• Archives of Pharmacal Research
• /
• v.22 no.2
• /
• pp.219-224
• /
• 1999

In our search for the anticonvulsant consitutent of Gastrodia elata repeated column chromatographies guided by activity assay led to isolation of an active compound, which was identified as gastrodin on the basis of spectral data. Brain succinic semialdehyde dehydrogenase (SSADH) was inactivated by preincubation with gastrodin in a time-dependent manner and the reaction was monitored by absorption and fluorescene spectroscopic methods. The inactivation followed pseudo-first-order kinetics with the second-rate order constant of $1.2{\times}10^{3} M^{-1} min^{-1}$. The time course of the reaction was significantly affected by the coenzyme NAD^{+}$, which affected complete protection against the loss of the catalytic activity, whereas substrate succinic semialdehyde failed to prevent the inactivation of the enzyme. It is postulated that the gastrodin is able to elevate the neurotransmitter GABA levels in central nervous system by inhibitory action on one of the GABA degradative enzymes, SSADH.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.11 no.12
• /
• pp.2374-2381
• /
• 2007

.We have studied to obtain the properly conditions about impedance matching of the SAW filter for the SPUDT type and the bidirectional transducer type later. And we have studied to obtain the SAW filter for the Slanted Finger Interdigital Transducer(SFIT), was formed on the Langasite substrate and was evaporated by Aluminum-Copper alloy and then we performed computer-simulated by simulator In case the SPUDT, we have employed that the number of pairs of the input and output IDT are 50 pairs and the thickness and the width of reflector are $5000{\AA}$ and $3.6{\mu}m$, respectively. And the of the bidirectional transducer, the width of IDT' fingers and the space between IDT' finger and reflector is $1.8{\mu}m$, respectively. Also, we have performed to series connected the SPUDT type with the bidirectional transducer type filter. The frequency response of the fabricated SAW filter has the property that the center frequency is about 190MHz and bahdwidth at the 3dB is probably 5.3MHz after when we have matched impedance. Also, we could obtain that ripple characteristics is less than 0.3dB and insert loss is probably -20dB after when we have matched impedance.

• Perinatology
• /
• v.28 no.1
• /
• pp.11-19
• /
• 2017

Objective: Human milk bank is known as best alternative option for sick infants. However, only two human milk banks (HMBs) are working in Korea. In the present study, we evaluated the awareness on the HMB in female health care provider to find out the issues that would help facilitating HMB establishment in Korea. Methods: The survey questionnaire was developed by a team composed with neonatologists, obstetricians, nurses, nutritionists, and health care specialists. The survey was performed for female health care workers in Soon Chun Hyang Cheonan Hospital between March and June in 2016. Eighty-eight of 110 questionnaires were collected and the results were analyzed. Results: Most of subjects were found to have correct knowledge on the breast milk feeding. However, only 49% of subjects had awareness of the presence of HMB. Unfortunately, less than half of them could get information about HMB by official way including mass media. In addition, 76% of subjects were found not to want to use HMB. Most important reason was found as a concern on the safety of donor milk including life style of donors, infection controls, and possible nutritional loss of banked milk. Conclusion: The purpose and function of HMB was not widely educated and it seems to be one of most important reasons why women have negative concept about HMB in Korea. Thus, further study is warranted with more numbers of subjects after active public education about the HMB.

• Journal of Korean Medical Science
• /
• v.33 no.48
• /
• pp.309.1-309.13
• /
• 2018

Background: The aim of this study was to observe long-term outcomes of very low birth weight infants (VLBWIs) born between 2013 and 2014 in Korea, especially focusing on neurodevelopmental outcomes. Methods: The data were collected from Korean Neonatal Network (KNN) registry from 43 and 54 participating units in 2013 and 2014, respectively. A standardized electronic case report form containing 30 items related to long-term follow up was used after data validation. Results: Of 2,660 VLBWI, the mean gestational age and birth weight were $29^{1/7}{\pm}2^{6/7}$ weeks and $1,093{\pm}268g$ in 2013 and $29^{2/7}{\pm}2^{6/7}$ weeks and $1,125{\pm}261g$ in 2014, respectively. The post-discharge mortality rate was 1.2%-1.5%. Weight < 50th percentile was 46.5% in 2013 and 66.1% in 2014. The overall prevalence of cerebral palsy among the follow up infants was 6.2% in 2013 and 6.6% in 2014. The Bayley Scales of Infant Developmental Outcomes version II showed 14%-25% of infants had developmental delay and 3%-8% of infants in Bayley version III. For the Korean developmental screening test for infants and children, the area "Further evaluation needed" was 5%-12%. Blindness in both eyes was reported to be 0.2%-0.3%. For hearing impairment, 0.8%-1.9% showed bilateral hearing loss. Almost 50% were readmitted to hospital with respiratory illness as a leading cause. Conclusion: The overall prevalence of long-term outcomes was not largely different among the VLBWI born between 2013 and 2014. This study is the first large national data study of long-term outcomes.

