Journal of Pharmacopuncture (대한약침학회지)

KOREAN PHARMACOPUNCTURE INSTITUTE (대한약침학회)
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A Case Series of Snake Venom Pharmacopuncture for Chemotherapy-Induced Peripheral Neuropathy: A Retrospective Observational Study

  • Song, Si Yeon (East-West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Bae, Kyeore (East-West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Shin, Kwhang Ho (Dalraechon Korean Medicine Clinic) ;
  • Yoo, Hwa-Seung (East-West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University)
  • Received : 2017.11.13
  • Accepted : 2017.11.28
  • Published : 2017.12.31
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Abstract

Objective: This case series aims to report the efficacy and the safety of using snake venom pharmacopuncture (SVP) for chemotherapy-induced peripheral neuropathy (CIPN). Methods: Three heterogeneous cancer (1 endometrium, 1 cervix, and 1 prostate cancer) patients were referred to the East-West Cancer Center (EWCC), Dunsan Korean Medicine Hospital of Daejeon University, from August 02, 2017, to September 15, 2017, for treatment with SVP, and they were treated with SVP 4 times, 6 times, and 8 times, respectively. During the treatment period, the efficacy of SVP therapy was assessed by using the Numerical Rating Scale (NRS) and the Common Terminology Criteria for Adverse Events (CTCAE), and the stability was evaluated by using blood tests. Following each session, all patients were examined closely for any allergenic responses or adverse effects. Results: All patients showed noticeable improvements of their NRS and CTCAE scores. Except for bleeding and bruising at the SVP injection site, no major side effects were noted. One of the patients reported mild chilling and a sore throat after receiving the second treatment; those symptoms went away after a few hours. No hematologic toxicity, hepatotoxicity, or nephrotoxicity was found on the blood test. Conclusion: The results of this research suggest positive potential benefits of using SVP for treating patients with CIPN. Also, the excellent safety results of SVP seen in this research should lead to larger clinical trials aimed at developing SVP into a potential intervention for managing patients with the symptoms of CIPN.

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References

  1. Hausheer FH, Schilsky RL, Bain S, Berghorn EJ, Lieberman F. Diagnosis, Management, and Evaluation of Chemotherapy-Induced Peripheral Neuropathy. Semin Oncol. 2006;33(1):15- 49. https://doi.org/10.1053/j.seminoncol.2005.12.010
  2. Pachman DR, Barton DL, Watson JC, Loprinzi CL. Chemotherapy-induced peripheral neuropathy: prevention and treatment. Clin Pharmacol Ther. 2011;90(3):377-87. https://doi.org/10.1038/clpt.2011.115
  3. Staff NP, Grisold A, Grisold W, Windebank AJ. Chemotherapy- induced peripheral neuropathy: A current review. Ann Neurol. 2017;81(6):772-81. https://doi.org/10.1002/ana.24951
  4. Wolf S, Barton D, Kottschade L, Grothey A, Loprinzi C. Chemotherapy-induced peripheral neuropathy: Prevention and treatment strategies. Eur J Cancer. 2008;44(11):1507-15. https://doi.org/10.1016/j.ejca.2008.04.018
  5. Calderon LA, Sobrinho JC, Zaqueo KD, de Moura AA, Grabner AN, Mazzi MV, et al. Antitumoral activity of snake venom proteins: new trends in cancer therapy. Biomed ResInt. 2014;2014:203639.
  6. Xu J, Song S, Feng F, Huang F, Yang Y, Xie G, et al. Cobrotoxin- containing analgesic compound to treat chronic moderate to severe cancer pain: results from a randomized, double-blind, cross-over study and from an open-label study. Oncol Rep. 2006;16(5):1077- 84.
  7. Chan YS, Cheung RC, Xia L, Wong JH, Ng TB, Chan WY. Snake venom toxins: toxicity and medicinal applications. Appl Microbiol Biotechnol. 2016;100(14):6165-81. https://doi.org/10.1007/s00253-016-7610-9
  8. Rajendra W, Armugam A, Jeyaseelan K. Toxins in anti-nociception and anti-inflammation. Toxicon. 2004;44(1):1-17. https://doi.org/10.1016/j.toxicon.2004.04.014
  9. Shanbhag VKL. Applications of snake venoms in treatment of cancer. Asian Pac J Trop Biomed. 2015;5(4):275-6. https://doi.org/10.1016/S2221-1691(15)30344-0
  10. Park JW, Jeon JH, Yoon J, Jung TY, Kwon KR, Cho CK, et al. Effects of sweet bee venom pharmacopuncture treatment for chemotherapy-induced peripheral neuropathy: a case series. Integr Cancer Ther. 2012;11(2):166-71. https://doi.org/10.1177/1534735411413265
  11. Yoon J, Jeon J-H, Lee Y-W, Cho C-K, Kwon K-R, Shin J-E, et al. Sweet Bee Venom Pharmacopuncture for Chemotherapy-Induced Peripheral Neuropathy. J Acupunct Meridian Stud. 2012;5(4):156-65. https://doi.org/10.1016/j.jams.2012.05.003
  12. National Cancer Institute. Common terminology criteria for adverse events (CTCAE) version 4.03. NCI, NIH, DHHS. May 29, 2009. NIH publication No. 09-7473.
  13. MacPherson H, Altman DG, Hammerschlag R, Youping L, Taixiang W, White A, et al. Revised STandards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA): Extending the CONSORT statement. J Evid Based Med. 2010;3(3):140-55. https://doi.org/10.1111/j.1756-5391.2010.01086.x
  14. Valentine DB, Altshuler LH. Acupuncture for Oxaliplatin Chemotherapy–Induced Peripheral Neuropathy in Colon Cancer: A Retrospective Case Series. Medical Acupuncture. 2015;27(3):216-23. https://doi.org/10.1089/acu.2015.1103
  15. Park SB, Goldstein D, Krishnan AV, Lin CS, Friedlander ML, Cassidy J, et al. Chemotherapy induced peripheral neurotoxicity: a critical analysis. CA Cancer J Clin. 2013;63(6):419-37. https://doi.org/10.3322/caac.21204
  16. Hershman DL, Lacchetti C, Dworkin RH, Lavoie Smith EM, Bleeker J, Cavaletti G, et al. Prevention and man-agement of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol. 2014;32(18):1941-67. https://doi.org/10.1200/JCO.2013.54.0914
  17. Vyas VK, Brahmbhatt K, Bhatt H, Parmar U. Therapeutic potential of snake venom in cancer therapy: current perspectives. Asian Pac J Trop Biomed. 2013;3(2):156-62. https://doi.org/10.1016/S2221-1691(13)60042-8
  18. Marsh N, Williams V. Practical applications of snake venom toxins in haemostasis. Toxicon. 2005;45(8):1171-81. https://doi.org/10.1016/j.toxicon.2005.02.016
  19. Koh CY, Kini RM. From snake venom toxins to therapeutics--cardiovascular examples. Toxicon. 2012;59(4):497- 506. https://doi.org/10.1016/j.toxicon.2011.03.017
  20. Mancin AC, Soares AM, Andriao-Escarso SH, Faca VM, Greene LJ, Zuccolotto S, et al. The analgesic activity of crotamine, a neurotoxin from Crotalus durissus terrificus (South American rattlesnake) venom: a biochemical and pharmacological study. Toxicon. 1998;36(12):1927-37. https://doi.org/10.1016/S0041-0101(98)00117-2