• Tuberculosis and Respiratory Diseases
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• 제51권2호
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• pp.135-146
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• 2001

배 경 : 암세포는 정상 세포와 다르므로 면역 기전에 의해 제거되어야 함에도 불구하고 암이 발생하는 것은 암세포가 면역 감시 체계를 회피하기 때문이다. 약제감수성 증강 유전자인 herpes simplex thymidine kinase(HSTK) 유전자를 이용하여 암세포를 파괴하여 종양 특이항원이 더 잘 유리되도록 하고 사이토카인 유전자를 이용하여 면역세포를 유도하여 이 장애를 극복할 수 있는지 보고자 이 실험을 하였다. 방 법 : Lewis 폐암 세포주(LLC)에 adenovirus를 이용하여 HSTK를 형질도입하고 이에 의해 ganciclovir에 대한 LLC의 감수성을 증강시키는지를 관찰하고 mixed population assay를 이용하여 bystander 효과를 관찰하였다. Ad-HSTK, Ad-IL-2, Ad-GMCSF의 형질도입이 LLC의 종양 형성 능력에 영향을 미치는지 관찰하였다. 또한 그러한 형질 도입이 기존의 종양에 대한 항암 효과를 가져오는지 관찰하였다. 항암 효과의 기전을 확인하기 위해 쥐의 비장을 관찰하였다. 결 과 : Ad-HSTK의 형질도입은 ganciclovir에 대한 LLC의 감수성을 현저하게 증강시켰다. Ad-HSTK, Ad-IL-2, Ad-GM-CSF를 형질도입한 LLC를 쥐에 주사하고 ganciclovir로 처리하였을 때 종양 형성 능력이 감소하였다. Ad-HSTK, Ad-IL-2, Ad-GM-CSF를 형질도입한 LLC를 종양백신으로 사용하였을때 종양 성장이 어느 정도 저해되는 것을 관찰하였다. 특히 HSTK와 GM-CSF를 복합 형질도입했을 때 더 강력한 항암효과가 일어나는 것을 관찰하였다. 그러나 HSTK와 IL-2을 복합 형질도입했을 때는 각각을 단독으로 형질도입했을 때보다 항암효과가 상승되지 않았다. HSTK와 GM-CSF의 복합 형질도입한 LLC를 종양백신으로 사용하였을 때 비장의 수상세포 침윤이 현저히 증가하였다. 결 론 : HSTK와 GM-CSF의 복합 형질도입으로 만든 종양백신은 수상세포를 활성화시키므로써 항암면역기능을 유의하게 증강시킬 수 있었다.

• Macromolecular Research
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• 제11권6호
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• pp.437-443
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• 2003

A series of alternating and alternating block copolycarbonates containing the constituent groups of polysulfone was synthesized through a multi-step solution condensation method. For the regulation of block length, monodisperse oligomers were prepared by using a large excess of the bisphenols and were subsequently incorporated into the copolymer chains. Separating the unreacted bisphenols from the oligomers by dissolution/precipitation steps took advantage of solubility differences. The structures of the monomers, oligomers, and copolymers were characterized and confirmed by GPC, NMR spectroscopy, mass spectrometry, and elemental analysis. Monodispersity of the oligomers, which is critical for control over the block length in the copolymers, was confirmed by GPC and mass spectrometry. Of the two constituent groups of the polysulfone, the sulfone linkage stiffens the polycarbonate copolymer chain, while the ether linkage softens it.

• Journal of Korean Neurosurgical Society
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• 제42권1호
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• pp.49-52
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• 2007

The authors report a unique case of unilateral Moyamoya disease with a rare combination of arteriovenous malformation (AVM) who presented with intracerebral hemorrhage (ICH). A 50-year-old man suffered from sudden onset of mental deterioration and right hemiparesis. Brain computed tomography (CT) showed intracerebral hemorrhage on left thalamus. Brain CT angiography and cerebral digital subtraction angiography (DSA) revealed AVM combined with unilateral moyamoya disease involving left middle cerebral artery (MCA) and choroid plexus in left lateral ventricle. Intraventricular hemorrhage and hydrocephalus were managed conservatively. A rare case of unilateral Moyamoya disease accompanied by a cerebral arteriovenous malformation is described and discussed with review of pertinent literature.

• Parasites, Hosts and Diseases
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• 제43권3호
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• pp.115-117
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• 2005

The Kato-Katz (KK) method is a well-known method of fecal examination for helminthiases. Its diagnostic sensitivity was found very high for clonorchiasis. The present study evaluated the correlation of Clonorchis sinensis egg counts by the KK method with those by direct smear and formalin-ether (FE) technique. The egg counts obtained by the KK method (Y) were correlated with the counts by direct smear (X) with the equation of Y = 659.4 + 0.266X ($r^2$ = 0.738), but not with those by the FE method. The present study demonstrated that the KK method and direct smear were useful for both qualitative and quantitative diagnosis of clonorchiasis, especially in the field.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2000년도 제1회 학술대회 논문집
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• pp.217-218
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• 2000

This paper describes a formation of the Mo-silicide on Mo tip to compare the emission characteristics of the Mo tip. Cone-shaped Mo tip arrays were fabricated and silicidized by evaporating a 15nm-thick a-Si film on Mo tip arrays and annealing it in inert ambient at the temperature of $1000\;^{\circ}C$ for 60 sec. The $Mo_5Si_3$ phase of Mo-silicide was observed through X-ray diffraction (XRD) analysis. Although the gate voltage of the Mo-silicide tip increased by 38 V to obtain the current level of 20 nA/tip, the dependence of emission current on vacuum level was improved.

• 대한생식의학회:학술대회논문집
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• 대한불임학회 2006년도 제51차 추계학술대회
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• pp.159-160
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• 2006

• 한국동물학회:학술대회논문집
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• 한국동물학회 1996년도 한국생물과학협회 국제학술대회
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• pp.151.2-151
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• 1996

No Abstract, See Full Text

• JSTS:Journal of Semiconductor Technology and Science
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• 제14권6호
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• pp.755-759
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• 2014

We propose an integrate-and-fire neuron circuit and synaptic devices with the floating body MOSFETs. The synaptic devices consist of a floating body MOSFET to imitate biological synaptic characteristics. The synaptic learning is performed by hole accumulation. The synaptic device has short-term and long-term memory in a single silicon device. I&F neuron circuit emulate the biological neuron characteristics such as integration, threshold triggering, output generation, and refractory period, using floating body MOSFET. The neuron circuit sends feedback signal to the synaptic transistor for long-term memory.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1993년도 하계학술대회 논문집 A
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• pp.323-325
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• 1993

In this paper, an output feedback controller is proposed for continuous time-invariant linear systems. The proposed controller, LQ-FIR consists of an LQ control gain and an optimal FIR filter. The LQ-FIR controller is derived, and the stability of the closed loop system is proved. The bounds of parameter variations guaranteeing the closed loop stability are obtained, when the LQ-FIR controller is applied to the system with model uncertainties.

• 한국자기학회:학술대회 개요집
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• 한국자기학회 2014년도 자성 및 자성재료 국제학술대회
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• pp.34-34
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• 2014