• Journal of the Korean Physical Society
• /
• v.73 no.10
• /
• pp.1420-1430
• /
• 2018

We investigate an entangled system, which is analogous to a composite system of a black hole and Hawking radiation. If Hawking radiation is well approximated by an outgoing particle generated from pair creation around the black hole, such a pair creation increases the total number of states. There should be a unitary mechanism to reduce the number of states inside the horizon for black hole evaporation. Because the infalling antiparticle has negative energy, as long as the infalling antiparticle finds its partner such that the two particles form a separable state, one can trace out such a zero energy system by maintaining unitarity. In this paper, based on some toy model calculations, we show that such a unitary tracing-out process is only possible before the Page time while it is impossible after the Page time. Hence, after the Page time, if we assume that the process is unitary and the Hawking pair forms a separable state, the internal number of states will monotonically increase, which is supported by the Almheiri-Marolf-Polchinski-Sully (AMPS) argument. In addition, the Hawking particles cannot generate randomness of the entire system; hence, the entanglement entropy cannot reach its maximum. Based on these results, we modify the correct form of the Page curve for the remnant picture. The most important conclusion is this: if we assume unitarity, semi-classical quantum field theory, and general relativity, then the black hole should violate the Bekenstein-Hawking entropy bound around the Page time at the latest; hence, the infinite production arguments for remnants might be applied for semi-classical black holes, which seems very problematic.

• Cross-Cultural Studies
• /
• v.39
• /
• pp.381-406
• /
• 2015

Russian nasal consonants / m /, / n / have a feature value not only [+consonant] in common with obstruents, but also [+sonorant] in common with vowels. Nasal / m /(bi-labial) and / n /(dental) have the same place of articulation but different manner of articulation. The feature value of / m / is [+cons, +son, +nas, +ant, -cor, -high, -low, -back, -cont, -del, rel, -strid, +voic], and that of / n / is [+cons, +son, +nas, +ant, +cor, -high, -low, -back, -cont, -del, rel, -strid, + voic]. There is a difference in feature [cor] value of / m / and / n /. In this study it is confirmed that it is a fact that the Russian nasal consonants behave differently from the other consonants in each phonological phenomenon due to their phonological characteristics. The preceding voiced obstruent is changed to an unvoiced one in a process where the last voiceless obstruent in the consonant cluster ' voiced obstruent + nasal /m/ + voiceless obstruent' skips the nasal consonant and spreads its feature value to the preceding voiced obstruent transparently because of the feature [+sonorant] of the nasal consonant. The coronal nasal /n/ participates in a palatalization with the following palatal actively and palatalize preceding plain consonants passively because of markedness hierarchy such as 'Velar > Labial > Coronal'. But the labial nasal /m/ is palatalized with the following velar palatal actively and participates in a palatalization with the following coronal palatal passively. This result helps us confirm the phonological difference of /m/ and /n/ in a palatalization. When the a final consonant is nasal, the unvoicing phenomenon of a final consonant doesn't occur. In such a case as cluster 'obstruent + nasal' the feature value [voiced] of the preceding obstruent doesn't change, but the following nasal can assimilate into the preceding obstruent. When continuing the same nasals / -nn- / in a consonant cluster, the feature value [+cont] of a weak position leads the preceding nasal / n / to be changed into [-cont] / l /. Through the analysis of the frequency of occurrences of consonants in syllabic onsets and codas that should observe the 'Sonority Sequence Principle', the sonority hierarchy of nasal consonants has been confirmed. In a diachronic perspective following nasal / m /, / n / there is a loss of the preceding labial stop and dental stop. But in clusters with the velar stop+nasal, the two-component cluster has been kept phonetically intact.

