. By applying time series and data trends, incidences were predicted until 2016 for the province and each city, with adjustment for population size. In colorectal cases, 413 (52%) were male, and 379 (48%) were female. The annual increasing rate in Kerman province overall was and can be expected to be 6%, and in the cities of the province Rafsanjan, Bardsir, Bam, Kerman, Baft, Sirjan, Jiroft, Kahnuj and Manujan had an increasing range from 5 to 14% by the year 2016. But in Ravar, Zarand and Shahrbabak reduction in rates of at least 2% could be predicted. The time series showed that the trend of colorectal cancer in female will increase 15% and in male 7% by year 2016. Given the trend of this cancer is increasing so that resources will be consumed in the treatment of the patients, efforts shoudlbe focused on prevention and early diagnosis of the disease. Screening could have an important role leading to improved survival.

Analysis of Cationic Surfactants in Cosmetics By Reverse phase Ion-Pair Chromatigraphy with Suressed Conductivity Detector and UV Detector

  • Jong-Keun Choi;Jae
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.23 no.3
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    • pp.161-167
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    • 1997
  • Determination of several cationic surfactants in cosmetics has been investigated. Reverse phase ion pair chromatography was used to identify and quantitate cationic surfactants. Cationic surfactants analyzed in this experiment were cetylpyridium chloride, stearyltrimetylammonium chloride, bezalkonium chloride, benzyldicethylcetylammonium chloride, and bihenyltrimethyl ammonium chloride. The separation was achieved on a reverse phase coumn with 10mM HCl-acetonitrile eluent. In this condition, the most of cationic surfactants with exception of CPC and CTAC respectively with suppressed conductivity detector and UV detector connected in series. The calibration curves obtained by plotting the peak areas of the cationic surfactants were linear at levels ranging from 0.005 to 0.1% correlation coefficient, r=0.9988. The detection limits were 1 to 5ppm in sample solution. The average recoveries of cationic surfactants added to hair treatment cream and hair rinse in three to five experiments were 96.7 105.2% and relative standard deviations were 1.1-3.8%. The case that there were CPC and CTAC in same solution was also tested. CPC and CTAC which couldn't be separated on reverse phase column were quantitated with suppressed conductivity detector and UV detector connected in series. Recovery of CPC and CTAC were 101.6 and 89.2% respectively. The proposed method was applied to the determination of cationic surfactants in commercial hair treatment cream.

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