• Proceedings of the Ginseng society Conference
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• 1998.06a
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• pp.253-262
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• 1998

Ochratoxin A (OA) is a potent mycotoxin causing considerable health hazard and economic loss- e,i. OA is of concern as it is hepato-nephrotoxic, mutagenic, and carcinogenic to a great variety of animals. LDso of crude OA was 8.5 mgf kg.b.w., i.p. The clinical symptoms, mortalities and necropsy were recorded in rats injected with OA (LD5o, i.p.) during 10 days of daily treatment. Ginseng treatments (20 mg 1 kg. b.w., i.p.) : before, mixed with, or after OA dose, completely prevented the mortality in rats. OA-treated animals showed microcytic normochromic anaemia, lucocytosis, hypoproteinaemia and elevation of serum ALT, AST, AP, urea, and creatinine values. These findings were declined near the normal levels when ginseng injected with OA. OA (115 LDso) induced chromosomal aberrations (65.66%) compared to the control. When ginseng given 10 min before OA injection, chromosomal aberrations were reduced to be 31.66% compared to OA-treated animals. In conclusion: ginseng has a protective effect against ochratoxicosis, it has anti-genotoxic activity and it can repair the chromosomal damage induced by ochratoxin A. Key words Ochratoxicosis, Chromosomal aberrations, Mycotoxins, Ochratoxin A, Korean gin sting, Protective effect of Panax ginseng, Rat

• International Journal of Advanced Culture Technology
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• v.11 no.2
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• pp.191-195
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• 2023

An X-event is an event that is difficult to predict and unlikely to occur, but if it occurs, it has a very large ripple effect, such as loss of life, property, territory, and emotional turmoil. Extreme events are unlikely to occur, but they can happen someday, and if they do, they have a great impact on society as a whole, so they must be prepared to minimize the impact and impact. For this purpose, we collected opinions from low-level experts at the Korea Army Research Center for Future & Innovation and the Army College on extreme events that can trigger the near future (10 years) in the field of high-tech science and technology, which is currently developing rapidly after the 4th Industrial Revolution. The researchers intend to synthesize and analyze this data to derive implications and provide a response direction to alleviate the ultra-uncertainty of extreme events and provide a cornerstone for crisis management strategies for the occurrence of serial and simultaneous extreme events.

• Archives of Metallurgy and Materials
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• v.65 no.3
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• pp.1019-1022
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• 2020

In the past few years, overhead copper transmission lines have been replaced by lightweight aluminum transmission lines to minimize the cost and prevent the sagging of heavier copper transmission lines. High strength aluminum alloys are used as the core of the overhead transmission lines because of the low strength of the conductor line. However, alloying copper with aluminum causes a reduction in electrical conductivity due to the solid solution of each component. Therefore, in this study, the authors attempt to study the effect of various Al/Cu ratios (9:1, 7:3, 5:5) to obtain a high strength Al-Cu alloy without a significant loss in its conductivity through powder metallurgy. Low-temperature extrusion of Al/Cu powder was done at 350℃ to minimize the alloying reactions. The as-extruded microstructure was analyzed and various phases (Cu9Al₄, CuAl₂) were determined. The tensile strength and electrical conductivity of different mixing ratios of Al and Cu powders were studied. The results suggest that the tensile strength of samples is improved considerably while the conductivity falls slightly but lies within the limits of applications.

• Molecules and Cells
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• v.39 no.5
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• pp.382-388
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• 2016