• Cross-Cultural Studies
• /
• v.38
• /
• pp.265-295
• /
• 2015

This article is concerned about a reason for which Cervantes participates an arabic author named Benengeli and morisco translator in his work instead of christian author. From the multi-cultural point of view, the time in which Don Qujote was published, belongs to the Golden Age. In other words, the society can not be supported by the ideology of Purity of Blood in that the morisco, converso (Christian Jewish) have been permitted to coexist in the name of christian proselyte or New Christian despite of invisible discrimination. An invisible discrimination is based on the prejudice and negative stereotype of Old Christian against the New Christian. Cervantes offers an o open space for readers to participate in the creative reading, giving up the absolute authority of author named Benengeli. The deep-rooted prejudice against morisco or muslim author makes the readers of Don Quijote do reinterpret the contents and have question about his sincerity. This disbelief is partly on the basis of hypothesis that Don Quijote would be passed on orally by an arabic or morisco. Leaving the hypothesis alone, Romance, festival performances of morisco or the aljamia literature in the Iberian Peninsula have the chivalry or knights of the Occident. The chivalry in Romance of morisco means that morisco would seek assimilation into the mainstream of Occidental Christian community. At the same time, morisco would be faced with the dilemma of loss of religious identity. But Taqiyya, islamic doctrine, offsets the dilemma between yearning to assimilate into mainstream and religious conscience of morisco in that Taqiyya permits morisco to convert to Christianity in case that they are in danger of life or the following risk. From this point of view, There is no room for doubt about the fact that Taqiyya contributed to social assimilation or multicultural society of the Iberian Peninsula. It has been a long time since a narrow-minded religious dogma and ideology became a anachronistic relic in multicultural society of Spain such as the Purity of Blood. From a relative viewpoint, Don Quijote provides a ground for the collective intelligence among christian, muslim(morisco) and converso through a liberal community between readers and authors who form a pluralistic society.

• Proceedings of the Korea Water Resources Association Conference
• /
• 2019.05a
• /
• pp.155-155
• /
• 2019

The Agricultural Policy/Environmental eXtender (APEX) models have been developed for assessing agricultural management efforts and their effects on soil and water at the field scale as well as more complex multi-subarea landscapes, whole farms, and watersheds. National Academy of Agricultural Sciences, Wanju, Korea, has modified a key component of APEX application, named APEX-Paddy for simulating water quality with considering appropriate paddy management practices, such as puddling and flood irrigation management. Calibration and validation are an anticipated step before any model application. Simple techniques are essential to assess whether or not a parameter should be adjusted for calibration. However, very few study has been done to evaluate the ability of APEX-Paddy to simulate the impact of multiple management scenarios on nutrients loss. In this study, the observation data from experimental fields at Iksan in South Kora was used in calibration and evaluation process during 2013-2015. The APEX auto- calibration tool (APEX-CUTE) was used for model calibration and sensitivity analysis. Four quantitative statistics, the coefficient of determination ($R^2$),Nash-Sutcliffe(NSE),percentbias(PBIAS)androotmeansquareerror(RMSE)were used in model evaluation. In this study, the hydrological process of the modified model, APEX-Paddy, is being calibrated and tested in predicting runoff discharge rate and nutrient yield. Field-scale calibration and validation processes are described with an emphasis on essential calibration parameters and direction regarding logical sequences of calibration steps. This study helps to understand the calibration and validation way is further provided for applications of APEX-Paddy at the field scales.

• Parasites, Hosts and Diseases
• /
• v.57 no.5
• /
• pp.543-547
• /
• 2019

Toxoplasma gondii can infect humans worldwide, causing serious diseases in pregnant women and immunocompromised individuals. T. gondii rhoptry protein 13 (ROP13) is known as one of the key proteins involved in host cell invasion. In this study, we generated virus-like particles (VLPs) vaccine expressing T. gondii rhoptry ROP13 and investigated VLPs vaccine efficacy in mice. Mice immunized with ROP13 VLPs vaccine elicited significantly higher levels of T. gondii-specific IgG, IgG1, IgG2a, and IgA antibody responses following boost immunization and challenge infection, whereas antibody inductions were insignificant upon prime immunization. Differing immunization routes resulted in differing antibody induction, as intranasal immunization (IN) induced greater antibody responses than intramuscular immunization (IM) after boost and challenge infection. IN immunization induced significantly higher levels of IgG and IgA antibody responses from feces, antibody-secreting cells (ASCs), $CD4^+$ T, $CD8^+$ T cells and germinal center B cell responses in the spleen compared to IM immunization. Compared to IM immunization, IN immunization resulted in significantly reduced cyst counts in the brain as well as lesser body weight loss, which contributed to better protection. All of the mice immunized through either route survived, whereas all na?ve control mice perished. These results indicate that the ROP13 VLPs vaccine could be a potential vaccine candidate against T. gondii infection.

• Korean Journal of Optics and Photonics
• /
• v.13 no.5
• /
• pp.449-454
• /
• 2002

We have studied the effects of incoherent pumping on EIA at the transition between the $F_g=2$ ground state and the $F_e=3$ excited state in $^{85}Rb\;D_1$-line. Generally, the studies about EIA have been done in the cycling transition, where the population has no loss to other states. In the case of EIA by using the $^{85}Rb\;D_1$ transition line, the population is transferred to the other hyperfine state due to optical pumping. We incoherently pumped the atoms from $F_g=3\;to\;F_g=2$ with the pumping beam, which is resonant at the transition from $F_g=3\;to\;F_g=2$. We were able to observe the effects of incoherent pumping depending on the power and the polarization of the pumping beam.