Inherited peripheral neuropathies (IPN), which are a group of clinically and genetically heterogeneous peripheral nerve disorders including Charcot-Marie-Tooth disease (CMT), exhibit progressive degeneration of muscles in the extremities and loss of sensory function. Over 70 genes have been reported as genetic causatives and the number is still growing. We prepared a targeted gene panel for IPN diagnosis based on next generation sequencing (NGS). The gene panel was designed to detect mutations in 73 genes reported to be genetic causes of IPN or related peripheral neuropathies, and to detect duplication of the chromosome 17p12 region, the major genetic cause of CMT1A. We applied the gene panel to 115 samples from 63 non-CMT1A families, and isolated 15 pathogenic or likelypathogenic mutations in eight genes from 25 patients (17 families). Of them, eight mutations were unreported variants. Of particular interest, this study revealed several very rare mutations in the SPTLC2, DCTN1, and MARS genes. In addition, the effectiveness of the detection of CMT1A was confirmed by comparing five 17p12-nonduplicated controls and 15 CMT1A cases. In conclusion, we developed a gene panel for one step genetic diagnosis of IPN. It seems that its time- and cost-effectiveness are superior to previous tiered-genetic diagnosis algorithms, and it could be applied as a genetic diagnostic system for inherited peripheral neuropathies.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.44 no.12
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• pp.7-11
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• 2007

In this paper, we proposed the dual-mode stepped impedance ring resonator bandpass filter for MMIC (Microwave Monolithic Integrated Circuit) applications using the dielectric-supported air-gapped microstrip line (DAML). The ring resonator fabricated by surface micromachining technology. This filter consists of a DAML resonator layer and a CPW feed line. The DAML ring resonator is elevated with $10{\mu}m$ height from GaAs substrate surface. This bandpass filter is $1-{\lambda}g$ type stepped impedance ring resonator including dual-mode resonance. From the measurements, we obtained attenuation of over 15 dB and insertion loss of 2.65 dB at the center frequency of 97 GHz. Relative bandwidth is about 12 % at 97 GHz. Furthermore, the proposed bandpass filter is useful to integrate with conventional MMICs.

• Journal of Korean Clinical Nursing Research
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• v.22 no.3
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• pp.345-351
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• 2016

Purpose: The specific aims of this study were to investigate the incidence, time of occurrence, intervention methods and related causes of abdominal discomfort after scoliosis corrective surgery. Methods: A retrospective review was carried out on all patients with diagnosis of adolescent idiopathic scoliosis (n=420) who received a posterior spinal fusion between January 2012 and December 2014. Logistic regression analysis was used to identify significant related factors. Results: One hundred eighty five of the patients in the study (44.0%) reported abdominal discomfort (AD group). The discomfort was worst on 2nd days after operation (31.4%), and 3rd days (27.0%). Ninety seven patients (52.4%) in the AD group received enema treatment. Significant related factors for developing abdominal discomfort were distal fusion levels (OR=2.43, p<.006) and increased operative blood loss (OR=1.03, p<.001). Conclusion: The incidence of abdominal discomfort after scoliosis corrective surgery in this study was 44%. Abdominal discomfort, therefore, is a main concern in reference to scoliosis corrective surgery, and solutions need to be searched and reported in future research.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.21 no.3
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• pp.168-176
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• 2011

Objectives: Hundreds of thousands of call center workers are wearing an acoustic device for their businesses, such as telemarketing and customer counseling, and the number of the workers are increasing sharply. Because call center workers always talk to dozens of customers over the headset, they would be placed under the state of a higher risk with their hearing ability. The purpose of this study is to investigate factors that affect the hearing thresholds for the call center workers. Methods: This study investigated hearing losses of 101 workers of 5 call centers in Korea by executing puretone audiometry and self-administered questionnaires. A cross table analysis was processed to compare gender differences between male and female. Male and female hearing thresholds were compared with the Students' t-test, and one-way ANOVA was conducted to observe the difference between non-occupational and occupational characteristics in 2, 3, 4, 6, and 8 kHz hearing thresholds for the female workers. Additionally, multiple regression analysis was conducted to find the factors that affect the 4 kHz hearing thresholds. Results and Conclusions: Male hearing thresholds were higher than those of female except for 8 kHz. In the group having an ear related disease, hearing threshold of male left ear was highly affected rather than that of female in 4 kHz. There were significant differences in the variables of alcohol drinking (2 kHz) and headset volume (8 kHz) in both ears. While this study does not show any significant factors that affect the hearing thresholds in the occupational characteristics, the gender and the previous ear related diseases, non-occupational characteristics, were found as the factors in 4 kHz. It is suggested that the more detailed survey be performed to identify the occupational factors that affect the hearing thresholds in the call center workers based on the result derived from this study.

• Natural Product Sciences
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• v.10 no.3
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• pp.124-128
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• 2004

Previously, $(1R,9S)-{\beta}-Hydrastine$ hydrochloride has been found to lower dopamine content in PC12 cells (Kim et al., 20001). In this study, the effects of $(1R,9S)-{\beta}-Hydrastine$ hydrochloride on L-DOPA-induced cytotoxicity in PC12 cells were investigated. Treatment with $(1R,9S)-{\beta}-Hydrastine$ hydrochloride at concentrations higher than $500\;{\mu}M$ caused cytotoxicity in PC12 cells. In addition, $(1R,9S)-{\beta}-Hydrastine$ hydrochloride at non-cytotoxic or cytotoxic concentrations significantly enhanced L-DOPA-induced cytotoxicity (L-DOPA concentration, $50\;{\mu}M$). Treatment of PC12 cells with $750\;{\mu}M$ $-1R,9S)-{\beta}-Hydrastine$ hydrochloride and $50\;{\mu}M$ L-DOPA, alone or in combination, also induced cell death via a mechanism which exhibited morphological and biochemical characteristics of apoptosis, including chromatin condensation and membrane blebbing. Exposure of PC12 cells to $(1R,9S)-{\beta}-Hydrastine$ hydrochloride, L-DOPA and $(1R,9S)-{\beta}-Hydrastine$ hydrochloride plus L-DOPA for 48 h resulted in a marked increase in the cell loss and percentage of apoptotic cells compared with exposure for 24 h. These data indicate that $(1R,9S)-{\beta}-Hydrastine$hydrochloride at higher concentration ranges aggravates L-DOPA-induced neurotoxicity cytotoxicity in PC12 cells. Therefore, it is proposed that the long-term L-DOPA therapeutic patients with $(1R,9S)-{\beta}-Hydrastine$ hydrochloride could be checked for the adverse symptoms.

• The Journal of the Korea institute of electronic communication sciences
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• v.14 no.6
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• pp.1109-1120
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• 2019

In the field of VLBI, If the quality of the connected network between the VLBI station and the correlation center is ensured, the existing inefficiency of repeatedly storing the observation data in each station and the correlation center can be overcome. In other words, the data center can be unified with the correlation center where data analysis is performed, which can improve data processing speed and productivity. In this paper, we design a massive VLBI data system that directly transmits and stores the observation data stream obtained from the VLBI station to the correlation center via the high - speed network KREONET. Based on this system, VLBI test observations confirmed that the observation data was stored perfectly in the recording system of the correlation center without a single packet loss.

• Journal of Preventive Medicine and Public Health
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• v.46 no.5
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• pp.282-290
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• 2013

Objectives: This study aimed to develop a health needs assessment (HNA) tool for persons with brain disorders and to assess the unmet needs of persons with brain disorders using the developed tool. Methods: The authors used consensus methods to develop a HNA tool. Using a randomized stratified systematic sampling method adjusted for sex, age, and districts, 57 registered persons (27 severe and 30 mild cases) with brain disorders dwelling in Seoul, South Korea were chosen and medical specialists investigated all of the subjects with the developed tools. Results: The HNA tool for brain disorders we developed included four categories: 1) medical interventions and operations, 2) assistive devices, 3) rehabilitation therapy, and 4) regular follow-up. This study also found that 71.9% of the subjects did not receive appropriate medical care, which implies that the severity of their disability is likely to be exacerbated and permanent, and the loss irrecoverable. Conclusions: Our results showed that the HNA tool for persons with brain disorders based on unmet needs defined by physicians can be a useful method for evaluating the appropriateness and necessity of medical services offered to the disabled, and it can serve as the norm for providing health care services for disabled persons. Further studies should be undertaken to increase validity and reliability of the tool. Fundamental research investigating the factors generating or affecting the unmet needs is necessary; its results could serve as basis for developing policies to eliminate or alleviate these factors.